WO2001001954A1 - Composition de comprime pour l'hygiene personnelle - Google Patents

Composition de comprime pour l'hygiene personnelle Download PDF

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Publication number
WO2001001954A1
WO2001001954A1 PCT/US1999/014900 US9914900W WO0101954A1 WO 2001001954 A1 WO2001001954 A1 WO 2001001954A1 US 9914900 W US9914900 W US 9914900W WO 0101954 A1 WO0101954 A1 WO 0101954A1
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WO
WIPO (PCT)
Prior art keywords
composition
personal hygiene
agent
tablet
tableting
Prior art date
Application number
PCT/US1999/014900
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English (en)
Inventor
Ashok Premchand Luhadiya
Venkatraman Narayanaswamy Iyer
Larry Savio Cardozo
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to PCT/US1999/014900 priority Critical patent/WO2001001954A1/fr
Priority to AU50867/99A priority patent/AU5086799A/en
Publication of WO2001001954A1 publication Critical patent/WO2001001954A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms

Definitions

  • the present invention generally relates to a personal hygiene composition in tablet form.
  • the present invention relates to a personal hygiene tablet composition for skin and hair cleansing comprising a cleansing component in combination with a tableting carrier.
  • liquid products are easy to use, e.g., lathering easily between the palms or on a sponge
  • liquid products may drain from a container and soil a container when used and/or stored.
  • such liquid products may be favorable for the growth of fungi and/or bacteria.
  • Tablet is a typical product form seen in various industries, because of the associated ease of manufacturing and handling, e.g., storing, carrying in bags, or using. Particularly, consumers prefer to use such portable, easy-to-handle products when traveling or participating in out door activities such as camping. Therefore, such convenience of tablets and the fact that products are stable and provide no messiness may be desirable in storage and carrying in various situations including that described above.
  • Examples of previously-known cleansing tablets include those described in Constantine et al. U.S. Patent 4,996,006 issued February 26, 1991 , disclosing a solid shampoo tablet composition containing a detergent and water; and Imperatori U.S. Patent 5,062,994 issued November 5, 1991 , disclosing water- free cleansing composition in tablet form which contains powder cleansing substances and powder absorbing powders.
  • conventional tablet products tend to have a hard solid compact matrix, such that may not soften or dissolve easily when used, particularly when only a small amount of water is applied.
  • the present invention is directed to a personal hygiene composition in tablet form comprising: (a) from about 3.0% to about 50% of a cleansing component; (b) from about 0.02% to about 5.5% of a thickening agent; (c) from about 0.25% to about 10% of a conditioning agent; and (d) from about 35% to about 85% a tableting carrier.
  • the thickening agent is preferably selected from the group consisting of xanthan, dextran, cellulose derivatives, and mixtures thereof.
  • ingredients useful herein may be categorized or described by their cosmetic and/or therapeutic benefit or their postulated mode of action. However, it is to be understood that such ingredients can, in some instances, provide more than one cosmetic and/or therapeutic benefit or operate via more than one mode of action. Therefore, classifications herein are made for the sake of convenience and are not intended to limit an ingredient to the particularly stated application or applications listed.
  • cosmetically-acceptable carrier means one or more compatible dermatologically-acceptable solid or liquid filler diluents or encapsulating substances.
  • compositions and/or emulsions or components thereof so described are suitable for use in contact with human skin without undue toxicity, incompatibility, instability, irritation allergic response, and the like, commensurate with a reasonable benefit/risk ratio.
  • solid tablet means a material which has a hard shape and is made by compressing granules pre-mixed into a predetermined shape or direct compression of ingredients contained, which includes, e.g., pills, lozenges, and troches.
  • paste means a material which is in smooth liquid form having higher or lower viscosity, e.g., gel form and cream form.
  • the present invention is directed to a personal hygiene composition in tablet form comprising: (a) from about 3.0% to about 50% of a cleansing component; (b) from about 0.02% to about 5.5% of a thickening agent; (c) from about 0.25% to about 10% of a conditioning agent; and (d) from about 35% to about 85% a tableting carrier.
  • the thickening agent of the present composition is preferably selected from the group consisting of xanthan, dextran, cellulose derivatives, and mixtures thereof.
  • personal hygiene composition means a composition for cleansing the human body, particularly used for skin or hair cleansing.
  • the personal hygiene composition of the present invention provides desirable dissolution, in that the solid matrix of the cleansing tablet quickly transforms into a thick and smooth viscous paste, when contacted with water.
  • Such desirable property is due to the tablet matrix having higher porosity than the conventional tablet composition.
  • water applied immediately penetrates into the tablet matrix when contacted so as to hydrate the tablet composition, even if the amount of water applied is small.
  • the hydration leads to transformation of the tablet composition into a smooth and thick viscous paste or soft gel form.
  • paste or soft gel can be easily scrubbed between the palms or on a body surface with the hand or with the use of a sponge or cloth.
  • the personal hygiene composition of the present invention has a tablet matrix having from about 1.87 g/cr ⁇ )3 to about 2.58 g/cm ⁇ , more preferably from about 1.92 g/cm ⁇ to about 2.35 g/cm ⁇ , of bulk density.
  • the personal hygiene tablet composition also provides improved stability of the products because it contains a low level of water.
  • the personal hygiene composition in tablet form of the present invention contains from about 3.0% to about 50%, preferably from about 7% to about 30%, of a cleansing component.
  • the cleansing component is selected from the group consisting of synthetic surfactants, soaps, and mixtures thereof.
  • the synthetic surfactant useful herein includes those selected from the group consisting of anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants, and mixtures thereof.
  • Suitable surfactants for use in the compositions of the present invention are disclosed in McCutcheon's, Detergents and Emulsifiers, North American edition (1986), published by allured Publishing Corporation; Steuri et al. U.S. Patent 5,151 ,210, issued September 29, 1992; McCall et al. U.S. Patent 5,151 ,209, issued September 29, 1992; Wells et al. U.S. Patent 5,120,532, issued June 9, 1992; Ciotti et al. U.S.
  • anionic surfactants include alkylglycerylether sulfonates, alkyl sulfates, essentially saturated C15.20 alkyl sulfates, acyl isethionates, acyl sarcosinates, alkyl monoglyceryl sulfates, trideceth sulfates, acyl lactylate, methylacyl taurates, paraffin sulfonates, linear alkyl benzene sulfonates, N-acyl glutamates, alkyl sulfosuccinates, alpha sulfo fatty acid esters, alkyl ether carboxylates, alkyl phosphate esters, ethoxylated alkyl phosphate esters, betaines, alkylglycerylether sulfonates, alkyl sulfates, essentially saturated C15.20 alkyl sulfates, acyl isethionates,
  • amphoteric and zwitterionic surfactants useful herein are those which are broadly described as derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be straight or branched chain and wherein one of the aliphatic substituents contains from about 8 to about 22 carbon atoms (preferably Cs-i ⁇ ) and one contains an anionic water solubilizing group, e.g., carboxy, sulfonate, sulfate, phosphate, or phosphonate.
  • an anionic water solubilizing group e.g., carboxy, sulfonate, sulfate, phosphate, or phosphonate.
  • betaines, sultaines, and hydroxysultaines such as cocamidopropylhydroxysultaine (available as Mirataine CBS from Rhone- Poulenc).
  • amphoteric surfactants can be used as a co-surfactant at a lower level of from about 1 % to about 10%, but not exist as the sole surfactant in this product. More preferably, those are selected from alkyl-ampho mono- and di-acetates, alkyl betaines, alkyl dimethyl amine oxides, alkyl sultaines, alkyl amidopropyl betaines, alkyl amidopropyl hydroxysultaines, and mixtures thereof, wherein said surfactants contain C-
  • nonionic surfactants that are useful herein are those that can be broadly defined as condensation products of long chain alcohols, i.e., Cs-30 alcohols, with sugar or starch polymers, i.e., glycosides.
  • Nonionic surfactants includes condensation products of alkylene oxides with fatty acids, i.e., alkylene oxide esters of fatty acids, alkylene oxide esters of 2 moles of fatty acids, alkylene oxide diesters of fatty acids; alkylene oxides with fatty alcohols, i.e., alkylene oxide ethers of fatty alcohols; and mixtures thereof; where the polyalkylene oxide portion is esterified on one end with a fatty acid and etherified (i.e., connected via an ether linkage) on the other end with a fatty alcohol.
  • alkylene oxides with fatty acids i.e., alkylene oxide esters of fatty acids, alkylene oxide esters of 2 moles of fatty acids, alkylene oxide diesters of fatty acids
  • alkylene oxides with fatty alcohols i.e., alkylene oxide ethers of fatty alcohols
  • mixtures thereof where the polyalkylene oxide portion is esterified on one end with
  • Nonlimiting examples of these alkylene oxide derived nonionic surfactants include ceteth-1 , ceteth-2, ceteth-6, ceteth-10, ceteth-12, ceteraeth-2, ceteareth6, ceteareth-10, ceteareth-12, steareth-1 , steareth-2, stearteth-6, steareth-10, steareth-12, PEG-2 stearate, PEG-4 stearate, PEG-6 stearate, PEG-10 stearate, PEG-12 stearate, PEG-20 glyceryl stearate, PEG-80 glyceryl tallowate, PPG-10 glyceryl stearate, PEG-30 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG-200 glyceryl tallowate, PEG-8 dilaurate, PEG-10 distearate, and mixtures thereof. Still other useful nonionic surfactants include polyhydroxy fatty acid
  • nonionic synthetic surfactant can be used as a co-surfactant at a lower level e.g., from about 1 % to about 15% by weight, but not as the sole surfactant in this product.
  • the cationic synthetic surfactant commonly used in cleansing composition and known in the arts are acceptable.
  • the cationic surfactant of the present composition are used as a co-surfactant, but not used as the sole surfactant.
  • the preferred cationic surfactants herein are selected from the group consisting of ammonium salts, particularly quaternary ammonium salts, aminoamides, and mixtures thereof; including alkyl trimonium chloride and methosulfate, dialkyldimonium chloride and methyl sulphate, and alkyl alkonium chloride and methyl sulphate.
  • ammonium salts particularly quaternary ammonium salts, aminoamides, and mixtures thereof; including alkyl trimonium chloride and methosulfate, dialkyldimonium chloride and methyl sulphate, and alkyl alkonium chloride and methyl sulphate.
  • These surfactants contain C-J2-24 alkyl, aromatic, aryl, or alkaryl chain groups.
  • Nonlimiting examples of cationic surfactant include dilauryl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dimyristyl dimethyl ammonium chloride, dipalmityl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearalkonium chloride, stearyltrimonium chloride, di-stearyl- dimonium chloride, stearamidopropyl PG-dimonium chloride phosphate, stearamidopropyl ethyldimonium ethosulfate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride, stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.
  • surfactants described above preferred for use herein are those selected from the group consisting of sodium cetearyl sulfate, sodium lauryl sulfate, sodium lauryl sarcosinate, sodium cocoyl isethionate, coamidopropyl betaine, sodium laureth sulfate, cetyl dimethyl betaine, ammonium lauryl sulfate, sodium tallow soap, sodium coconut soap, ceteth-10, steareth-21 , steareth-2, ceteth-2, glyceryl stearate, glucose amides, dilauryl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dimyristyl dimethyl ammonium chloride, dipalmityl dimethyl ammonium chloride, and mixtures thereof.
  • the soap includes an alkali metal soap (e.g., sodium or potassium salts) or mixture of soaps of fatty acids containing typically from about 8 to about 24 carbon atoms, preferably from about 10 to about 20 carbon atoms.
  • the fatty acids used in making the soaps can be obtained from natural sources such as, for instance, plant or animal-derived glycerides (e.g., palm oil, coconut oil, soybean oil, castor oil, tallow, lard, etc.)
  • the fatty acids can also be synthetically prepared. Soaps are described in more detail in U.S. Patent 4,557,853, cited above.
  • the composition of the present invention can contain a combination of synthetic surfactant and soap materials.
  • the preferable ratio of soap to surfactant is 1 to 25 and more preferably 1 to 18.
  • the personal hygiene tablet composition of the present invention contains from about 0.02% to about 5.5%, preferably from about 0.25% to about 3.5%, of a thickening agent.
  • thickening agent refers to a material which provides a desirable consistency, such as swelling the personal hygiene tablet compositions quickly when contacted with water.
  • Such thickening agents in the composition have characteristics such as wetting quickly and absorbing water when contacted, thereby swelling and converting into a paste or a soft gel form. It is believed that water is absorbed into the structure of the composition maintaining cohesiveness of the composition structure. When more and more water enters the composition structure, more swelling takes place and a paste is formed.
  • the thickening agents useful herein are selected from the group consisting of xanthan, dextran, cellulose derivatives such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose and mixtures thereof.
  • the preferable cellulose derivatives is sodium carboxymethyl cellulose.
  • the thickening agent of the present hygiene tablet composition may be applied as a co-thickener; as a combination of xanthan with cellulose derivatives or dextran with cellulose derivatives. Particularly, such combination can shorten the hydration time of the cleansing tablet than of xanthan or dextran alone. Further, such combination can improve smoothness of the cleansing composition.
  • the concentration of sodium carboxymethyl cellulose to xanthan or dextran is from about 0.2% to about 3.0%, preferably from about 0.5% to about 2.2% by weight.
  • the personal hygiene tablet composition of the present invention contains from about 0.25% to about 10%, preferably from about 0.5% to about 7%, of a conditioning agent.
  • conditioning agent refers to a material providing benefits of skin feeling after cleansing, e.g., skin mildness, skin moisturizing, treating of skin irritation, dye controlling particularly for hair.
  • the conditioning agent is silicone-containing components, particularly those having high molecular weight in the range of 10,000 and higher.
  • silicone containing components include, but are not limited to, silicone gums, silicone graft polymers, and the like.
  • Other types of conditioning agent include materials derived from natural sources such as aloe vera, plant extracts, pro-vitamins (i.e., panthenol), vitamins, and the like.
  • the preferred conditioning agent is polydimethly siloxane.
  • the personal hygiene tablet composition of the present invention contains from about 35% to about 85%, preferably from about 50% to about 80%, of a tableting carrier.
  • tabletteing carrier refers to a material used to enhance softness of the composition and help in dissolution of the composition.
  • the tableting carriers useful herein include those selected from the group consisting of sugar, sugar alcohols, and mixtures thereof. Preferably, the concentration of sugar to sugar alcohol is less than 40% by weight.
  • Nonlimiting examples of sugars useful herein include lactose, glucose, maltodextrins, and sucrose.
  • Sugar alcohols useful herein include sorbitol, xylitol, mannitol and maltitol.
  • the tableting carrier herein is sugar alcohol in combination with lower level of sugar, preferably from 0 to about 40% of sugar and from about 60% to about 100% of sugar alcohol by weight of tableting carrier.
  • a preferred combination of the tableting carriers in the present invention is mannitol with a lower level of sucrose.
  • the tableting carrier may further include an insoluble agent.
  • Inclusion of the insoluble agent is surprisingly effective for the porosity of the composition, resulting in improving dissolution of composition.
  • the addition of insoluble agent is depending on its process for making tablet.
  • the insoluble agent particularly useful for conventional tableting process.
  • the insoluble agent useful herein is calcium carbonate, dicalcium phosphate, tricalcium phosphate and precipitated silica.
  • the insoluble agent is present less than 70% by weight of the tableting carrier.
  • the tableting carrier of the present invention may further include a binding agent, if needed.
  • a binding agent such as mannitol
  • Inclusion of the binding agent is particularly useful when a tableting carrier, such as mannitol, may have a limited ability to bind the components used for the composition. It is believed that insufficiencies in binding ability tend to cause tablets to break off into two pieces along the length during the manufacturing process. This splitting of the tablet is commonly referred to as "capping.”
  • the levels and types of binding agent are selected depending upon the character of the carriers, compatibility with other components, and desired characteristic of the final product.
  • tableting carriers of the present invention may also have properties as a binding agent for making tablets.
  • Most of tableting carriers herein, preferably sugar, may be useful for providing improved binding properties of the personal hygiene tablet composition to prevent the tablet from breaking into two pieces.
  • useful binding agents other than those described as tableting carriers above include starches such as starch paste and pregelatinized starch, polyvinylpyrrolidone, cellulose derivatives, gelatin, gums, and mixtures thereof.
  • the binding agent and the tableting carrier may be made of the same material. Alternatively, the binding agent and the tableting carrier may be altogether different.
  • the binding agents may be present in an effective amount, preferably from about 0.1 % to about 5% by weight, more preferably from about 0.5% to about 3%.
  • the personal hygiene tablet composition of the present invention may further comprise optional components.
  • optional components means one or more compatible solid or liquid fillers, diluents, extenders and the like, which are commonly used in cosmetics as defined herein.
  • compatible herein means that the components of this invention are capable of being co- mingled with each other, in a manner such that there is no interaction which would substantially reduce the efficacy of the composition under ordinary use situations.
  • Optional components useful herein include, but are not limited to, a tableting aid, humectant, an active, a preservative, an effervescent agent, a color agent, and perfume.
  • a tableting aid can be added in order to facilitate forming the cleansing tablets.
  • tablette refers to an ingredient that is generally added to the granules in small quantities, to provide flowability to the granules, to reduce friction, and/or to ease removal of the tablet from the tableting machine.
  • the tableting aid useful herein includes, for example, magnesium stearate, stearic acid, aerosol, talc, and mixtures thereof.
  • the tableting aid in the compositions of the present invention is preferably present in an amount sufficient to prevent the tablet from sticking to the machine and improve flow characteristic of the compression mixture.
  • the tabelting aid is present at the levels from about 2% to about 8%.
  • humectant material in personal hygiene tablet composition of the present invention to keep it from hardening upon exposure to air.
  • Suitable humectants include polyethylene glycol, sorbitol, xyiitol, other polyhydric alcohols, and mixtures thereof, at a level of from about 0% to about 70%, preferably from about 2% to about 55%, by weight.
  • the optional component useful herein can also contain actives.
  • actives include, but are not limited to, anti-oxidants and radical scavengers, anti-inflammatory agents, antimicrobial agents, sunscreens and sunblocks, and chelators.
  • Other actives useful herein include vitamin derivatives such as vitamin A (e.g., retinoid which are commercially available from a number of sources, for example, Sigma Chemical Company (St. Louis, MO), and Boerhinger Mannheim (Indianapolis, IN) and described in Parish et al. U.S. Patent 4,677,120, issued June 30, 1987; Parish et al. U.S. Patent 4,885,311 issued December 5, 1989; Purcell et al. U.S.
  • vitamin A e.g., retinoid which are commercially available from a number of sources, for example, Sigma Chemical Company (St. Louis, MO), and Boerhinger Mannheim (Indianapolis, IN) and described in Parish et al. U.S. Patent 4,67
  • Patent 5,049,584 issued September 17, 1991 and U.S. Patent 5,124,356 issued June. 23, 1992; and Purcell et al. Reissue Patent 34,075, issued September. 22, 1992), vitamin B3 compound; vitamin C, vitamin E, and vitamin K.
  • Anti-Oxidants and Radical Scavengers are especially useful for providing protection against UV radiation which can cause increased scaling or texture changes in the stratum corneum and against other environmental agents which can cause skin damage.
  • Anti-oxidants and radical scavengers such as tocopherol (vitamin E), tocopherol sorbate, tocopherol acetate, other esters of tocopherol, propyl gallate, alkyl esters of uric acid, amines (i.e., N,N-diethylhydroxylamine, amino- guanidine), sulfhydryl compounds (i.e., glutathione), lycine pidolate, arginine pilolate, bioflavonoids, lysine, methionine, proline, superoxide dismutase, silymarin, tea extracts, grape skin/seed extracts, melanin, and rosemary extracts may be used.
  • tocopherol vitamin E
  • tocopherol sorbate tocopherol acetate
  • other esters of tocopherol propyl gallate
  • alkyl esters of uric acid amines (i.e., N,N-diethylhydroxy
  • Preferred anti-oxidants/radical scavengers are selected from tocopherol sorbate and other esters of tocopherol, more preferably tocopherol sorbate.
  • tocopherol sorbate in topical emulsions and applicable to the present invention is described in U.S. Patent 4,847,071 , Bissett et al, issued July 11 , 1989.
  • Antimicrobial agent means a compound capable of destroying microbes, preventing the development of microbes or preventing the pathogenic action of microbes.
  • Antimicrobal agents are useful, for example, in controlling acne.
  • Preferred antimicrobial agents useful in the present invention are benzoyl peroxide, erythromycin, tetracycline, clindamycin, azelaic acid, sulfur resorcinol, phenoxyethanol, and IrgasanTM DP 300 (Ciba Geigy Corp., U.S.A.).
  • a safe and effective amount of an antimicrobial agent may be added to emulsions of the present invention, preferably from about 0.001% to about 10%, more preferably from about 0.01 % to about 5%, still more preferably from about 0.05% to about 2%.
  • chelator refers to a compound that reacts for removing a metal ion from a system by forming a complex so that the metal ion cannot readily participate in or catalyze chemical reactions.
  • the inclusion of a chelator is especially useful for providing protection against UV radiation which can contribute to excessive scaling or skin texture changes and against other environmental agents which can cause skin damage.
  • Exemplary chelators that are useful herein are disclosed in Bissett et al. U.S. Patent 5,487,884, issued January 30, 1996; Bush et al. PCT application 91/16035 and 91/16034, published October 31 , 1995.
  • Preferred chelators are furildioxime and derivatives thereof.
  • Preservatives and preservative enhancers may also present in the composition. Such preservatives and preservative enhancers prevent microbial growth in the compositions.
  • Nonlimiting examples of such preservatives and preservative enhancers include water-soluble or solubiiizable preservatives including Germall 115, methyl, ethyl, propyl and butyl esters of hydroxybenzoic acid, benzyl alcohol, EDTA, Bronopol (2-bromo-2-nitropropane-1 ,3-diol) and phenoxypropanol; antifoaming agents; preferably methylparaben, propylparaben, and benzoates.
  • the preservatives generally comprise from about 0.02% to about 0.3%.
  • the optional component may further include an effervescent agent to provide bubbles which are sometimes desired for aesthetic purposes.
  • effervescent agent herein means a material that provides effervescence by the reaction of a carbonate source with an acidic source, for example, a carbonate salt and a carboxylic acid. Any ingredients which would be useful conventionally as an effervescence agent in the pharmaceutical and/or cosmetic area may be acceptable herein.
  • the carbonate sources herein include calcium carbonate, sodium carbonate, and sodium bicarbonate.
  • Preferred acid sources useful herein include a citric acid, and a malic acid.
  • the effervescent agent may be present at levels of from about 0.5% to about 20% by weight.
  • the optional component of the present invention may further include a coloring agent.
  • the coloring agent is added with liquid-type ingredients or solution to facilitate uniform distribution and mixing.
  • the coloring agent is present at an effective level, preferably from about 10ppm to about
  • 500ppm more preferably from about 20ppm to about 250ppm by weight.
  • composition of the present invention may further include antifoaming agents; binders; biological additives; bulking agents; perfumes, essential oils, and solubilizers thereof; natural extracts; compounds which stimulate collagen production.
  • antifoaming agents e.g., antifoaming agents, binders; biological additives; bulking agents; perfumes, essential oils, and solubilizers thereof; natural extracts; compounds which stimulate collagen production.
  • F. Method of making tablets The personal hygiene tablet composition of the present invention can be produced by any method useful for forming conventional tablets known in the art. These conventional methods include granulating methods: either wet or dry granulating method, preferably wet granulating. Depending on the properties of the ingredients (e.g., cleansing components, thickening agents, conditioning agents, tableting carriers, and the like) to be formulated into granules, one method may provide a more favorable end product over the other method.
  • the ingredients e.g., cleansing components, thickening agents, conditioning agents, tableting
  • Direct compression without granulation step may also be chosen for the present composition, as long as producing non-gritty tablets does not cause capping.
  • a method for making a personal hygiene tablet composition of the present invention comprises: (1 ) adding cleansing component, thickening agent, conditioning agent and tableting carriers, and any of optional component (e.g., humectant, preservative), if needed, to make granules;
  • optional component e.g., humectant, preservative
  • step (4) drying the sieved granules by conventional drying techniques; (4) sieving again the dried granules through #14 mesh; (5) mixing the granules of step (4) with oral carriers other than those of step(1 ) (e.g., thickening agent, sweetening agent, perfume, tableting aids); and
  • step (6) compressing the mixture of step (5) to form tablets by conventional method.
  • compositions of the present invention can be used to clean the skin by:
  • the tablets of Examples IV and V are made by the method described in "Method for making tablets" section, except that after the step 1 , the mix is heated in a closed container to a temperature of at least about 80 °C for about 20 minutes with continuous agitation to agglomerate the mix.

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Abstract

L'invention concerne une composition sous forme de comprimé pour l'hygiène personnelle en vue de produire une composition nettoyante sous forme de comprimé comprenant: (a) environ 3 à 50 % de composant lavant, (b) environ 0.02 à 5,5 % d'agent épaississant, (c) environ 0,25 à 10 % d'agent de conditionnement, et (d) environ 35 à 85 % d'un excipient à comprimés. L'agent épaississant est choisi dans le groupe constitué de dérivés xanthane, dextrane et cellulose.
PCT/US1999/014900 1999-06-30 1999-06-30 Composition de comprime pour l'hygiene personnelle WO2001001954A1 (fr)

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PCT/US1999/014900 WO2001001954A1 (fr) 1999-06-30 1999-06-30 Composition de comprime pour l'hygiene personnelle
AU50867/99A AU5086799A (en) 1999-06-30 1999-06-30 Personal hygiene tablet composition

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Cited By (9)

* Cited by examiner, † Cited by third party
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EP1370206A1 (fr) * 2001-01-09 2003-12-17 Lavipharm Laboratories, Inc. Dispositif d'administration locale et systemique de substances actives, et ses procedes de fabrication
EP1961409A3 (fr) * 2006-12-20 2009-09-09 José Alejandro Mumoli Particules solides compressibles, procédures pour leur obtention et procédures pour l'utilisation desdites particules solides dans des comprimés pour le nettoyage du corps
US20120040919A1 (en) * 2008-10-07 2012-02-16 Cosmetic Warriors Ltd. Exfoliating composition based on cream of tartar and bicarbonate
WO2017011774A1 (fr) * 2015-07-15 2017-01-19 Nohbo, LLC Comprimé de produit d'hygiène et ses procédés de formation
USD893800S1 (en) 2018-08-03 2020-08-18 Nohbo, LLC Hygiene product pod
US11045397B2 (en) 2019-11-06 2021-06-29 Nohbo, LLC Hygiene product pod and methods of using same
WO2021174183A1 (fr) * 2020-02-27 2021-09-02 Henkel IP & Holding GmbH Composition de nettoyage encapsulée
USD931526S1 (en) 2018-08-03 2021-09-21 Nohbo, LLC Hygiene product pod
US11744786B2 (en) 2018-01-18 2023-09-05 Nohbo, Inc. Hygiene product pod and methods of using same

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EP0471967A1 (fr) * 1990-07-19 1992-02-26 MERCK PATENT GmbH Comprimé à mâcher à base de sucralfate
FR2736261A1 (fr) * 1995-07-07 1997-01-10 Elisabeth Bac Produit d'hygiene capillaire ou de traitement pileux

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EP0232830A1 (fr) * 1986-02-04 1987-08-19 Crinos Industria Farmacobiologica S.p.A. Composition pour la préparation extemporanée de formulations pharmaceutiques et cosmétiques pour applications topiques
EP0471967A1 (fr) * 1990-07-19 1992-02-26 MERCK PATENT GmbH Comprimé à mâcher à base de sucralfate
FR2736261A1 (fr) * 1995-07-07 1997-01-10 Elisabeth Bac Produit d'hygiene capillaire ou de traitement pileux

Cited By (11)

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EP1370206A1 (fr) * 2001-01-09 2003-12-17 Lavipharm Laboratories, Inc. Dispositif d'administration locale et systemique de substances actives, et ses procedes de fabrication
EP1370206A4 (fr) * 2001-01-09 2006-04-05 Lavipharm Lab Inc Dispositif d'administration locale et systemique de substances actives, et ses procedes de fabrication
EP1961409A3 (fr) * 2006-12-20 2009-09-09 José Alejandro Mumoli Particules solides compressibles, procédures pour leur obtention et procédures pour l'utilisation desdites particules solides dans des comprimés pour le nettoyage du corps
US20120040919A1 (en) * 2008-10-07 2012-02-16 Cosmetic Warriors Ltd. Exfoliating composition based on cream of tartar and bicarbonate
US9457203B2 (en) * 2008-10-07 2016-10-04 Cosmetic Warriors Limited Exfoliating composition based on cream of tartar and bicarbonate
WO2017011774A1 (fr) * 2015-07-15 2017-01-19 Nohbo, LLC Comprimé de produit d'hygiène et ses procédés de formation
US11744786B2 (en) 2018-01-18 2023-09-05 Nohbo, Inc. Hygiene product pod and methods of using same
USD893800S1 (en) 2018-08-03 2020-08-18 Nohbo, LLC Hygiene product pod
USD931526S1 (en) 2018-08-03 2021-09-21 Nohbo, LLC Hygiene product pod
US11045397B2 (en) 2019-11-06 2021-06-29 Nohbo, LLC Hygiene product pod and methods of using same
WO2021174183A1 (fr) * 2020-02-27 2021-09-02 Henkel IP & Holding GmbH Composition de nettoyage encapsulée

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