WO2000038590A1 - Stent endoluminal - Google Patents

Stent endoluminal Download PDF

Info

Publication number
WO2000038590A1
WO2000038590A1 PCT/GB1999/004388 GB9904388W WO0038590A1 WO 2000038590 A1 WO2000038590 A1 WO 2000038590A1 GB 9904388 W GB9904388 W GB 9904388W WO 0038590 A1 WO0038590 A1 WO 0038590A1
Authority
WO
WIPO (PCT)
Prior art keywords
core
agents
therapeutic agent
lining
endoluminal stent
Prior art date
Application number
PCT/GB1999/004388
Other languages
English (en)
Inventor
Stephen George Edward Barker
Original Assignee
Stephen George Edward Barker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9828592.7A external-priority patent/GB9828592D0/en
Application filed by Stephen George Edward Barker filed Critical Stephen George Edward Barker
Priority to AU18790/00A priority Critical patent/AU1879000A/en
Publication of WO2000038590A1 publication Critical patent/WO2000038590A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body

Definitions

  • This invention relates to an improved construction of an endoluminal stent, such devices being used for example, to hold open blood vessels dilated by angioplasty, particularly blood vessels having a higher flow, such as the iliac arteries.
  • endoluminal stent devices may be deployed elsewhere in the mammalian body (usually human) for example, along the length of the gut, the bile duct, the pancreatic duct or the urethra.
  • Such devices usually comprise a tubular cage structure which is inserted collapsed into a blood vessel, or other tubular structure, and thereafter expanded using a balloon catheter or using the self-expanding properties of the alloy from which it is constructed, for example.
  • Stent devices having an open lattice structure are used normally with the lattices providing for expansion of the stent after insertion.
  • a disadvantage of such constructions, however, is that the interstices allow for smooth muscle cell growth to invade through the stent, thus once again blocking the lumen.
  • One of the objects of this invention is to provide an endoluminal stent giving an improved blood flow and longer in situ therapeutic life.
  • a further and preferred object of this invention is to provide a stent which is capable of delivering a therapeutic agent or agents over a period of time.
  • an agent might be directed specifically at preventing the growth of smooth
  • an endoluminal stent having a rigid or semi-rigid, preferably metallic,
  • outer expandable preferably a porous or semi-porous, absorbent or fabric
  • the linings, within and without, may or may not in themselves be covered
  • bio-polymer carrier medium for example, collagen or gelatin and may be a
  • an endoluminal stent comprising a preferably metallic self-supporting core with a plurality of regularly or irregularly extending slits or cuts running longitudinally along the core whereby the core may be expanded such that the slits open up to define the interstices with preferably an outer covering of an expandable material provided over the core and an internal expandable lining within the core, one or other or both of said coverings or linings being capable of both part-retaining and permitting diffusion of a therapeutic agent or agents held therein retained in the slits or interstices of the core, preferably incorporated or held within a biologically inert, biodegradable bio-polymer.
  • the construction according to a first aspect of this invention thus provides for a covering and lining of a fabric material to be provided preferably on both external and internal surfaces of the stent, thus preventing external intrusion through the interstices of the rigid core as well as improving blood flow through the internal passage formed by the core.
  • the therapeutic agent or agents may be carried, for example, by means of an impregnated collagen sponge or gel film or the like which may form an additional layer preferably enclosed on both sides by the coverings or linings.
  • Other carriers may be used to hold the therapeutic agent or agents.
  • Figure 1 shows in side elevation a stent with a part of the core and the outer covering removed for clarity
  • Figure 2 shows an end elevation of the stent shown in Figure 1.
  • the endoluminal stent of this invention includes a core 1 of stainless steel or an alloy such as nitinol which has an expandable capability. The construction is such that after assisted or self-expansion, the core is sufficiently rigid to support the vessel into which it is inserted.
  • the core 1 is shown here in a partially expanded state. Interstices or the spaces between the metal parts are here referenced 1a.
  • the core 1 has an outer covering 2 of a material such as Dacron or PTFE. Where Dacron material is used, this may be coated on a single surface or both surfaces with an agent or agents such as collagen or gelatin, in order to decrease the material porosity and enhance incorporation into surrounding tissues. This coating in itself may in turn be bonded with or incorporate a therapeutic agent or agents such as Heparin or an antibiotic.
  • a material such as Dacron or PTFE.
  • the core 1 includes a lining 3 of a similar or other material to the outer covering layer. Where Dacron material is used, this may be coated on a single surface or both surfaces with an agent or agents such as collagen or gelatin, in order to decrease the material porosity and enhance incorporation
  • This coating in itself may in turn be bonded with or
  • a therapeutic agent or agents such as Heparin or an antibiotic.
  • the outer covering layer may be connected with the inner lining layer at
  • the covering and lining may also be any other means.
  • the covering and lining may also be any other means.
  • therapeutic agent or agents may be diffused over a period of time into the
  • the material used to cover the metallic stent core should have certain properties
  • outer covering 2 and lining 3 may be bonded by
  • the bonding agent or agents itself may incorporate a required therapeutic agents.
  • This invention also contemplates a method of treatment of the body and particularly any blood vessel or other tubular or elongate structure, for example a urethra or bile duct or other part of the gastro-intestine tract or uro-genital tract, which comprises the insertion of an endoluminal stent substantially as hereinbefore disclosed with the stent device incorporating means for retention of a therapeutic agent or agents, the agent or agents being effective on an ongoing basis following insertion of the stent.
  • an endoluminal stent substantially as described and disclosed herein for the purpose of administering a therapeutic agent or agents to the flow of blood through a vessel in a mammalian body or other tubular or elongate structure, for example a urethra or bile duct or other part of the gastro-intestine tract or uro- genital tract.

Landscapes

  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention se rapporte à un stent endoluminal comportant une âme (1) d'acier inoxydable qui possède la capacité de se déployer grâce à la présence de fentes qui forment des interstices (1a) après un déploiement automatique ou assisté conférant à ladite âme une rigidité suffisante pour supporter le vaisseau à l'intérieur duquel il est inséré. L'âme (1) est présentée en position partiellement déployée. Elle possède une couverture externe (2) composée d'une matière telle que le Dacron ou le PTFE qui est recouverte en surface d'un ou de plusieurs agents du type collagène ou gélatine, ladite couche réduisant la porosité de la matière et améliorant la pénétration dans les tissus environnants. Ledit revêtement peut lui-même être lié au moyen d'un ou de plusieurs agents thérapeutiques tels que l'héparine ou un antibiotique, ou peut comporter de tels agents. L'intérieur de l'âme comporte une garniture (3) de matière similaire à celle de la couche de revêtement externe, qui peut également être recouverte d'un ou de plusieurs agents du type collagène ou gélatine, ce qui permet de réduire la porosité de la matière et améliore la pénétration dans les tissus environnants. Le revêtement externe et la garniture sont soudés sur le pourtour des extrémités de l'âme. Ce cathéter permet un écoulement sanguin lisse et une réduction de la resténose due à la croissance des cellules musculaires. Il constitue en outre un moyen d'administration d'un agent thérapeutique sur une longue période.
PCT/GB1999/004388 1998-12-23 1999-12-23 Stent endoluminal WO2000038590A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18790/00A AU1879000A (en) 1998-12-23 1999-12-23 Endoluminal stent

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9828592.7A GB9828592D0 (en) 1998-12-23 1998-12-23 Endoluminal stent
GB9828592.7 1998-12-23
GBGB9912729.2A GB9912729D0 (en) 1998-12-23 1999-06-01 Endoluminal stent
GB9912729.2 1999-06-01

Publications (1)

Publication Number Publication Date
WO2000038590A1 true WO2000038590A1 (fr) 2000-07-06

Family

ID=26314918

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/004388 WO2000038590A1 (fr) 1998-12-23 1999-12-23 Stent endoluminal

Country Status (3)

Country Link
AU (1) AU1879000A (fr)
GB (1) GB2346559A (fr)
WO (1) WO2000038590A1 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021102A1 (fr) * 1999-09-23 2001-03-29 Edwards Lifesciences Corporation Greffe intraluminale a couche double
WO2002091956A1 (fr) * 2001-05-16 2002-11-21 Dias Maues, Christiane Stent garni d'un revetement liberant des medicaments et systeme de mise en place
WO2002100473A1 (fr) * 2001-06-08 2002-12-19 Graeme Cocks Tuteur coronarien et catheter d'administration
US6503556B2 (en) 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
DE10135275A1 (de) * 2001-07-13 2003-01-30 Jotec Gmbh Implantat und Verfahren zu seiner Herstellung
US6540776B2 (en) 2000-12-28 2003-04-01 Advanced Cardiovascular Systems, Inc. Sheath for a prosthesis and methods of forming the same
WO2003090810A1 (fr) * 2002-04-26 2003-11-06 Medtronic Vascular, Inc. Endoprotheses enrobees superposees
WO2004019821A1 (fr) * 2002-08-28 2004-03-11 Boston Scientific Limited Appareils medicaux et procedes de fabrication
WO2005096988A1 (fr) * 2004-04-01 2005-10-20 Cook Incorporated Dispositif pour retracter les parois d'un vaisseau corporel a l'aide d'un materiau remodelable
EP1600123A3 (fr) * 2004-05-26 2006-02-08 Medtronic Vascular, Inc. Extenseurs pour l'administration semi-directionelle de médicaments
WO2007100456A1 (fr) * 2006-03-01 2007-09-07 Boston Scientific Scimed, Inc. dispositifs de GREFFON DE STENT flexible ET PROCÉDÉS DE FABRICATION
US7737060B2 (en) * 2006-03-31 2010-06-15 Boston Scientific Scimed, Inc. Medical devices containing multi-component fibers
US7846199B2 (en) 2007-11-19 2010-12-07 Cook Incorporated Remodelable prosthetic valve
US7854756B2 (en) 2004-01-22 2010-12-21 Boston Scientific Scimed, Inc. Medical devices
US8961588B2 (en) 2002-03-27 2015-02-24 Advanced Cardiovascular Systems, Inc. Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin
USRE45744E1 (en) 2003-12-01 2015-10-13 Abbott Cardiovascular Systems Inc. Temperature controlled crimping
US9205177B2 (en) 2009-03-04 2015-12-08 Peytant Solutions, Inc. Stents modified with material comprising amnion tissue and corresponding processes
EP3085334A1 (fr) * 2001-08-27 2016-10-26 Boston Scientific Scimed, Inc. Dispositifs de rassasiement

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2023032084A1 (fr) * 2021-09-01 2023-03-09

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009006A1 (fr) * 1995-09-01 1997-03-13 Emory University Dispositif de maintien endovasculaire et son mode d'utilisation
US5693085A (en) * 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
WO1998023228A1 (fr) * 1996-11-25 1998-06-04 Alza Corporation Stent destine a l'administration dirigee de medicaments

Family Cites Families (4)

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US5334201A (en) * 1993-03-12 1994-08-02 Cowan Kevin P Permanent stent made of a cross linkable material
US5735892A (en) * 1993-08-18 1998-04-07 W. L. Gore & Associates, Inc. Intraluminal stent graft
DE69518435T3 (de) * 1994-06-08 2004-07-22 CardioVascular Concepts, Inc., Portola Valley System zur Herstellung eines abzweigenden Transplantats
EP0767684B1 (fr) * 1994-06-27 2005-05-25 Bard Peripheral Vascular, Inc. Polytetrafluoroethylene expanse radialement, et extenseurs endovasculaires expansibles formes avec cette matiere

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693085A (en) * 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
WO1997009006A1 (fr) * 1995-09-01 1997-03-13 Emory University Dispositif de maintien endovasculaire et son mode d'utilisation
WO1998023228A1 (fr) * 1996-11-25 1998-06-04 Alza Corporation Stent destine a l'administration dirigee de medicaments

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021102A1 (fr) * 1999-09-23 2001-03-29 Edwards Lifesciences Corporation Greffe intraluminale a couche double
US6503556B2 (en) 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
US6540776B2 (en) 2000-12-28 2003-04-01 Advanced Cardiovascular Systems, Inc. Sheath for a prosthesis and methods of forming the same
WO2002091956A1 (fr) * 2001-05-16 2002-11-21 Dias Maues, Christiane Stent garni d'un revetement liberant des medicaments et systeme de mise en place
WO2002100473A1 (fr) * 2001-06-08 2002-12-19 Graeme Cocks Tuteur coronarien et catheter d'administration
EP1275405B1 (fr) * 2001-07-13 2006-10-11 JOTEC GmbH Implant avec des matrices protéiques poreuses et leur procédé de fabrication
DE10135275A1 (de) * 2001-07-13 2003-01-30 Jotec Gmbh Implantat und Verfahren zu seiner Herstellung
US7175852B2 (en) 2001-07-13 2007-02-13 Jotec Gmbh Implant and process for producing it
US9788984B2 (en) 2001-08-27 2017-10-17 Boston Scientific Scimed, Inc. Satiation devices and methods
EP3085334A1 (fr) * 2001-08-27 2016-10-26 Boston Scientific Scimed, Inc. Dispositifs de rassasiement
US8961588B2 (en) 2002-03-27 2015-02-24 Advanced Cardiovascular Systems, Inc. Method of coating a stent with a release polymer for 40-O-(2-hydroxy)ethyl-rapamycin
WO2003090810A1 (fr) * 2002-04-26 2003-11-06 Medtronic Vascular, Inc. Endoprotheses enrobees superposees
US7771464B2 (en) 2002-04-26 2010-08-10 Medtronic Vascular, Inc. Overlapping coated stents method
US7993391B2 (en) 2002-08-28 2011-08-09 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US7029495B2 (en) 2002-08-28 2006-04-18 Scimed Life Systems, Inc. Medical devices and methods of making the same
WO2004019821A1 (fr) * 2002-08-28 2004-03-11 Boston Scientific Limited Appareils medicaux et procedes de fabrication
USRE45744E1 (en) 2003-12-01 2015-10-13 Abbott Cardiovascular Systems Inc. Temperature controlled crimping
US7854756B2 (en) 2004-01-22 2010-12-21 Boston Scientific Scimed, Inc. Medical devices
US8048143B2 (en) 2004-01-22 2011-11-01 Boston Scientific Scimed, Inc. Medical devices
US8216299B2 (en) 2004-04-01 2012-07-10 Cook Medical Technologies Llc Method to retract a body vessel wall with remodelable material
WO2005096988A1 (fr) * 2004-04-01 2005-10-20 Cook Incorporated Dispositif pour retracter les parois d'un vaisseau corporel a l'aide d'un materiau remodelable
EP1600123A3 (fr) * 2004-05-26 2006-02-08 Medtronic Vascular, Inc. Extenseurs pour l'administration semi-directionelle de médicaments
WO2007100456A1 (fr) * 2006-03-01 2007-09-07 Boston Scientific Scimed, Inc. dispositifs de GREFFON DE STENT flexible ET PROCÉDÉS DE FABRICATION
US7737060B2 (en) * 2006-03-31 2010-06-15 Boston Scientific Scimed, Inc. Medical devices containing multi-component fibers
US7846199B2 (en) 2007-11-19 2010-12-07 Cook Incorporated Remodelable prosthetic valve
US9205177B2 (en) 2009-03-04 2015-12-08 Peytant Solutions, Inc. Stents modified with material comprising amnion tissue and corresponding processes

Also Published As

Publication number Publication date
AU1879000A (en) 2000-07-31
GB9930534D0 (en) 2000-02-16
GB2346559A (en) 2000-08-16

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