WO2000069906A1 - Gene derive de $i(lawsonia), polypeptides, peptides et proteines d'hemolysine et leurs utilisations - Google Patents
Gene derive de $i(lawsonia), polypeptides, peptides et proteines d'hemolysine et leurs utilisations Download PDFInfo
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- WO2000069906A1 WO2000069906A1 PCT/AU2000/000439 AU0000439W WO0069906A1 WO 2000069906 A1 WO2000069906 A1 WO 2000069906A1 AU 0000439 W AU0000439 W AU 0000439W WO 0069906 A1 WO0069906 A1 WO 0069906A1
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- amino acid
- polypeptide
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- intracellularis
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- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000001124 posttranscriptional effect Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000001500 prolyl group Chemical class [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000010474 transient expression Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention concerne d'une manière générale des compositions thérapeutiques destinées au traitement et/ou à la prophylaxie de maladies intestinales chez des animaux et des oiseaux, provoquées ou exacerbées par Lawsonia intracellularis ou un autre micro-organisme similaire ou associé. L'invention concerne en particulier un nouveau gène dérivé de Lawsonia intracellularis codant pour un peptide, un polypeptide ou une protéine d'hémolysine immunogène, particulièrement utiles en tant qu'antigène dans des préparations vaccinales pour générer chez des animaux hôtes une immunité humorale contre Lawsonia intracellularis et les agents pathogènes associés. L'invention concerne également des méthodes de traitement et/ou de prophylaxie de telles maladies intestinales, ainsi que des agents de diagnostic et des procédés de détection de Lawsonia intracellularis ou de micro-organismes similaires ou associés.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00924978A EP1177213A4 (fr) | 1999-05-13 | 2000-05-11 | Gene derive de lawsonia, polypeptides, peptides et proteines d'hemolysine et leurs utilisations |
| AU43861/00A AU775323B2 (en) | 1999-05-13 | 2000-05-11 | Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses |
| US10/009,919 US7029683B1 (en) | 1999-05-13 | 2000-05-11 | Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses |
| NZ515363A NZ515363A (en) | 1999-05-13 | 2000-05-11 | Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses |
| CA002372105A CA2372105A1 (fr) | 1999-05-13 | 2000-05-11 | Gene derive de $i(lawsonia), polypeptides, peptides et proteines d'hemolysine et leurs utilisations |
| AU2004224903A AU2004224903A1 (en) | 1999-05-13 | 2004-10-27 | Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13402299P | 1999-05-13 | 1999-05-13 | |
| US60/134,022 | 1999-05-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2000069906A1 true WO2000069906A1 (fr) | 2000-11-23 |
Family
ID=22461415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/AU2000/000439 WO2000069906A1 (fr) | 1999-05-13 | 2000-05-11 | Gene derive de $i(lawsonia), polypeptides, peptides et proteines d'hemolysine et leurs utilisations |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1177213A4 (fr) |
| AU (2) | AU775323B2 (fr) |
| CA (1) | CA2372105A1 (fr) |
| NZ (1) | NZ515363A (fr) |
| PE (1) | PE20010239A1 (fr) |
| WO (1) | WO2000069906A1 (fr) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605696B1 (en) | 1999-10-22 | 2003-08-12 | Pfizer, Inc. | Lawsonia intracellularis proteins, and related methods and materials |
| US6921536B2 (en) | 2000-12-20 | 2005-07-26 | Akzo Nobel N.V. | Lawsonia intracellularis vaccine |
| WO2006099561A1 (fr) | 2005-03-14 | 2006-09-21 | Boehringer Ingelheim Vetmedica, Inc. | Compositions immunogenes comprenant de la lawsonia intracellularis |
| EP2204184A1 (fr) | 2005-07-15 | 2010-07-07 | BOEHRINGER INGELHEIM VETMEDICA, Inc. | Vaccin contre lawsonia et procédés d'utilisation de celui-ci |
| US20110033496A1 (en) * | 2008-04-18 | 2011-02-10 | Antonius Arnoldus Christiaan Jacobs | Vaccine for protection against lawsonia intracellulars |
| WO2012177520A3 (fr) * | 2011-06-20 | 2013-04-04 | Matthias Rath | Oligopeptides et leur utilisation pour le traitement de maladies infectieuses |
| EP2859900A1 (fr) | 2006-12-11 | 2015-04-15 | Boehringer Ingelheim Vetmedica, Inc. | Procédé efficace de traitement du circovirus porcin et des infections par lawsonia intracellularis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996039629A1 (fr) * | 1995-06-05 | 1996-12-12 | Boehringer Ingelheim/Nobl Laboratories, Inc. | Culture de lawsonia intracellularis, vaccin contre lawsonia intracellularis et agents de diagnostic |
| WO1997020050A1 (fr) * | 1995-11-30 | 1997-06-05 | Daratech Pty. Ltd. | Compositions therapeutiques et diagnostiques |
-
2000
- 2000-05-11 AU AU43861/00A patent/AU775323B2/en not_active Ceased
- 2000-05-11 CA CA002372105A patent/CA2372105A1/fr not_active Abandoned
- 2000-05-11 EP EP00924978A patent/EP1177213A4/fr not_active Withdrawn
- 2000-05-11 NZ NZ515363A patent/NZ515363A/en unknown
- 2000-05-11 WO PCT/AU2000/000439 patent/WO2000069906A1/fr not_active Application Discontinuation
- 2000-05-12 PE PE2000000447A patent/PE20010239A1/es not_active Application Discontinuation
-
2004
- 2004-10-27 AU AU2004224903A patent/AU2004224903A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996039629A1 (fr) * | 1995-06-05 | 1996-12-12 | Boehringer Ingelheim/Nobl Laboratories, Inc. | Culture de lawsonia intracellularis, vaccin contre lawsonia intracellularis et agents de diagnostic |
| WO1997020050A1 (fr) * | 1995-11-30 | 1997-06-05 | Daratech Pty. Ltd. | Compositions therapeutiques et diagnostiques |
Non-Patent Citations (2)
| Title |
|---|
| BOYE M. ET AL.: "Specific detection of lawsonia intracellularis in porcine proliferative enteropathy inferred from fluorescent tRNA in situ hybridization", VETERINARY PATHOLOGY, vol. 35, no. 2, March 1998 (1998-03-01), pages 153 - 156, XP000984238 * |
| See also references of EP1177213A4 * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605696B1 (en) | 1999-10-22 | 2003-08-12 | Pfizer, Inc. | Lawsonia intracellularis proteins, and related methods and materials |
| US7491401B2 (en) | 2000-12-20 | 2009-02-17 | Intervet International B.V. | Lawsonia intracellularis vaccine |
| US6921536B2 (en) | 2000-12-20 | 2005-07-26 | Akzo Nobel N.V. | Lawsonia intracellularis vaccine |
| US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| WO2006099561A1 (fr) | 2005-03-14 | 2006-09-21 | Boehringer Ingelheim Vetmedica, Inc. | Compositions immunogenes comprenant de la lawsonia intracellularis |
| EP2992897A1 (fr) | 2005-03-14 | 2016-03-09 | Boehringer Ingelheim Vetmedica, Inc. | Compositions immunogènes comprenant du lawsonia intercellularis |
| EP3354279A2 (fr) | 2005-03-14 | 2018-08-01 | Boehringer Ingelheim Vetmedica, Inc. | Compositions immunogènes comprenant du lawsonia intracellularis |
| EP3906941A1 (fr) | 2005-03-14 | 2021-11-10 | Boehringer Ingelheim Animal Health USA Inc. | Compositions immunogènes comprenant du lawsonia intercellularis |
| EP2204184A1 (fr) | 2005-07-15 | 2010-07-07 | BOEHRINGER INGELHEIM VETMEDICA, Inc. | Vaccin contre lawsonia et procédés d'utilisation de celui-ci |
| EP2859900A1 (fr) | 2006-12-11 | 2015-04-15 | Boehringer Ingelheim Vetmedica, Inc. | Procédé efficace de traitement du circovirus porcin et des infections par lawsonia intracellularis |
| US20110033496A1 (en) * | 2008-04-18 | 2011-02-10 | Antonius Arnoldus Christiaan Jacobs | Vaccine for protection against lawsonia intracellulars |
| JP2011516600A (ja) * | 2008-04-18 | 2011-05-26 | インターベツト・インターナシヨナル・ベー・ベー | ローソニア・イントラセルラーリスに対する保護のためのワクチン |
| US8597662B2 (en) | 2008-04-18 | 2013-12-03 | Intervet International B.V. | Vaccine for protection against Lawsonia intracellularis |
| US9198963B2 (en) | 2008-04-18 | 2015-12-01 | Intervet International B.V. | Vaccine for protection against Lawsonia intracellularis |
| WO2012177520A3 (fr) * | 2011-06-20 | 2013-04-04 | Matthias Rath | Oligopeptides et leur utilisation pour le traitement de maladies infectieuses |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1177213A1 (fr) | 2002-02-06 |
| EP1177213A4 (fr) | 2002-08-28 |
| CA2372105A1 (fr) | 2000-11-23 |
| AU2004224903A1 (en) | 2004-11-25 |
| AU4386100A (en) | 2000-12-05 |
| AU775323B2 (en) | 2004-07-29 |
| PE20010239A1 (es) | 2001-02-28 |
| NZ515363A (en) | 2003-07-25 |
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