WO2000033887A3 - Procedes et formulations permettant de reduire des anticorps circulants - Google Patents
Procedes et formulations permettant de reduire des anticorps circulants Download PDFInfo
- Publication number
- WO2000033887A3 WO2000033887A3 PCT/US1999/029336 US9929336W WO0033887A3 WO 2000033887 A3 WO2000033887 A3 WO 2000033887A3 US 9929336 W US9929336 W US 9929336W WO 0033887 A3 WO0033887 A3 WO 0033887A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- reducing circulating
- formulations
- antibodies
- circulating antibodies
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU21735/00A AU2173500A (en) | 1998-12-09 | 1999-12-09 | Methods and formulations for reducing circulating antibodies |
CA002353620A CA2353620A1 (fr) | 1998-12-09 | 1999-12-09 | Procedes et formulations permettant de reduire des anticorps circulants |
JP2000586377A JP2002531531A (ja) | 1998-12-09 | 1999-12-09 | 循環している抗体を減少させるための方法および処方物 |
EP99966115A EP1135167A2 (fr) | 1998-12-09 | 1999-12-09 | Procedes et formulations permettant de reduire des anticorps circulants |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45787598A | 1998-12-08 | 1998-12-08 | |
US11163998P | 1998-12-09 | 1998-12-09 | |
US60/111,639 | 1998-12-09 | ||
US45787599A | 1999-12-08 | 1999-12-08 | |
US09/457,875 | 1999-12-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000033887A2 WO2000033887A2 (fr) | 2000-06-15 |
WO2000033887A3 true WO2000033887A3 (fr) | 2000-08-17 |
Family
ID=26809097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/029336 WO2000033887A2 (fr) | 1998-12-08 | 1999-12-09 | Procedes et formulations permettant de reduire des anticorps circulants |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1135167A2 (fr) |
JP (1) | JP2002531531A (fr) |
AU (1) | AU2173500A (fr) |
CA (1) | CA2353620A1 (fr) |
WO (1) | WO2000033887A2 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001041813A2 (fr) | 1999-11-28 | 2001-06-14 | La Jolla Pharmaceutical Company | Procedes de traitement de lupus sur la base de l'affinite aux anticorps et procedes de criblage et compositions associees |
WO2006115509A2 (fr) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence |
CN106103461B (zh) | 2014-03-13 | 2019-05-10 | 巴塞尔大学 | 结合抗髓鞘相关糖蛋白的IgM抗体的碳水化合物配体 |
AU2016323377B2 (en) | 2015-09-16 | 2021-04-15 | Universität Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
US11986536B2 (en) | 2019-03-23 | 2024-05-21 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
EP3715376A1 (fr) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Composé pour la prévention ou le traitement de la myasthénie grave |
EP3715374A1 (fr) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Composé de séquestration d'anticorps indésirables chez un patient |
EP3715375A1 (fr) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Composé pour la prévention ou le traitement de la pré-éclampsie |
TW202228784A (zh) | 2020-09-23 | 2022-08-01 | 奧地利商艾柏力維亞生技有限公司 | 用以於一患者中螯合非預期的抗peg抗體的化合物 |
US20230355784A1 (en) | 2020-09-23 | 2023-11-09 | Ablevia Biotech Gmbh | Compound for the prevention or treatment of autoantibody-mediated conditions |
US20230381334A1 (en) | 2020-09-23 | 2023-11-30 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
WO2022063892A1 (fr) | 2020-09-23 | 2022-03-31 | Ablevia Biotech Gmbh | Composé pour augmenter l'efficacité de vecteurs viraux |
JP2023542388A (ja) | 2020-09-23 | 2023-10-06 | アブレヴィア バイオテック ゲーエムベーハー | 第viii因子補充療法の有効性を増加させるための化合物 |
WO2022063880A1 (fr) | 2020-09-24 | 2022-03-31 | Ablevia Biotech Gmbh | Composé pour prévenir ou traiter la myasthénie grave |
WO2023180502A1 (fr) | 2022-03-24 | 2023-09-28 | Ablevia Biotech Gmbh | Composé pour augmentation de l'efficacité des virus oncolytiques |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993003735A1 (fr) * | 1991-08-23 | 1993-03-04 | Alberta Research Council | Procedes et compositions d'attenuation de rejet de xenogrephe induit par les anticorps chez les receveurs humains |
WO1995007073A1 (fr) * | 1993-09-08 | 1995-03-16 | La Jolla Pharmaceutical Company | Molecules plates-formes non polymeres a valence, chimiquement definies, et leur conjugues |
US5782792A (en) * | 1986-11-21 | 1998-07-21 | Cypress Bioscience, Inc. | Method for treatment of rheumatoid arthritis |
WO1998047915A1 (fr) * | 1997-04-18 | 1998-10-29 | Novartis Ag | Neoglycoproteines |
WO1999052561A1 (fr) * | 1998-04-15 | 1999-10-21 | Baxter International Inc. | Inhibition d'anticorps xenoreactifs |
-
1999
- 1999-12-09 EP EP99966115A patent/EP1135167A2/fr not_active Withdrawn
- 1999-12-09 CA CA002353620A patent/CA2353620A1/fr not_active Abandoned
- 1999-12-09 WO PCT/US1999/029336 patent/WO2000033887A2/fr not_active Application Discontinuation
- 1999-12-09 JP JP2000586377A patent/JP2002531531A/ja not_active Withdrawn
- 1999-12-09 AU AU21735/00A patent/AU2173500A/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5782792A (en) * | 1986-11-21 | 1998-07-21 | Cypress Bioscience, Inc. | Method for treatment of rheumatoid arthritis |
WO1993003735A1 (fr) * | 1991-08-23 | 1993-03-04 | Alberta Research Council | Procedes et compositions d'attenuation de rejet de xenogrephe induit par les anticorps chez les receveurs humains |
WO1995007073A1 (fr) * | 1993-09-08 | 1995-03-16 | La Jolla Pharmaceutical Company | Molecules plates-formes non polymeres a valence, chimiquement definies, et leur conjugues |
WO1998047915A1 (fr) * | 1997-04-18 | 1998-10-29 | Novartis Ag | Neoglycoproteines |
WO1999052561A1 (fr) * | 1998-04-15 | 1999-10-21 | Baxter International Inc. | Inhibition d'anticorps xenoreactifs |
Also Published As
Publication number | Publication date |
---|---|
AU2173500A (en) | 2000-06-26 |
EP1135167A2 (fr) | 2001-09-26 |
JP2002531531A (ja) | 2002-09-24 |
WO2000033887A2 (fr) | 2000-06-15 |
CA2353620A1 (fr) | 2000-06-15 |
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