MX9700020A - Cyclic benzazepine urea derivatives with aggregation-inhibiting effect. - Google Patents

Cyclic benzazepine urea derivatives with aggregation-inhibiting effect.

Info

Publication number
MX9700020A
MX9700020A MX9700020A MX9700020A MX9700020A MX 9700020 A MX9700020 A MX 9700020A MX 9700020 A MX9700020 A MX 9700020A MX 9700020 A MX9700020 A MX 9700020A MX 9700020 A MX9700020 A MX 9700020A
Authority
MX
Mexico
Prior art keywords
aggregation
urea derivatives
cyclic
benzazepine
inhibiting effect
Prior art date
Application number
MX9700020A
Other languages
Spanish (es)
Inventor
Frank Himmelsbach
Volkhard Austel
Helmut Pieper
Johannes Weisenberger
Brian Guth
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of MX9700020A publication Critical patent/MX9700020A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cyclic urea derivatives having the general formula (I), in which R1 to R9, Ra, Rb, A, D, E and F have the definitions given in the first claim, their tautomers, their stereoisomers, including their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids or bases, have valuable pharmacological and other properties, preferably aggregation-inhibiting effects. Also disclosed are medicaments containing said compounds, their use and a process for producing the same.
MX9700020A 1994-08-17 1995-08-16 Cyclic benzazepine urea derivatives with aggregation-inhibiting effect. MX9700020A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4429079A DE4429079A1 (en) 1994-08-17 1994-08-17 Cyclic urea derivatives, pharmaceutical compositions containing them and processes for their preparation
PCT/EP1995/003233 WO1996005194A1 (en) 1994-08-17 1995-08-16 Cyclic benzazepine urea derivatives with aggregation-inhibiting effect

Publications (1)

Publication Number Publication Date
MX9700020A true MX9700020A (en) 1997-12-31

Family

ID=6525854

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700020A MX9700020A (en) 1994-08-17 1995-08-16 Cyclic benzazepine urea derivatives with aggregation-inhibiting effect.

Country Status (9)

Country Link
EP (1) EP0777667A1 (en)
JP (1) JPH10504298A (en)
AU (1) AU3345995A (en)
CA (1) CA2197789A1 (en)
CO (1) CO4410324A1 (en)
DE (1) DE4429079A1 (en)
IL (1) IL114980A0 (en)
MX (1) MX9700020A (en)
WO (1) WO1996005194A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19624069A1 (en) * 1996-06-17 1997-12-18 Thomae Gmbh Dr K Benzazepine derivatives, pharmaceutical compositions containing them and methods for their preparation
PE20020689A1 (en) 2000-11-17 2002-08-03 Upjohn Co OXAZOLIDINONES WITH A HETEROCYCLE OF 6 OR 7 MEMBERS UNITED WITH ANNULAR LINK TO BENZENE
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
BR0317483A (en) 2002-12-20 2005-11-16 Glaxo Group Ltd Benzodiazepine derivatives for the treatment of neurological disorders
CN1805939B (en) 2003-06-17 2010-10-13 艾尼纳制药公司 Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
HUE028976T2 (en) 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochloride
GB0329214D0 (en) * 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) * 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
DK1838677T3 (en) 2004-12-21 2010-01-11 Arena Pharm Inc Crystalline forms of (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
SI1833473T1 (en) 2004-12-23 2010-01-29 Arena Pharm Inc 5ht2c receptor modulator compositions and methods of use
JP5199997B2 (en) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド Process for preparing 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and related intermediates
SG177128A1 (en) 2006-12-05 2012-01-30 Arena Pharm Inc Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
EP2443080A2 (en) 2009-06-18 2012-04-25 Arena Pharmaceuticals, Inc. Process for the preparation of 5-ht2c receptor agonists
KR20130112848A (en) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. Processes for the preparation of 5-ht2c receptor agonists
CN103347523A (en) 2010-09-01 2013-10-09 艾尼纳制药公司 Administration of lorcaserin to individual with renal impairment
CA2808904A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
EP2611782A1 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
EP3485878A1 (en) 2010-09-01 2019-05-22 Arena Pharmaceuticals, Inc. Modified-release dosage forms of 5-ht2c agonists useful for weight management
MY181736A (en) 2012-10-09 2021-01-05 Arena Pharm Inc Method of weight management
US10853589B2 (en) 2014-04-25 2020-12-01 Mentor Acquisition One, Llc Language translation with head-worn computing
CA3080959A1 (en) * 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulators of the integrated stress pathway
BR112020008834A2 (en) 2017-11-02 2020-12-22 Calico Life Sciences Llc MODULATORS OF THE INTEGRATED STRESS ROUTE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4107857A1 (en) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K CYCLIC UREA DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE4127404A1 (en) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K CYCLIC IMINODERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE4332168A1 (en) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclic derivatives, pharmaceutical compositions containing these compounds and process for their preparation

Also Published As

Publication number Publication date
CO4410324A1 (en) 1997-01-09
IL114980A0 (en) 1995-12-08
WO1996005194A1 (en) 1996-02-22
EP0777667A1 (en) 1997-06-11
AU3345995A (en) 1996-03-07
CA2197789A1 (en) 1996-02-22
JPH10504298A (en) 1998-04-28
DE4429079A1 (en) 1996-02-22

Similar Documents

Publication Publication Date Title
MX9700020A (en) Cyclic benzazepine urea derivatives with aggregation-inhibiting effect.
BG101582A (en) Piperazine derivatives, medicaments containing the same, their use and process for preparing the same
NO933248L (en) Cyclic urea derivatives, drugs containing these compounds, and process for their preparation
TW226377B (en)
PL298717A1 (en) Cyclic imine derivatives, method of obtaining them and therapeutic agents containing such compounds
MX9803954A (en) Amino acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them.
BG105111A (en) Benzimidazoles, production thereof and use thereof as medicaments
MX9605128A (en) Neurokinine (tachykinine) antagonists.
NO923466L (en) Heterocyclic Compounds with 5 Sections, PROCEDURE PREPARATION, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS
NO934501L (en) Carboxylic acid derivatives, drugs containing these compounds, and process for their preparation
HK1008742A1 (en) Cyclic imino derivatives process for their preparation and drugs containing them
TW281675B (en)
WO2000008014A8 (en) Disubstituted bicyclic heterocycles having, in particular, a thrombin inhibitive effect
YU50002A (en) Substituted piperidines, medicaments containing these compounds,and methods for the production thereof
YU30902A (en) Novel cyclopropanes as cgrp antagonists, medicaments containing said compounds and method for the production thereof
NZ325259A (en) Phospholipid derivatives of phosphono-carboxylic acids, the production of said derivatives and the use of said derivatives as antiviral medicaments
YU3701A (en) Substituted phenylamidines with antithrombotic action
GR3036023T3 (en) Substituted phenyl amidines, medicaments containing these compounds and process for producing them
BG105326A (en) Novel benzoylguanadine derivatives with advantageous properties, method for producing them and their use in the production of medicaments
MX9804752A (en) Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments.
MX9803556A (en) Amino acid derivatives, medicaments containing said compounds and methods of producing them.
MX9803557A (en) Amino acid derivatives, medicaments containing said compounds and methods of producing said compounds.
WO1995022544A3 (en) Substituted 1,3,8-triaza-spiro(4,5)-decan-4-one derivatives useful as preliminary stages in the production of pharmaceuticals
WO2000018732A3 (en) Disubstituted pyrrolidinones, medicaments containing these compounds, their use and the production thereof
MX9802988A (en) 5-membered heterocycles, pharmaceutical agents containing said compounds and the use thereof and methods of producing them.