WO2000036398A3 - Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen - Google Patents

Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen Download PDF

Info

Publication number
WO2000036398A3
WO2000036398A3 PCT/DE1999/003981 DE9903981W WO0036398A3 WO 2000036398 A3 WO2000036398 A3 WO 2000036398A3 DE 9903981 W DE9903981 W DE 9903981W WO 0036398 A3 WO0036398 A3 WO 0036398A3
Authority
WO
WIPO (PCT)
Prior art keywords
support
detector
molecules
optical properties
directly
Prior art date
Application number
PCT/DE1999/003981
Other languages
English (en)
French (fr)
Other versions
WO2000036398A2 (de
WO2000036398A8 (de
WO2000036398A9 (de
Inventor
Annemarie Poustka
Frank Breitling
Karl-Heinz Gross
Stefan Duebel
Rainer Saffrich
Original Assignee
Deutsches Krebsforsch
Europ Lab Molekularbiolog
Annemarie Poustka
Frank Breitling
Gross Karl Heinz
Stefan Duebel
Rainer Saffrich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Europ Lab Molekularbiolog, Annemarie Poustka, Frank Breitling, Gross Karl Heinz, Stefan Duebel, Rainer Saffrich filed Critical Deutsches Krebsforsch
Priority to EP99966859A priority Critical patent/EP1153282A2/de
Publication of WO2000036398A2 publication Critical patent/WO2000036398A2/de
Publication of WO2000036398A8 publication Critical patent/WO2000036398A8/de
Publication of WO2000036398A3 publication Critical patent/WO2000036398A3/de
Publication of WO2000036398A9 publication Critical patent/WO2000036398A9/de
Priority to US09/880,681 priority patent/US20020008871A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezo-electric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00441—Maskless processes using lasers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00542—Alphanumeric characters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Abstract

Bei einem Verfahren zur Erfassung optischer Eigenschaften, insbesondere von Lumineszenzreaktionen und Brechungsverhalten, von auf einem Träger (12) direkt oder indirekt gebundenen Molekülen (14) werden elektromagnetische Wellen, insbesondere Laserlicht (26), auf den Träger eingestrahlt. Von den Molekülen emittiertes oder gebrochenes Licht wird von einem Detektor (28) erfaßt. Während und nach dem Einstrahlen der elektromagnetischen Wellen werden Detektor und Träger relativ zueinander bewegt. Als Träger wird insbesondere ein transparenter Träger mit integrierten und von einem Detektor, insbesondere einem optoeletronischen Abtastsystem erfassbare Positionsmarkierungen (20) verwendet. Hierbei wird wenigstens eine der integrierten Positionsmarkierungen während oder nach der Relativbewegung von Träger und Detektor ausgelesen, so dass eine Zuordnung des von dem Detektor erfassten Lichts zu einem Ort auf dem Träger möglich wird. Bei einer Vorrichtung zur Durchfühnung des Verfahrens ist ein Detektor, insbesondere ein optoelektronisches Abtastsystem zur Erfassung von in dem Träger integrierten Positionsmarkierungen vorgesehen.
PCT/DE1999/003981 1998-12-14 1999-12-14 Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen WO2000036398A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99966859A EP1153282A2 (de) 1998-12-14 1999-12-14 Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen
US09/880,681 US20020008871A1 (en) 1998-12-14 2001-06-13 Method and device for detecting optical properties, especially luminescence reactions and refraction behavior of molecules which are directly or indirectly bound on a support

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19857529 1998-12-14
DE19857529.7 1998-12-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/880,681 Continuation US20020008871A1 (en) 1998-12-14 2001-06-13 Method and device for detecting optical properties, especially luminescence reactions and refraction behavior of molecules which are directly or indirectly bound on a support

Publications (4)

Publication Number Publication Date
WO2000036398A2 WO2000036398A2 (de) 2000-06-22
WO2000036398A8 WO2000036398A8 (de) 2000-08-17
WO2000036398A3 true WO2000036398A3 (de) 2000-10-19
WO2000036398A9 WO2000036398A9 (de) 2001-04-05

Family

ID=7890965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/003981 WO2000036398A2 (de) 1998-12-14 1999-12-14 Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen

Country Status (3)

Country Link
US (1) US20020008871A1 (de)
EP (1) EP1153282A2 (de)
WO (1) WO2000036398A2 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962803A1 (de) * 1999-12-23 2001-07-05 Basf Ag Verfahren und Vorrichtung zur maskenfreien Herstellung von Biopolymeren
DE10030588A1 (de) * 2000-06-21 2002-01-03 Deutsches Krebsforsch Verfahren und Vorrichtung zur Synthese und Analyse von trägergebundenen Arrays von Oligomeren, insbesondere von Primerpaaren für die PCR, sowie Träger mit Oligomeren
DE10004659A1 (de) * 2000-02-03 2001-08-16 Deutsches Krebsforsch Verfahren und Vorrichtung zur Synthese und Analyse von trägergebundenen Arrays von Oligomeren, insbesondere von Primerpaaren für die PCR, sowie Träger mit Oligomeren
WO2002026376A2 (en) * 2000-09-27 2002-04-04 Surmodics, Inc. High density arrays
US20030082604A1 (en) * 2000-09-27 2003-05-01 Swanson Melvin J. High density arrays
DE10052823B4 (de) * 2000-10-24 2014-11-20 Ruprecht-Karls-Universität Heidelberg Verfahren zur lichtmikroskopischen Analyse der Topologie molekularer Strukturen in Rasteranordnungen
WO2002045845A2 (en) * 2000-10-27 2002-06-13 Dumas David P Apparatus for light directed chemical synthesis
EP1249499A1 (de) * 2001-04-10 2002-10-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Bestimmung und Selektion von Molekül-Molekül-Wechselwirkungen
US20050026148A1 (en) * 2001-05-23 2005-02-03 Rexhausen Ulrich Method for the biochemical detection of analytes
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
ATE422241T1 (de) * 2003-06-04 2009-02-15 Inverness Medical Switzerland Optische anordnung für ein assay-lesegerät
US7170605B2 (en) * 2003-08-25 2007-01-30 Evan Francis Cromwell Active sensor and method for optical illumination and detection
US7113285B2 (en) * 2003-12-09 2006-09-26 Beckman Coulter, Inc. Multimode reader
US7122799B2 (en) * 2003-12-18 2006-10-17 Palo Alto Research Center Incorporated LED or laser enabled real-time PCR system and spectrophotometer
US7545495B2 (en) * 2004-04-27 2009-06-09 Abbott Laboratories Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample
US20070023643A1 (en) * 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
WO2006083917A2 (en) * 2005-02-01 2006-08-10 Purdue Research Foundation Laser scanning interferometric surface metrology
US7910356B2 (en) * 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
WO2007131103A2 (en) * 2006-05-03 2007-11-15 Quadraspec, Inc. Direct printing of patterned hydrophobic wells
HU226837B1 (hu) 2006-05-31 2009-12-28 Semmelweis Egyetem Folyadéksugárral mûködõ deszorpciós ionizációs eljárás és eszköz
US7532128B2 (en) * 2006-10-25 2009-05-12 Alverix, Inc. Position sensitive indicator detection
US7522282B2 (en) * 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US20080144899A1 (en) * 2006-11-30 2008-06-19 Manoj Varma Process for extracting periodic features from images by template matching
US20080230605A1 (en) * 2006-11-30 2008-09-25 Brian Weichel Process and apparatus for maintaining data integrity
WO2008089495A2 (en) 2007-01-19 2008-07-24 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
CA2681722A1 (en) * 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
DE102008023438B4 (de) * 2008-05-14 2011-06-30 Bruker Daltonik GmbH, 28359 Verfahren zur Analyse von Gewebeschnitten
CA2763145C (en) * 2009-05-27 2021-05-25 Medimass Kft System and method for identification of biological tissues
WO2012099889A2 (en) * 2011-01-17 2012-07-26 Biosynergetics, Inc. In-line flow meter
GB201109414D0 (en) 2011-06-03 2011-07-20 Micromass Ltd Diathermy -ionisation technique
US9281174B2 (en) 2011-12-28 2016-03-08 Micromass Uk Limited System and method for rapid evaporative ionization of liquid phase samples
CN104254901B (zh) 2011-12-28 2018-05-04 英国质谱有限公司 碰撞离子发生器和分离器
TWI518316B (zh) 2014-04-01 2016-01-21 財團法人工業技術研究院 光學測讀系統及使用該系統之生化檢測方法
US11543407B2 (en) 2014-05-01 2023-01-03 Arizona Board Of Regents On Behalf Of Arizona State University Flexible optical biosensor for point of use multi-pathogen detection
CN107530065A (zh) 2015-03-06 2018-01-02 英国质谱公司 活体内内窥镜下组织识别工具
CN108700590B (zh) 2015-03-06 2021-03-02 英国质谱公司 细胞群体分析
EP3265823B1 (de) 2015-03-06 2020-05-06 Micromass UK Limited Bildgebungsplattform für umgebungsionisierungsmassenspektrometrie für direkte abbildung aus gesamtgewebe
CN107645938B (zh) 2015-03-06 2020-11-20 英国质谱公司 成像导引的敞开式电离质谱测定
KR101956496B1 (ko) 2015-03-06 2019-03-08 마이크로매스 유케이 리미티드 전기수술 응용분야에 대한 액체 트랩 또는 세퍼레이터
DE202016008460U1 (de) 2015-03-06 2018-01-22 Micromass Uk Limited Zellpopulationsanalyse
WO2016142681A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Spectrometric analysis of microbes
WO2016142679A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Chemically guided ambient ionisation mass spectrometry
US11289320B2 (en) 2015-03-06 2022-03-29 Micromass Uk Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
WO2016142692A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Spectrometric analysis
WO2016142690A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device
KR102017409B1 (ko) 2015-03-06 2019-10-21 마이크로매스 유케이 리미티드 기체성 샘플의 개선된 이온화 방법
EP4257967A3 (de) 2015-03-06 2024-03-27 Micromass UK Limited Kollisionsfläche für verbesserte ionisierung
EP3265817B1 (de) 2015-03-06 2020-08-12 Micromass UK Limited Schnelle verdampfungsionisationsmassenspektrometrie- und desorptionselektrosprayionisationsmassenspektrometrieanalyse von tupfern und biopsieproben
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
US11454611B2 (en) 2016-04-14 2022-09-27 Micromass Uk Limited Spectrometric analysis of plants
DE102018111033A1 (de) * 2018-05-08 2019-11-14 Byonoy Gmbh Transmissionsvorrichtung zur Untersuchung von Proben in Kavitäten einer Mikrotiterplatte und Verfahren zum Untersuchen von Proben in Kavitäten einer Mikrotiterplatte mittels Transmission

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376231A2 (de) * 1988-12-28 1990-07-04 MITSUI TOATSU CHEMICALS, Inc. Optischer Aufzeichnungsträger
US5294465A (en) * 1989-10-10 1994-03-15 The United States Of America As Represented By The Secretary Of Commerce Microtip-controlled nanostructure fabrication and multi-tipped field emission tool for parallel-process nanostructure fabrication
DE4233686A1 (de) * 1992-10-02 1994-04-07 Ism Ingenieurbuero Fuer Spezia Verfahren zur selektiven optischen Darstellung bzw. Markierung vorbestimmter Atome, Moleküle oder Molekülgruppen
DE4307042A1 (de) * 1993-03-05 1994-09-08 S & L Ges Fuer Wissenschaftlic Verfahren zum optischen qualitativen und quantitativen Nachweis von Molekülen, Biomolekülen und Mikroorganismen
EP0819930A2 (de) * 1996-07-19 1998-01-21 Bayer Ag Verfahren und Vorrichtung zum Screening von Molekülen bezüglich ihres individuellen Bindungsverhaltens zu mindestens einem vorgegebenen Ligand

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376231A2 (de) * 1988-12-28 1990-07-04 MITSUI TOATSU CHEMICALS, Inc. Optischer Aufzeichnungsträger
US5294465A (en) * 1989-10-10 1994-03-15 The United States Of America As Represented By The Secretary Of Commerce Microtip-controlled nanostructure fabrication and multi-tipped field emission tool for parallel-process nanostructure fabrication
DE4233686A1 (de) * 1992-10-02 1994-04-07 Ism Ingenieurbuero Fuer Spezia Verfahren zur selektiven optischen Darstellung bzw. Markierung vorbestimmter Atome, Moleküle oder Molekülgruppen
DE4307042A1 (de) * 1993-03-05 1994-09-08 S & L Ges Fuer Wissenschaftlic Verfahren zum optischen qualitativen und quantitativen Nachweis von Molekülen, Biomolekülen und Mikroorganismen
EP0819930A2 (de) * 1996-07-19 1998-01-21 Bayer Ag Verfahren und Vorrichtung zum Screening von Molekülen bezüglich ihres individuellen Bindungsverhaltens zu mindestens einem vorgegebenen Ligand

Also Published As

Publication number Publication date
WO2000036398A2 (de) 2000-06-22
EP1153282A2 (de) 2001-11-14
WO2000036398A8 (de) 2000-08-17
US20020008871A1 (en) 2002-01-24
WO2000036398A9 (de) 2001-04-05

Similar Documents

Publication Publication Date Title
WO2000036398A8 (de) Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen
FR2715241B1 (fr) Procédé et dispositif de compensation de déformations dans un système d'inspection optique automatique.
TW340209B (en) A method of optically detecting a printed value sheet for a printed value sheet validation apparatus
AU7765594A (en) Method and apparatus for very large scale immobilised polymer synthesis
HK1140830A1 (en) Lighting optical device, exposure system and exposure method
DE69624505T2 (de) Athermale optische einrichtung
GB9626099D0 (en) Distributed strain and temperature measuring system
EP0774657A3 (de) Verfahren und Vorrichtung zum Nachweis einer Flüssigkeit
DE69614602T2 (de) Optische Halbleitervorrichtung, Verfahren zu ihrer Ansteuerung, Verwendung der Vorrichtung als Lichtquelle und optisches Kommunikationssystemes mit einer derartigen Lichtquelle
WO1998052025A1 (fr) Procede et instrument de controle de surface
FR2640044B1 (fr) Dispositif de detection de rayonnements optiques
DE50106782D1 (de) Vorrichtung und verfahren zur erfassung von papierbögen
DE59813254D1 (de) Optische Positionsmesseinrichtung
DE69502643T2 (de) Licht-detektierende Vorrichtung unter Verwendung eines Halbleiterlasers
CA2250688A1 (en) Fiber-optic sensing device
WO1996027808A3 (en) Method and apparatus for detecting the presence and location of objects in a field
DK1010126T3 (da) Fremgangsmåde ved læsning af relieffer på en gennemsigtig eller gennemskinnelig beholder og indretning til udövelse af fremgangsmåden
DE69800827D1 (de) Vorrichtung mit einem mit seltenen Erden dotierten optischen Faserlaser
WO2002058856A8 (en) Detection system
EP1081458A3 (de) Verfahren und Apparat zur Detektion von Kanten
DE59913486D1 (de) Optisches System
SE9900610D0 (sv) Optoelektronischer Fadensensor
EP1041358A3 (de) Fluchtungsmessanordnung
EP0432977A3 (en) Optical device for detecting modulation in a light beam
DE50012962D1 (de) Verfahren zum Betrieb eines optoelektronischen Kontrasttasters

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CN KR US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 25/2000 UNDER (81) REPLACE THE EXISTING TEXT BY "AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU,ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW; AP (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW); EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM); EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE); OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG)"

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: C2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGE 54, CLAIMS, REPLACED BY A NEW PAGE 54; AFTER RECTIFICATION OF OBVIOUS ERRORS AS AUTHORIZED BY THE INTERNATIONAL SEARCHING AUTHORITY

WWE Wipo information: entry into national phase

Ref document number: 09880681

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1999966859

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999966859

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1999966859

Country of ref document: EP