WO2000023061A3 - Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation - Google Patents

Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation Download PDF

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Publication number
WO2000023061A3
WO2000023061A3 PCT/US1999/024557 US9924557W WO0023061A3 WO 2000023061 A3 WO2000023061 A3 WO 2000023061A3 US 9924557 W US9924557 W US 9924557W WO 0023061 A3 WO0023061 A3 WO 0023061A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonist
pain
solution
inflammation
inhibitor
Prior art date
Application number
PCT/US1999/024557
Other languages
English (en)
Other versions
WO2000023061A2 (fr
Inventor
Gregory A Demopulos
Pamela P Palmer
Jeffrey M Herz
Original Assignee
Omeros Med Sys Inc
Gregory A Demopulos
Pamela P Palmer
Jeffrey M Herz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Med Sys Inc, Gregory A Demopulos, Pamela P Palmer, Jeffrey M Herz filed Critical Omeros Med Sys Inc
Priority to AU12148/00A priority Critical patent/AU1214800A/en
Publication of WO2000023061A2 publication Critical patent/WO2000023061A2/fr
Publication of WO2000023061A3 publication Critical patent/WO2000023061A3/fr
Priority to US09/839,633 priority patent/US7091181B2/en
Priority to US09/839,633 priority patent/US20020028798A1/en
Priority to US11/409,919 priority patent/US20060229588A1/en
Priority to US11/410,406 priority patent/US20060205657A1/en
Priority to US11/410,407 priority patent/US20060205658A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une méthode et une solution d'inhibition périopératoire de différentes sortes de manifestations de douleur et d'inflammation de plaies suite à des interventions chirurgicales y compris des interventions buccales/dentaires. La solution comprend de préférence au moins un inhibiteur de COX-2 et, éventuellement, plusieurs agents supplémentaires d'inhibition de douleur et d'inflammation dans des concentrations diluées dans un excipient physiologique tel qu'un soluté salin ou un soluté lactate de Ringer. On applique la solution par irrigation continue d'une plaie pendant une intervention chirurgicale pour favoriser une inhibition préventive de la douleur et éviter des effets secondaires indésirables associés à l'administration par voie orale, intramusculaire, sous-cutanée ou intraveineuse de doses plus importantes de ces agents. De préférence, une solution d'inhibition de douleur et d'inflammation comprend un inhibiteur de COX-2, un antagoniste de sérotonine2, un antagoniste de sérotonine3, un antagoniste d'histamine, un agoniste de sérotonine, un inhibiteur de cyclooxygénase, un antagoniste de neurokinine1, un antagoniste de neurokinine2, un antagoniste de purinocepteur, un élément d'ouverture du canal potassique sensible à l'ATP, un antagoniste du canal potassique, un antagoniste de bradykinine1, un antagoniste de bradikynine2 et un agoniste d'ν-opioïde.
PCT/US1999/024557 1994-12-12 1999-10-20 Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation WO2000023061A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU12148/00A AU1214800A (en) 1998-10-21 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation
US09/839,633 US7091181B2 (en) 1994-12-12 2001-04-20 Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US09/839,633 US20020028798A1 (en) 1995-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10516698P 1998-10-21 1998-10-21
US60/105,166 1998-10-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/072,913 Continuation-In-Part US6261279B1 (en) 1994-12-12 1998-05-04 Surgical irrigation solution and method for inhibition of pain and inflammation

Related Child Applications (5)

Application Number Title Priority Date Filing Date
PCT/US1999/024558 Continuation-In-Part WO2000023062A2 (fr) 1994-12-12 1999-10-20 Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation
US09/839,633 Continuation-In-Part US20020028798A1 (en) 1994-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 Continuation-In-Part US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 Continuation-In-Part US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 Continuation-In-Part US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Publications (2)

Publication Number Publication Date
WO2000023061A2 WO2000023061A2 (fr) 2000-04-27
WO2000023061A3 true WO2000023061A3 (fr) 2000-11-16

Family

ID=22304411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024557 WO2000023061A2 (fr) 1994-12-12 1999-10-20 Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation

Country Status (2)

Country Link
AU (1) AU1214800A (fr)
WO (1) WO2000023061A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087343A2 (fr) * 2000-05-15 2001-11-22 Merck Frosst Canada & Co. Polytherapie faisant appel a un inhibiteur selectif de cox-2 et a un inhibiteur de la thromboxane ainsi que des compositions contenant ceux-ci
CN101327325A (zh) 2002-07-30 2008-12-24 奥默罗斯公司 眼科冲洗液及方法
US20100105688A1 (en) 2007-01-24 2010-04-29 Glaxo Group Limited Pharmaceutical compositions comprising 3,5-diamino-6-(2,3-dichlophenyl)-1,2,4-triazine or r(-)-2,4-diamino-5-(2,3-dichlorophenyl)-6-fluoromethyl pyrimidine and an nk1
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI809304B (zh) 2014-12-01 2023-07-21 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5373022A (en) * 1991-03-04 1994-12-13 The Warner-Lambert Company Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
US5820583A (en) * 1995-12-12 1998-10-13 Omeros Medical Systems, Inc. Surgical irrigation solution and method for inhibition of pain and inflammation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5373022A (en) * 1991-03-04 1994-12-13 The Warner-Lambert Company Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
US5820583A (en) * 1995-12-12 1998-10-13 Omeros Medical Systems, Inc. Surgical irrigation solution and method for inhibition of pain and inflammation

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BURITOVA JAROSLAVA; CHAPMAN VICTORIA; HONORE PRISCA; BESSON JEAN-MARIE: "Selective cyclooxygenase-2 inhibition reduces carrageenan oedema and associated spinal c-Fos expression in the rat.", BRAIN RESEARCH, vol. 715, no. 1-2, 1996, pages 217 - 220, XP000905607 *
ENGELHARDT G: "Pharmacology of meloxicam, a new non-steroidal anti-inflammatory drug with an improved safety profile through preferential inhibition of COX-2.", BRITISH JOURNAL OF RHEUMATOLOGY, vol. 35, no. suppl. 1, 1996, pages 4 - 12, XP000905630 *
HAY CATRIONA; DE BELLEROCHE JACQUELINE: "Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord.", NEUROREPORT, vol. 8, no. 5, 1997, pages 1249 - 1251, XP000905625 *
JOSHI G.P.: "Postoperative pain management.", INTERNATIONAL ANESTHESIOLOGY CLINICS, (1994) 32/3 (113-126)., XP000905593 *
MEHLISCH D R; HUBBARD R C; ISAKSON P; KARIM A; WEAVER M; MILLS S: "Analgesic efficacy and plasma levels of a highly selective inhibitor of COX-2 (SC-58635;SC) in patients with post-surgical dental pain.", CLINICAL PHARMACOLOGY & THERAPEUTICS, vol. 61, no. 2, 1997, pages 195, XP000905616 *
OSIPOVA N A: "[Antinociceptive components of general anesthesia and postoperative analgesia]. Antinotsitseptivnye komponenty obschchei anestezii i posleoperatsionnoi analgezii.", ANESTEZIOLOGIIA I REANIMATOLOGIIA, (1998 SEP-OCT) (5) 11-5. REF: 21, XP000905655 *
REYNOLDS J.: "Martindale - The Extra Pharmacopoeia Edition 31", 1996, ROYAL PHARMACEUTICAL SOCIETY, LONDON GB, XP002137139, 224540 *
SCHWEIZER A; BROM R; WIESENBERG-BOETTCHER I: "INHIBITION OF INTERLEUKIN-1 IL-1 ENHANCED PAIN REFLEXES IN THE RABBIT BY CGP-28238", AGENTS AND ACTIONS, vol. 32, no. 1-2, 1991, pages 67 - 69, XP000905639 *
SEIBERT KAREN; ZHANG YAN; LEAHY KATHLEEN; HAUSER SCOTT; MASFERRER JAIME; PERKINS WILLIAM; LEE LEN; ISAKSON PETER: "Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 91, no. 25, 1994, pages 12013 - 12017, XP000604765 *
SOUTER A J ET AL: "CONTROVERSIES IN THE PERIOPERATIVE USE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS", ANESTHESIA AND ANALGESIA, (DEC 1994) VOL. 79, NO. 6, PP. 1178-1190. ISSN: 0003-2999., UNIV TEXAS, SW MED CTR, DEPT ANESTHESIOL & PAIN MANAGEMENT, 5323 HARRY HINES BLVD, DALLAS, TX, 75235 (Reprint);UNIV TEXAS, SW MED CTR, DEPT ANESTHESIOL & PAIN MANAGEMENT, DALLAS, TX, 75235, XP000905591 *

Also Published As

Publication number Publication date
WO2000023061A2 (fr) 2000-04-27
AU1214800A (en) 2000-05-08

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