WO2001002355A3 - Syntheses d'indoles - Google Patents

Syntheses d'indoles Download PDF

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Publication number
WO2001002355A3
WO2001002355A3 PCT/US2000/017580 US0017580W WO0102355A3 WO 2001002355 A3 WO2001002355 A3 WO 2001002355A3 US 0017580 W US0017580 W US 0017580W WO 0102355 A3 WO0102355 A3 WO 0102355A3
Authority
WO
WIPO (PCT)
Prior art keywords
indole synthesis
array
present
compounds
formula
Prior art date
Application number
PCT/US2000/017580
Other languages
English (en)
Other versions
WO2001002355A2 (fr
Inventor
Barry A Bunin
Original Assignee
Axys Pharm Inc
Barry A Bunin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharm Inc, Barry A Bunin filed Critical Axys Pharm Inc
Priority to AU57687/00A priority Critical patent/AU5768700A/en
Publication of WO2001002355A2 publication Critical patent/WO2001002355A2/fr
Publication of WO2001002355A3 publication Critical patent/WO2001002355A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Cette invention concerne un procédé de synthèse d'indoles substitués ou non ou d'un ensemble d'indoles substitués ou non. Elle porte en particulier sur un procédé de synthèse d'un composé ou d'un ensemble de composés représentés par la formule . L'invention concerne également un ensemble de composés de formule (I).
PCT/US2000/017580 1999-07-01 2000-06-26 Syntheses d'indoles WO2001002355A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57687/00A AU5768700A (en) 1999-07-01 2000-06-26 Indole synthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14216399P 1999-07-01 1999-07-01
US60/142,163 1999-07-01

Publications (2)

Publication Number Publication Date
WO2001002355A2 WO2001002355A2 (fr) 2001-01-11
WO2001002355A3 true WO2001002355A3 (fr) 2001-06-28

Family

ID=22498789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/017580 WO2001002355A2 (fr) 1999-07-01 2000-06-26 Syntheses d'indoles

Country Status (2)

Country Link
AU (1) AU5768700A (fr)
WO (1) WO2001002355A2 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62138469A (ja) * 1985-12-11 1987-06-22 Yoshitomi Pharmaceut Ind Ltd インド−ル誘導体
EP0299076A1 (fr) * 1987-01-23 1989-01-18 Yoshitomi Pharmaceutical Industries, Ltd. Compose de 5-hydroxyindole-3-carboxamide et son usage en medecine
WO1995002566A1 (fr) * 1993-07-16 1995-01-26 Ontogen Corporation Synthese d'agencements combinatoires de composes organiques grace a la synthese d'agencements combinatoires a constituants multiples
WO1997044319A1 (fr) * 1996-05-23 1997-11-27 Pharmacia & Upjohn S.P.A. Synthese combinatoire en phase solide d'une banque de derives d'indole
GB2316941A (en) * 1996-07-02 1998-03-11 Merck & Co Inc Combinatorial sythesis on soluble polyvalent supports
WO1998035923A1 (fr) * 1997-02-14 1998-08-20 Massachusetts Institute Of Technology Procede permettant de creer de la diversite moleculaire
WO1999009007A1 (fr) * 1997-08-21 1999-02-25 American Home Products Corporation Synthese en phase solide de composes d'indole a disubstitution en position 2,3

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62138469A (ja) * 1985-12-11 1987-06-22 Yoshitomi Pharmaceut Ind Ltd インド−ル誘導体
EP0299076A1 (fr) * 1987-01-23 1989-01-18 Yoshitomi Pharmaceutical Industries, Ltd. Compose de 5-hydroxyindole-3-carboxamide et son usage en medecine
WO1995002566A1 (fr) * 1993-07-16 1995-01-26 Ontogen Corporation Synthese d'agencements combinatoires de composes organiques grace a la synthese d'agencements combinatoires a constituants multiples
WO1997044319A1 (fr) * 1996-05-23 1997-11-27 Pharmacia & Upjohn S.P.A. Synthese combinatoire en phase solide d'une banque de derives d'indole
GB2316941A (en) * 1996-07-02 1998-03-11 Merck & Co Inc Combinatorial sythesis on soluble polyvalent supports
WO1998035923A1 (fr) * 1997-02-14 1998-08-20 Massachusetts Institute Of Technology Procede permettant de creer de la diversite moleculaire
WO1999009007A1 (fr) * 1997-08-21 1999-02-25 American Home Products Corporation Synthese en phase solide de composes d'indole a disubstitution en position 2,3

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CORINNE E. AUGELLI-SZAFRAN ET AL.: "Identification and Characterization of m4 selective muscarinic antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, 1998, pages 1991 - 1996, XP004137172 *
INGEMAR NILSSON ET AL.: "Studies of Chiral indoles. Part III. The Absolute configuration of 1-(1_phenylethyl)indole", ACTA CHEMICA SCANDINAVICA, vol. B41, 1987, pages 261 - 266, XP000961035 *
J. M. PAWLAK ET AL.: "A Practical Nenitzescu-Based Synthesis of LY311727, the First Potent and Selective s-PLA2 Inhibitor", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 61, no. 25, 1996, pages 9055 - 9059, XP002154025 *
MASAHIKO KINUGAWA ET AL.: "facile synthesis of the key intermediate of EO 9 via the formation of the indole skeleton using the nenitzescu reaction", JOURNAL OF THE CHEMICAL SOCIETY PERKIN TRANSACTIONS 1, 1995, pages 2677 - 2678, XP002154024 *
PATENT ABSTRACTS OF JAPAN vol. 011, no. 369 (C - 461) 2 December 1987 (1987-12-02) *
RODNEY W. PARR ET AL.: "An Application of the Nenitszescu Reaction to the Synthesis of 1,2-Annulated Indoles and Benz[g]indoles", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 37, 1984, pages 1263 - 70, XP000965379 *

Also Published As

Publication number Publication date
WO2001002355A2 (fr) 2001-01-11
AU5768700A (en) 2001-01-22

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