WO2000062932A3 - VERFAHREN UND VORRICHTUNG ZUR DOSIERTEN AUSGABE VON FLÜSSIGKEITSMENGEN IM BEREICH VON 0,1 NL BIS 100 νL - Google Patents
VERFAHREN UND VORRICHTUNG ZUR DOSIERTEN AUSGABE VON FLÜSSIGKEITSMENGEN IM BEREICH VON 0,1 NL BIS 100 νL Download PDFInfo
- Publication number
- WO2000062932A3 WO2000062932A3 PCT/EP2000/003346 EP0003346W WO0062932A3 WO 2000062932 A3 WO2000062932 A3 WO 2000062932A3 EP 0003346 W EP0003346 W EP 0003346W WO 0062932 A3 WO0062932 A3 WO 0062932A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dosed
- gas surge
- dosing
- liquids
- liquid
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00364—Pipettes
- B01J2219/00367—Pipettes capillary
- B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Fluid-Pressure Circuits (AREA)
Abstract
Kleinste Flüssigkeitsmengen werden bisher mittels als Pumpen arbeitende Magnetventile oder mittels Aktuator betriebener Mikropumpen ausdosiert. Diese Technologien sind unwirtschaftlich, unter anderem weil die effektive Reinigung der Systeme problematisch ist und dies oft zum Ausfall des Gesamtsystems führt. Des weiteren sind die Systeme nicht in der Lage, bei Luftblasen in den Fluidkanälen, die aber kaum zu verhindern sind, zu dosieren. Das Andosieren der Flüssigkeit wird über einen Gasstoss gesteuert. Durch eine an die Kapillare (5a, b) angeschlossene Gasleitung (6) wird ein Gasstoss eingeleitet. Mittels dieses Gasstosses wird eine sich in einem Abschnitt der Kapillare (5b) befindliche Flüssigkeitsmenge (V) ausdosiert. Dies hat den Vorteil, dass der Gasstoss nur auf das Volumen (V) appliziert wied, das auch ausdosiert werden soll. Dosierte Ausgabe von Flüssigkeitsmengen im Bereich von 0,1 nl bis 100 νl.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1999117029 DE19917029C2 (de) | 1999-04-15 | 1999-04-15 | Verfahren und Vorrichtung zur dosierten Ausgabe von Flüssigkeitsmengen im Bereich von 0,1 nl bis 100 mul |
DE19917029.0 | 1999-04-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000062932A2 WO2000062932A2 (de) | 2000-10-26 |
WO2000062932A3 true WO2000062932A3 (de) | 2001-03-01 |
Family
ID=7904667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2000/003346 WO2000062932A2 (de) | 1999-04-15 | 2000-04-13 | VERFAHREN UND VORRICHTUNG ZUR DOSIERTEN AUSGABE VON FLÜSSIGKEITSMENGEN IM BEREICH VON 0,1 NL BIS 100 νL |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE19917029C2 (de) |
WO (1) | WO2000062932A2 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19941871A1 (de) | 1999-09-02 | 2001-04-19 | Hahn Schickard Ges | Vorrichtung und Verfahren zum Aufbringen einer Mehrzahl von Mikrotröpfchen auf ein Substrat |
DE10102152C1 (de) | 2001-01-18 | 2002-06-20 | Roland Zengerle | Vorrichtung und Verfahren zum Dosieren kleiner Flüssigkeitsmengen |
US7344002B2 (en) | 2003-03-31 | 2008-03-18 | Minebea Co., Ltd. | Method and apparatus for filling the bearing gap of a hydrodynamic bearing with a lubricant |
EP2392402A3 (de) | 2004-02-18 | 2012-03-21 | Life Technologies Corporation | Mehrstufige Biotests auf modularen Mikrofluidanwendungsplattformen |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3186808A (en) * | 1960-06-24 | 1965-06-01 | Anscherlik Arnost | Device for dosing reagents in automatic analyzers or other intermittently operating chemical apparatus |
US3771366A (en) * | 1971-03-26 | 1973-11-13 | Aga Ab | Device for collection and measurement of liquid volumes |
US5441878A (en) * | 1987-12-08 | 1995-08-15 | Thies Technology, Inc. | Preparation of uniform droplets by using gas pressure to force liquid from a syringe and flowing gas to detach droplets |
JPH08252913A (ja) * | 1995-03-15 | 1996-10-01 | Matsushita Electric Ind Co Ltd | 液体噴射装置および液体噴射方法 |
WO1999036176A1 (en) * | 1998-01-17 | 1999-07-22 | Central Research Laboratories Limited | Apparatus for dispensing a predetermined volume of a liquid |
WO1999042805A1 (en) * | 1998-02-18 | 1999-08-26 | Orchid Biosciences, Inc. | Device for delivering defined volumes |
WO1999047906A1 (en) * | 1998-03-16 | 1999-09-23 | Partec Partikelzählgeräte GmbH | Electronic apparatus for dispensing precise small quantities of fluid |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4877745A (en) * | 1986-11-17 | 1989-10-31 | Abbott Laboratories | Apparatus and process for reagent fluid dispensing and printing |
DE4014588A1 (de) * | 1990-05-07 | 1991-11-14 | Hirschmann Glasgeraete | Pipettiergeraet |
DE4024545A1 (de) * | 1990-08-02 | 1992-02-06 | Boehringer Mannheim Gmbh | Verfahren und vorrichtung zum dosierten zufuehren einer biochemischen analysefluessigkeit auf ein target |
-
1999
- 1999-04-15 DE DE1999117029 patent/DE19917029C2/de not_active Revoked
-
2000
- 2000-04-13 WO PCT/EP2000/003346 patent/WO2000062932A2/de active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3186808A (en) * | 1960-06-24 | 1965-06-01 | Anscherlik Arnost | Device for dosing reagents in automatic analyzers or other intermittently operating chemical apparatus |
US3771366A (en) * | 1971-03-26 | 1973-11-13 | Aga Ab | Device for collection and measurement of liquid volumes |
US5441878A (en) * | 1987-12-08 | 1995-08-15 | Thies Technology, Inc. | Preparation of uniform droplets by using gas pressure to force liquid from a syringe and flowing gas to detach droplets |
JPH08252913A (ja) * | 1995-03-15 | 1996-10-01 | Matsushita Electric Ind Co Ltd | 液体噴射装置および液体噴射方法 |
WO1999036176A1 (en) * | 1998-01-17 | 1999-07-22 | Central Research Laboratories Limited | Apparatus for dispensing a predetermined volume of a liquid |
WO1999042805A1 (en) * | 1998-02-18 | 1999-08-26 | Orchid Biosciences, Inc. | Device for delivering defined volumes |
WO1999047906A1 (en) * | 1998-03-16 | 1999-09-23 | Partec Partikelzählgeräte GmbH | Electronic apparatus for dispensing precise small quantities of fluid |
Non-Patent Citations (2)
Title |
---|
PANDA D ET AL: "SIMPLE APPARATUS FOR PRODUCING SINGLE LIQUID DROPS", REVIEW OF SCIENTIFIC INSTRUMENTS,US,AMERICAN INSTITUTE OF PHYSICS. NEW YORK, vol. 65, no. 7, 1 July 1994 (1994-07-01), pages 2388 - 2394, XP000458562, ISSN: 0034-6748 * |
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 02 28 February 1997 (1997-02-28) * |
Also Published As
Publication number | Publication date |
---|---|
DE19917029A1 (de) | 2000-11-09 |
WO2000062932A2 (de) | 2000-10-26 |
DE19917029C2 (de) | 2001-08-09 |
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