WO2000041473A3 - Use of 3-isoxazolidinones and hydroxylamine acids for the treatment of infections - Google Patents

Use of 3-isoxazolidinones and hydroxylamine acids for the treatment of infections Download PDF

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Publication number
WO2000041473A3
WO2000041473A3 PCT/EP2000/000165 EP0000165W WO0041473A3 WO 2000041473 A3 WO2000041473 A3 WO 2000041473A3 EP 0000165 W EP0000165 W EP 0000165W WO 0041473 A3 WO0041473 A3 WO 0041473A3
Authority
WO
WIPO (PCT)
Prior art keywords
infections
treatment
isoxazolidinones
hydroxylamine
acids
Prior art date
Application number
PCT/EP2000/000165
Other languages
German (de)
French (fr)
Other versions
WO2000041473A2 (en
Inventor
Hassan Jomaa
Original Assignee
Jomaa Pharmaka Gmbh
Hassan Jomaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19903666A external-priority patent/DE19903666A1/en
Priority to SK950-2001A priority Critical patent/SK9502001A3/en
Priority to IL14379500A priority patent/IL143795A0/en
Priority to JP2000593097A priority patent/JP2002534440A/en
Priority to EP00902582A priority patent/EP1143941A3/en
Priority to BR0007491-8A priority patent/BR0007491A/en
Application filed by Jomaa Pharmaka Gmbh, Hassan Jomaa filed Critical Jomaa Pharmaka Gmbh
Priority to EA200100768A priority patent/EA200100768A1/en
Priority to AU24366/00A priority patent/AU2436600A/en
Priority to CA002360366A priority patent/CA2360366A1/en
Publication of WO2000041473A2 publication Critical patent/WO2000041473A2/en
Priority to NO20013464A priority patent/NO20013464L/en
Publication of WO2000041473A3 publication Critical patent/WO2000041473A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to medicaments containing at least one compound of the formula (I) and to their use for the therapeutic and prophylactic treatment of bacterial, fungal and parasitic infections in humans and animals.
PCT/EP2000/000165 1999-01-13 2000-01-12 Use of 3-isoxazolidinones and hydroxylamine acids for the treatment of infections WO2000041473A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002360366A CA2360366A1 (en) 1999-01-13 2000-01-12 Use of 3-isoxazolidinones and hydroxylamine acids for the treatment of infections
IL14379500A IL143795A0 (en) 1999-01-13 2000-01-12 Use of 3-isoxazolidinones and hydroxylamic acids for the treatment of infections
JP2000593097A JP2002534440A (en) 1999-01-13 2000-01-12 Use of 3-isoxazolidinone and hydroxylamic acid for the treatment of infectious diseases
EP00902582A EP1143941A3 (en) 1999-01-13 2000-01-12 Use of 3-isoxazolidinones and hydroxylamine acids for the treatment of infections
BR0007491-8A BR0007491A (en) 1999-01-13 2000-01-12 Use of 3-isoxazolidinones and hydroxylamic acids to treat infections
SK950-2001A SK9502001A3 (en) 1999-01-13 2000-01-12 Use of 3-isoxazolidinones and hydroxylamine acids for the treatment of infections
EA200100768A EA200100768A1 (en) 1999-01-13 2000-01-12 APPLICATION OF 3-ISOXASOZOLIDINONES AND HYDROXYAMINO ACIDS FOR THE TREATMENT OF INFECTIONS
AU24366/00A AU2436600A (en) 1999-01-13 2000-01-12 Use of 3-isoxazolidinones and hydroxylamine acids for the treatment of infections
NO20013464A NO20013464L (en) 1999-01-13 2001-07-12 Use of 3-isoxazolidinones and hydroxylamino acids for the treatment of infections

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19900907.4 1999-01-13
DE19900907 1999-01-13
DE19903666A DE19903666A1 (en) 1999-01-13 1999-01-30 Medicines containing 3-isoxazolidinones and hydroxylamic acids as an active ingredient and their use
DE19903666.7 1999-01-30

Publications (2)

Publication Number Publication Date
WO2000041473A2 WO2000041473A2 (en) 2000-07-20
WO2000041473A3 true WO2000041473A3 (en) 2001-11-29

Family

ID=26051290

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/000165 WO2000041473A2 (en) 1999-01-13 2000-01-12 Use of 3-isoxazolidinones and hydroxylamine acids for the treatment of infections

Country Status (14)

Country Link
EP (1) EP1143941A3 (en)
JP (1) JP2002534440A (en)
CN (1) CN1342078A (en)
AU (1) AU2436600A (en)
BR (1) BR0007491A (en)
CA (1) CA2360366A1 (en)
CZ (1) CZ20012380A3 (en)
HU (1) HUP0105412A2 (en)
IL (1) IL143795A0 (en)
NO (1) NO20013464L (en)
PL (1) PL350128A1 (en)
SK (1) SK9502001A3 (en)
TR (1) TR200102019T2 (en)
WO (1) WO2000041473A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
GB202209172D0 (en) * 2022-06-22 2022-08-10 Syngenta Crop Protection Ag Improvements in or relating to organic compounds

Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911007A (en) * 1974-08-08 1975-10-07 Searle & Co N-substituted N-benzyloxy-2-methyl-2-(4-halophenoxy)propionamides
FR2290442A1 (en) * 1974-11-06 1976-06-04 Aries Robert Cycloserine-(hexahydro)rifamycin SV condensates - antibiotics, prepd from 3-formyl rifamycins and opt N-alkylated cycloserine
GB1457950A (en) * 1973-08-10 1976-12-08 Merck & Co Inc Antibacterial compositions
WO1987004152A1 (en) * 1985-12-30 1987-07-16 The Wellcome Foundation Ltd. New aryl derivatives
JPS63119476A (en) * 1986-11-05 1988-05-24 Takeda Chem Ind Ltd Isoxazolidone derivative
JPS63119462A (en) * 1986-11-05 1988-05-24 Takeda Chem Ind Ltd 5-membered-ring n-sulfo compound
US4851422A (en) * 1985-04-30 1989-07-25 Takeda Chemical Industries, Ltd. Antibiotic 2-(3-oxo-2-isoxazolidinyl)-5-oxo-2-tetrahydrofuran-carboxylates
US5288896A (en) * 1992-01-15 1994-02-22 Warner-Lambert Company 3,5-di-t-butyl-4-hydroxylphenylmethylhydroxylamines and their derivatives, pharmaceutical compositions, and methods of use therefor
WO1995006031A1 (en) * 1993-08-23 1995-03-02 Immunex Corporation Inhibitors of tnf-alpha secretion
WO1995019957A1 (en) * 1994-01-21 1995-07-27 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as metalloproteinase inhibitors
WO1996013263A2 (en) * 1994-11-01 1996-05-09 Research Corporation Technologies, Inc. Methods of treatment of viral disease with inhibitors of sphingolipid biosynthesis
US5652262A (en) * 1993-03-16 1997-07-29 British Biotech Pharmaceutical, Ltd. Hydroxamic acid derivatives as metalloproteinase inhibitors
WO1998043959A1 (en) * 1997-03-28 1998-10-08 Zeneca Limited Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor
WO1998055449A1 (en) * 1997-06-06 1998-12-10 The University Of Queensland Hydroxamic acid compounds having anticancer and anti-parasitic properties
US5919790A (en) * 1996-10-11 1999-07-06 Warner-Lambert Company Hydroxamate inhibitors of interleukin-1β converting enzyme

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1457950A (en) * 1973-08-10 1976-12-08 Merck & Co Inc Antibacterial compositions
US3911007A (en) * 1974-08-08 1975-10-07 Searle & Co N-substituted N-benzyloxy-2-methyl-2-(4-halophenoxy)propionamides
FR2290442A1 (en) * 1974-11-06 1976-06-04 Aries Robert Cycloserine-(hexahydro)rifamycin SV condensates - antibiotics, prepd from 3-formyl rifamycins and opt N-alkylated cycloserine
US4851422A (en) * 1985-04-30 1989-07-25 Takeda Chemical Industries, Ltd. Antibiotic 2-(3-oxo-2-isoxazolidinyl)-5-oxo-2-tetrahydrofuran-carboxylates
WO1987004152A1 (en) * 1985-12-30 1987-07-16 The Wellcome Foundation Ltd. New aryl derivatives
JPS63119462A (en) * 1986-11-05 1988-05-24 Takeda Chem Ind Ltd 5-membered-ring n-sulfo compound
JPS63119476A (en) * 1986-11-05 1988-05-24 Takeda Chem Ind Ltd Isoxazolidone derivative
US5288896A (en) * 1992-01-15 1994-02-22 Warner-Lambert Company 3,5-di-t-butyl-4-hydroxylphenylmethylhydroxylamines and their derivatives, pharmaceutical compositions, and methods of use therefor
US5652262A (en) * 1993-03-16 1997-07-29 British Biotech Pharmaceutical, Ltd. Hydroxamic acid derivatives as metalloproteinase inhibitors
WO1995006031A1 (en) * 1993-08-23 1995-03-02 Immunex Corporation Inhibitors of tnf-alpha secretion
WO1995019957A1 (en) * 1994-01-21 1995-07-27 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as metalloproteinase inhibitors
WO1996013263A2 (en) * 1994-11-01 1996-05-09 Research Corporation Technologies, Inc. Methods of treatment of viral disease with inhibitors of sphingolipid biosynthesis
US5919790A (en) * 1996-10-11 1999-07-06 Warner-Lambert Company Hydroxamate inhibitors of interleukin-1β converting enzyme
WO1998043959A1 (en) * 1997-03-28 1998-10-08 Zeneca Limited Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor
WO1998055449A1 (en) * 1997-06-06 1998-12-10 The University Of Queensland Hydroxamic acid compounds having anticancer and anti-parasitic properties

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
BALDWIN, JACK E. ET AL: "Synthesis of phenoxyacetyl-N-sulfonyl cycloserine", TETRAHEDRON LETT. (1987), 28(37), 4319-20, 1987, XP000990044 *
BALDWIN, JACK E. ET AL: "The synthesis of potential.gamma.-lactam antibiotics containing a cycloserine nucleus", TETRAHEDRON LETT. (1990), 31(15), 2211-12, 1990, XP000990045 *
GEARY, TIMOTHY G. ET AL: "Nutritional requirements of Plasmodium falciparum in culture. II. Effects of antimetabolites in a semi-defined medium", J. PROTOZOOL. (1985), 32(1), 65-9, 1985, XP000952017 *
GERARDIN, PHILIPPE ET AL: "Synthesis of potential.gamma.-lactam antibiotics", BIOORG. MED. CHEM. LETT. (1995), 5(14), 1467-70, 1995, XP004135426 *
KHALIL, ZARIF HALEEM ET AL: "Synthesis and application of some 1-[8-hydroxy-5(or 7)-quinolinyl]alkylidene-substituted heterocycles as bactericides, fungicides, and bioregulators", BULL. CHEM. SOC. JPN. (1988), 61(4), 1345-9, 1988, XP000990042 *
MITTENDORF, JOACHIM: "Enantioselective synthesis of (R)- and (S)-4-methylcycloserine by the bislactim ether method", LIEBIGS ANN. CHEM. (1988), (12), 1201-2, 1988, XP000990041 *
NICHTERLEIN, THOMAS ET AL: "Subinhibitory concentrations of.beta.-lactams and other cell-wall antibiotics inhibit listeriolysin production by Listeria monocytogenes", INT. J. ANTIMICROB. AGENTS (1996), 7(1), 75-81, 1996, XP000991436 *
O'GRADY, F.: "Cycloserine, amino acid analogs and oligopeptides", ANTIBIOT. CHEMOTHER. (7TH ED.) (1997), 344-345. EDITOR(S): O'GRADY, FRANCIS. PUBLISHER: CHURCHILL LIVINGSTONE, EDINBURGH, UK., 1997, XP000951569 *
OMAR, M. T.: "Synthesis of some new isoxazolidine-3,5-diones, pyrazolidine-3,5- diones, and barbituric acids of expected antimicrobial activity", EGYPT. J. PHARM. SCI. (1998), VOLUME DATE 1997, 38(4-6), 281-289, 1998, XP000991461 *
PATENT ABSTRACTS OF JAPAN vol. 012, no. 365 (C - 532) 29 September 1988 (1988-09-29) *
STAMMER, CHARLES H. ET AL: "5-Carboxamido-4-amino-3-isoxazolidone, an asparagine analog", J. MED. CHEM. (1978), 21(7), 709-12, 1978, XP000990040 *
TAMURA, NORIKAZU ET AL: "Synthesis and antibacterial activity of lactivicin derivatives", CHEM. PHARM. BULL. (1990), 38(1), 116-22, 1990, XP000990010 *
UEDA, Y. ET AL: "Synthesis of phenoxyacetyl-N-(hydroxydioxocyclobutenyl)cycloserines", TETRAHEDRON LETT. (1991), 32(31), 3767-70, 1991, XP000990046 *
VIGORITA, M. GABRIELLA ET AL: "Fluoro-containing D-cycloserines. Synthesis and in vitro evaluation of antimicrobial and antiviral activities", FARMACO (1992), 47(6), 907-18, 1992, XP000991416 *
WEWALKA, G. ET AL: "Sensitivity of bacteria causing urinary tract infections towards Terizidone", WIEN. KLIN. WOCHENSCHR. (1976), 88(11), 355-60, 1976, XP000991442 *
WISE, R. ET AL: "In vitro activity of fludalanine combined with pentizidone compared with those of other agents", ANTIMICROB. AGENTS CHEMOTHER. (1984), 25(5), 612-17, 1984, XP000991424 *

Also Published As

Publication number Publication date
JP2002534440A (en) 2002-10-15
SK9502001A3 (en) 2002-05-09
WO2000041473A2 (en) 2000-07-20
PL350128A1 (en) 2002-11-04
NO20013464D0 (en) 2001-07-12
BR0007491A (en) 2001-11-20
CA2360366A1 (en) 2000-07-20
EP1143941A2 (en) 2001-10-17
IL143795A0 (en) 2002-04-21
AU2436600A (en) 2000-08-01
NO20013464L (en) 2001-09-12
CN1342078A (en) 2002-03-27
CZ20012380A3 (en) 2002-01-16
HUP0105412A2 (en) 2002-05-29
TR200102019T2 (en) 2002-04-22
EP1143941A3 (en) 2002-02-06

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