WO2000058022A1 - Procede et appareil de nebulisation d'un liquide particulierement utile a l'administration d'agents biopharmaceutiques en aerosol - Google Patents

Procede et appareil de nebulisation d'un liquide particulierement utile a l'administration d'agents biopharmaceutiques en aerosol Download PDF

Info

Publication number
WO2000058022A1
WO2000058022A1 PCT/IL2000/000181 IL0000181W WO0058022A1 WO 2000058022 A1 WO2000058022 A1 WO 2000058022A1 IL 0000181 W IL0000181 W IL 0000181W WO 0058022 A1 WO0058022 A1 WO 0058022A1
Authority
WO
WIPO (PCT)
Prior art keywords
rigid porous
reservoir
porous body
liquid
aerosol
Prior art date
Application number
PCT/IL2000/000181
Other languages
English (en)
Inventor
Matitiau Fichman
Boris Goldman
Original Assignee
Liposol Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposol Ltd. filed Critical Liposol Ltd.
Priority to AU33219/00A priority Critical patent/AU3321900A/en
Publication of WO2000058022A1 publication Critical patent/WO2000058022A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0615—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced at the free surface of the liquid or other fluent material in a container and subjected to the vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Special Spraying Apparatus (AREA)

Abstract

Procédé et appareil de nébulisation d'un liquide afin de produire un aérosol à fines particules. Le liquide à nébuliser est introduit dans un réservoir (2) contenant un corps rigide poreux (3), afin d'obtenir un contact avec la face supérieure du corps rigide poreux. Du gaz sous pression à la face inférieure du corps rigide poreux (3) et le corps rigide poreux est soumis à des vibrations à une fréquence ultrasonore.
PCT/IL2000/000181 1999-03-28 2000-03-23 Procede et appareil de nebulisation d'un liquide particulierement utile a l'administration d'agents biopharmaceutiques en aerosol WO2000058022A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33219/00A AU3321900A (en) 1999-03-28 2000-03-23 A method and apparatus for nebulizing a liquid particularly useful for the aerosol delivery of biopharmaceuticals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL129208 1999-03-28
IL12920899A IL129208A0 (en) 1999-03-28 1999-03-28 A method and apparatus for nebulizing a liquid particulary useful for the aerosol delivery of biopharmaceuticals

Publications (1)

Publication Number Publication Date
WO2000058022A1 true WO2000058022A1 (fr) 2000-10-05

Family

ID=11072651

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2000/000181 WO2000058022A1 (fr) 1999-03-28 2000-03-23 Procede et appareil de nebulisation d'un liquide particulierement utile a l'administration d'agents biopharmaceutiques en aerosol

Country Status (3)

Country Link
AU (1) AU3321900A (fr)
IL (1) IL129208A0 (fr)
WO (1) WO2000058022A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1258264A2 (fr) * 2001-05-16 2002-11-20 InAMed GmbH Appareil pour l'administration d'aérosol
FR2835435A1 (fr) * 2002-02-01 2003-08-08 Diffusion Tech Francaise Sarl Dispositif de protection du circuit sonique d'un generateur d'aerosol therapeutique
EP1358004A2 (fr) * 2001-01-18 2003-11-05 Ultrasonic Dryer Ltd. Procede et appareil de production de goutelettes
WO2006006963A3 (fr) * 2004-04-02 2006-06-01 Us Gov Health & Human Serv Systemes et procedes de distribution par aerosols
EP1700614A1 (fr) * 2005-03-08 2006-09-13 Activaero GmbH Dispositif d'inhalation
US7225807B2 (en) 2001-03-15 2007-06-05 Creare Incorporated Systems and methods for aerosol delivery of agents
GB2450536A (en) * 2007-06-29 2008-12-31 John Deal Mist generating device and control means
CN102511425A (zh) * 2011-12-30 2012-06-27 中国水产科学研究院黑龙江水产研究所 用于水产养殖的水中雾化消毒给药的方法
CN102580885A (zh) * 2011-12-30 2012-07-18 中国水产科学研究院黑龙江水产研究所 用于水产养殖的药物超声雾化装置及与其配套使用的容器
KR101309960B1 (ko) * 2010-12-28 2013-09-17 주식회사 포스코 에어로졸 공급장치
CN103345273A (zh) * 2013-07-25 2013-10-09 重庆市正川玻璃有限公司 共振差频玻璃窑炉高温液面监控系统
WO2016059630A1 (fr) * 2014-10-13 2016-04-21 Omega Life Science Ltd. Nébuliseurs et leurs utilisations
JP2016209825A (ja) * 2015-05-11 2016-12-15 国立大学法人群馬大学 気体の微細化装置
US10857311B2 (en) 2010-01-12 2020-12-08 Omega Life Science Ltd. Method and apparatus for producing fine concentrated aerosol

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790079A (en) * 1972-06-05 1974-02-05 Rnb Ass Inc Method and apparatus for generating monodisperse aerosol
US3918640A (en) * 1973-06-20 1975-11-11 Stern Freres Sa Mist generator
US4087495A (en) * 1976-03-25 1978-05-02 Mikuni Kogyo Kabushiki Kaisha Ultrasonic air humidifying apparatus
US4708826A (en) * 1985-03-06 1987-11-24 Sharp Kabushiki Kaisha Supersonic humidifier
US4793714A (en) * 1985-12-05 1988-12-27 Achmed N. Sadik Apparatus for mixing fluids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3790079A (en) * 1972-06-05 1974-02-05 Rnb Ass Inc Method and apparatus for generating monodisperse aerosol
US3918640A (en) * 1973-06-20 1975-11-11 Stern Freres Sa Mist generator
US4087495A (en) * 1976-03-25 1978-05-02 Mikuni Kogyo Kabushiki Kaisha Ultrasonic air humidifying apparatus
US4708826A (en) * 1985-03-06 1987-11-24 Sharp Kabushiki Kaisha Supersonic humidifier
US4793714A (en) * 1985-12-05 1988-12-27 Achmed N. Sadik Apparatus for mixing fluids

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1500002B (zh) * 2001-01-18 2011-07-27 超音速干燥机有限公司 产生液滴的方法和设备
EP1358004A2 (fr) * 2001-01-18 2003-11-05 Ultrasonic Dryer Ltd. Procede et appareil de production de goutelettes
EP1358004A4 (fr) * 2001-01-18 2004-04-28 Ultrasonic Dryer Ltd Procede et appareil de production de goutelettes
US6899322B2 (en) 2001-01-18 2005-05-31 Ultrasonic Dryer Ltd. Method and apparatus for production of droplets
AU2002217410B2 (en) * 2001-01-18 2008-05-01 Ultrasonic Dryer Ltd. Method and apparatus for production of droplets
US8544462B2 (en) 2001-03-15 2013-10-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Systems and methods for aerosol delivery of agents
US7225807B2 (en) 2001-03-15 2007-06-05 Creare Incorporated Systems and methods for aerosol delivery of agents
EP1258264A3 (fr) * 2001-05-16 2004-03-31 InAMed GmbH Appareil pour l'administration d'aérosol
EP1258264A2 (fr) * 2001-05-16 2002-11-20 InAMed GmbH Appareil pour l'administration d'aérosol
FR2835435A1 (fr) * 2002-02-01 2003-08-08 Diffusion Tech Francaise Sarl Dispositif de protection du circuit sonique d'un generateur d'aerosol therapeutique
US8656908B2 (en) 2004-04-02 2014-02-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Aerosol delivery systems and methods
US7954486B2 (en) 2004-04-02 2011-06-07 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Aerosol delivery systems and methods
WO2006006963A3 (fr) * 2004-04-02 2006-06-01 Us Gov Health & Human Serv Systemes et procedes de distribution par aerosols
EP1700614A1 (fr) * 2005-03-08 2006-09-13 Activaero GmbH Dispositif d'inhalation
US7866317B2 (en) 2005-03-08 2011-01-11 Activaero Gmbh Inhalation device
GB2450536B (en) * 2007-06-29 2011-06-15 John Deal Mist generating device and control system
GB2450536A (en) * 2007-06-29 2008-12-31 John Deal Mist generating device and control means
US10857311B2 (en) 2010-01-12 2020-12-08 Omega Life Science Ltd. Method and apparatus for producing fine concentrated aerosol
KR101309960B1 (ko) * 2010-12-28 2013-09-17 주식회사 포스코 에어로졸 공급장치
CN102511425A (zh) * 2011-12-30 2012-06-27 中国水产科学研究院黑龙江水产研究所 用于水产养殖的水中雾化消毒给药的方法
CN102511425B (zh) * 2011-12-30 2013-07-03 中国水产科学研究院黑龙江水产研究所 用于水产养殖的水中雾化消毒给药的方法
CN102580885A (zh) * 2011-12-30 2012-07-18 中国水产科学研究院黑龙江水产研究所 用于水产养殖的药物超声雾化装置及与其配套使用的容器
CN103345273A (zh) * 2013-07-25 2013-10-09 重庆市正川玻璃有限公司 共振差频玻璃窑炉高温液面监控系统
WO2016059630A1 (fr) * 2014-10-13 2016-04-21 Omega Life Science Ltd. Nébuliseurs et leurs utilisations
EP3206740A4 (fr) * 2014-10-13 2018-08-01 Omega Life Science Ltd Nébuliseurs et leurs utilisations
US10052443B2 (en) 2014-10-13 2018-08-21 Omega Life Science Ltd. Nebulizers and uses thereof
US10369301B2 (en) 2014-10-13 2019-08-06 Omega Life Science Ltd. Nebulizers and uses thereof
JP2016209825A (ja) * 2015-05-11 2016-12-15 国立大学法人群馬大学 気体の微細化装置

Also Published As

Publication number Publication date
AU3321900A (en) 2000-10-16
IL129208A0 (en) 2000-02-17

Similar Documents

Publication Publication Date Title
WO2000058022A1 (fr) Procede et appareil de nebulisation d'un liquide particulierement utile a l'administration d'agents biopharmaceutiques en aerosol
EP1436090B1 (fr) Procedes et dispositifs de production, d'extraction et de distribution de brume a gouttelettes ultra-fines
JP3659593B2 (ja) 液体スプレー装置及び方法
US5823428A (en) Liquid spray apparatus and method
US6315215B1 (en) Apparatus and method for ultrasonically self-cleaning an orifice
US6837445B1 (en) Integral pump for high frequency atomizer
US5145113A (en) Ultrasonic generation of a submicron aerosol mist
CA2730242C (fr) Atomiseur ultrasonore multi-element
JP4305729B2 (ja) 液体吐出装置及びマイクロカプセルの製造方法
JPS61141955A (ja) 液体噴射装置
JPS6246230B2 (fr)
JPS6321541B2 (fr)
GB2388062A (en) Generating a controlled amount of mist
JPS58202070A (ja) 霧化装置
JPS5912776A (ja) 霧化装置
JPH0618581Y2 (ja) 液滴製造装置
JPS5843262A (ja) 液体の均一径微粒化方法及びその実施のための装置
JPS61153172A (ja) 液体噴射装置
JPS59230659A (ja) 霧化装置
JPS62237935A (ja) 均一粒径液滴製造装置
CN114849587A (zh) 一种基于气流加速的微小液滴发生装置
JPS5867372A (ja) 霧化装置
JPS59154160A (ja) 霧化装置
JPS6312665B2 (fr)
JPS59354A (ja) 霧化装置

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)