WO2000025763A3 - Phenolderivaten enthaltendes mittel mit proliferationshemmender wirkung auf tumorzellen - Google Patents
Phenolderivaten enthaltendes mittel mit proliferationshemmender wirkung auf tumorzellen Download PDFInfo
- Publication number
- WO2000025763A3 WO2000025763A3 PCT/DE1999/003524 DE9903524W WO0025763A3 WO 2000025763 A3 WO2000025763 A3 WO 2000025763A3 DE 9903524 W DE9903524 W DE 9903524W WO 0025763 A3 WO0025763 A3 WO 0025763A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- proliferation
- tumour cells
- inhibiting effect
- cells
- phenol derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Die Erfindung betrifft die Bereitstellung von Mitteln mit proliferationshemmender Wirkung auf Tumorzellen. Die erfindungsgemäßen Mittel enthalten als wirksame Komponenten Phenolderivate, insbesondere Thymol, Eugenol, Hydroxybenzoesäuren bzw. deren Derivate sowie Gemische dieser Komponenten. Als Testzellen sind kultivierbare Tumorzellen menschlicher Herkunft, wie Lymphomzellen oder Melanomzellen, eingesetzt worden.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19851706.8 | 1998-10-30 | ||
DE19851706 | 1998-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000025763A2 WO2000025763A2 (de) | 2000-05-11 |
WO2000025763A3 true WO2000025763A3 (de) | 2000-11-09 |
Family
ID=7887244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1999/003524 WO2000025763A2 (de) | 1998-10-30 | 1999-10-29 | Phenolderivaten enthaltendes mittel mit proliferationshemmender wirkung auf tumorzellen |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE19954040A1 (de) |
WO (1) | WO2000025763A2 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9132103B2 (en) | 2009-09-24 | 2015-09-15 | Conopco, Inc. | Disinfecting agent comprising eugenol, terpineol and thymol |
US9408870B2 (en) | 2010-12-07 | 2016-08-09 | Conopco, Inc. | Oral care composition |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1909778T3 (en) * | 2005-07-28 | 2018-03-19 | Academisch Ziekenhuis Bij De Univ Van Amsterdam | Monophenol, benzenediol or sulfhydryl compounds for use in the treatment of melanomas |
WO2013064360A2 (en) | 2011-11-03 | 2013-05-10 | Unilever N.V. | A personal cleaning composition |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4418796A1 (de) * | 1993-06-02 | 1994-12-15 | Colgate Palmolive Co | Oral anwendbare und gegen Plaque und Gingivitis wirkende Zusammensetzungen |
WO1996030003A1 (de) * | 1995-03-30 | 1996-10-03 | Werner Kreutz | Arzneistoffe zur selektiven bekämpfung von tumorgewebe |
US5753270A (en) * | 1987-09-16 | 1998-05-19 | Patrick A. Beauchamp | Topical treatment of diseased skin disorders |
JPH11315012A (ja) * | 1998-03-04 | 1999-11-16 | Shiseido Co Ltd | サイクリックamp誘導剤 |
-
1999
- 1999-10-29 WO PCT/DE1999/003524 patent/WO2000025763A2/de active Application Filing
- 1999-10-29 DE DE19954040A patent/DE19954040A1/de not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753270A (en) * | 1987-09-16 | 1998-05-19 | Patrick A. Beauchamp | Topical treatment of diseased skin disorders |
DE4418796A1 (de) * | 1993-06-02 | 1994-12-15 | Colgate Palmolive Co | Oral anwendbare und gegen Plaque und Gingivitis wirkende Zusammensetzungen |
WO1996030003A1 (de) * | 1995-03-30 | 1996-10-03 | Werner Kreutz | Arzneistoffe zur selektiven bekämpfung von tumorgewebe |
JPH11315012A (ja) * | 1998-03-04 | 1999-11-16 | Shiseido Co Ltd | サイクリックamp誘導剤 |
Non-Patent Citations (6)
Title |
---|
"martindale 30th edition", PHARMACEUTICAL PRESS, XP002134890 * |
BUCCELLATO, G. ET AL: "Possible cytolytic activity of p-methylisopropylphenol (thymol)and of som chemically related compounds", BOLL. - SOC. ITAL. BIOL. SPER. (1966), 42(24), 1890-3, XP000901383 * |
BUCCELLATO, G.: "Routes of administration of p-methylisopropylphenol (thymol) and its 24-hr. urinary elimination", BOLL. - SOC. ITAL. BIOL. SPER. (1966), 42(24), 1886-90, XP000901382 * |
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OTA, MASAHIRO ET AL: "Cyclic AMP inducers for activation of tyrosinase and prevention of hair graying", XP002134891, retrieved from STN Database accession no. 131:327324 * |
DATABASE WPI Section Ch Derwent World Patents Index; Class B07, AN 1970-67604R, XP002134892 * |
SIVROPOULOU, AFRODITI ET AL: "Antimicrobial and cytotoxic activities of Origanum essential oils", J. AGRIC. FOOD CHEM. (1996), 44(5), 1202-5, XP000583841 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9132103B2 (en) | 2009-09-24 | 2015-09-15 | Conopco, Inc. | Disinfecting agent comprising eugenol, terpineol and thymol |
US9408870B2 (en) | 2010-12-07 | 2016-08-09 | Conopco, Inc. | Oral care composition |
Also Published As
Publication number | Publication date |
---|---|
DE19954040A1 (de) | 2000-05-04 |
WO2000025763A2 (de) | 2000-05-11 |
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