WO2000014119A3 - Bifunctional antibodies and their use in targeting anti-tumour agents - Google Patents

Bifunctional antibodies and their use in targeting anti-tumour agents Download PDF

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Publication number
WO2000014119A3
WO2000014119A3 PCT/GB1999/002938 GB9902938W WO0014119A3 WO 2000014119 A3 WO2000014119 A3 WO 2000014119A3 GB 9902938 W GB9902938 W GB 9902938W WO 0014119 A3 WO0014119 A3 WO 0014119A3
Authority
WO
WIPO (PCT)
Prior art keywords
bifunctional antibodies
tumour agents
targeting anti
affinity
antibody
Prior art date
Application number
PCT/GB1999/002938
Other languages
French (fr)
Other versions
WO2000014119A2 (en
Inventor
Peter John Harrison
Original Assignee
Ks Biomedix Ltd
Peter John Harrison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU56412/99A priority Critical patent/AU5641299A/en
Priority to MXPA01002349A priority patent/MXPA01002349A/en
Application filed by Ks Biomedix Ltd, Peter John Harrison filed Critical Ks Biomedix Ltd
Priority to EA200100311A priority patent/EA200100311A1/en
Priority to JP2000568876A priority patent/JP2002524470A/en
Priority to CA002341753A priority patent/CA2341753A1/en
Priority to PL99346861A priority patent/PL346861A1/en
Priority to KR1020017002437A priority patent/KR20010072988A/en
Priority to BR9913429-2A priority patent/BR9913429A/en
Priority to EP99943138A priority patent/EP1107995A2/en
Priority to IL14152499A priority patent/IL141524A0/en
Priority to HU0104091A priority patent/HUP0104091A2/en
Publication of WO2000014119A2 publication Critical patent/WO2000014119A2/en
Publication of WO2000014119A3 publication Critical patent/WO2000014119A3/en
Priority to BG105293A priority patent/BG105293A/en
Priority to NO20011102A priority patent/NO20011102L/en
Priority to HR20010154A priority patent/HRP20010154A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A bifunctional antibody has affinity for a target site and affinity for an organic molecule covalently linked to a cytotoxic agent or an enzyme capable of converting a prodrug into its cytotoxic form. The antibody may be used in therapy or diagnosis, especially in the treatment of tumours.
PCT/GB1999/002938 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents WO2000014119A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
EP99943138A EP1107995A2 (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents
BR9913429-2A BR9913429A (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting antitumor agents
EA200100311A EA200100311A1 (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their application for targeted delivery of antitumor agents
MXPA01002349A MXPA01002349A (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents.
CA002341753A CA2341753A1 (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents
PL99346861A PL346861A1 (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents
IL14152499A IL141524A0 (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumor agents
AU56412/99A AU5641299A (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents
JP2000568876A JP2002524470A (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeted antitumor agents
KR1020017002437A KR20010072988A (en) 1998-09-04 1999-09-06 Bifunctional Antibodies and Their Use In Targeting Anti-tumour Agents
HU0104091A HUP0104091A2 (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents
BG105293A BG105293A (en) 1998-09-04 2001-02-26 Bifunctional antibodies and their use in targeting anti-tumour agents
NO20011102A NO20011102L (en) 1998-09-04 2001-03-02 Bifunctional antibodies and their use in targeting anti-tumor agents
HR20010154A HRP20010154A2 (en) 1998-09-04 2001-03-02 Bifunctional antibodies and their use in targeting anti-tumour agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9819411.1 1998-09-04
GBGB9819411.1A GB9819411D0 (en) 1998-09-04 1998-09-04 Antibodies

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09786013 A-371-Of-International 2001-04-24
US10/445,132 Continuation US20030215387A1 (en) 1998-09-04 2003-05-22 Bifunctional antibodies and their use in targeting anti-tumour agents

Publications (2)

Publication Number Publication Date
WO2000014119A2 WO2000014119A2 (en) 2000-03-16
WO2000014119A3 true WO2000014119A3 (en) 2000-11-30

Family

ID=10838416

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/002938 WO2000014119A2 (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents

Country Status (20)

Country Link
EP (1) EP1107995A2 (en)
JP (1) JP2002524470A (en)
KR (1) KR20010072988A (en)
CN (1) CN1315967A (en)
AU (1) AU5641299A (en)
BG (1) BG105293A (en)
BR (1) BR9913429A (en)
CA (1) CA2341753A1 (en)
EA (1) EA200100311A1 (en)
GB (1) GB9819411D0 (en)
HR (1) HRP20010154A2 (en)
HU (1) HUP0104091A2 (en)
ID (1) ID28873A (en)
IL (1) IL141524A0 (en)
MX (1) MXPA01002349A (en)
NO (1) NO20011102L (en)
PL (1) PL346861A1 (en)
TR (2) TR200103405T2 (en)
WO (1) WO2000014119A2 (en)
ZA (1) ZA200101574B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117442717A (en) 2018-06-01 2024-01-26 大有华夏生物医药集团有限公司 Compositions for treating diseases or conditions and uses thereof
EP3826673A4 (en) * 2018-07-26 2022-03-09 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and methods for imaging
CN110811820B (en) * 2019-12-11 2022-07-12 江西华晨医疗设备有限公司 Straight rod type flushing and suction electrocoagulation cutter

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
EP0369566A2 (en) * 1988-11-17 1990-05-23 Hybritech Incorporated Bifunctional chimeric antibodies
WO1991009134A1 (en) * 1989-12-15 1991-06-27 Takeda Chemical Industries, Ltd. Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
JPH05184383A (en) * 1990-06-19 1993-07-27 Dainabotsuto Kk Bispecific antibody
WO1998038513A1 (en) * 1997-02-26 1998-09-03 Khaw Ban An Signal enhancement of bispecific antibody-polymer probe for immunoassay use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
EP0369566A2 (en) * 1988-11-17 1990-05-23 Hybritech Incorporated Bifunctional chimeric antibodies
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
WO1991009134A1 (en) * 1989-12-15 1991-06-27 Takeda Chemical Industries, Ltd. Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics
JPH05184383A (en) * 1990-06-19 1993-07-27 Dainabotsuto Kk Bispecific antibody
WO1998038513A1 (en) * 1997-02-26 1998-09-03 Khaw Ban An Signal enhancement of bispecific antibody-polymer probe for immunoassay use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRITISH JOURNAL OF CANCER, vol. 67 367, no. 3, 1993, UK, pages 436 - 440, XP002901232, ISSN: 0007-0920 *
DATABASE DIALOG [online] BRUYNCK A ET AL: "Characterisation of a humanised bispecific monoclonal antibody for cancer therapy", XP002900882, retrieved from EMBASE accession no. 1993077634 *
DATABASE WPI Section Ch Week 199334, Derwent World Patents Index; Class B04, AN 1993-269042, XP002901224 *
HUI ZHU ET AL: "Tumor Pretargeting for Radioimmunodetection and Radioimmunotherapy", J NUCL MED, vol. 39, no. 1, January 1998 (1998-01-01), pages 65 - 76, XP002901225 *

Also Published As

Publication number Publication date
HUP0104091A2 (en) 2002-03-28
HRP20010154A2 (en) 2002-02-28
NO20011102L (en) 2001-03-05
IL141524A0 (en) 2002-03-10
AU5641299A (en) 2000-03-27
BR9913429A (en) 2001-09-25
BG105293A (en) 2001-12-29
JP2002524470A (en) 2002-08-06
CN1315967A (en) 2001-10-03
GB9819411D0 (en) 1998-10-28
WO2000014119A2 (en) 2000-03-16
TR200100651T2 (en) 2001-07-23
ID28873A (en) 2001-07-12
EP1107995A2 (en) 2001-06-20
NO20011102D0 (en) 2001-03-02
PL346861A1 (en) 2002-03-11
KR20010072988A (en) 2001-07-31
EA200100311A1 (en) 2001-08-27
MXPA01002349A (en) 2003-10-15
TR200103405T2 (en) 2002-06-21
CA2341753A1 (en) 2000-03-16
ZA200101574B (en) 2002-02-26

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