WO2001026536A3 - Methods of diagnosing and treating hepatic cell proliferative disorders - Google Patents

Methods of diagnosing and treating hepatic cell proliferative disorders Download PDF

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Publication number
WO2001026536A3
WO2001026536A3 PCT/US2000/028427 US0028427W WO0126536A3 WO 2001026536 A3 WO2001026536 A3 WO 2001026536A3 US 0028427 W US0028427 W US 0028427W WO 0126536 A3 WO0126536 A3 WO 0126536A3
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WO
WIPO (PCT)
Prior art keywords
methods
proliferative disorders
diagnosing
cell proliferative
hepatic cell
Prior art date
Application number
PCT/US2000/028427
Other languages
French (fr)
Other versions
WO2001026536A2 (en
Inventor
William G Nelson
Xiaohui Lin
Julia C Tchou
Jila Bakker
Original Assignee
Univ Johns Hopkins Med
William G Nelson
Xiaohui Lin
Julia C Tchou
Jila Bakker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med, William G Nelson, Xiaohui Lin, Julia C Tchou, Jila Bakker filed Critical Univ Johns Hopkins Med
Priority to AU80215/00A priority Critical patent/AU8021500A/en
Publication of WO2001026536A2 publication Critical patent/WO2001026536A2/en
Publication of WO2001026536A3 publication Critical patent/WO2001026536A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/9116—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • G01N2333/91165—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1)
    • G01N2333/91171—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1) with definite EC number (2.5.1.-)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Provided are methods and compositions useful for the diagnosis, prognosis and treatment of hepatic cellular proliferative disorders. The methods include the modulation or analysis of hypermethylated glutathione-S-transferase nucleic acid sequence in hepatic samples and biological fluids.
PCT/US2000/028427 1999-10-13 2000-10-12 Methods of diagnosing and treating hepatic cell proliferative disorders WO2001026536A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU80215/00A AU8021500A (en) 1999-10-13 2000-10-12 Methods of diagnosing and treating hepatic cell proliferative disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15916899P 1999-10-13 1999-10-13
US60/159,168 1999-10-13

Publications (2)

Publication Number Publication Date
WO2001026536A2 WO2001026536A2 (en) 2001-04-19
WO2001026536A3 true WO2001026536A3 (en) 2002-01-31

Family

ID=22571369

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028427 WO2001026536A2 (en) 1999-10-13 2000-10-12 Methods of diagnosing and treating hepatic cell proliferative disorders

Country Status (2)

Country Link
AU (1) AU8021500A (en)
WO (1) WO2001026536A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102627L (en) * 2001-07-27 2002-11-19 Geneinvent Bbl Ab Vectors resistant to methylation
KR20060026595A (en) 2004-09-21 2006-03-24 (주)지노믹트리 Method for detecting methylaion of promoter using restriction enzyme and dna chip
KR101302173B1 (en) 2012-12-07 2013-08-30 이화여자대학교 산학협력단 Composition for diagnosing alzheimer's disease using methylation status of hmox1 gene and method for diagnosing alzheimer's disease using the same
JP6369857B2 (en) * 2013-05-29 2018-08-08 シスメックス株式会社 Method for obtaining information on hepatocellular carcinoma, and marker and kit for obtaining information on hepatocellular carcinoma
CN114829631A (en) 2019-10-14 2022-07-29 建喾立嗣股份公司 Composition for diagnosing liver cancer by using CPG methylation change in specific gene and use thereof
AU2021252396A1 (en) 2020-04-08 2022-11-17 Gencurix Inc. Composition for diagnosing colorectal cancer, rectal cancer, or colorectal adenoma using cpg methylation change of glrb gene, and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046705A1 (en) * 1996-06-03 1997-12-11 The Johns Hopkins University School Of Medicine Methylation specific detection
US5891628A (en) * 1994-06-03 1999-04-06 Brigham And Women's Hospital Identification of polycystic kidney disease gene, diagnostics and treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891628A (en) * 1994-06-03 1999-04-06 Brigham And Women's Hospital Identification of polycystic kidney disease gene, diagnostics and treatment
WO1997046705A1 (en) * 1996-06-03 1997-12-11 The Johns Hopkins University School Of Medicine Methylation specific detection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JHAVERI M.S. ET AL.: "Methylation-mediated regulation of the glutathione-S-transferase P1 gene in human breast cancer cells", GENE, vol. 210, 1998, pages 1 - 7, XP002938223 *
STEINMETZ K.L. ET AL.: "Hypomethylation of the rat glutathione S-transferase pi (GSTP) promoter region isolated from methyl-deficient livers and GSTP positive liver neoplasms", CARCINOGENESIS, vol. 19, no. 8, 1988, pages 1487 - 1494, XP002938224 *

Also Published As

Publication number Publication date
WO2001026536A2 (en) 2001-04-19
AU8021500A (en) 2001-04-23

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