WO2000043535A3 - Composition and device for detecting leukocytes in urine - Google Patents

Composition and device for detecting leukocytes in urine Download PDF

Info

Publication number
WO2000043535A3
WO2000043535A3 PCT/US2000/001333 US0001333W WO0043535A3 WO 2000043535 A3 WO2000043535 A3 WO 2000043535A3 US 0001333 W US0001333 W US 0001333W WO 0043535 A3 WO0043535 A3 WO 0043535A3
Authority
WO
WIPO (PCT)
Prior art keywords
unsubstituted
substituted
blocked
thiazole
leukocytes
Prior art date
Application number
PCT/US2000/001333
Other languages
French (fr)
Other versions
WO2000043535A2 (en
Inventor
Nam-Won Huh
Original Assignee
Chronimed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/365,322 external-priority patent/US6348324B1/en
Priority claimed from US09/365,592 external-priority patent/US6528652B1/en
Application filed by Chronimed Inc filed Critical Chronimed Inc
Priority to EP00904434A priority Critical patent/EP1163360A2/en
Priority to AU26195/00A priority patent/AU2619500A/en
Priority to JP2000594943A priority patent/JP2002535342A/en
Priority to CA002359689A priority patent/CA2359689A1/en
Publication of WO2000043535A2 publication Critical patent/WO2000043535A2/en
Publication of WO2000043535A3 publication Critical patent/WO2000043535A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Thiazole esters are suitable for detecting the presence of leukocytes in urine. Such thiazole esters are suitable for use in compositions, diagnostic devices, and methods for detecting the presence of leukocytes. In one embodiment, a thiazole ester is of formula (I) or a salt or solvated salt thereof, in which A is an N-blocked amino acid residue or an N-blocked peptide chain, preferably N-blocked alanine or N-blocked polyalanine; and R1 is unsubstituted or substituted heteroaryl; alkenyl substituted with unsubstituted or substituted aryl; or alkenyl substituted with unsubstituted or substituted heteroaryl. For example, R1 may be thienyl, pyridyl, furyl, styryl, pyrrolyl, or indolyl. In still another embodiment, the thiazole ester includes unsubstituted or substituted fused hydrocarbyl rings as a substituent. In one embodiment, fused hydrocarbyl rings include naphthyl. In another embodiment, fused hydrocarbyl rings include anthryl.
PCT/US2000/001333 1999-01-21 2000-01-20 Composition and device for detecting leukocytes in urine WO2000043535A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00904434A EP1163360A2 (en) 1999-01-21 2000-01-20 Composition and device for detecting leukocytes in urine
AU26195/00A AU2619500A (en) 1999-01-21 2000-01-20 Composition and device for detecting leukocytes in urine
JP2000594943A JP2002535342A (en) 1999-01-21 2000-01-20 Compositions and devices for assaying leukocytes in urine
CA002359689A CA2359689A1 (en) 1999-01-21 2000-01-20 Composition and device for detecting leukocytes in urine

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US11661399P 1999-01-21 1999-01-21
US60/116,613 1999-01-21
US14338399P 1999-07-12 1999-07-12
US60/143,383 1999-07-12
US09/365,592 1999-07-30
US09/365,322 US6348324B1 (en) 1999-01-21 1999-07-30 Composition and device for detecting leukocytes in urine
US09/365,322 1999-07-30
US09/365,592 US6528652B1 (en) 1999-01-21 1999-07-30 Composition and device for detecting leukocytes in urine

Publications (2)

Publication Number Publication Date
WO2000043535A2 WO2000043535A2 (en) 2000-07-27
WO2000043535A3 true WO2000043535A3 (en) 2000-11-30

Family

ID=27494092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001333 WO2000043535A2 (en) 1999-01-21 2000-01-20 Composition and device for detecting leukocytes in urine

Country Status (6)

Country Link
EP (1) EP1163360A2 (en)
JP (1) JP2002535342A (en)
AU (1) AU2619500A (en)
CA (1) CA2359689A1 (en)
HU (1) HUP0105041A2 (en)
WO (1) WO2000043535A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750359A (en) * 1996-07-30 1998-05-12 Chung-Do Pharmaceutical Co., Ltd. Composition for detecting leucocyte and proteinase in urine and its measuring device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750359A (en) * 1996-07-30 1998-05-12 Chung-Do Pharmaceutical Co., Ltd. Composition for detecting leucocyte and proteinase in urine and its measuring device

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent World Patents Index; XP002901012 *
DATABASE WPI Derwent World Patents Index; XP002901013 *

Also Published As

Publication number Publication date
AU2619500A (en) 2000-08-07
HUP0105041A2 (en) 2002-05-29
JP2002535342A (en) 2002-10-22
CA2359689A1 (en) 2000-07-27
WO2000043535A2 (en) 2000-07-27
EP1163360A2 (en) 2001-12-19

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