WO2000060078A3 - Latheo encodes a subunit of the origin of recognition complex - Google Patents

Latheo encodes a subunit of the origin of recognition complex Download PDF

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Publication number
WO2000060078A3
WO2000060078A3 PCT/US2000/008844 US0008844W WO0060078A3 WO 2000060078 A3 WO2000060078 A3 WO 2000060078A3 US 0008844 W US0008844 W US 0008844W WO 0060078 A3 WO0060078 A3 WO 0060078A3
Authority
WO
WIPO (PCT)
Prior art keywords
latheo
identifying
present
agent
relates
Prior art date
Application number
PCT/US2000/008844
Other languages
French (fr)
Other versions
WO2000060078A2 (en
Inventor
Timothy Tully
Anindya Dutta
Kendal Broadie
Original Assignee
Cold Spring Harbor Lab
Brigham And Women S Hospitals
Univ Utah
Timothy Tully
Anindya Dutta
Kendal Broadie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Lab, Brigham And Women S Hospitals, Univ Utah, Timothy Tully, Anindya Dutta, Kendal Broadie filed Critical Cold Spring Harbor Lab
Priority to AU40672/00A priority Critical patent/AU4067200A/en
Publication of WO2000060078A2 publication Critical patent/WO2000060078A2/en
Publication of WO2000060078A3 publication Critical patent/WO2000060078A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to isolated nucleic acid which encodes mammalian latheo protein (e.g., human). The present invention also relates to an isolated mammalian latheo protein (e.g., human). Also encompassed by the present invention are nucleic acid constructs, host cells, fusion proteins, antibodies and antisense nucleic acid. The present invention also relates to a method of producing a mammalian latheo protein. Also encompassed by the present invention are methods of identifying an agent that modulates (enhances, inhibits) interaction of latheo with a member of the origin recognition complex (e.g., ORC2, ORC4, ORC5, ORC6), a method of identifying an agent that modulates cell proliferation which results from latheo activity, a method of identifying sequence variants of latheo, a method of identifying an agent for use in the treatment of cancer, a method of identifying an agent to treat defects in synaptic function associated with a defective latheo and a method of identifying an agent to treat a cognitive dysfunction associated with latheo. Agents identified by the methods are also encompassed. The present invention also relates to methods of treating cancer, a defect in synaptic plasticity associated with a defective latheo and cognitive dysfunction associated with a defective latheo.
PCT/US2000/008844 1999-04-01 2000-04-03 Latheo encodes a subunit of the origin of recognition complex WO2000060078A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40672/00A AU4067200A (en) 1999-04-01 2000-04-03 Latheo encodes a subunit of the origin of recognition complex

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12738399P 1999-04-01 1999-04-01
US12733899P 1999-04-01 1999-04-01
US60/127,338 1999-04-01
US60/127,383 1999-04-01

Publications (2)

Publication Number Publication Date
WO2000060078A2 WO2000060078A2 (en) 2000-10-12
WO2000060078A3 true WO2000060078A3 (en) 2001-01-18

Family

ID=26825552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/008844 WO2000060078A2 (en) 1999-04-01 2000-04-03 Latheo encodes a subunit of the origin of recognition complex

Country Status (2)

Country Link
AU (1) AU4067200A (en)
WO (1) WO2000060078A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000279A1 (en) * 2001-06-21 2003-01-03 The Brigham And Women's Hospital, Inc. GEMININ AND orc3N INHIBIT REPLICATION OF HERPESVIRUSES, PAPILLOMAVIRUSES, AND POLYOMAVIRUSES
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010067A1 (en) * 1996-09-03 1998-03-12 Cold Spring Harbor Laboratory Human homolog of the latheo gene
WO1999058642A2 (en) * 1998-05-14 1999-11-18 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010067A1 (en) * 1996-09-03 1998-03-12 Cold Spring Harbor Laboratory Human homolog of the latheo gene
WO1999058642A2 (en) * 1998-05-14 1999-11-18 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BOYNTON S ET AL: "LATHEO A NEW GENE INVOLVED IN ASSOCIATIVE LEARNING AND MEMORY IN DROSOPHILA-MELANOGASTER IDENTIFIED FROM P ELEMENT MUTAGENESIS", GENETICS, vol. 131, no. 3, 1992, pages 655 - 672, XP000616518, ISSN: 0016-6731 *
DEAN F.B., O'DONNELL M.;: "Homo sapiens origin recognition complex subunit 3 (ORC3) mRNA, complete cds", EMBL DATABASE ; ACESSION NUMBER AF125507, 12 March 1999 (1999-03-12), XP002143865 *
FOSS MARGIT ET AL: "Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.", SCIENCE (WASHINGTON D C), vol. 262, no. 5141, 1993, pages 1838 - 1844, XP002150944, ISSN: 0036-8075 *
HARDY CHRISTOPHER F J: "Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.", MOLECULAR AND CELLULAR BIOLOGY, vol. 16, no. 4, 1996, pages 1832 - 1841, XP000953078, ISSN: 0270-7306 *
MIHALEK R., HOMANICS G.E.;: "Human infant brain unknown product mRNA, complete cds.", EMBL DATABSE ; ACCESSION NUMBER U50950, 9 April 1996 (1996-04-09), XP002143866 *
PINTO SHIRLY ET AL: "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant.", NEURON, vol. 23, no. 1, May 1999 (1999-05-01), pages 45 - 54, XP000929518, ISSN: 0896-6273 *
ROHRBOUGH JEFFREY ET AL: "latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity.", NEURON, vol. 23, no. 1, May 1999 (1999-05-01), pages 55 - 70, XP000929519, ISSN: 0896-6273 *
TUGAL TAMARA ET AL: "The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 49, 4 December 1998 (1998-12-04), pages 32421 - 32429, XP002143864, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU4067200A (en) 2000-10-23
WO2000060078A2 (en) 2000-10-12

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