WO2000073313A1 - Nouveaux derives d'amidine tricyclique inhibiteurs de synthase d'oxyde nitrique - Google Patents

Nouveaux derives d'amidine tricyclique inhibiteurs de synthase d'oxyde nitrique Download PDF

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Publication number
WO2000073313A1
WO2000073313A1 PCT/SE2000/001034 SE0001034W WO0073313A1 WO 2000073313 A1 WO2000073313 A1 WO 2000073313A1 SE 0001034 W SE0001034 W SE 0001034W WO 0073313 A1 WO0073313 A1 WO 0073313A1
Authority
WO
WIPO (PCT)
Prior art keywords
thieno
amine
jbenzazepin
formula
compound
Prior art date
Application number
PCT/SE2000/001034
Other languages
English (en)
Inventor
James Matz
James Mcdonald
Edwin Wu
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to AU51195/00A priority Critical patent/AU5119500A/en
Publication of WO2000073313A1 publication Critical patent/WO2000073313A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

L'invention concerne de nouveaux composés de la formule (I) où R1, R2, A et X ont la définition donnée dans la description, et leurs énantiomorphes, racémates et tautomères et leurs sels pharmaceutiquement compatibles. L'invention concerne également leurs procédés de production, les compositions les contenant et leur utilisation en thérapie. Ces composés sont des inhibiteurs de l'enzyme de synthase de monoxyde d'azote.
PCT/SE2000/001034 1999-05-26 2000-05-23 Nouveaux derives d'amidine tricyclique inhibiteurs de synthase d'oxyde nitrique WO2000073313A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU51195/00A AU5119500A (en) 1999-05-26 2000-05-23 New tricyclic amidine derivatives as inhibitors of nitric oxide synthase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9901901-0 1999-05-26
SE9901901A SE9901901D0 (sv) 1999-05-26 1999-05-26 Compounds

Publications (1)

Publication Number Publication Date
WO2000073313A1 true WO2000073313A1 (fr) 2000-12-07

Family

ID=20415733

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2000/001034 WO2000073313A1 (fr) 1999-05-26 2000-05-23 Nouveaux derives d'amidine tricyclique inhibiteurs de synthase d'oxyde nitrique

Country Status (3)

Country Link
AU (1) AU5119500A (fr)
SE (1) SE9901901D0 (fr)
WO (1) WO2000073313A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077100A2 (fr) * 2000-04-10 2001-10-18 Pfizer Products Inc. Composes contenant benzoamide piperidine et composes apparentes
EP1284141A2 (fr) * 2001-08-15 2003-02-19 Pfizer Products Inc. Combinaisons pharmaceutiques pour le traitement de maladies neurodégénératives comprenant des inhibiteurs de la synthase d'oxyde nitrique neuronale
JP2004531517A (ja) * 2001-04-05 2004-10-14 メルク シャープ エンド ドーム リミテッド γ−セクレターゼの作用を調節するスルホン
US7119207B2 (en) 2000-04-10 2006-10-10 Pfizer Inc Benzoamide piperidine containing compounds and related compounds
WO2007096150A2 (fr) * 2006-02-23 2007-08-30 Novartis Ag Domaine technique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH476753A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von 11-basisch substituierter Dibenzo(b,f)(1,4)thiazepine
US5605897A (en) * 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
WO1997017344A1 (fr) * 1995-11-07 1997-05-15 Astra Aktiebolag Derives d'amidine et d'isothio-uree en tant qu'inhibiteurs de la synthase de l'oxyde nitrique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH476753A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von 11-basisch substituierter Dibenzo(b,f)(1,4)thiazepine
US5605897A (en) * 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
WO1997017344A1 (fr) * 1995-11-07 1997-05-15 Astra Aktiebolag Derives d'amidine et d'isothio-uree en tant qu'inhibiteurs de la synthase de l'oxyde nitrique

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077100A2 (fr) * 2000-04-10 2001-10-18 Pfizer Products Inc. Composes contenant benzoamide piperidine et composes apparentes
WO2001077100A3 (fr) * 2000-04-10 2002-03-07 Pfizer Prod Inc Composes contenant benzoamide piperidine et composes apparentes
EA005409B1 (ru) * 2000-04-10 2005-02-24 Пфайзер Продактс Инк. Производные бензамидопиперидина в качестве антагонистов рецепторов вещества p
US7119207B2 (en) 2000-04-10 2006-10-10 Pfizer Inc Benzoamide piperidine containing compounds and related compounds
JP2004531517A (ja) * 2001-04-05 2004-10-14 メルク シャープ エンド ドーム リミテッド γ−セクレターゼの作用を調節するスルホン
EP1284141A2 (fr) * 2001-08-15 2003-02-19 Pfizer Products Inc. Combinaisons pharmaceutiques pour le traitement de maladies neurodégénératives comprenant des inhibiteurs de la synthase d'oxyde nitrique neuronale
EP1284141A3 (fr) * 2001-08-15 2003-07-30 Pfizer Products Inc. Combinaisons pharmaceutiques pour le traitement de maladies neurodégénératives comprenant des inhibiteurs de la synthase d'oxyde nitrique neuronale
WO2007096150A2 (fr) * 2006-02-23 2007-08-30 Novartis Ag Domaine technique
WO2007096150A3 (fr) * 2006-02-23 2007-10-25 Novartis Ag Domaine technique
US8258128B2 (en) 2006-02-23 2012-09-04 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
SE9901901D0 (sv) 1999-05-26
AU5119500A (en) 2000-12-18

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