WO2001001784A1 - Method for producing melatonin rich milk - Google Patents
Method for producing melatonin rich milk Download PDFInfo
- Publication number
- WO2001001784A1 WO2001001784A1 PCT/FI2000/000589 FI0000589W WO0101784A1 WO 2001001784 A1 WO2001001784 A1 WO 2001001784A1 FI 0000589 W FI0000589 W FI 0000589W WO 0101784 A1 WO0101784 A1 WO 0101784A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- milk
- melatonin
- ught
- light
- lux
- Prior art date
Links
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title claims abstract description 42
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title claims abstract description 41
- 229960003987 melatonin Drugs 0.000 title claims abstract description 41
- 239000008267 milk Substances 0.000 title claims abstract description 32
- 235000013336 milk Nutrition 0.000 title claims abstract description 32
- 210000004080 milk Anatomy 0.000 title claims abstract description 32
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 13
- 230000033764 rhythmic process Effects 0.000 claims abstract description 12
- 241000124008 Mammalia Species 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 11
- 206010021033 Hypomenorrhoea Diseases 0.000 claims abstract description 5
- 241000283690 Bos taurus Species 0.000 description 22
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 230000036765 blood level Effects 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000012260 Accidental injury Diseases 0.000 description 1
- 206010017999 Gastrointestinal pain Diseases 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 208000013469 light sensitivity Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002613 pineal body hormone Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
Definitions
- the invention relates to the management method for producing milk of high melatonin concentration by milk producing mammals, especially the dairy cow.
- Melatonin has evoked much interest lately since it has been found to participate in many physiological processes. Melatonin bolsters the immune system, it has anti- oxidative actions and it releases e.g. gastro-intestinal pain. Studies on animals have shown that melatonin can protect tissues from the damaging effect of toxic substances in the surroundings lengthening the lifespan of the experimental animals. Melatonin has also shown to hasten falling asleep. In early life melatonin production is abundant but the production declines steadily into old age in both humans and animals. So sleep disturbances are more common in the elderly people.
- the invention relates to a method for producing high enough concentration of melatonin in nightmilk of a mammal like cow so the milk can be used as a natural source of melatonin for people. This is obtained according to the invention as presented in the claims.
- the invention is described applied to cattle, a species whose sensitivity to light is known, but the method can be used for all milking mammals after their species-specific light sensitivity has been determined.
- the protein fraction of milk contains most of the melatonin. Outside the organism melatonin is relatively stable and cooking, freezing or pasteurisation does not degrade it, so nightmilk can be used for milk products like cheese. One kilogram of cheese contains more than two times more melatonin than one litre of nightmilk.
- Routine day for an ordinary cow house starts with feeding and milking around 5.30 am and lasts a couple of hours. As the farmer enters the shed and starts the feeding he turns the lights on. The lights are kept on for the time of the routines and then they are switched off as the farmer leaves. The evening routine, which is similar to morning one, starts around 4-6 pm and again the lights are turned on and off. During the day only occasional visits are paid to cow house, during which the lights are turned on. For the remaining time the only light source for cow house is natural light.
- An evening call is made to cow house to check the welfare of the animals.
- the call is made approximately 5 hours later than the evening routine.
- the lamp(s) create enough light for the cows to shape figures and movement of other cows and humans. This prevents accidental injuries, which are caused by frightening in the total darkness.
- some alterations may occur in the milking routines under the time spent in the paddock.
- the pattern of melatonin secretion of a cow in different seasons according to the invention is presented in Figure 1. Elevated blood levels of melatonin during winter nights are lowest and longest. The curves in autumn and spring are higher than in winter. The peak concentration of melatonin is highest in summer while its duration is shortest.
- the melatonin concentration in nightmilk of a single cow may vary without control from 10 to 60 pg/ml, while the mean concentration of the herd may vary between 10 and 25 pg/ml.
- the mean concentration of the herd may vary between 10 and 25 pg/ml.
- the natural daily light and dark rhythm has to be altered according to the invention. Duration of the dark time of the day must be controlled since seasonal variation of day length varies greatly depending on the latitude.
- the light rhythm can be adjusted with timed lights and shutters.
- the objective of the present invention is to maintain the farmer's normal daily rhythm and in the same time to modify the rhythm of cows for optimal and steady melatonin production.
- Characteristic of the method according to the invention is that the daily rhythm of the milk producing mammal is altered such that it includes a dark period substantially invariable in length and a light period substantially invariable in length and that the milk is collected before the end of the dark period.
- the cows are held in conditions where their 24 hours contains from 2 to 11 hours of darkness and from 13 to 22 hours of light time.
- dark means conditions where the amount of light is 40 lux at maximum, preferably approximately 10 lux
- Ught means conditions where the amount of light is higher than approximately 150 lux, yet at minimum 7 times more than the night time light, preferably more than 250 lux.
- the minimum value of day light is however 50 lux. Even at this level of light the melatonin concentration of the organism can be lowered, assuming that night time is darker than this.
- the daily rhythm of cows is adjusted so that one of their daily milking times takes place just before the end of the dark period. In practice this milking time is the morning milking but the cows are allowed exposure to light only approximately 30 minutes after the milking in order the prevent ceasing of the secretion of melatonin before milking. At milking the light allowed to the cow's eyes is 40 lux at maximum. This ensures the highest possible melatonin concentration in the milk.
- the light in the cow house between 11 pm and 7 am is kept at 10 lux, before which the milking takes place in a normal way and ordinary milk is obtained.
- the morning milking takes place in a way that it is completed before 6.30 am.
- the cows may be outside, excluding the night time, in winter time a day time light of 150 lux at minimum must be ensured.
- the production of nightmilk can be standardized so that the melatonin concentration in milk at all annual seasons, at all stages of the milking season with all producers following the programme, remains over 20 pg/ml. It is even possible to obtain concentrations considerably higher than this.
- the effectiveness of the invention was examined by comparing the melatonin levels of milk in a farm in earlier used lightening conditions during milking and after adjusting lighting conditions according to the invention.
- light intensity at night was less than 4 lux and lightness being at least 250 lux.
- the right light intensity for the night time milking was also taken into account in both occasions, being less than 10 lux.
- the only modifier that differed from the invention was the light-dark duration rhythm, being 12 hours light and 12 hours dark in the first occasion.
- the light-dark rhythm was then adjusted according to the invention so that the Ughted time was 17 hours and the dark time was 7 hours.
- the melatonin level in tank milk rose considerably from 8.9 pg/ml before to 56.4 pg/ml after the Ught-dark rhythm was altered to match the invention (see table 1).
- Table 1 Melatonin in milk of a farm using lightening conditions 12h dark - 12 h Ught and after adjusting the conditions according the conditions within the limits of the invention.
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- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Housing For Livestock And Birds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a method for producing milk with high melatonin concentration, in which method the daily rhythm of the mammal producing the milk is altered such that it contains a dark period substantially invariable in length and a light period substantially invariable in length and that the milk is collected before the end of the dark period.
Description
Method for producing melatonin rich milk
The invention relates to the management method for producing milk of high melatonin concentration by milk producing mammals, especially the dairy cow.
Melatonin has evoked much interest lately since it has been found to participate in many physiological processes. Melatonin bolsters the immune system, it has anti- oxidative actions and it releases e.g. gastro-intestinal pain. Studies on animals have shown that melatonin can protect tissues from the damaging effect of toxic substances in the surroundings lengthening the lifespan of the experimental animals. Melatonin has also shown to hasten falling asleep. In early life melatonin production is abundant but the production declines steadily into old age in both humans and animals. So sleep disturbances are more common in the elderly people.
Melatonin is secreted during night time and the levels in blood are high during the night, falling fast when light hits the eye. Melatonin in the blood is degraded in the liver and its concentration declines immediately after the synthesis ceases. It is also known that melatonin production increases some time after darkness onset and returns to daytime level at about the time lights on. As the dark phase of the day gets longer, duration of the maximal concentration of melatonin is prolonged, and when nights get shorter, melatonin is secreted for a shorter period. It has now been unexpectedly found that when the duration of the dark period gets longer the maximal blood level of melatonin drops and respectively during short nights the peak melatonin levels are high.
During milk production in a mammal like cow some substances transfer unchanged from the blood into the milk. Many hormones are like this. However, their concentration in milk is mostly so low that their significance is not apparent and they do not have any nutritive value. One of the substances transporting easily to milk is melatonin, the pineal hormone of mammals that is produced during the night and synchronizes the rhythms of the day and the season.
It has now been found that the concentration of melatonin in milk is clearly higher in night time milk (nightmilk) than in daytime milk. The invention relates to a method for producing high enough concentration of melatonin in nightmilk of a mammal like cow so the milk can be used as a natural source of melatonin for people. This is obtained according to the invention as presented in the claims.
In the following, the invention is described applied to cattle, a species whose sensitivity to light is known, but the method can be used for all milking mammals after their species-specific light sensitivity has been determined.
The protein fraction of milk contains most of the melatonin. Outside the organism melatonin is relatively stable and cooking, freezing or pasteurisation does not degrade it, so nightmilk can be used for milk products like cheese. One kilogram of cheese contains more than two times more melatonin than one litre of nightmilk.
Routine day for an ordinary cow house starts with feeding and milking around 5.30 am and lasts a couple of hours. As the farmer enters the shed and starts the feeding he turns the lights on. The lights are kept on for the time of the routines and then they are switched off as the farmer leaves. The evening routine, which is similar to morning one, starts around 4-6 pm and again the lights are turned on and off. During the day only occasional visits are paid to cow house, during which the lights are turned on. For the remaining time the only light source for cow house is natural light.
An evening call is made to cow house to check the welfare of the animals. The call is made approximately 5 hours later than the evening routine. During the check the lights of the cow house are on and after the check only a tarnished light is left on. The lamp(s) create enough light for the cows to shape figures and movement of other cows and humans. This prevents accidental injuries, which are caused by frightening in the total darkness. During the pasturing season some alterations may occur in the milking routines under the time spent in the paddock. Some farmers take the cows indoors only for milking, else they spend their time outdoors.
In nature the light conditions vary a lot according to the season. This reflects in even great changes of the duration of melatonin secretion and concentration in blood and consequently in milk. The melatonin concentration in milk is also dependent on the reproduction and lactation period of the cow.
The pattern of melatonin secretion of a cow in different seasons according to the invention is presented in Figure 1. Elevated blood levels of melatonin during winter nights are lowest and longest. The curves in autumn and spring are higher than in winter. The peak concentration of melatonin is highest in summer while its duration is shortest.
In the studies behind the invention it was found that in normal milk production conditions the melatonin concentration in nightmilk of a single cow may vary
without control from 10 to 60 pg/ml, while the mean concentration of the herd may vary between 10 and 25 pg/ml. By normal daily routines nightmilk with melatonin concentrations over 20 pg/ml are reached only occasionally.
In order to make the mghtmilk production profitable, efficient and practical the natural daily light and dark rhythm has to be altered according to the invention. Duration of the dark time of the day must be controlled since seasonal variation of day length varies greatly depending on the latitude. The light rhythm can be adjusted with timed lights and shutters. The objective of the present invention is to maintain the farmer's normal daily rhythm and in the same time to modify the rhythm of cows for optimal and steady melatonin production.
Characteristic of the method according to the invention is that the daily rhythm of the milk producing mammal is altered such that it includes a dark period substantially invariable in length and a light period substantially invariable in length and that the milk is collected before the end of the dark period. In the method according to the invention the cows are held in conditions where their 24 hours contains from 2 to 11 hours of darkness and from 13 to 22 hours of light time. In this connection, dark means conditions where the amount of light is 40 lux at maximum, preferably approximately 10 lux, and Ught means conditions where the amount of light is higher than approximately 150 lux, yet at minimum 7 times more than the night time light, preferably more than 250 lux. The minimum value of day light is however 50 lux. Even at this level of light the melatonin concentration of the organism can be lowered, assuming that night time is darker than this.
The daily rhythm of cows is adjusted so that one of their daily milking times takes place just before the end of the dark period. In practice this milking time is the morning milking but the cows are allowed exposure to light only approximately 30 minutes after the milking in order the prevent ceasing of the secretion of melatonin before milking. At milking the light allowed to the cow's eyes is 40 lux at maximum. This ensures the highest possible melatonin concentration in the milk.
In one advantageous embodiment, the light in the cow house between 11 pm and 7 am is kept at 10 lux, before which the milking takes place in a normal way and ordinary milk is obtained. The morning milking takes place in a way that it is completed before 6.30 am. At summer the cows may be outside, excluding the night time, in winter time a day time light of 150 lux at minimum must be ensured.
Within the predestined values the production of nightmilk can be standardized so that the melatonin concentration in milk at all annual seasons, at all stages of the milking season with all producers following the programme, remains over 20 pg/ml. It is even possible to obtain concentrations considerably higher than this.
The present invention will hereafter be described by way of an example.
Example 1
The effectiveness of the invention was examined by comparing the melatonin levels of milk in a farm in earlier used lightening conditions during milking and after adjusting lighting conditions according to the invention. In both occasions light intensity at night was less than 4 lux and lightness being at least 250 lux. The right light intensity for the night time milking was also taken into account in both occasions, being less than 10 lux. The only modifier that differed from the invention was the light-dark duration rhythm, being 12 hours light and 12 hours dark in the first occasion. The light-dark rhythm was then adjusted according to the invention so that the Ughted time was 17 hours and the dark time was 7 hours. The melatonin level in tank milk rose considerably from 8.9 pg/ml before to 56.4 pg/ml after the Ught-dark rhythm was altered to match the invention (see table 1).
Table 1 Melatonin in milk of a farm using lightening conditions 12h dark - 12 h Ught and after adjusting the conditions according the conditions within the limits of the invention.
LD 12:12 LD 17:7
Length of night (h) 12 7
Light intensity of night (max lux) 4 4
Length of day (h) 12 17
Light intensity of day (min lux) 250 250
Light intensity during milking (max 10 10 lux)
Milk melatonin concentration 8,9 56,4
(pg/ml)
As the table shows, the shortened time in dark and the prolonged light period increased the melatonin levels in nightmilk.
For a person skiUed in the art it is evident that the various embodiments of the invention are not limited to those presented above by way of an example, but may vary within the scope of the appended claims.
Claims
1. A method for producing milk of high melatonin concentration, characterized in that the daily rhythm of the milk producing mammal is altered so that it contains a dark period substantiaUy invariable length and a Ught period substantiaUy invariable in length and that the milk is collected before the end of the dark period.
2. A method according to claim 1, characterized in that the amount of Ught during the dark period is less than approximately 40 lux and that the amount of Ught during the light period is more than approximately 150 lux.
3. A method according to claim 2, characterized in that during the dark period the amount of Ught is less than 10 lux and that the amount of Ught during the light period is more than 250 lux.
4. A method according to claim 1, characterized in that during the milking the Ught exposure to the mammal's eyes is 40 lux at maximum.
5. A method according to claim 1, characterized in that the dark period is from 2 to 11 hours in length and that the Ught period is from 13 to 22 hours in length.
6. A method according to claim 5, characterized in that the dark period is approximately 7 hours in length and that the Ught period is approximately 17 hours in length.
7. A method according to claim 1, characterized in that the mammal is allowed exposure to Ught only after approximately 30 minutes after miUαng.
8. A method according to claim 1, characterized in that the mammal is a cow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU56876/00A AU5687600A (en) | 1999-06-30 | 2000-06-29 | Method for producing melatonin rich milk |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI991488A FI111324B (en) | 1999-06-30 | 1999-06-30 | Process for producing milk with high melatonin content |
| FI991488 | 1999-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001001784A1 true WO2001001784A1 (en) | 2001-01-11 |
Family
ID=8554991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/FI2000/000589 WO2001001784A1 (en) | 1999-06-30 | 2000-06-29 | Method for producing melatonin rich milk |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU5687600A (en) |
| FI (1) | FI111324B (en) |
| WO (1) | WO2001001784A1 (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2387099A (en) * | 2002-03-05 | 2003-10-08 | Red Kite Farms Ltd | Method for producing milk with an enhanced content of naturally expressed melatonin |
| WO2007068361A1 (en) * | 2005-12-13 | 2007-06-21 | Tony Gnann | Method for the production of milk or milk products having a high melatonin content |
| NL1035899C (en) * | 2008-09-05 | 2010-03-15 | Lely Patent Nv | METHOD AND DEVICE FOR CONTROLLING STALL LIGHTING |
| CN101791006A (en) * | 2010-04-22 | 2010-08-04 | 黑龙江省乳品工业技术开发中心 | Raw milk with high melatonin content and method for obtaining raw milk with high melatonin content |
| CN103277690A (en) * | 2013-06-08 | 2013-09-04 | 上海宏源照明电器有限公司 | Supplementary lighting system for cows in lactation period and based on electromagnetic induction lamps |
| WO2017159491A1 (en) * | 2016-03-14 | 2017-09-21 | 昭和電工株式会社 | Method for raising livestock and method for producing milk |
| CN108719193A (en) * | 2018-06-05 | 2018-11-02 | 江苏省家禽科学研究所 | A kind of high-quality sexually matured illumination cultural method of Breeder hens of regulation and control |
| NL2029936B1 (en) * | 2021-11-28 | 2022-11-17 | Wang Linfeng | Production method of circadian rhythm milk |
| CN115777624A (en) * | 2023-02-08 | 2023-03-14 | 北京三元食品股份有限公司 | Method for improving melatonin content in milk and application thereof |
| CN116171932A (en) * | 2023-02-24 | 2023-05-30 | 北京首农畜牧发展有限公司 | An integrated approach to increasing melatonin content in milk |
-
1999
- 1999-06-30 FI FI991488A patent/FI111324B/en not_active IP Right Cessation
-
2000
- 2000-06-29 WO PCT/FI2000/000589 patent/WO2001001784A1/en active Application Filing
- 2000-06-29 AU AU56876/00A patent/AU5687600A/en not_active Abandoned
Non-Patent Citations (3)
| Title |
|---|
| GUNNELA M. GUSTAFSON: "Effect of changes in light on hormonal secretion and milk production of dairy cows in early lactation", ACTA AGRIC. SCAND., SECT. A. ANIMAL SCI., vol. 44, 1994, pages 160 - 168, XP002933606 * |
| L. ERIKSSON ET AL.: "Diurnal rhythm of melatonin in bovine milk: Pharmacokinetics of exogenous melatonin in lactating cows and goats", ACTA VET. SCAND., vol. 39, 1998, pages 301 - 310, XP002933605 * |
| MAIJA VALTONEN: "Yomaito - unimaito", RAVITSEMUSKATSAUS, vol. 1, 1998, pages 1 PAGE, XP002933604 * |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2387099A (en) * | 2002-03-05 | 2003-10-08 | Red Kite Farms Ltd | Method for producing milk with an enhanced content of naturally expressed melatonin |
| WO2007068361A1 (en) * | 2005-12-13 | 2007-06-21 | Tony Gnann | Method for the production of milk or milk products having a high melatonin content |
| JP2009519021A (en) * | 2005-12-13 | 2009-05-14 | トニー グナン | Method for producing milk or dairy products having a high proportion of melatonin |
| AU2006326734B2 (en) * | 2005-12-13 | 2011-08-11 | Raichle, Marianne | Method for the production of milk or milk products having a high melatonin content |
| US8003130B2 (en) | 2005-12-13 | 2011-08-23 | Tony Gnann | Method for the production of milk or milk products with a high proportion of melatonin |
| US8410728B2 (en) | 2008-09-05 | 2013-04-02 | Lely Patent N.V. | Method of and device for controlling shed lighting |
| NL1035899C (en) * | 2008-09-05 | 2010-03-15 | Lely Patent Nv | METHOD AND DEVICE FOR CONTROLLING STALL LIGHTING |
| EP2160940A3 (en) * | 2008-09-05 | 2011-03-30 | Lely Patent N.V. | Method of and device for controlling shed lighting |
| CN101791006A (en) * | 2010-04-22 | 2010-08-04 | 黑龙江省乳品工业技术开发中心 | Raw milk with high melatonin content and method for obtaining raw milk with high melatonin content |
| CN103277690A (en) * | 2013-06-08 | 2013-09-04 | 上海宏源照明电器有限公司 | Supplementary lighting system for cows in lactation period and based on electromagnetic induction lamps |
| WO2017159491A1 (en) * | 2016-03-14 | 2017-09-21 | 昭和電工株式会社 | Method for raising livestock and method for producing milk |
| CN108719193A (en) * | 2018-06-05 | 2018-11-02 | 江苏省家禽科学研究所 | A kind of high-quality sexually matured illumination cultural method of Breeder hens of regulation and control |
| NL2029936B1 (en) * | 2021-11-28 | 2022-11-17 | Wang Linfeng | Production method of circadian rhythm milk |
| CN115777624A (en) * | 2023-02-08 | 2023-03-14 | 北京三元食品股份有限公司 | Method for improving melatonin content in milk and application thereof |
| CN115777624B (en) * | 2023-02-08 | 2023-09-26 | 北京三元食品股份有限公司 | Method for increasing melatonin content in milk and application thereof |
| WO2024165052A1 (en) * | 2023-02-08 | 2024-08-15 | 北京三元食品股份有限公司 | Method for increasing content of melatonin in milk, and use thereof |
| CN116171932A (en) * | 2023-02-24 | 2023-05-30 | 北京首农畜牧发展有限公司 | An integrated approach to increasing melatonin content in milk |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5687600A (en) | 2001-01-22 |
| FI991488A0 (en) | 1999-06-30 |
| FI991488L (en) | 2000-12-31 |
| FI111324B (en) | 2003-07-15 |
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