HUP0104091A2 - Bifunctional antibodies and their use in targeting anti-tumour agents - Google Patents
Bifunctional antibodies and their use in targeting anti-tumour agentsInfo
- Publication number
- HUP0104091A2 HUP0104091A2 HU0104091A HUP0104091A HUP0104091A2 HU P0104091 A2 HUP0104091 A2 HU P0104091A2 HU 0104091 A HU0104091 A HU 0104091A HU P0104091 A HUP0104091 A HU P0104091A HU P0104091 A2 HUP0104091 A2 HU P0104091A2
- Authority
- HU
- Hungary
- Prior art keywords
- bifunctional antibodies
- tumour agents
- targeting anti
- agent
- therapeutic
- Prior art date
Links
- 230000001588 bifunctional effect Effects 0.000 title abstract 2
- 230000008685 targeting Effects 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány bifunkcionális antitestekre és alkalmazásukra vonatkoziktumorellenes szerek in vivo célba juttatására. A találmány szerintiantitestek egy tumorhelynél lévő antigén iránt és egy terápiás vagydiagnosztikai szer iránt is affinitással rendelkeznek, ahol a szer egyszerves molekula, mely radioaktívan jelölt vagy kovalensen egycitotoxikus szerhez kötött. Az antitest terápiás vagy diagnosztikaicélra szolgáló készítmények előállítására alkalmazható. ÓThe invention relates to bifunctional antibodies and their use for in vivo targeting of antitumor agents. The antibodies according to the invention have an affinity for an antigen at a tumor site and for a therapeutic or diagnostic agent, where the agent is a simple molecule that is radioactively labeled or covalently bound to a cytotoxic agent. The antibody can be used to produce preparations for therapeutic or diagnostic purposes. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9819411.1A GB9819411D0 (en) | 1998-09-04 | 1998-09-04 | Antibodies |
| PCT/GB1999/002938 WO2000014119A2 (en) | 1998-09-04 | 1999-09-06 | Bifunctional antibodies and their use in targeting anti-tumour agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0104091A2 true HUP0104091A2 (en) | 2002-03-28 |
Family
ID=10838416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104091A HUP0104091A2 (en) | 1998-09-04 | 1999-09-06 | Bifunctional antibodies and their use in targeting anti-tumour agents |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1107995A2 (en) |
| JP (1) | JP2002524470A (en) |
| KR (1) | KR20010072988A (en) |
| CN (1) | CN1315967A (en) |
| AU (1) | AU5641299A (en) |
| BG (1) | BG105293A (en) |
| BR (1) | BR9913429A (en) |
| CA (1) | CA2341753A1 (en) |
| EA (1) | EA200100311A1 (en) |
| GB (1) | GB9819411D0 (en) |
| HR (1) | HRP20010154A2 (en) |
| HU (1) | HUP0104091A2 (en) |
| ID (1) | ID28873A (en) |
| IL (1) | IL141524A0 (en) |
| MX (1) | MXPA01002349A (en) |
| NO (1) | NO20011102L (en) |
| PL (1) | PL346861A1 (en) |
| TR (2) | TR200103405T2 (en) |
| WO (1) | WO2000014119A2 (en) |
| ZA (1) | ZA200101574B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11987629B2 (en) | 2018-06-01 | 2024-05-21 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and uses thereof for treating disease or condition |
| EP3826673A4 (en) * | 2018-07-26 | 2022-03-09 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| CN110811820B (en) * | 2019-12-11 | 2022-07-12 | 江西华晨医疗设备有限公司 | Straight rod type flushing and suction electrocoagulation cutter |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| IL89491A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Bifunctional chimeric antibodies |
| US5217713A (en) * | 1988-12-27 | 1993-06-08 | Takeda Chemical Industries, Ltd. | Cytotoxic bispecific monoclonal antibody, its production and use |
| WO1991009134A1 (en) * | 1989-12-15 | 1991-06-27 | Takeda Chemical Industries, Ltd. | Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics |
| JPH05184383A (en) * | 1990-06-19 | 1993-07-27 | Dainabotsuto Kk | Bispecific antibody |
| US6451980B1 (en) * | 1997-02-26 | 2002-09-17 | Ban-An Khaw | Signal enhancement of bispecific antibody-polymer probe for immunoassay use |
-
1998
- 1998-09-04 GB GBGB9819411.1A patent/GB9819411D0/en not_active Ceased
-
1999
- 1999-09-06 HU HU0104091A patent/HUP0104091A2/en unknown
- 1999-09-06 WO PCT/GB1999/002938 patent/WO2000014119A2/en not_active Application Discontinuation
- 1999-09-06 JP JP2000568876A patent/JP2002524470A/en active Pending
- 1999-09-06 KR KR1020017002437A patent/KR20010072988A/en not_active Application Discontinuation
- 1999-09-06 PL PL99346861A patent/PL346861A1/en not_active Application Discontinuation
- 1999-09-06 TR TR2001/03405T patent/TR200103405T2/en unknown
- 1999-09-06 CA CA002341753A patent/CA2341753A1/en not_active Abandoned
- 1999-09-06 EA EA200100311A patent/EA200100311A1/en unknown
- 1999-09-06 MX MXPA01002349A patent/MXPA01002349A/en not_active Application Discontinuation
- 1999-09-06 CN CN99810368A patent/CN1315967A/en active Pending
- 1999-09-06 EP EP99943138A patent/EP1107995A2/en not_active Withdrawn
- 1999-09-06 ID IDW20010752A patent/ID28873A/en unknown
- 1999-09-06 IL IL14152499A patent/IL141524A0/en unknown
- 1999-09-06 TR TR2001/00651T patent/TR200100651T2/en unknown
- 1999-09-06 AU AU56412/99A patent/AU5641299A/en not_active Abandoned
- 1999-09-06 BR BR9913429-2A patent/BR9913429A/en not_active IP Right Cessation
-
2001
- 2001-02-26 BG BG105293A patent/BG105293A/en unknown
- 2001-02-26 ZA ZA200101574A patent/ZA200101574B/en unknown
- 2001-03-02 NO NO20011102A patent/NO20011102L/en unknown
- 2001-03-02 HR HR20010154A patent/HRP20010154A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL346861A1 (en) | 2002-03-11 |
| HRP20010154A2 (en) | 2002-02-28 |
| BR9913429A (en) | 2001-09-25 |
| AU5641299A (en) | 2000-03-27 |
| NO20011102D0 (en) | 2001-03-02 |
| JP2002524470A (en) | 2002-08-06 |
| TR200103405T2 (en) | 2002-06-21 |
| EP1107995A2 (en) | 2001-06-20 |
| MXPA01002349A (en) | 2003-10-15 |
| NO20011102L (en) | 2001-03-05 |
| BG105293A (en) | 2001-12-29 |
| ZA200101574B (en) | 2002-02-26 |
| CA2341753A1 (en) | 2000-03-16 |
| CN1315967A (en) | 2001-10-03 |
| WO2000014119A2 (en) | 2000-03-16 |
| KR20010072988A (en) | 2001-07-31 |
| ID28873A (en) | 2001-07-12 |
| IL141524A0 (en) | 2002-03-10 |
| TR200100651T2 (en) | 2001-07-23 |
| EA200100311A1 (en) | 2001-08-27 |
| GB9819411D0 (en) | 1998-10-28 |
| WO2000014119A3 (en) | 2000-11-30 |
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