WO2000007728A3 - Micro-systeme a multiples points d'analyse chimique ou biologique - Google Patents
Micro-systeme a multiples points d'analyse chimique ou biologique Download PDFInfo
- Publication number
- WO2000007728A3 WO2000007728A3 PCT/FR1999/001900 FR9901900W WO0007728A3 WO 2000007728 A3 WO2000007728 A3 WO 2000007728A3 FR 9901900 W FR9901900 W FR 9901900W WO 0007728 A3 WO0007728 A3 WO 0007728A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- micro
- cup
- chemical
- multiple points
- electrode
- Prior art date
Links
- 239000000126 substance Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000004020 conductor Substances 0.000 abstract 2
- 230000005684 electric field Effects 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00709—Type of synthesis
- B01J2219/00713—Electrochemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/744,252 US6630359B1 (en) | 1998-07-31 | 1999-07-30 | Micro-system with multiple points for chemical or biological analysis |
JP2000563399A JP4562914B2 (ja) | 1998-07-31 | 1999-07-30 | 化学的または生物学的分析マルチポイントマイクロシステム |
EP99936658A EP1101102A2 (fr) | 1998-07-31 | 1999-07-30 | Micro-systeme a multiples points d'analyse chimique ou biologique |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9809868A FR2781886B1 (fr) | 1998-07-31 | 1998-07-31 | Micro-systeme a multiple points d'analyse chimique ou biologique |
FR98/09868 | 1998-07-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000007728A2 WO2000007728A2 (fr) | 2000-02-17 |
WO2000007728A3 true WO2000007728A3 (fr) | 2000-05-11 |
Family
ID=9529280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1999/001900 WO2000007728A2 (fr) | 1998-07-31 | 1999-07-30 | Micro-systeme a multiples points d'analyse chimique ou biologique |
Country Status (5)
Country | Link |
---|---|
US (1) | US6630359B1 (fr) |
EP (1) | EP1101102A2 (fr) |
JP (1) | JP4562914B2 (fr) |
FR (1) | FR2781886B1 (fr) |
WO (1) | WO2000007728A2 (fr) |
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FR2789401B1 (fr) * | 1999-02-08 | 2003-04-04 | Cis Bio Int | Procede de fabrication de matrices de ligands adresses sur un support |
WO2001017670A1 (fr) * | 1999-09-09 | 2001-03-15 | Ben-Gurion University Of The Negev | Matrices de sondes et preparation de celles-ci |
US6645359B1 (en) * | 2000-10-06 | 2003-11-11 | Roche Diagnostics Corporation | Biosensor |
US6649343B1 (en) * | 1999-10-22 | 2003-11-18 | Ngk Insulators, Ltd. | DNA chip and method for producing the same |
WO2001094666A2 (fr) * | 2000-06-08 | 2001-12-13 | Ylektra Inc. | Plate-forme d'electrolyse adressable spatialement et procedes d'utilisation |
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US20020048534A1 (en) | 2000-08-24 | 2002-04-25 | David Storek | Sample preparing arrangement and a method relating to such an arrangement |
US7998746B2 (en) | 2000-08-24 | 2011-08-16 | Robert Otillar | Systems and methods for localizing and analyzing samples on a bio-sensor chip |
JPWO2002066969A1 (ja) * | 2001-02-19 | 2004-06-24 | 協和メデックス株式会社 | 荷電成分検出装置及びその使用方法並びに検出パネル |
FR2823999B1 (fr) * | 2001-04-27 | 2003-06-27 | Commissariat Energie Atomique | Dispositif miniature de separation et d'isolement d'objets biologiques et utilisations |
FR2824143B1 (fr) * | 2001-04-27 | 2003-06-27 | Commissariat Energie Atomique | Utilisations d'un dispositif miniature de separation et d'isolement d'objets biologiques et procedes mis en oeuvre |
EP2420824B1 (fr) | 2001-06-29 | 2018-11-28 | Meso Scale Technologies LLC | Plaque multipuits ayant un réseau de puits et un kit pour l'utilisation dans la conduite d'un essai ECL |
US7074519B2 (en) * | 2001-10-26 | 2006-07-11 | The Regents Of The University Of California | Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device |
FR2834299B1 (fr) * | 2001-12-27 | 2004-05-21 | Commissariat Energie Atomique | Procede de fixation par electrodeposition de reactifs sur une face plane d'un substrat |
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FR2836071B1 (fr) * | 2002-02-21 | 2005-02-04 | Commissariat Energie Atomique | Composant pour microsysteme d'analyse biologique ou biochimique |
US20050100938A1 (en) * | 2002-03-14 | 2005-05-12 | Infineon Technologies Ag | Vertical impedance sensor arrangement and method for producing a vertical impedance sensor arrangement |
GB2386949A (en) * | 2002-03-26 | 2003-10-01 | Sensor Tech Ltd | A multiwell plate for electrochemical detection |
WO2005047482A2 (fr) | 2003-11-12 | 2005-05-26 | Xiao Xu | Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules |
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US7470533B2 (en) * | 2002-12-20 | 2008-12-30 | Acea Biosciences | Impedance based devices and methods for use in assays |
US7560269B2 (en) | 2002-12-20 | 2009-07-14 | Acea Biosciences, Inc. | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
US7732127B2 (en) | 2002-12-20 | 2010-06-08 | Acea Biosciences, Inc. | Dynamic monitoring of cell adhesion and spreading using the RT-CES system |
CN100487133C (zh) * | 2002-07-20 | 2009-05-13 | 艾森生物(杭州)有限公司 | 基于阻抗的检测装置和方法 |
US20040099531A1 (en) * | 2002-08-15 | 2004-05-27 | Rengaswamy Srinivasan | Methods and apparatus for electrochemically testing samples for constituents |
FR2843829A1 (fr) * | 2002-08-26 | 2004-02-27 | Commissariat Energie Atomique | Support de garniture par voie electrochimique, systeme d'adressage d'un tel support, et procede pour un depot selectif |
US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
FR2855269B1 (fr) * | 2003-05-21 | 2007-06-08 | Commissariat Energie Atomique | Dispositif et procedes d'accrochage/decrochage d'une cible ou d'un objet present dans un echantillon |
EP1682259A1 (fr) * | 2003-10-15 | 2006-07-26 | Oxford Gene Technology Ip Limited | Traitement electrochimique de substrats |
DE102004024364A1 (de) * | 2004-05-17 | 2005-12-15 | Apibio Sas | Verfahren zur Herstellung von Polymeren |
US8053774B2 (en) | 2005-06-06 | 2011-11-08 | Intel Corporation | Method and apparatus to fabricate polymer arrays on patterned wafers using electrochemical synthesis |
US8940143B2 (en) | 2007-06-29 | 2015-01-27 | Intel Corporation | Gel-based bio chip for electrochemical synthesis and electrical detection of polymers |
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KR20090033166A (ko) * | 2006-03-16 | 2009-04-01 | 알-아민 디라니 | 유전 감지 방법 및 시스템 |
US20120284921A9 (en) * | 2006-03-17 | 2012-11-15 | Monica Blake Ross | Sheet set for a sofa |
FR2901884B1 (fr) * | 2006-05-31 | 2008-09-05 | Commissariat Energie Atomique | Procede, dispositif et systeme de microanalyse d'ions |
US8041515B2 (en) * | 2006-09-20 | 2011-10-18 | Acea Biosciences, Inc. | Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents |
FR2916367B1 (fr) * | 2007-05-25 | 2009-07-31 | Commissariat Energie Atomique | Procede de fixation sur un microsysteme de composes a liaisons peptidiques, tels que des proteines, et microsysteme incorporant ces composes. |
EP2291645B1 (fr) | 2008-05-05 | 2015-09-09 | Acea Biosciences, Inc. | Surveillance sans marqueur d'un couplage excitation-contraction et cellules pouvant être excitées utilisant des systèmes fondés sur l'impédance avec une résolution dans le temps de l'ordre de la milliseconde |
JP4914403B2 (ja) * | 2008-05-29 | 2012-04-11 | 日本電信電話株式会社 | 細胞外マイクロ電極及びその製造方法 |
WO2011146531A1 (fr) | 2010-05-18 | 2011-11-24 | Acea Biosciences, Inc | Analyse de données de signaux de battements de cardiomyocytes à base d'impédance tels que détectés sur des instruments cardiologiques d'analyse de cellules en temps réel (rtca) |
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US10424523B2 (en) | 2017-09-07 | 2019-09-24 | Texas Instruments Incorporated | Hermetically sealed molecular spectroscopy cell with buried ground plane |
US10549986B2 (en) | 2017-09-07 | 2020-02-04 | Texas Instruments Incorporated | Hermetically sealed molecular spectroscopy cell |
US10131115B1 (en) | 2017-09-07 | 2018-11-20 | Texas Instruments Incorporated | Hermetically sealed molecular spectroscopy cell with dual wafer bonding |
US10444102B2 (en) | 2017-09-07 | 2019-10-15 | Texas Instruments Incorporated | Pressure measurement based on electromagnetic signal output of a cavity |
US10551265B2 (en) | 2017-09-07 | 2020-02-04 | Texas Instruments Incorporated | Pressure sensing using quantum molecular rotational state transitions |
US10544039B2 (en) * | 2017-09-08 | 2020-01-28 | Texas Instruments Incorporated | Methods for depositing a measured amount of a species in a sealed cavity |
CN110743643B (zh) * | 2019-11-27 | 2021-11-30 | 南京轩世琪源软件科技有限公司 | 一种培养基制备机的试管架 |
USD941488S1 (en) | 2020-02-07 | 2022-01-18 | Agilent Technologies, Inc. | Instrument for analyzing biological cells |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0402917A2 (fr) * | 1989-06-15 | 1990-12-19 | Biocircuits Corporation | Biocapteurs utilisant des signaux électriques, optiques et mécaniques |
WO1993006237A1 (fr) * | 1991-09-13 | 1993-04-01 | Allage Associates, Inc. | Procede analytique pour dispositifs chimiques et biodetecteurs formes a partir de films minces polymeres electroactifs |
WO1996028538A1 (fr) * | 1995-03-10 | 1996-09-19 | Meso Scale Technologies, Llc | Essai par electrochimioluminescence multispecifique et multirangee |
US5653939A (en) * | 1991-11-19 | 1997-08-05 | Massachusetts Institute Of Technology | Optical and electrical methods and apparatus for molecule detection |
US5776791A (en) * | 1995-11-17 | 1998-07-07 | Commissariat A L'energie Atomique | Process for collective manufacture of chips with electrodes selectively covered by a deposit |
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---|---|---|---|---|
US4886625A (en) * | 1987-10-29 | 1989-12-12 | Miles Inc. | Functionalized conducting polymers and their use in diagnostic devices |
GB9325946D0 (en) * | 1993-12-18 | 1994-02-23 | Japat Ltd | Protein absorbed shapable electroconductive polymer film |
US6103552A (en) * | 1998-08-10 | 2000-08-15 | Lin; Mou-Shiung | Wafer scale packaging scheme |
-
1998
- 1998-07-31 FR FR9809868A patent/FR2781886B1/fr not_active Expired - Fee Related
-
1999
- 1999-07-30 JP JP2000563399A patent/JP4562914B2/ja not_active Expired - Fee Related
- 1999-07-30 WO PCT/FR1999/001900 patent/WO2000007728A2/fr active Application Filing
- 1999-07-30 EP EP99936658A patent/EP1101102A2/fr not_active Withdrawn
- 1999-07-30 US US09/744,252 patent/US6630359B1/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0402917A2 (fr) * | 1989-06-15 | 1990-12-19 | Biocircuits Corporation | Biocapteurs utilisant des signaux électriques, optiques et mécaniques |
WO1993006237A1 (fr) * | 1991-09-13 | 1993-04-01 | Allage Associates, Inc. | Procede analytique pour dispositifs chimiques et biodetecteurs formes a partir de films minces polymeres electroactifs |
US5653939A (en) * | 1991-11-19 | 1997-08-05 | Massachusetts Institute Of Technology | Optical and electrical methods and apparatus for molecule detection |
WO1996028538A1 (fr) * | 1995-03-10 | 1996-09-19 | Meso Scale Technologies, Llc | Essai par electrochimioluminescence multispecifique et multirangee |
US5776791A (en) * | 1995-11-17 | 1998-07-07 | Commissariat A L'energie Atomique | Process for collective manufacture of chips with electrodes selectively covered by a deposit |
Non-Patent Citations (1)
Title |
---|
COSNIER, S.: "Electropolymerization of amphiphilic monomers for designing amperometric biosensors.", ELECTROANALYSIS, vol. 9, no. 12, 1997, pages 894 - 902, XP002101569 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000007728A2 (fr) | 2000-02-17 |
JP4562914B2 (ja) | 2010-10-13 |
JP2002522749A (ja) | 2002-07-23 |
US6630359B1 (en) | 2003-10-07 |
FR2781886B1 (fr) | 2001-02-16 |
EP1101102A2 (fr) | 2001-05-23 |
FR2781886A1 (fr) | 2000-02-04 |
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