WO2000029391A1 - Processus visant la preparation de quinazolinones - Google Patents

Processus visant la preparation de quinazolinones Download PDF

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Publication number
WO2000029391A1
WO2000029391A1 PCT/US1999/027357 US9927357W WO0029391A1 WO 2000029391 A1 WO2000029391 A1 WO 2000029391A1 US 9927357 W US9927357 W US 9927357W WO 0029391 A1 WO0029391 A1 WO 0029391A1
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compound
substituted
alkyl
acid
Prior art date
Application number
PCT/US1999/027357
Other languages
English (en)
Inventor
Pasquale Nicholas Confalone
Nicholas Andrew Magnus
Louis Storace
Original Assignee
Du Pont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharmaceuticals Company filed Critical Du Pont Pharmaceuticals Company
Priority to AU18219/00A priority Critical patent/AU1821900A/en
Publication of WO2000029391A1 publication Critical patent/WO2000029391A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Abstract

L'invention concerne de manière générale un procédé de synthèse asymétrique de 3,4-dihydro-2(1H)-quinazolinones 4,4-disubstitutués et de leurs intermédiaires. Les composants cibles sons utiles dans le traitement de l'immunodéficience humaine (VIH), en tant qu'inhibiteur de transcriptase inverse.
PCT/US1999/027357 1998-11-19 1999-11-18 Processus visant la preparation de quinazolinones WO2000029391A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18219/00A AU1821900A (en) 1998-11-19 1999-11-18 Process for the preparation of quinazolinones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10925198P 1998-11-19 1998-11-19
US60/109,251 1998-11-19

Publications (1)

Publication Number Publication Date
WO2000029391A1 true WO2000029391A1 (fr) 2000-05-25

Family

ID=22326647

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027357 WO2000029391A1 (fr) 1998-11-19 1999-11-18 Processus visant la preparation de quinazolinones

Country Status (3)

Country Link
AU (1) AU1821900A (fr)
HR (1) HRP990359A2 (fr)
WO (1) WO2000029391A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103524430A (zh) * 2013-09-30 2014-01-22 天津大学 4-(反-4-取代-3-丁烯-1-炔基)-4-三氟甲基-3,4-二氢取代喹唑啉-2(1h)-酮类化合物及制备方法和应用
US10752040B2 (en) 2017-02-03 2020-08-25 De La Rue International Limited Method of forming a security device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0530994A1 (fr) * 1991-08-16 1993-03-10 Merck & Co. Inc. Dérivés de quinazoline utilisés comme inhibiteurs de transcriptase inverse de HIV
WO1998045276A2 (fr) * 1997-04-09 1998-10-15 Du Pont Pharmaceuticals Company 4,4-disubstituees-3,4-dihydro-2(1h)-quinazolinones utilisees comme inhibiteurs de la transcriptase inverse du vih

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0530994A1 (fr) * 1991-08-16 1993-03-10 Merck & Co. Inc. Dérivés de quinazoline utilisés comme inhibiteurs de transcriptase inverse de HIV
WO1998045276A2 (fr) * 1997-04-09 1998-10-15 Du Pont Pharmaceuticals Company 4,4-disubstituees-3,4-dihydro-2(1h)-quinazolinones utilisees comme inhibiteurs de la transcriptase inverse du vih

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103524430A (zh) * 2013-09-30 2014-01-22 天津大学 4-(反-4-取代-3-丁烯-1-炔基)-4-三氟甲基-3,4-二氢取代喹唑啉-2(1h)-酮类化合物及制备方法和应用
US10752040B2 (en) 2017-02-03 2020-08-25 De La Rue International Limited Method of forming a security device

Also Published As

Publication number Publication date
AU1821900A (en) 2000-06-05
HRP990359A2 (en) 2000-08-31

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