HUP0105041A2 - Composition and device for detecting leukocytes in urine - Google Patents
Composition and device for detecting leukocytes in urineInfo
- Publication number
- HUP0105041A2 HUP0105041A2 HU0105041A HUP0105041A HUP0105041A2 HU P0105041 A2 HUP0105041 A2 HU P0105041A2 HU 0105041 A HU0105041 A HU 0105041A HU P0105041 A HUP0105041 A HU P0105041A HU P0105041 A2 HUP0105041 A2 HU P0105041A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- optionally substituted
- urine
- optionally
- hydrogen atom
- Prior art date
Links
- 210000000265 leukocyte Anatomy 0.000 title abstract 2
- 210000002700 urine Anatomy 0.000 title abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Chemical group 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/918—Carboxylic ester hydrolases (3.1.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
A találmány szerinti vegyületek (I), (II) és (III) általánosképletében A jelentése nitrogénatomján védett aminosavmaradék vagynitrogénatomján védett peptidlánc, Rl jelentése adott esetbenszubsztituált heteroarilcsoport, adott esetben szubsztituáltarilcsoporttal szubsztituált alkenilcsoport vagy adott esetbenszubsztituált heteroarilcsoporttal szubsztituált alkenilcsoport, R2jelentése adott esetben szubsztituált fuzionált szénhidrogéngyűrű,amely legalább egy aromás gyűrűt tartalmaz, R3 és R4 jelentéseegymástól függetlenül hidrogénatom, adott esetben szubsztituáltarilcsoport, adott esetben szubsztituált heteroarilcsoport, adottesetben szubsztituált alkilcsoport, adott esetben szubsztituáltalkenilcsoport, adott esetben szubsztituált alkoxicsoport,aminocsoport, adott esetben szubsztituált acilcsoport, halogénatom,nitrocsoport, cianocsoport, -SO3H képletű csoport vagyhidroxilcsoport, azzal a megszorítással, hogy R3 és R4 közül legalábbaz egyik jelentése hidrogénatomtól eltérő. A találmány kiterjed afenti vegyületeket tartalmazó készítményekre és leukociták vizeletbentörténő kimutatására alkalmas eszközre és eljárásra. ÓIn the general formulas (I), (II) and (III) of the compounds according to the invention, A is an amino acid residue protected at its nitrogen atom or a peptide chain protected at its nitrogen atom, Rl is an optionally substituted heteroaryl group, optionally an alkenyl group substituted with a substituted aryl group or an optionally substituted alkenyl group with a substituted heteroaryl group, R2 is an optionally substituted fused hydrocarbon ring, which contains at least one aromatic ring, R3 and R4 are independently a hydrogen atom, optionally substituted aryl group, optionally substituted heteroaryl group, optionally substituted alkyl group, optionally substituted alkenyl group, optionally substituted alkoxy group, amino group, optionally substituted acyl group, halogen atom, nitro group, cyano group, - A group with the formula SO3H or a hydroxyl group, with the restriction that at least one of R3 and R4 has a meaning other than a hydrogen atom. The invention covers preparations containing afentic compounds and a device and method suitable for the detection of leukocytes in urine. HE
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11661399P | 1999-01-21 | 1999-01-21 | |
| US14338399P | 1999-07-12 | 1999-07-12 | |
| US09/365,322 US6348324B1 (en) | 1999-01-21 | 1999-07-30 | Composition and device for detecting leukocytes in urine |
| US09/365,592 US6528652B1 (en) | 1999-01-21 | 1999-07-30 | Composition and device for detecting leukocytes in urine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0105041A2 true HUP0105041A2 (en) | 2002-05-29 |
Family
ID=27494092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105041A HUP0105041A2 (en) | 1999-01-21 | 2000-01-20 | Composition and device for detecting leukocytes in urine |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1163360A2 (en) |
| JP (1) | JP2002535342A (en) |
| AU (1) | AU2619500A (en) |
| CA (1) | CA2359689A1 (en) |
| HU (1) | HUP0105041A2 (en) |
| WO (1) | WO2000043535A2 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR980010425A (en) * | 1996-07-30 | 1998-04-30 | 안홍원 | Compositions and measuring instruments for the detection of urine leukocytes and proteolytic enzymes |
-
2000
- 2000-01-20 JP JP2000594943A patent/JP2002535342A/en active Pending
- 2000-01-20 CA CA002359689A patent/CA2359689A1/en not_active Abandoned
- 2000-01-20 HU HU0105041A patent/HUP0105041A2/en unknown
- 2000-01-20 EP EP00904434A patent/EP1163360A2/en not_active Withdrawn
- 2000-01-20 WO PCT/US2000/001333 patent/WO2000043535A2/en active Search and Examination
- 2000-01-20 AU AU26195/00A patent/AU2619500A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2619500A (en) | 2000-08-07 |
| WO2000043535A3 (en) | 2000-11-30 |
| JP2002535342A (en) | 2002-10-22 |
| WO2000043535A2 (en) | 2000-07-27 |
| CA2359689A1 (en) | 2000-07-27 |
| EP1163360A2 (en) | 2001-12-19 |
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