WO2000023062A3 - Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation - Google Patents

Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation Download PDF

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Publication number
WO2000023062A3
WO2000023062A3 PCT/US1999/024558 US9924558W WO0023062A3 WO 2000023062 A3 WO2000023062 A3 WO 2000023062A3 US 9924558 W US9924558 W US 9924558W WO 0023062 A3 WO0023062 A3 WO 0023062A3
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WO
WIPO (PCT)
Prior art keywords
antagonist
pain
solution
inflammation
agonist
Prior art date
Application number
PCT/US1999/024558
Other languages
English (en)
Other versions
WO2000023062A2 (fr
Inventor
Gregory A Demopulos
Pamela P Palmer
Jeffrey M Herz
Original Assignee
Omeros Med Sys Inc
Gregory A Demopulos
Pamela P Palmer
Jeffrey M Herz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Med Sys Inc, Gregory A Demopulos, Pamela P Palmer, Jeffrey M Herz filed Critical Omeros Med Sys Inc
Priority to AU12149/00A priority Critical patent/AU1214900A/en
Priority to EP99970596A priority patent/EP1434573A2/fr
Publication of WO2000023062A2 publication Critical patent/WO2000023062A2/fr
Publication of WO2000023062A3 publication Critical patent/WO2000023062A3/fr
Priority to US09/839,633 priority patent/US20020028798A1/en
Priority to US09/839,633 priority patent/US7091181B2/en
Priority to US11/410,407 priority patent/US20060205658A1/en
Priority to US11/409,919 priority patent/US20060229588A1/en
Priority to US11/410,406 priority patent/US20060205657A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une méthode et une solution d'inhibition périopératoire de différentes sortes de manifestations de douleur et d'inflammation de plaies suite à des interventions chirurgicales, y compris des interventions buccales/dentaires. La solution contient de préférence au moins un agoniste de récepteurs neuronaux d'acétylcholine nicotinique et, éventuellement, de multiples autres agents d'inhibition de douleur et d'inflammation dans des concentrations diluées dans un excipient physiologique tel qu'un soluté salin ou un soluté lactate de Ringer. On applique la solution par irrigation continue d'une plaie lors d'une intervention chirurgicale afin de favoriser une inhibition préventive de la douleur tout en évitant des effets secondaires indésirables associés à l'administration par voie orale, intramusculaire, sous-cutanée ou intraveineuse de doses plus importantes de ces agents. De préférence, une solution d'inhibition de douleur et d'inflammation comprend un agoniste de récepteurs neuronaux d'acétylcholine nicotinique, un antagoniste de sérotonine2, un antagoniste de sérotonine3, un antagoniste d'histamine, un agoniste de sérotonine, un inhibiteur de cyclooxygénase, un antagoniste de neurokinine1, un antagoniste de neurokinine2, un antagoniste de purinocepteur, un élément d'ouverture du canal potassique sensible à l'ATP, un antagoniste du canal potassique, un antagoniste de bradykinine1, un antagoniste de bradikynine2 et un agoniste d'ν-opioïde.
PCT/US1999/024558 1994-12-12 1999-10-20 Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation WO2000023062A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU12149/00A AU1214900A (en) 1998-10-20 1999-10-20 Irrigation solution and method for inhibition of pain and inflammation
EP99970596A EP1434573A2 (fr) 1998-10-20 1999-10-20 Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation
US09/839,633 US20020028798A1 (en) 1995-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US09/839,633 US7091181B2 (en) 1994-12-12 2001-04-20 Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US11/410,407 US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10504498P 1998-10-20 1998-10-20
US60/105,044 1998-10-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024557 Continuation-In-Part WO2000023061A2 (fr) 1994-12-12 1999-10-20 Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation

Related Child Applications (5)

Application Number Title Priority Date Filing Date
PCT/US1999/024625 Continuation-In-Part WO2000023072A1 (fr) 1994-12-12 1999-10-20 Solution d'irrigation contenant des inhibiteurs de mapk et son utilisation pour traiter la douleur et l'inflammation
US09/839,633 Continuation-In-Part US20020028798A1 (en) 1994-12-12 2001-04-20 Irrigation solution and method for inhibition of pain and inflammation
US11/410,406 Continuation-In-Part US20060205657A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/409,919 Continuation-In-Part US20060229588A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation
US11/410,407 Continuation-In-Part US20060205658A1 (en) 1994-12-12 2006-04-24 Irrigation solution and method for inhibition of pain and inflammation

Publications (2)

Publication Number Publication Date
WO2000023062A2 WO2000023062A2 (fr) 2000-04-27
WO2000023062A3 true WO2000023062A3 (fr) 2000-07-27

Family

ID=22303751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024558 WO2000023062A2 (fr) 1994-12-12 1999-10-20 Solution et methode d'irrigation destinees a l'inhibition d'une douleur et d'une inflammation

Country Status (3)

Country Link
EP (1) EP1434573A2 (fr)
AU (1) AU1214900A (fr)
WO (1) WO2000023062A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2313900T3 (es) 1999-07-28 2009-03-16 The Board Of Trustees Of The Leland Stanford Junior University Nicotina en angiogenesis y vasculogenesis terapeutica.
CA2380052C (fr) * 1999-07-28 2007-10-23 John Cooke Agoniste du recepteur de la nicotine, present dans une cellule souche, et mobilisation de cellules souches
US7838539B2 (en) 1999-07-28 2010-11-23 The Board Of Trustees Of The Leland Stanford Junior University Nicotine receptor agonists in stem cell and progenitor cell recruitment
US8188043B2 (en) 1999-07-28 2012-05-29 The Board Of Trustees Of The Leland Stanford Jr. University Nicotine in therapeutic angiogenesis and vasculogenesis
CA2341952A1 (fr) 2001-03-23 2002-09-23 Universite Laval Agonistes du recepteur de la nicotine pour le traitement des maladies pulmonaires inflammatoires
US8557804B2 (en) 2002-03-25 2013-10-15 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
US8039459B2 (en) 2004-07-15 2011-10-18 Universite Laval Nicotinic receptor agonists for the treatment of inflammatory diseases
AU2003261304A1 (en) 2002-07-30 2004-02-16 Omeros Corporation Ophthalmologic irrigation solutions and method
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
EP2129381A1 (fr) 2007-01-24 2009-12-09 Glaxo Group Limited Nouvelles compositions pharmaceutiques
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820583A (en) * 1995-12-12 1998-10-13 Omeros Medical Systems, Inc. Surgical irrigation solution and method for inhibition of pain and inflammation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820583A (en) * 1995-12-12 1998-10-13 Omeros Medical Systems, Inc. Surgical irrigation solution and method for inhibition of pain and inflammation

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CHIARI A, EISENACH J C: "ANTINOCICEPTIVE EFFECTS OF RJR 2403, A SELECTIVE NICOTINIC AGONIST, IN MALE AND FEMALE RATS.", FASEB JOURNAL, vol. 12, no. 4 PART 1, SUPP. [S], 17 March 1998 (1998-03-17), pages 920, XP000906769 *
DECKER ET AL: "Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice", EUROPEAN JOURNAL OF PHARMACOLOGY,NL,AMSTERDAM, vol. 346, no. 1, 3 April 1998 (1998-04-03), pages 23 - 33-33, XP002110643, ISSN: 0014-2999 *
DONNELLY-ROBERTS ET AL: "ABT-594: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,US,AMERICAN SOCIETY FOR PHARMACOLOGY AND, vol. 285, no. 2, May 1998 (1998-05-01), pages 777 - 786-786, XP002105019, ISSN: 0022-3565 *
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Also Published As

Publication number Publication date
EP1434573A2 (fr) 2004-07-07
WO2000023062A2 (fr) 2000-04-27
AU1214900A (en) 2000-05-08

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