WO2000047062A3 - Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same - Google Patents

Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same Download PDF

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Publication number
WO2000047062A3
WO2000047062A3 PCT/US2000/002687 US0002687W WO0047062A3 WO 2000047062 A3 WO2000047062 A3 WO 2000047062A3 US 0002687 W US0002687 W US 0002687W WO 0047062 A3 WO0047062 A3 WO 0047062A3
Authority
WO
WIPO (PCT)
Prior art keywords
filtrate
proanthocyanidin
proanthocyanidin polymer
dietary supplements
retentate
Prior art date
Application number
PCT/US2000/002687
Other languages
French (fr)
Other versions
WO2000047062A2 (en
Inventor
David F Sesin
Shivanand D Jolad
Chow San-Laung
George J Lee
John W S Chow
Thomas J Carlson
Original Assignee
Shaman Pharmaceuticals Inc
David F Sesin
Shivanand D Jolad
San Laung Chow
George J Lee
John W S Chow
Thomas J Carlson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shaman Pharmaceuticals Inc, David F Sesin, Shivanand D Jolad, San Laung Chow, George J Lee, John W S Chow, Thomas J Carlson filed Critical Shaman Pharmaceuticals Inc
Priority to AU29790/00A priority Critical patent/AU2979000A/en
Publication of WO2000047062A2 publication Critical patent/WO2000047062A2/en
Publication of WO2000047062A3 publication Critical patent/WO2000047062A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Botany (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides for a method for preparing a proanthocyanidin enriched composition useful as a dietary supplement. The proanthocyanidin polymer composition can be synthesized by the method comprising the steps of precipitating Croton ssp latex by adjusting the pH of the latex; removing precipitated residue from the precipitated latex to produce a filtrate; concentrating the filtrate to obtain a retentate; and drying the filtrate, the filtrate being essentially free of anti-foaming agents. A further optional additional step includes removing additional taspine from the retentate by contacting said retentate with chromatographic media. A proanthocyanidin composition product made by this process is also described. Dietary supplements containing a proanthocyanidin polymer enriched composition as well as dietary supplements containing a proanthocyanidin polymer enriched composition and an additional herbal agent, e.g., ginger, cinnamon, and peppermint oil are also described.
PCT/US2000/002687 1999-02-01 2000-02-01 Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same WO2000047062A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU29790/00A AU2979000A (en) 1999-02-01 2000-02-02 Enteric formulations of proanthocyanidin polymer dietary supplements and methodsfor preparing same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24319799A 1999-02-01 1999-02-01
US09/243,197 1999-02-01
US36424899A 1999-07-29 1999-07-29
US09/364,248 1999-07-29

Publications (2)

Publication Number Publication Date
WO2000047062A2 WO2000047062A2 (en) 2000-08-17
WO2000047062A3 true WO2000047062A3 (en) 2000-12-14

Family

ID=26935660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/002687 WO2000047062A2 (en) 1999-02-01 2000-02-01 Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same

Country Status (2)

Country Link
AU (1) AU2979000A (en)
WO (1) WO2000047062A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6764900A (en) * 1999-08-13 2001-03-13 Dry Creek Nutrition, Inc. Novel polyphenolic polymeric compositions, method of their isolation, and a method of altering and improving taste characteristics of edible consumables
US6960360B2 (en) 2000-08-31 2005-11-01 Phenolics, Llc Efficient method for producing compositions enriched in total phenols
FR2825899B1 (en) * 2001-06-14 2004-10-01 Phytosynthese PREPARATION FOR ANIMALS, ESPECIALLY POULTRY
US7208183B2 (en) * 2002-10-05 2007-04-24 Bobrowski Paul J Methods and preparations of the latex from the croton species
FR2852842A1 (en) * 2003-03-31 2004-10-01 Silab Sa Process for preparing an active component from the resin exudate of fruits of Daemonorops or Croton, useful for dermatological application to protect against free radicals
EP1502594A1 (en) * 2003-07-31 2005-02-02 Pynogin GmbH A health care composition for decreasing the risk of thrombosis including a mixture of proanthocyanidins and sesquiterpenes
KR20090009292A (en) * 2006-05-01 2009-01-22 나포 팔마큐티칼스 인코퍼레이션 Method for treatment of constipation-predominant irritable bowel syndrome
US20070254050A1 (en) * 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
AU2013205344B2 (en) * 2006-05-01 2016-11-10 Napo Pharmaceuticals, Inc. Method for treatment of diarrhea-predominant irritable bowel syndrome
AU2007248183B2 (en) 2006-05-01 2013-08-01 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer
US8048413B2 (en) * 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
BRPI0704096E2 (en) 2006-12-27 2009-09-15 Kraft Foods Holdings Inc method for significantly reducing astringency and bitterness levels in polyphenol compositions, and, composition
US8445040B2 (en) 2008-02-19 2013-05-21 Management and Holdings—Ardom Extracts of Sclerocarya birrea
US9210945B2 (en) 2009-07-31 2015-12-15 The Iams Company Animal food having low water activity
US20110027417A1 (en) 2009-07-31 2011-02-03 Patrick Joseph Corrigan Process for Dusting Animal Food
US8691303B2 (en) 2009-07-31 2014-04-08 The Iams Company Dusted animal food
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
US9173423B2 (en) 2009-07-31 2015-11-03 The Iams Company Animal food kibble with electrostatically adhered dusting
WO2011024049A2 (en) * 2009-08-26 2011-03-03 Glenmark Pharmaceuticals Ltd Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations
ES2635435T3 (en) * 2010-10-31 2017-10-03 Napo Pharmaceuticals, Inc. Procedures and compositions for treating HIV-associated diarrhea
WO2012101008A1 (en) * 2011-01-27 2012-08-02 Glenmark Pharmaceuticals Limited Process for the production of proanthocyanidin polymeric composition
CN104383491A (en) * 2014-11-20 2015-03-04 王正琦 Traditional Chinese medicine composition for treating chronic diarrhea
KR20170103834A (en) * 2015-01-09 2017-09-13 재규어 애니멀 헬스 How to treat diarrhea in companion animals
CN104587352A (en) * 2015-02-15 2015-05-06 赵世明 Traditional Chinese medicinal composition for treating diarrhea
CA2975219C (en) 2015-02-16 2022-02-22 Mars, Incorporated Interlocking kibble
CN107529789A (en) 2015-04-28 2018-01-02 马斯公司 Method for preparing sterilized wet pet food
JOP20190276A1 (en) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc Methods and compositions for treating bile acid diarrhea, diarrhea associated with small intestine resection or gallbladder removal, and short bowel syndrome
JOP20190275A1 (en) 2017-05-31 2019-11-27 Napo Pharmaceuticals Inc Methods and compositions for treating congenital diarrhea disorder

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211944A (en) * 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
WO1997044407A1 (en) * 1996-05-23 1997-11-27 Ian Alexander Gilmour Process for extraction of proanthocyanidins from botanical material
WO1998016111A1 (en) * 1996-10-16 1998-04-23 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211944A (en) * 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
US5494661A (en) * 1990-10-12 1996-02-27 Shaman Pharmaceuticals, Inc. Methods for using proanthocyanidin polymers having antiviral activity
WO1997044407A1 (en) * 1996-05-23 1997-11-27 Ian Alexander Gilmour Process for extraction of proanthocyanidins from botanical material
WO1998016111A1 (en) * 1996-10-16 1998-04-23 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1987, NAMBA T. ET AL.: "Studies on the natural medicinal resources from Sri-Lanka ...", XP002142639 *

Also Published As

Publication number Publication date
WO2000047062A2 (en) 2000-08-17
AU2979000A (en) 2000-08-29

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