WO2000069841A3 - Benzofuranylaminoalcools - Google Patents

Benzofuranylaminoalcools Download PDF

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Publication number
WO2000069841A3
WO2000069841A3 PCT/EP2000/004015 EP0004015W WO0069841A3 WO 2000069841 A3 WO2000069841 A3 WO 2000069841A3 EP 0004015 W EP0004015 W EP 0004015W WO 0069841 A3 WO0069841 A3 WO 0069841A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzofuranylaminoalcohols
medicaments
preparation
treatment
general formula
Prior art date
Application number
PCT/EP2000/004015
Other languages
English (en)
Other versions
WO2000069841A2 (fr
Inventor
Gabriele Braeunlich
Mazen Es-Sayed
Ruediger Fischer
Burkhard Fugmann
Rolf Henning
Stephan Schneider
Michael Sperzel
Karl-Heinz Schlemmer
Graham Sturton
Mary Fitzgerald
Barbara Briggs
Arnel Conception
William Bullock
Original Assignee
Bayer Ag
Gabriele Braeunlich
Es Sayed Mazen
Ruediger Fischer
Burkhard Fugmann
Rolf Henning
Stephan Schneider
Michael Sperzel
Schlemmer Karl Heinz
Graham Sturton
Mary Fitzgerald
Barbara Briggs
Arnel Conception
William Bullock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Gabriele Braeunlich, Es Sayed Mazen, Ruediger Fischer, Burkhard Fugmann, Rolf Henning, Stephan Schneider, Michael Sperzel, Schlemmer Karl Heinz, Graham Sturton, Mary Fitzgerald, Barbara Briggs, Arnel Conception, William Bullock filed Critical Bayer Ag
Priority to AU45616/00A priority Critical patent/AU4561600A/en
Publication of WO2000069841A2 publication Critical patent/WO2000069841A2/fr
Publication of WO2000069841A3 publication Critical patent/WO2000069841A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des benzofuranylaminoalcools de formule générale (I), ainsi que leur méthode de préparation et leur utilisation dans des médicaments, en particulier pour traiter les inflammations.
PCT/EP2000/004015 1999-05-17 2000-05-04 Benzofuranylaminoalcools WO2000069841A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45616/00A AU4561600A (en) 1999-05-17 2000-05-04 Benzofuranylaminoalcohols

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9911453.0 1999-05-17
GB9911453A GB2350110A (en) 1999-05-17 1999-05-17 Pharmaceutically active benzofurans

Publications (2)

Publication Number Publication Date
WO2000069841A2 WO2000069841A2 (fr) 2000-11-23
WO2000069841A3 true WO2000069841A3 (fr) 2002-05-02

Family

ID=10853621

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/004015 WO2000069841A2 (fr) 1999-05-17 2000-05-04 Benzofuranylaminoalcools

Country Status (3)

Country Link
AU (1) AU4561600A (fr)
GB (1) GB2350110A (fr)
WO (1) WO2000069841A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153871B2 (en) 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
US7144885B2 (en) 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
RU2350609C2 (ru) 2002-02-22 2009-03-27 БАЙЕР ХелсКер ЛЛСи Производные бензофурана и бензотиофена, применяемые при лечении гиперпролиферативных заболеваний
MXPA05000827A (es) 2002-07-19 2005-08-29 Memory Pharm Corp Inhibidores de fosfodiesterasa 4, incluyendo analogos de anilina y difenilamina n-sustituidos.
CN100381425C (zh) * 2002-07-19 2008-04-16 记忆药物公司 作为磷酸二酯酶4抑制剂的6-氨基-1h-吲唑及其药物组合物和用途
CN100513397C (zh) 2002-11-19 2009-07-15 记忆药物公司 磷酸二酯酶4抑制剂
EP3137454A1 (fr) 2014-04-28 2017-03-08 Pfizer Inc. Composés hétéroaromatiques et leur utilisation en tant que ligands de la dopamine d1

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146243A1 (fr) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Inhibiteurs de la lipoxygénase
EP0731099A1 (fr) * 1995-03-06 1996-09-11 Bayer Ag Dérivés de N-(3-benzofuranyl)urée
EP0779291A1 (fr) * 1995-12-11 1997-06-18 Bayer Ag Benzofuranyl-urée substitué par un héterocycliquecarbonyle
WO1998002440A1 (fr) * 1996-07-12 1998-01-22 Bayer Aktiengesellschaft 3-ureido-pyridofurans et -pyridothiophenes pour le traitement des troubles inflammatoires

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056626A (en) * 1971-05-13 1977-11-01 Kakenyaku Kako Co., Ltd. Pharmaceutical composition containing benzofuran derivative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146243A1 (fr) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Inhibiteurs de la lipoxygénase
EP0731099A1 (fr) * 1995-03-06 1996-09-11 Bayer Ag Dérivés de N-(3-benzofuranyl)urée
EP0779291A1 (fr) * 1995-12-11 1997-06-18 Bayer Ag Benzofuranyl-urée substitué par un héterocycliquecarbonyle
WO1998002440A1 (fr) * 1996-07-12 1998-01-22 Bayer Aktiengesellschaft 3-ureido-pyridofurans et -pyridothiophenes pour le traitement des troubles inflammatoires

Also Published As

Publication number Publication date
GB9911453D0 (en) 1999-07-14
GB2350110A (en) 2000-11-22
AU4561600A (en) 2000-12-05
WO2000069841A2 (fr) 2000-11-23

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