WO2000031238A3 - Methods and reagents for increasing proliferative capacity and preventing replicative senescence - Google Patents

Methods and reagents for increasing proliferative capacity and preventing replicative senescence Download PDF

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Publication number
WO2000031238A3
WO2000031238A3 PCT/US1999/027907 US9927907W WO0031238A3 WO 2000031238 A3 WO2000031238 A3 WO 2000031238A3 US 9927907 W US9927907 W US 9927907W WO 0031238 A3 WO0031238 A3 WO 0031238A3
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WO
WIPO (PCT)
Prior art keywords
reagents
methods
proliferative capacity
replicative senescence
increasing proliferative
Prior art date
Application number
PCT/US1999/027907
Other languages
French (fr)
Other versions
WO2000031238A2 (en
Inventor
Gregory J Hannon
David H Beach
Original Assignee
Genetica Inc
Gregory J Hannon
David H Beach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetica Inc, Gregory J Hannon, David H Beach filed Critical Genetica Inc
Priority to IL14332899A priority Critical patent/IL143328A0/en
Priority to CA002352486A priority patent/CA2352486A1/en
Priority to AU21566/00A priority patent/AU2156600A/en
Priority to JP2000584049A priority patent/JP2002530436A/en
Priority to EP99965890A priority patent/EP1133552A2/en
Publication of WO2000031238A2 publication Critical patent/WO2000031238A2/en
Publication of WO2000031238A3 publication Critical patent/WO2000031238A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to methods and reagents for extending the life-span, e.g. the number of mitotic divisions, of a cell. In general, the subject method relies on the activation of a telomerase activity and inhibition of one or both of an Rb/p16 pathway or a p53 pathway.
PCT/US1999/027907 1998-11-25 1999-11-24 Methods and reagents for increasing proliferative capacity and preventing replicative senescence WO2000031238A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL14332899A IL143328A0 (en) 1998-11-25 1999-11-24 Methods and reagents for increasing proliferative capacity and preventing replicative senescence
CA002352486A CA2352486A1 (en) 1998-11-25 1999-11-24 Methods and reagents for increasing proliferative capacity and preventing replicative senescence
AU21566/00A AU2156600A (en) 1998-11-25 1999-11-24 Methods and reagents for increasing proliferative capacity and preventing replicative senescence
JP2000584049A JP2002530436A (en) 1998-11-25 1999-11-24 Method and reagent for enhancing proliferation ability and preventing replication senescence
EP99965890A EP1133552A2 (en) 1998-11-25 1999-11-24 Methods and reagents for increasing proliferative capacity and preventing replicative senescence

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10989198P 1998-11-25 1998-11-25
US12054999P 1999-02-17 1999-02-17
US60/120,549 1999-02-17
US60/109.891 1999-02-17

Publications (2)

Publication Number Publication Date
WO2000031238A2 WO2000031238A2 (en) 2000-06-02
WO2000031238A3 true WO2000031238A3 (en) 2000-11-09

Family

ID=26807479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027907 WO2000031238A2 (en) 1998-11-25 1999-11-24 Methods and reagents for increasing proliferative capacity and preventing replicative senescence

Country Status (6)

Country Link
EP (1) EP1133552A2 (en)
JP (1) JP2002530436A (en)
AU (1) AU2156600A (en)
CA (1) CA2352486A1 (en)
IL (1) IL143328A0 (en)
WO (1) WO2000031238A2 (en)

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US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE556713T1 (en) 1999-01-13 2012-05-15 Bayer Healthcare Llc OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS P38 KINASE INHIBITORS
EP1170378A1 (en) * 2000-06-26 2002-01-09 Boehringer Ingelheim International GmbH Method for monitoring the effect of cancer therapies
DE10054974A1 (en) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnosis of diseases associated with Cdk4
AU2002242854A1 (en) 2001-03-21 2002-10-03 Geron Corporation Use of telomerase reverse transcriptase to create homozygous knockout animals
US7262174B2 (en) 2001-05-09 2007-08-28 Geron Corporation Treatment for wounds
AU2003208580A1 (en) * 2002-02-05 2003-09-02 Technion Research And Development Foundation Ltd Lineage committed stem cells selected for telomerase promoter activity
AU2003209116A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
WO2004076483A1 (en) * 2003-02-26 2004-09-10 Japan Science And Technology Agency Transcriptional factor inducing apoptosis in cancer cell
PT1636585E (en) 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diaryl ureas with kinase inhibiting activity
DK1644009T3 (en) 2003-06-23 2018-03-05 Telomerase Activation Sciences Inc Compositions for increasing telomerase activity and treating HIV infection
US9248088B2 (en) 2003-06-25 2016-02-02 Telomerase Activation Sciences, Inc. Compositions and methods for skin conditioning
US8431123B2 (en) 2003-07-14 2013-04-30 Cls Therapeutics Limited Method for treating systemic bacterial, fungal and protozoan infection
US8388951B2 (en) 2003-07-14 2013-03-05 Cls Therapeutics Limited Method for treating systemic DNA mutation disease
US8710012B2 (en) 2003-07-14 2014-04-29 Cls Therapeutics Limited Method for treating oncological diseases
JP4777887B2 (en) 2003-07-23 2011-09-21 バイエル、ファーマシューテイカルズ、コーポレイション Fluoro-substituted omegacarboxyaryl diphenylureas for the treatment and prevention of diseases and conditions
JP4991547B2 (en) * 2004-09-28 2012-08-01 クアーク・ファーマスーティカルス、インコーポレイテッド Oligoribonucleotides and methods of use thereof for the treatment of alopecia, acute renal failure and other diseases
EP1880733A4 (en) 2005-04-25 2009-08-12 Genkin Dmitry Dmitrievich Method for increasing longevity of a human being and animals
JP2006325444A (en) * 2005-05-24 2006-12-07 Toyobo Co Ltd Medium for cell proliferation
EP1951881A4 (en) * 2005-11-07 2009-03-11 Gen Hospital Corp Methods and compositions for modulation of stem cell aging
JP5372769B2 (en) 2006-11-28 2013-12-18 シーエルエス セラピューティック リミティド Method for treating human disease associated with increased amount of deoxyribonucleic acid in the extracellular space of tissue and pharmaceutical formulation for performing the method
US8598150B1 (en) 2008-04-02 2013-12-03 Jonathan R. Brestoff Composition and method for affecting obesity and related conditions
US8987245B2 (en) 2008-04-02 2015-03-24 Jonathan R. Brestoff Parker Composition and method for affecting obesity and related conditions
CN106008707A (en) 2009-03-09 2016-10-12 生物蛋白有限公司 Mirac proteins
PL2437606T3 (en) 2009-05-18 2017-07-31 Telomerase Activation Sciences, Inc. Compositions and methods for increasing telomerase activity
KR20130024888A (en) 2010-02-16 2013-03-08 오슬로 유니버시티 하스피탈 에이치에프 Polypeptides
GB201202228D0 (en) * 2012-02-08 2012-03-28 Queen Mary & Westfield College Reversal of replicative senescence
US10617743B2 (en) 2014-06-19 2020-04-14 Cls Therapeutics Limited Method to improve safety and efficacy of anti-cancer therapy
RU2726131C2 (en) 2015-05-22 2020-07-09 Дмитрий Дмитриевич Генкин Extracellular dna as a therapeutic target in neurodegeneration
CA3047140A1 (en) 2017-01-09 2018-07-12 Oisin Biotechnologies Constructs for expression of therapeutic proteins in target cells
AU2019209770A1 (en) 2018-01-16 2020-09-03 Cls Therapeutics Limited Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity
WO2019166702A1 (en) 2018-02-28 2019-09-06 Hagalife Use of a flash irradiation method to increase longevity and/or to delay the effects of ageing in mammals
US11603543B2 (en) 2018-04-18 2023-03-14 Oisin Biotechnologies, Inc. Fusogenic lipid nanoparticles for target cell-specific production of a therapeutic protein
CN113774020B (en) * 2021-08-24 2023-04-14 河北朋和生物科技有限公司 Construction method of adipose-derived mesenchymal stem cell bank

Citations (8)

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Publication number Priority date Publication date Assignee Title
EP0537008A1 (en) * 1991-10-11 1993-04-14 E.R. SQUIBB & SONS, INC. Use of biphosphonates for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes
EP0618221A2 (en) * 1993-04-02 1994-10-05 Bristol-Myers Squibb Company Heterocyclic inhibitors of farnesyl protein transferase
WO1996012820A1 (en) * 1994-10-24 1996-05-02 Cold Spring Harbor Laboratory INTERACTIONS BETWEEN Raf PROTO-ONCOGENES AND CDC25 PHOSPHATASES, AND USES RELATED THERETO
US5624936A (en) * 1995-03-29 1997-04-29 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein
WO1999035243A2 (en) * 1998-01-12 1999-07-15 Cold Spring Harbor Laboratory Extension of cellular lifespan, methods and reagents
WO1999042578A2 (en) * 1998-01-30 1999-08-26 Cold Spring Harbor Laboratory Modulation of cell proliferation, methods and reagents

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
EP0537008A1 (en) * 1991-10-11 1993-04-14 E.R. SQUIBB & SONS, INC. Use of biphosphonates for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes
EP0618221A2 (en) * 1993-04-02 1994-10-05 Bristol-Myers Squibb Company Heterocyclic inhibitors of farnesyl protein transferase
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
WO1996012820A1 (en) * 1994-10-24 1996-05-02 Cold Spring Harbor Laboratory INTERACTIONS BETWEEN Raf PROTO-ONCOGENES AND CDC25 PHOSPHATASES, AND USES RELATED THERETO
US5624936A (en) * 1995-03-29 1997-04-29 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1998037181A2 (en) * 1997-02-20 1998-08-27 Whitehead Institute For Biomedical Research Telomerase catalytic subunit gene and encoded protein
WO1999035243A2 (en) * 1998-01-12 1999-07-15 Cold Spring Harbor Laboratory Extension of cellular lifespan, methods and reagents
WO1999042578A2 (en) * 1998-01-30 1999-08-26 Cold Spring Harbor Laboratory Modulation of cell proliferation, methods and reagents

Non-Patent Citations (7)

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Title
EILEEN M. ROGAN ET AL: "Alterations in p53 and p16INK4a Expression and Telomere Length during spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts", MOLECULAR AND CELLULAR BIOLOGY, vol. 15, no. 9, September 1995 (1995-09-01), pages 4745 - 4753, XP002142068 *
G. I. SHAPIRO ET AL: "p16INK14a Participates in a G1 arrest Checkpoint in Response to DNA Damage", MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 1, January 1998 (1998-01-01), pages 378 - 387, XP002142070 *
M KUBBUTAT ET AL: "Regulation of p53 stability by mdm2", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 387, 15 May 1997 (1997-05-15), pages 299 - 303, XP002075660, ISSN: 0028-0836 *
M. MEYYAPPAN ET AL: "Increased Expression of Cyclin D2 during Multiple States of Growth Arrest in Primary and Established Cells", MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 6, June 1998 (1998-06-01), pages 3163 - 3172, XP002142069 *
T. KIYONO ET AL: "both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells", NATURE, vol. 396, 5 November 1998 (1998-11-05), pages 84 - 88, XP002142067 *
VAZIRI H ET AL: "ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase", EMBO JOURNAL,GB,OXFORD UNIVERSITY PRESS, SURREY, vol. 16, no. 19, 1 October 1997 (1997-10-01), pages 6018 - 6033, XP002118901, ISSN: 0261-4189 *
XU H -J ET AL: "REEXPRESSION OF THE RETINOBLASTOMA PROTEIN IN TUMOR CELLS INDUCES SENESCENCE AND TELOMERASE INHIBITION", ONCOGENE,GB,BASINGSTOKE, HANTS, vol. 15, no. 21, 1 January 1997 (1997-01-01), pages 2589 - 2596, XP002068735, ISSN: 0950-9232 *

Also Published As

Publication number Publication date
WO2000031238A2 (en) 2000-06-02
CA2352486A1 (en) 2000-06-02
IL143328A0 (en) 2002-04-21
EP1133552A2 (en) 2001-09-19
JP2002530436A (en) 2002-09-17
AU2156600A (en) 2000-06-13

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