WO2000039581A3 - Test system for detecting different markers, and production and use thereof - Google Patents

Test system for detecting different markers, and production and use thereof Download PDF

Info

Publication number
WO2000039581A3
WO2000039581A3 PCT/EP1999/010333 EP9910333W WO0039581A3 WO 2000039581 A3 WO2000039581 A3 WO 2000039581A3 EP 9910333 W EP9910333 W EP 9910333W WO 0039581 A3 WO0039581 A3 WO 0039581A3
Authority
WO
WIPO (PCT)
Prior art keywords
test system
production
different markers
detecting different
test
Prior art date
Application number
PCT/EP1999/010333
Other languages
German (de)
French (fr)
Other versions
WO2000039581A2 (en
Inventor
Thomas Wagner
Norbert Windhab
Original Assignee
Aventis Res & Tech Gmbh & Co
Thomas Wagner
Norbert Windhab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Res & Tech Gmbh & Co, Thomas Wagner, Norbert Windhab filed Critical Aventis Res & Tech Gmbh & Co
Priority to EP99968373A priority Critical patent/EP1141725A2/en
Priority to JP2000591429A priority patent/JP2002533724A/en
Priority to CA002353920A priority patent/CA2353920A1/en
Priority to AU25390/00A priority patent/AU773046B2/en
Publication of WO2000039581A2 publication Critical patent/WO2000039581A2/en
Publication of WO2000039581A3 publication Critical patent/WO2000039581A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

Abstract

The invention relates to a test system containing at least two detection species, which detect at least two different markers by forming a complex. The invention also relates to the production of said test system and to its use in a suitable detection method. It was found that it is possible to achieve a qualitatively very good, simple and economical analyte test by combining two or more test results at a molecular level in the manner of a boolean chain. The different test results do not essentially interfere with each other.
PCT/EP1999/010333 1998-12-23 1999-12-22 Test system for detecting different markers, and production and use thereof WO2000039581A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99968373A EP1141725A2 (en) 1998-12-23 1999-12-22 Test system for detecting different analytes
JP2000591429A JP2002533724A (en) 1998-12-23 1999-12-22 Test system for the recognition of different markers, its preparation and use
CA002353920A CA2353920A1 (en) 1998-12-23 1999-12-22 Test system for detecting different markers, and production and use thereof
AU25390/00A AU773046B2 (en) 1998-12-23 1999-12-22 Test system for detecting different markers, and production and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19859912.9 1998-12-23
DE19859912A DE19859912C2 (en) 1998-12-23 1998-12-23 Test system for the detection of different markers, its production and use

Publications (2)

Publication Number Publication Date
WO2000039581A2 WO2000039581A2 (en) 2000-07-06
WO2000039581A3 true WO2000039581A3 (en) 2000-11-23

Family

ID=7892569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/010333 WO2000039581A2 (en) 1998-12-23 1999-12-22 Test system for detecting different markers, and production and use thereof

Country Status (6)

Country Link
EP (1) EP1141725A2 (en)
JP (1) JP2002533724A (en)
AU (1) AU773046B2 (en)
CA (1) CA2353920A1 (en)
DE (1) DE19859912C2 (en)
WO (1) WO2000039581A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1947459A3 (en) * 2000-08-24 2008-09-24 Nanogen, Inc. Differential immunoassay
US6673562B2 (en) * 2000-08-24 2004-01-06 Spectral Diagnostics, Inc. Differential immunoassay
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
US8012770B2 (en) 2009-07-31 2011-09-06 Invisible Sentinel, Inc. Device for detection of antigens and uses thereof
WO2011044574A1 (en) 2009-10-09 2011-04-14 Invisible Sentinel Device for detection of antigens and uses thereof
AU2012211141B2 (en) 2011-01-27 2016-11-03 Invisible Sentinel, Inc. Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof
US9347938B2 (en) * 2012-03-09 2016-05-24 Invisible Sentinel, Inc. Methods for detecting multiple analytes with a single signal
US11604186B2 (en) * 2018-10-17 2023-03-14 Molecular Devices (Austria) GmbH Real time western blot assays utilizing fluorescence resonance energy transfer (FRET)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018866A1 (en) * 1991-04-10 1992-10-29 Biosite Diagnostics Incorporated Novel conjugates and assays for simultaneous detection of multiple ligands
WO1998023956A1 (en) * 1996-11-28 1998-06-04 University College London Capture assays

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320109A (en) * 1979-06-29 1982-03-16 The University Of Southern California Immunoradiometric assay employing terminal radionuclide labeling and synthesis of conjugates for such assay
JPH081438B2 (en) * 1986-05-13 1996-01-10 三洋化成工業株式会社 Enzyme immunoassay
US5296347A (en) * 1991-02-08 1994-03-22 Ciba Corning Diagnostics Corp. Bridge immunoassay

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018866A1 (en) * 1991-04-10 1992-10-29 Biosite Diagnostics Incorporated Novel conjugates and assays for simultaneous detection of multiple ligands
WO1998023956A1 (en) * 1996-11-28 1998-06-04 University College London Capture assays

Also Published As

Publication number Publication date
WO2000039581A2 (en) 2000-07-06
EP1141725A2 (en) 2001-10-10
AU2539000A (en) 2000-07-31
AU773046B2 (en) 2004-05-13
JP2002533724A (en) 2002-10-08
DE19859912C2 (en) 2001-06-21
CA2353920A1 (en) 2000-07-06
DE19859912A1 (en) 2000-07-06

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