WO2000012067A1 - Nouvelle forme saline pharmaceutique - Google Patents
Nouvelle forme saline pharmaceutique Download PDFInfo
- Publication number
- WO2000012067A1 WO2000012067A1 PCT/US1999/019575 US9919575W WO0012067A1 WO 2000012067 A1 WO2000012067 A1 WO 2000012067A1 US 9919575 W US9919575 W US 9919575W WO 0012067 A1 WO0012067 A1 WO 0012067A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- salt
- agent
- base
- useful
- saccharinate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the present invention relates to a novel salt form of certain pharmacologically active organic bases and their preparation.
- the class will be exemplified by the saccharinate salt of buspirone, a useful anti-anxiety agent.
- the present invention involves stable crystalline saccharinate salts of orally administrable medicinal bases.
- Saccharin chemically 1 ,2- benzisothiazol-3(2H)-one 1 ,1 , dioxide, is used as a sweetener, most commonly in the form of its sodium salt dihydrate. While it is used as a sweetener in pharmaceutical applications, its use is as a component of a mixture of ingredients.
- saccharine provides a sweet taste in dilute aqueous solutions where it is about 500 times sweeter than sugar with the sweet taste still detectable in 1 :100,000 dilution; nonetheless saccharin has a bitter, metallic aftertaste. Because saccharin's taste is most pleasant in dilute solution, care must be exercised in formulating saccharin in its solid state because of a very objectionable taste.
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002341522A CA2341522A1 (fr) | 1998-08-27 | 1999-08-26 | Nouvelle forme saline pharmaceutique |
AU60211/99A AU6021199A (en) | 1998-08-27 | 1999-08-26 | Novel pharmaceutical salt form |
EP99968215A EP1107738A4 (fr) | 1998-08-27 | 1999-08-26 | Nouvelle forme saline pharmaceutique |
JP2000567187A JP2003525855A (ja) | 1998-08-27 | 1999-08-26 | 新規な薬剤塩形態 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9815498P | 1998-08-27 | 1998-08-27 | |
US60/098,154 | 1998-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000012067A1 true WO2000012067A1 (fr) | 2000-03-09 |
Family
ID=22267557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/019575 WO2000012067A1 (fr) | 1998-08-27 | 1999-08-26 | Nouvelle forme saline pharmaceutique |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1107738A4 (fr) |
JP (1) | JP2003525855A (fr) |
CN (1) | CN1348363A (fr) |
AU (1) | AU6021199A (fr) |
CA (1) | CA2341522A1 (fr) |
WO (1) | WO2000012067A1 (fr) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001015682A1 (fr) * | 1999-08-31 | 2001-03-08 | Grünenthal GmbH | Sels pharmaceutiques de tramadol |
EP1136487A1 (fr) * | 2000-03-20 | 2001-09-26 | Nutrinova Nutrition Specialties & Food Ingredients GmbH | Sels de la nicotine, procédé pour leur préparation et leur utilisation comme agents pour la cessation de fumer |
WO2002067916A2 (fr) * | 2001-02-28 | 2002-09-06 | Grünenthal GmbH | Sels pharmaceutiques |
US6849623B2 (en) | 2001-06-25 | 2005-02-01 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Xanthine and phenazone-acesulfame-H complexes having improved taste, process for their preparation and their use |
DE202010001237U1 (de) | 2010-01-21 | 2010-04-01 | Grünenthal GmbH | Kombination aus Tramadol und Acetaminophen als Brausetablette |
WO2010099217A1 (fr) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine |
EP2258357A2 (fr) | 2005-08-26 | 2010-12-08 | Braincells, Inc. | Neurogenèse avec inhibiteur de l'acetylcholinestérase |
US20110009368A1 (en) * | 2007-12-12 | 2011-01-13 | Ultimorphix Technologies B.V. | Solid forms of tenofovir disoproxil |
EP2275095A2 (fr) | 2005-08-26 | 2011-01-19 | Braincells, Inc. | Neurogenese par modulation des recepteurs muscariniques |
EP2314289A1 (fr) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Modulation de la neurogenese dont la médiation est assurée par récepteur gaba |
US7935817B2 (en) | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
WO2011063115A1 (fr) | 2009-11-19 | 2011-05-26 | Braincells Inc. | Combinaison d'un agent nootropique avec un ou plusieurs agents neurogènes ou à effet neurogène par synergie pour stimuler ou intensifier la neurogenèse |
WO2011091033A1 (fr) | 2010-01-20 | 2011-07-28 | Braincells, Inc. | Modulation de la neurogenèse par des agents ppar |
EP2377530A2 (fr) | 2005-10-21 | 2011-10-19 | Braincells, Inc. | Modulation de neurogénèse par inhibition PDE |
EP2377531A2 (fr) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogénèse par modulation de l'angiotensine |
US20160175295A1 (en) * | 2013-07-25 | 2016-06-23 | Almirall, S.A. | Combinations comprising maba compounds and corticosteroids |
US20170137370A1 (en) * | 2001-02-28 | 2017-05-18 | Grünenthal GmbH | Pharmaceutical salts |
US10005771B2 (en) | 2014-09-26 | 2018-06-26 | Almirall, S.A. | Bicyclic derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities |
US10300072B2 (en) | 2011-11-11 | 2019-05-28 | Almirall, S.A. | Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities |
WO2023177294A1 (fr) | 2022-03-18 | 2023-09-21 | Plethora Therapeutics B.V. | Administration transmucosale de composés psychoactifs |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10045521A1 (de) | 2000-03-31 | 2001-10-04 | Roche Diagnostics Gmbh | Nukleinsäureamplifikationen |
CN107868117B (zh) * | 2016-09-28 | 2021-04-23 | 中国科学院苏州纳米技术与纳米仿生研究所 | 司坦唑醇糖精盐及其制备方法和应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1288002A (fr) * | 1954-06-14 | 1962-03-24 | Pfizer & Co C | Perfectionnements apportés aux procédés de fabrication de composés d'imidazoline |
US5837277A (en) * | 1992-06-04 | 1998-11-17 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES271829A1 (es) * | 1960-12-19 | 1962-03-01 | Tanabe Seiyaku Co | Un procedimiento para preparar una sal comestible de acido benzofenoma-2-carboxilico y 1-metil-3-(di-2-tienilmetilen) piperidina |
US4711784A (en) * | 1986-01-07 | 1987-12-08 | Warner-Lambert Company | Encapsulation composition for use with chewing gum and edible products |
-
1999
- 1999-08-26 CA CA002341522A patent/CA2341522A1/fr not_active Abandoned
- 1999-08-26 WO PCT/US1999/019575 patent/WO2000012067A1/fr not_active Application Discontinuation
- 1999-08-26 CN CN99810139A patent/CN1348363A/zh active Pending
- 1999-08-26 AU AU60211/99A patent/AU6021199A/en not_active Abandoned
- 1999-08-26 JP JP2000567187A patent/JP2003525855A/ja active Pending
- 1999-08-26 EP EP99968215A patent/EP1107738A4/fr not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1288002A (fr) * | 1954-06-14 | 1962-03-24 | Pfizer & Co C | Perfectionnements apportés aux procédés de fabrication de composés d'imidazoline |
US5837277A (en) * | 1992-06-04 | 1998-11-17 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
Non-Patent Citations (1)
Title |
---|
See also references of EP1107738A4 * |
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU781852B2 (en) * | 1999-08-31 | 2005-06-16 | Grunenthal Gmbh | Pharmaceutical tramadol salts |
WO2001015682A1 (fr) * | 1999-08-31 | 2001-03-08 | Grünenthal GmbH | Sels pharmaceutiques de tramadol |
KR100730502B1 (ko) * | 1999-08-31 | 2007-06-22 | 그뤼넨탈 게엠베하 | 약제학적 트라마돌 염 및 이를 함유하는 투여 제형 |
US6723343B2 (en) | 1999-08-31 | 2004-04-20 | Gruenenthal Gmbh | Pharmaceutical tramadol salts |
EP1136487A1 (fr) * | 2000-03-20 | 2001-09-26 | Nutrinova Nutrition Specialties & Food Ingredients GmbH | Sels de la nicotine, procédé pour leur préparation et leur utilisation comme agents pour la cessation de fumer |
CN100352431C (zh) * | 2001-02-28 | 2007-12-05 | 格吕伦塔尔有限公司 | 药用盐 |
JP2004527491A (ja) * | 2001-02-28 | 2004-09-09 | グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬学的塩 |
WO2002067916A3 (fr) * | 2001-02-28 | 2003-12-18 | Gruenenthal Gmbh | Sels pharmaceutiques |
WO2002067916A2 (fr) * | 2001-02-28 | 2002-09-06 | Grünenthal GmbH | Sels pharmaceutiques |
US10160719B2 (en) | 2001-02-28 | 2018-12-25 | Grunenthal Gmbh | Pharmaceutical salts |
CZ306998B6 (cs) * | 2001-02-28 | 2017-11-08 | Grünenthal GmbH | Farmaceutické soli |
US20170137370A1 (en) * | 2001-02-28 | 2017-05-18 | Grünenthal GmbH | Pharmaceutical salts |
JP4737583B2 (ja) * | 2001-02-28 | 2011-08-03 | グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬学的塩 |
JP2011079843A (ja) * | 2001-02-28 | 2011-04-21 | Gruenenthal Gmbh | 薬学的塩 |
US6849623B2 (en) | 2001-06-25 | 2005-02-01 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Xanthine and phenazone-acesulfame-H complexes having improved taste, process for their preparation and their use |
EP2275095A2 (fr) | 2005-08-26 | 2011-01-19 | Braincells, Inc. | Neurogenese par modulation des recepteurs muscariniques |
EP2258359A2 (fr) | 2005-08-26 | 2010-12-08 | Braincells, Inc. | Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline |
EP2275096A2 (fr) | 2005-08-26 | 2011-01-19 | Braincells, Inc. | Neurogenese par modulation des recepteurs muscariniques |
EP2258358A2 (fr) | 2005-08-26 | 2010-12-08 | Braincells, Inc. | Neurogenèse avec un inhibiteur de l'acetylcholinestérase |
EP2258357A2 (fr) | 2005-08-26 | 2010-12-08 | Braincells, Inc. | Neurogenèse avec inhibiteur de l'acetylcholinestérase |
EP2377530A2 (fr) | 2005-10-21 | 2011-10-19 | Braincells, Inc. | Modulation de neurogénèse par inhibition PDE |
EP2314289A1 (fr) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Modulation de la neurogenese dont la médiation est assurée par récepteur gaba |
EP2377531A2 (fr) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogénèse par modulation de l'angiotensine |
EP2382975A2 (fr) | 2006-05-09 | 2011-11-02 | Braincells, Inc. | Neurogénèse par modulation d'angiotensine |
US20110009368A1 (en) * | 2007-12-12 | 2011-01-13 | Ultimorphix Technologies B.V. | Solid forms of tenofovir disoproxil |
US7935817B2 (en) | 2008-03-31 | 2011-05-03 | Apotex Pharmachem Inc. | Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof |
WO2010099217A1 (fr) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine |
WO2011063115A1 (fr) | 2009-11-19 | 2011-05-26 | Braincells Inc. | Combinaison d'un agent nootropique avec un ou plusieurs agents neurogènes ou à effet neurogène par synergie pour stimuler ou intensifier la neurogenèse |
WO2011091033A1 (fr) | 2010-01-20 | 2011-07-28 | Braincells, Inc. | Modulation de la neurogenèse par des agents ppar |
DE202010001237U1 (de) | 2010-01-21 | 2010-04-01 | Grünenthal GmbH | Kombination aus Tramadol und Acetaminophen als Brausetablette |
US10300072B2 (en) | 2011-11-11 | 2019-05-28 | Almirall, S.A. | Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities |
US20160175295A1 (en) * | 2013-07-25 | 2016-06-23 | Almirall, S.A. | Combinations comprising maba compounds and corticosteroids |
US10456390B2 (en) * | 2013-07-25 | 2019-10-29 | Almirall, S.A. | Combinations comprising MABA compounds and corticosteroids |
US10005771B2 (en) | 2014-09-26 | 2018-06-26 | Almirall, S.A. | Bicyclic derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities |
WO2023177294A1 (fr) | 2022-03-18 | 2023-09-21 | Plethora Therapeutics B.V. | Administration transmucosale de composés psychoactifs |
Also Published As
Publication number | Publication date |
---|---|
CN1348363A (zh) | 2002-05-08 |
JP2003525855A (ja) | 2003-09-02 |
EP1107738A4 (fr) | 2003-01-22 |
CA2341522A1 (fr) | 2000-03-09 |
EP1107738A1 (fr) | 2001-06-20 |
AU6021199A (en) | 2000-03-21 |
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