WO2000063385A2 - Nucleic acid immunization - Google Patents
Nucleic acid immunization Download PDFInfo
- Publication number
- WO2000063385A2 WO2000063385A2 PCT/US2000/010766 US0010766W WO0063385A2 WO 2000063385 A2 WO2000063385 A2 WO 2000063385A2 US 0010766 W US0010766 W US 0010766W WO 0063385 A2 WO0063385 A2 WO 0063385A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- use according
- sequence
- particles
- polysaccharide
- Prior art date
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- JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
Definitions
- transdermal delivery intends intradermal (e.g., into the dermis or epidermis), transdermal (e.g., "percutaneous") and transmucosal administration, i.e., delivery by passage of an agent into or through skin or mucosal tissue.
- transdermal Drug Delivery Developmental Issues and Research Initiatives, Hadgraft and Guy (eds.), Marcel Dekker, Inc., (1989); Controlled Drug Delivery:
- T cell epitopes comprise linear peptide determinants that assume extended conformations within the peptide- binding cleft of MHC molecules, (Unanue et al. (1987) Science 236:551-557).
- a T cell epitope is generally a peptide having at least about 3-5 amino acid residues, and preferably at least 5-10 or more amino acid residues.
- the peptide mimics correspond to an antigen containing one or more B cell epitopes.
- a "B cell epitope” generally refers to the site on an antigen to which a specific antibody molecule binds. The identification of epitopes which are able to elicit an antibody response is readily accomplished using techniques well known in the art. See, e.g., Geysen et al. (1984) Proc. Natl. Acad. Sci. USA 81.3998-4002 (general method of rapidly synthesizing peptides to determine the location of immunogenic epitopes in a given antigen); U.S. Patent No.
- Recombinant is used herein to describe a nucleic acid molecule (polynucleotide) of genomic, cDNA, semisynthetic, or synthetic origin which, by virtue of its origin or manipulation is not associated with all or a portion of the polynucleotide with which it is associated in nature and/or is linked to a polynucleotide other than that to which it is linked in nature.
- Two nucleic acid sequences which are contained within a single recombinant nucleic acid molecule are "heterologous" relative to each other when they are not normally associated with each other in nature.
- HBcAg can be readily expressed in Escherichia coli and other prokaryotes where it self-assembles into particles. For this reason, numerous peptide antigens have been fused to the HBcAg to provide hybrid core carrier particles that exhibit enhanced B cell immunogenicity.
- particulate nucleic acid compositions can administered transdermally using a conventional needleless syringe device.
- a particulate composition comprising the nucleic acid molecules of the present invention can be obtained using general pharmaceutical methods such as simple evaporation (crystallization), vacuum drying, spray drying or lyophilization.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00926234A EP1180150A2 (de) | 1999-04-21 | 2000-04-21 | Nukleinksäure immunizierung |
| NZ515041A NZ515041A (en) | 1999-04-21 | 2000-04-21 | Nucleic acid immunization |
| AU44797/00A AU4479700A (en) | 1999-04-21 | 2000-04-21 | Nucleic acid immunization |
| JP2000612464A JP2002542264A (ja) | 1999-04-21 | 2000-04-21 | 核酸による免疫化 |
| CA002370646A CA2370646A1 (en) | 1999-04-21 | 2000-04-21 | Nucleic acid immunization |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13024999P | 1999-04-21 | 1999-04-21 | |
| US60/130,249 | 1999-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2000063385A2 true WO2000063385A2 (en) | 2000-10-26 |
| WO2000063385A3 WO2000063385A3 (en) | 2001-02-22 |
Family
ID=22443785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2000/010766 WO2000063385A2 (en) | 1999-04-21 | 2000-04-21 | Nucleic acid immunization |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1180150A2 (de) |
| JP (1) | JP2002542264A (de) |
| AU (1) | AU4479700A (de) |
| CA (1) | CA2370646A1 (de) |
| NZ (1) | NZ515041A (de) |
| WO (1) | WO2000063385A2 (de) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002043774A2 (en) * | 2000-11-02 | 2002-06-06 | Powderject Vaccines, Inc. | Compositions and therapeutical use of polynucleotides encoding tcrs |
| WO2006027244A2 (en) * | 2004-09-10 | 2006-03-16 | Bracco Imaging S.P.A. | Paramagnetic metal polyamino complexes for mri visualization of internalized polynucleotides |
| WO2006133497A1 (en) * | 2005-06-15 | 2006-12-21 | Adelaide Research & Innovation Pty Ltd | Combination treatment |
| WO2007087758A2 (es) * | 2006-01-31 | 2007-08-09 | Centro De Ingenieria Genetica Y Biotecnologia | Mimotopos de polisacáridos capsulares de neisseria meningitidis y formulaciones farmacéuticas |
| WO2008043157A1 (en) | 2006-10-12 | 2008-04-17 | The University Of Queensland | Compositions and methods for modulating immune responses |
| WO2012058715A1 (en) | 2010-11-01 | 2012-05-10 | University Of Technology, Sydney | Immune-modulating agents and uses therefor |
| US9714283B2 (en) | 2014-10-28 | 2017-07-25 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| US11541110B2 (en) | 2017-10-13 | 2023-01-03 | The Research Foundation For The State University Of New York | Comprehensive vaccine design for commensal disease progression |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1671655A4 (de) * | 2003-08-29 | 2009-08-12 | Anges Mg Inc | Gentherapie für hauterkrankungen mit nadelfreier spritze |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027435A1 (en) * | 1993-06-01 | 1994-12-08 | Life Technologies, Inc. | Genetic immunization with cationic lipids |
| WO1997011605A1 (en) * | 1995-09-28 | 1997-04-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Stimulation of cell-mediated immune responses by targeted particulate genetic immunization |
| WO1998022145A1 (en) * | 1996-11-22 | 1998-05-28 | Mount Sinai School Of Medicine Of The City University Of New York | Immunization of infants |
| US5766878A (en) * | 1996-05-01 | 1998-06-16 | Smithkline Beecham Corporation | Polynucleotides encoding a transcriptional response regulator of streptococcus pneumoniae |
| US5865796A (en) * | 1994-01-21 | 1999-02-02 | Powderject Vaccines, Inc | Gas driven gene delivery instrument |
-
2000
- 2000-04-21 WO PCT/US2000/010766 patent/WO2000063385A2/en not_active Application Discontinuation
- 2000-04-21 CA CA002370646A patent/CA2370646A1/en not_active Abandoned
- 2000-04-21 JP JP2000612464A patent/JP2002542264A/ja not_active Withdrawn
- 2000-04-21 NZ NZ515041A patent/NZ515041A/xx unknown
- 2000-04-21 AU AU44797/00A patent/AU4479700A/en not_active Abandoned
- 2000-04-21 EP EP00926234A patent/EP1180150A2/de not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027435A1 (en) * | 1993-06-01 | 1994-12-08 | Life Technologies, Inc. | Genetic immunization with cationic lipids |
| US5865796A (en) * | 1994-01-21 | 1999-02-02 | Powderject Vaccines, Inc | Gas driven gene delivery instrument |
| WO1997011605A1 (en) * | 1995-09-28 | 1997-04-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Stimulation of cell-mediated immune responses by targeted particulate genetic immunization |
| US5766878A (en) * | 1996-05-01 | 1998-06-16 | Smithkline Beecham Corporation | Polynucleotides encoding a transcriptional response regulator of streptococcus pneumoniae |
| WO1998022145A1 (en) * | 1996-11-22 | 1998-05-28 | Mount Sinai School Of Medicine Of The City University Of New York | Immunization of infants |
Non-Patent Citations (3)
| Title |
|---|
| MILICH D R ET AL: "THE HEPATITIS NUCLEOCAPSID AS A VACCINE CARRIER MOIETY" ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY,US, vol. 754, 31 May 1995 (1995-05-31), pages 187-201, XP000891480 ISSN: 0077-8923 * |
| SCHOEDEL F ET AL: "IMMUNITY TO MALARIA ELICITED BY HYBRID HEPATITIS B VIRUS CORE PARTICLES CARRYING CIRCUMSPOROZOITE PROTEIN EPITOPES" JOURNAL OF EXPERIMENTAL MEDICINE,TOKYO,JP, vol. 180, no. 3, September 1994 (1994-09), pages 1037-1046, XP000891465 ISSN: 0022-1007 * |
| WESTERINK ET AL.: "Peptide mimicry of the meningococcal group C capsular polysaccharide" PROC NATL ACAD SCI USA, vol. 92, April 1995 (1995-04), pages 4021-4025, XP002150633 cited in the application * |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002043774A2 (en) * | 2000-11-02 | 2002-06-06 | Powderject Vaccines, Inc. | Compositions and therapeutical use of polynucleotides encoding tcrs |
| WO2002043774A3 (en) * | 2000-11-02 | 2003-12-04 | Powderject Vaccines Inc | Compositions and therapeutical use of polynucleotides encoding tcrs |
| WO2006027244A2 (en) * | 2004-09-10 | 2006-03-16 | Bracco Imaging S.P.A. | Paramagnetic metal polyamino complexes for mri visualization of internalized polynucleotides |
| WO2006027244A3 (en) * | 2004-09-10 | 2006-11-30 | Bracco Imaging Spa | Paramagnetic metal polyamino complexes for mri visualization of internalized polynucleotides |
| WO2006133497A1 (en) * | 2005-06-15 | 2006-12-21 | Adelaide Research & Innovation Pty Ltd | Combination treatment |
| WO2007087758A2 (es) * | 2006-01-31 | 2007-08-09 | Centro De Ingenieria Genetica Y Biotecnologia | Mimotopos de polisacáridos capsulares de neisseria meningitidis y formulaciones farmacéuticas |
| WO2007087758A3 (es) * | 2006-01-31 | 2007-11-15 | Ct Ingenieria Genetica Biotech | Mimotopos de polisacáridos capsulares de neisseria meningitidis y formulaciones farmacéuticas |
| WO2008043157A1 (en) | 2006-10-12 | 2008-04-17 | The University Of Queensland | Compositions and methods for modulating immune responses |
| EP3590503A1 (de) | 2006-10-12 | 2020-01-08 | The University of Queensland | Zusammensetzungen und verfahren zur modulation von immunreaktionen |
| WO2012058715A1 (en) | 2010-11-01 | 2012-05-10 | University Of Technology, Sydney | Immune-modulating agents and uses therefor |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US9969793B2 (en) | 2014-10-28 | 2018-05-15 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US9714283B2 (en) | 2014-10-28 | 2017-07-25 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US10683343B2 (en) | 2014-10-28 | 2020-06-16 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US11339206B2 (en) | 2014-10-28 | 2022-05-24 | Adma Biomanufacturing, Llc | Compositions and methods for the treatment of immunodeficiency |
| US11780906B2 (en) | 2014-10-28 | 2023-10-10 | Adma Biomanufacturing, Llc | Compositions and methods for the treatment of immunodeficiency |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| US11084870B2 (en) | 2017-03-15 | 2021-08-10 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| US11897943B2 (en) | 2017-03-15 | 2024-02-13 | Adma Biomanufacturing, Llc | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| US11541110B2 (en) | 2017-10-13 | 2023-01-03 | The Research Foundation For The State University Of New York | Comprehensive vaccine design for commensal disease progression |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2370646A1 (en) | 2000-10-26 |
| EP1180150A2 (de) | 2002-02-20 |
| AU4479700A (en) | 2000-11-02 |
| JP2002542264A (ja) | 2002-12-10 |
| WO2000063385A3 (en) | 2001-02-22 |
| NZ515041A (en) | 2004-03-26 |
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