WO1999035243A3 - Extension of cellular lifespan, methods and reagents - Google Patents

Extension of cellular lifespan, methods and reagents Download PDF

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Publication number
WO1999035243A3
WO1999035243A3 PCT/US1999/000682 US9900682W WO9935243A3 WO 1999035243 A3 WO1999035243 A3 WO 1999035243A3 US 9900682 W US9900682 W US 9900682W WO 9935243 A3 WO9935243 A3 WO 9935243A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagents
methods
extension
vivo
cellular lifespan
Prior art date
Application number
PCT/US1999/000682
Other languages
French (fr)
Other versions
WO1999035243A2 (en
WO1999035243A9 (en
Inventor
Gregory J Hannon
Jing Wang
David H Beach
Original Assignee
Cold Spring Harbor Lab
Gregory J Hannon
Jing Wang
David H Beach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Lab, Gregory J Hannon, Jing Wang, David H Beach filed Critical Cold Spring Harbor Lab
Priority to EP99903059A priority Critical patent/EP1045697A2/en
Priority to AU23172/99A priority patent/AU759437B2/en
Priority to JP2000527629A priority patent/JP2002500040A/en
Priority to CA002315265A priority patent/CA2315265A1/en
Priority to IL13710199A priority patent/IL137101A0/en
Publication of WO1999035243A2 publication Critical patent/WO1999035243A2/en
Publication of WO1999035243A3 publication Critical patent/WO1999035243A3/en
Publication of WO1999035243A9 publication Critical patent/WO1999035243A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

The present invention relates to methods and reagents for extending the life-span, e.g., the number of mitotic divisions, of a cell. In general, the subject method relies on the ectopic expression of the telomerase catalytic subunit EST2, or a bioactive fragment thereof. The subject method is useful both in vivo, ex vivo and in situ.
PCT/US1999/000682 1998-01-12 1999-01-12 Extension of cellular lifespan, methods and reagents WO1999035243A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99903059A EP1045697A2 (en) 1998-01-12 1999-01-12 Extension of cellular lifespan, methods and reagents
AU23172/99A AU759437B2 (en) 1998-01-12 1999-01-12 Extension of cellular lifespan, methods and reagents
JP2000527629A JP2002500040A (en) 1998-01-12 1999-01-12 Extending cell life, methods and reagents
CA002315265A CA2315265A1 (en) 1998-01-12 1999-01-12 Extension of cellular lifespan, methods and reagents
IL13710199A IL137101A0 (en) 1998-01-12 1999-01-12 Extension of cellular lifespan, methods and reagents

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US7122098P 1998-01-12 1998-01-12
US60/071,220 1998-01-12
US7145598P 1998-01-13 1998-01-13
US60/071,455 1998-01-13
US6365798A 1998-04-21 1998-04-21
US09/063,657 1998-04-21

Publications (3)

Publication Number Publication Date
WO1999035243A2 WO1999035243A2 (en) 1999-07-15
WO1999035243A3 true WO1999035243A3 (en) 1999-09-16
WO1999035243A9 WO1999035243A9 (en) 1999-10-28

Family

ID=27370514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/000682 WO1999035243A2 (en) 1998-01-12 1999-01-12 Extension of cellular lifespan, methods and reagents

Country Status (6)

Country Link
EP (1) EP1045697A2 (en)
JP (1) JP2002500040A (en)
AU (1) AU759437B2 (en)
CA (1) CA2315265A1 (en)
IL (1) IL137101A0 (en)
WO (1) WO1999035243A2 (en)

Families Citing this family (34)

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US6572845B2 (en) * 1998-10-16 2003-06-03 Burt D. Ensley Recombinant hair treatment compositions
IL143328A0 (en) * 1998-11-25 2002-04-21 Genetica Inc Methods and reagents for increasing proliferative capacity and preventing replicative senescence
ATE514772T1 (en) * 1999-08-05 2011-07-15 Abt Holding Co MULTIPOTENT ADULT STEM CELLS AND METHOD FOR ISOLATION THEREOF
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US8609412B2 (en) 1999-08-05 2013-12-17 Regents Of The University Of Minnesota Mapc generation of lung tissue
AU2006202072B2 (en) * 1999-08-05 2010-12-09 Abt Holding Company Multipotent adult stem cells and methods for isolation
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
EP1103615A1 (en) * 1999-11-25 2001-05-30 Universite De Geneve Vectors capable of immortalizing non-dividing cells and cells immortalized with said vectors
FR2810046B1 (en) * 2000-06-07 2004-09-10 Neurotech PROCESS FOR CONDITIONAL IMMORTALIZATION OF CELLS AND PROTEIN CONSTRUCTIONS FOR ITS IMPLEMENTATION
US20020045219A1 (en) * 2000-08-02 2002-04-18 Whitehead Institute For Biomedical Research Production of human monoclonal antibodies
WO2002016657A1 (en) 2000-08-24 2002-02-28 Sierra Sciences, Inc. Methods and compositions for modulating telomerase reverse transcriptase (tert) expression
IL157332A0 (en) 2001-02-14 2004-02-19 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US7211435B2 (en) 2001-06-21 2007-05-01 Sierra Sciences, Inc. Telomerase expression repressor proteins and methods of using the same
EP1472340A4 (en) * 2002-02-05 2006-11-08 Rappaport Family Inst For Res Lineage committed stem cells selected for telomerase promoter activity
US20060228798A1 (en) 2002-11-27 2006-10-12 Catherine Verfaillie Homologous recombination in multipotent adult progenitor cells
JP5583882B2 (en) 2003-06-23 2014-09-03 テロメラーゼ アクティベーション サイエンシーズ， インコーポレイテッド Compositions and methods for increasing telomerase activity
US9248088B2 (en) 2003-06-25 2016-02-02 Telomerase Activation Sciences, Inc. Compositions and methods for skin conditioning
US8426200B2 (en) 2003-07-02 2013-04-23 Regents Of The University Of Minnesota Neuronal differentiation of stem cells
JP2009511061A (en) 2005-10-14 2009-03-19 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Differentiation of non-embryonic stem cells into cells with pancreatic phenotype
AU2007321928A1 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
AU2009205886B2 (en) 2008-01-18 2015-08-27 Katholieke Universiteit Leuven Stem cell aggregates and methods for making and using
US9057051B2 (en) 2008-10-31 2015-06-16 Katholieke Universiteit Leuven Optimized methods for differentiation of cells into cells with hepatocyte progenitor phenotypes, cells produced by the methods, and methods of using the cells
ES2661310T3 (en) 2009-03-09 2018-03-28 Bioatla, Llc Mirac proteins
HUE030253T2 (en) 2009-05-18 2017-04-28 Telomerase Activation Sciences Inc Compositions and methods for increasing telomerase activity
DK2536830T3 (en) 2010-02-16 2019-10-21 Ultimovacs As POLYPEPTIDES
CA3128483A1 (en) 2010-05-12 2011-11-17 Abt Holding Company Modulation of splenocytes in cell therapy
US9090878B2 (en) 2010-06-17 2015-07-28 Katholieke Universiteit Leuven Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells
EP2402038B1 (en) * 2010-07-02 2016-05-25 Fundación Centro Nacional De Investigaciones Oncológicas Carlos III Telomerase reverse transcriptase for protection against ageing
AU2011293440B2 (en) 2010-08-24 2016-05-05 Katholieke Universiteit Leuven Non-static suspension culture of cell aggregates
KR102161726B1 (en) 2013-04-12 2020-10-06 사베리오 라프란체스카 Improving organs for transplantation
CN114657281A (en) * 2020-12-22 2022-06-24 中国科学院动物研究所 Endogenous virus as marker of aging degree and application of endogenous virus as aging intervention target
CN114601747A (en) * 2022-03-07 2022-06-10 广州市万千粉丝化妆品有限公司 Application of nucleoprotein telomerase with functions of promoting growth of protein and RNA, prolonging cell telomere and proliferating in cosmetics
WO2024075819A1 (en) * 2022-10-07 2024-04-11 Ａｇｃ株式会社 Virus vector production method employing cell

Citations (3)

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WO1995013382A1 (en) * 1993-11-12 1995-05-18 Geron Corporation Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
WO1996040868A1 (en) * 1995-06-07 1996-12-19 Cold Spring Harbor Laboratory Essential oligonucleotides of vertebrate telomerase
US5830644A (en) * 1992-05-13 1998-11-03 Geron Corporation Method for screening for agents which increase telomerase activity in a cell

Patent Citations (3)

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US5830644A (en) * 1992-05-13 1998-11-03 Geron Corporation Method for screening for agents which increase telomerase activity in a cell
WO1995013382A1 (en) * 1993-11-12 1995-05-18 Geron Corporation Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
WO1996040868A1 (en) * 1995-06-07 1996-12-19 Cold Spring Harbor Laboratory Essential oligonucleotides of vertebrate telomerase

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AUTEXIER C ET AL: "RECONSTITUTION OF HUMAN TELOMERASE ACTIVITY AND IDENTIFICATION OF AMINIMAL FUNCTIONAL REGION OF THE HUMAN TELOMERASE RNA", EMBO JOURNAL, vol. 15, no. 21, 1 November 1996 (1996-11-01), pages 5928 - 5935, XP002056802 *
H. VAZIRI AND S. BENCHIMOL: "RECONSTITUTION OF TELOMERASE ACTIVITY IN NORMAL HUMAN CELLS LEADS TO ELONGATION OF TELOMERES AND EXTENDED REPLICATIVE LIFE SPAN", CURRENT BIOLOGY, vol. 8, no. 5, 26 February 1998 (1998-02-26), pages 279 - 282, XP002107653 *
J. WANG ET AL.: "MYC ACTIVATES TELOMERASE", GENES & DEVELOPMENT, vol. 12, 1998, pages 1769 - 1774, XP002107654 *
K. FUJIMOTO AND M. TAKAHASHI: "TELOMERASE ACTIVITY IN HUMAN LEUKEMIC CELL LINES IS INHIBITED BY ANTISENSE PENTADECADEOXYNUCLEOTIDES TARGETED AGAINST C-MYC MRNA", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 241, 1997, pages 775 - 781, XP002107655 *
K. HIYAMA ET AL.: "ACTIVATION OF TELOMERASE IN HUMAN LYMPHOCYTES AND HEMATOPOIETIC PROGENITOR CELLS", J. IMMUNOLOGY, vol. 155, no. 8, 1995, pages 3711 - 3715, XP002107651 *
S.L. WEINRICH ET AL.: "RECONSTITUTION OF HUMAN TELOMERASE WITH THE TEMPLATE RNA COMPONENT HTR AND THE CATALYTIC PROTEIN SUBUBIT HTRT", NATURE GENETICS, vol. 17, 1997, pages 498 - 502, XP002107652 *

Also Published As

Publication number Publication date
EP1045697A2 (en) 2000-10-25
AU2317299A (en) 1999-07-26
WO1999035243A2 (en) 1999-07-15
IL137101A0 (en) 2001-06-14
JP2002500040A (en) 2002-01-08
CA2315265A1 (en) 1999-07-15
AU759437B2 (en) 2003-04-17
WO1999035243A9 (en) 1999-10-28

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