WO2000018732A3 - Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof - Google Patents

Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof Download PDF

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Publication number
WO2000018732A3
WO2000018732A3 PCT/EP1999/007141 EP9907141W WO0018732A3 WO 2000018732 A3 WO2000018732 A3 WO 2000018732A3 EP 9907141 W EP9907141 W EP 9907141W WO 0018732 A3 WO0018732 A3 WO 0018732A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
production
medicaments containing
relates
pyrrolidinones
Prior art date
Application number
PCT/EP1999/007141
Other languages
German (de)
French (fr)
Other versions
WO2000018732A2 (en
Inventor
Frank Himmelsbach
Brian Guth
Hans-Dieter Schubert
Original Assignee
Boehringer Ingelheim Pharma
Frank Himmelsbach
Brian Guth
Schubert Hans Dieter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Frank Himmelsbach, Brian Guth, Schubert Hans Dieter filed Critical Boehringer Ingelheim Pharma
Priority to AU60875/99A priority Critical patent/AU6087599A/en
Publication of WO2000018732A2 publication Critical patent/WO2000018732A2/en
Publication of WO2000018732A3 publication Critical patent/WO2000018732A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to disubstituted pyrrolidinones of general formula (I) in which R1 and R2 are defined in Claim No. 1. The invention also relates to the tautomers thereof, stereoisomers thereof, including their mixtures and their salts, especially the physiologically compatible salts with inorganic or organic acids or bases which comprise valuable pharmacological properties, preferably antithrombotic effects. In addition, the invention relates to medicaments containing these compounds, to their use and to a method for the production thereof.
PCT/EP1999/007141 1998-09-30 1999-09-25 Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof WO2000018732A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60875/99A AU6087599A (en) 1998-09-30 1999-09-25 Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19844787.6 1998-09-30
DE19844787A DE19844787A1 (en) 1998-09-30 1998-09-30 Disubstituted pyrrolidinones, medicaments containing them and their use and their preparation

Publications (2)

Publication Number Publication Date
WO2000018732A2 WO2000018732A2 (en) 2000-04-06
WO2000018732A3 true WO2000018732A3 (en) 2000-05-25

Family

ID=7882751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/007141 WO2000018732A2 (en) 1998-09-30 1999-09-25 Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof

Country Status (3)

Country Link
AU (1) AU6087599A (en)
DE (1) DE19844787A1 (en)
WO (1) WO2000018732A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0483667A2 (en) * 1990-11-02 1992-05-06 Dr. Karl Thomae GmbH Cyclic imino derivatives, process for their preparation and drugs containing them
EP0567966A1 (en) * 1992-04-28 1993-11-03 Dr. Karl Thomae GmbH Cyclic imino derivatives, medicaments containing these compounds and processes for the production thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0483667A2 (en) * 1990-11-02 1992-05-06 Dr. Karl Thomae GmbH Cyclic imino derivatives, process for their preparation and drugs containing them
EP0567966A1 (en) * 1992-04-28 1993-11-03 Dr. Karl Thomae GmbH Cyclic imino derivatives, medicaments containing these compounds and processes for the production thereof

Also Published As

Publication number Publication date
AU6087599A (en) 2000-04-17
WO2000018732A2 (en) 2000-04-06
DE19844787A1 (en) 2000-04-13

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