WO2000002533A2 - Dry-copying method for producing flat, individually dosed preparations of active agents - Google Patents

Dry-copying method for producing flat, individually dosed preparations of active agents Download PDF

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Publication number
WO2000002533A2
WO2000002533A2 PCT/EP1999/004612 EP9904612W WO0002533A2 WO 2000002533 A2 WO2000002533 A2 WO 2000002533A2 EP 9904612 W EP9904612 W EP 9904612W WO 0002533 A2 WO0002533 A2 WO 0002533A2
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Prior art keywords
roller
active ingredient
transferred
active substance
active
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Application number
PCT/EP1999/004612
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German (de)
French (fr)
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WO2000002533A3 (en
Inventor
Walter Müller
Original Assignee
Lts Lohmann Therapie-Systeme Ag
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Publication date
Application filed by Lts Lohmann Therapie-Systeme Ag filed Critical Lts Lohmann Therapie-Systeme Ag
Priority to EP99932794A priority Critical patent/EP1094794B1/en
Priority to AT99932794T priority patent/ATE256459T1/en
Priority to HU0104919A priority patent/HUP0104919A2/en
Priority to AU49055/99A priority patent/AU750142B2/en
Priority to JP2000558794A priority patent/JP4252215B2/en
Priority to CA002336713A priority patent/CA2336713A1/en
Priority to BR9911961-7A priority patent/BR9911961A/en
Priority to DK99932794T priority patent/DK1094794T3/en
Priority to IL14074599A priority patent/IL140745A0/en
Priority to DE59908117T priority patent/DE59908117D1/en
Priority to IL140745A priority patent/IL140745A/en
Publication of WO2000002533A2 publication Critical patent/WO2000002533A2/en
Publication of WO2000002533A3 publication Critical patent/WO2000002533A3/en

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    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G13/00—Electrographic processes using a charge pattern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G9/00—Developers
    • G03G9/08—Developers with toner particles
    • G03G9/09—Colouring agents for toner particles
    • G03G9/0926—Colouring agents for toner particles characterised by physical or chemical properties

Definitions

  • Single-dose active substance preparations are understood to mean preparations which contain a predetermined amount of active substance in divided and individually manageable units of the preparation.
  • an active ingredient in the sense of this invention e.g. a drug, an insecticide, a pesticide, a reagent, etc. can be understood.
  • an active substance is understood to mean a medicinally active substance
  • such single-dose pharmaceutical forms are, for example, tablets, capsules, suppositories or transdermal therapeutic systems (TTS).
  • Non-dosed dosage forms would be e.g. Sprays, juices, ointments and drops, in which the actual dosage is made just before use.
  • the active ingredient is to be processed in a measured amount together with any necessary auxiliary substances to form the active ingredient preparations ready for use.
  • This technique can be considered mature in the manufacture of tablets and capsules. Modern tablet presses and capsule filling machines guarantee high production speeds and very precise dosing in a range of 95-105% of the target value.
  • Transdermal therapeutic systems are still a relatively young drug form, which is applied externally in the form of a patch on the skin and releases the active ingredient through the skin to the organism.
  • TTS Transdermal therapeutic systems
  • the active ingredient is contained directly in the adhesive and is metered in the form of a sheet onto a film together with the adhesive.
  • TTS the only pharmaceutical form that depends on dosing a medicinal active ingredient in a predetermined amount on a specified surface. If you think of non-medical active ingredients, e.g. Insecticides, pesticides or reagents, surface preparations in the form of impregnated papers, foils or boxes have been known for some time. However, for these applications, the accuracy of the metering in the area is not particularly demanding.
  • non-medical active ingredients e.g. Insecticides, pesticides or reagents
  • surface preparations in the form of impregnated papers, foils or boxes have been known for some time. However, for these applications, the accuracy of the metering in the area is not particularly demanding.
  • the present invention has for its object to provide a method for metering powdered active ingredients on a given surface.
  • the dry copy process or xerography works in the manner described below.
  • a roller coated with a photoconductive material is provided with a positive electrical charge and exposed to the original to be copied via suitable optics. Through this process, the charge is at least partially removed where the conductivity of the photoconductive material increases due to the exposure.
  • negatively charged color particles toner are applied to the roller, which, however, only adhere to the still charged areas of the roller in an amount dependent on the size of the load and create a visible image there.
  • the color particles (toner) are then transferred to a positively charged paper or film and fixed there by heat treatment.
  • a modern variant of the process is used in the so-called laser printers.
  • the roller is directly exposed to a laser beam without a template and the image is thus computer-controlled written directly on the roller. Otherwise, the same technology is used for laser printers as for dry copiers.
  • the present invention is based on the use of these processes in order to transfer active substance particles onto paper or generally foils instead of the color pigments.
  • the film used is a large commercial polyester film in A4 format.
  • a deep black sheet of paper was used as the template and the heaviest degree of blackening was selected for the copy. The results are shown in the following table.
  • the amount transferred in a copying process is small, but this disadvantage can be overcome by copying several times without the accuracy of the dosage being impaired.
  • the amount of toner or active ingredient transferred depends on the charge state of the copying roller and can be increased by a higher charge than is usual in copiers.
  • the exposure cut can be dispensed with entirely.
  • the copying roller need not be made of a photoconductive material.
  • the exposure cut and the use of a photo-conductive material e.g. Selenium, coated KopierwalZ ⁇ necessary.
  • the exposure can take place using a template or else computer-controlled using a laser. The greatest variability is of course with the computer-controlled laser exposure.
  • the flat substrate to which the active substance is transferred can in principle consist of any materials, as long as it is flexible and suitable to survive the fixing process. It is conceivable that the material is used in the form of sheets or comes from a roll. This material is then cut into smaller parts in the course of further processing and thus transferred to the individually dosed active ingredient preparation. Alternatively, the material can also be perforated, in which case the dosage is predetermined by the perforation.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Coating Apparatus (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Combination Of More Than One Step In Electrophotography (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Paper Feeding For Electrophotography (AREA)
  • Drying Of Solid Materials (AREA)
  • Storage Of Fruits Or Vegetables (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Color Printing (AREA)

Abstract

The invention relates to a method for dosing active agents in powder form onto a given surface. The method is characterised in that the active agent is transferred onto a roller in the form of an electrically charged powder, said roller having an opposite electric charge, in that the active agent transferred to the roller is then transferred onto a flat substrate with the opposite electric charge to the active agent and in that the active agent transferred onto the substrate is fixed by means of heat treatment.

Description

Trockenkopierprozeß zur Herstellung flächiger, einzeldosierter WirkstoffZubereitungenDry copying process for the production of flat, individually dosed active substance preparations
Unter einzeldosierten Wirkstoffzubereitungen werden Zubereitungen verstanden, die eine vorgegebene Menge an aktive Substanz in abgeteilten und einzeln handhabbaren Einheiten der Zubereitung enthalten.Single-dose active substance preparations are understood to mean preparations which contain a predetermined amount of active substance in divided and individually manageable units of the preparation.
Unter einem Wirkstoff im Sinne dieser Erfindung kann dabei z.B. ein Arzneistoff, ein Insektizid, ein Pestizid, ein Reagenz etc. verstanden werden.Under an active ingredient in the sense of this invention, e.g. a drug, an insecticide, a pesticide, a reagent, etc. can be understood.
Wird unter einer aktiven Substanz beispielhaft ein medizinischer Wirkstoff verstanden, sind solche einzeldosierten Arzneiformen etwa Tabletten, Kapseln, Suppositorien oder transdermale therapeutische Systeme (TTS) .If, by way of example, an active substance is understood to mean a medicinally active substance, such single-dose pharmaceutical forms are, for example, tablets, capsules, suppositories or transdermal therapeutic systems (TTS).
Nichteinzeldosierte Arzneiformen wären z.B. Sprays, Säfte, Salben und Tropfen, bei denen die eigentliche Dosierung erst unmittelbar vor Gebrauch erfolgt.Non-dosed dosage forms would be e.g. Sprays, juices, ointments and drops, in which the actual dosage is made just before use.
Bei einzeln dosierten WirkstoffZubereitungen ist dabei der Wirkstoff in abgemessener Menge zusammen mit eventuell notwendigen Hilfsstoffen zu der für die Anwendung fertiger WirkstoffZubereitungen zu verarbeiten. Diese Technik kann bei der Herstellung von Tabletten und Kapseln als ausgereift betrachtet werden. Moderne Tablettenpressen und Kapselfüllmaschinen garantieren eine hohe Produktionsgeschwin- digkeit und einer sehr genaue Dosierung in einem Bereich von 95-105 % des Sollwertes.In the case of individually dosed active ingredient preparations, the active ingredient is to be processed in a measured amount together with any necessary auxiliary substances to form the active ingredient preparations ready for use. This technique can be considered mature in the manufacture of tablets and capsules. Modern tablet presses and capsule filling machines guarantee high production speeds and very precise dosing in a range of 95-105% of the target value.
Transdermale therapeutische Systeme sind noch eine relative junge Arzneiform, die extern in Form eines Pflasters auf der Haut angewendet wird und den Wirkstoff durch die Haut an den Organismus abgibt. Zur Herstellung dieser TTS werden spezielle Dosiertechniken angewendet und weitere Innovationen bezüglich neuer Dosiertechniken sind möglich.Transdermal therapeutic systems are still a relatively young drug form, which is applied externally in the form of a patch on the skin and releases the active ingredient through the skin to the organism. To make these TTS special dosing techniques applied and further innovations regarding new dosing techniques are possible.
Bei einer Ausführung dieser TTS ist der Wirkstoff direkt in dem Kleber enthalten und wird bei der Herstellung zusammen mit dem Kleber flächenförmig auf eine Folie dosiert.In the case of a version of this TTS, the active ingredient is contained directly in the adhesive and is metered in the form of a sheet onto a film together with the adhesive.
Damit sind TTS die einzige Arzneiform, bei der es darauf ankommt, einen medizinischen Wirkstoff auf eine vorgegeene Fläche in vorgegebener Menge zu dosieren. Denkt man an nichtmedizinische Wirkstoffe, wie z.B. Insektizide, Pestizide oder Reagenzien, so sind flächige Zubereitungen in Form von imprägnierten Papieren, Folien oder Kartons schon länger bekannt. Allerdings werden für diese Anwendungen an die Genauigkeit der Dosierung in der Fläche keine großen Anforderungen gestellt.This makes TTS the only pharmaceutical form that depends on dosing a medicinal active ingredient in a predetermined amount on a specified surface. If you think of non-medical active ingredients, e.g. Insecticides, pesticides or reagents, surface preparations in the form of impregnated papers, foils or boxes have been known for some time. However, for these applications, the accuracy of the metering in the area is not particularly demanding.
Der vorliegenden Erfindung liegt die Aufgabe zugrunde, ein Verfahren zur Dosierung von pulverförmigen Wirkstoffen auf eine vorgegebene Fläche bereitzustellen.The present invention has for its object to provide a method for metering powdered active ingredients on a given surface.
Diese Aufgabe wird unter Verwendung der aus dem Trockenkopierprozeß bekannten Techniken gelöst durch ein Verfahren gemäß den Merkmalen des Hauptanspruchs 1.This object is achieved using the techniques known from the dry copying process by a method according to the features of main claim 1.
Es hat sich gezeigt, daß diese Technik in der Lage ist, pulverförmige Wirkstoffe mit einer auch für Arzneimittel genügenden Genauigkeit auf eine Fläche zu dosieren. Unmittelbar einsichtig ist dies bei Farbkopierern, bei denen jede Farbe getrennt dosiert wird und größere Ungenauigkeiten zu einer Farbverfälschung führen würden.It has been shown that this technique is able to dispense powdered active ingredients onto a surface with an accuracy that is also sufficient for pharmaceuticals. This is immediately clear with color copiers, where each color is dosed separately and greater inaccuracies would lead to color falsification.
Der Trockenkopierprozeß oder die Xerographie funktioniert in der nachfolgend beschriebenen Weise. Eine mit einem photoleitfähigen Material beschichtete Walze wird mit einer positiven elektrischen Ladung versehen und über eine geeignete Optik mit der zu kopierenden Vorlage belichtet. Durch diesen Vorgang wird die Ladung jeweils dort zumindest teilweise entfernt, wo durch die Belichtung die Leitfähigkeit des photoleitfähigen Materials ansteigt.The dry copy process or xerography works in the manner described below. A roller coated with a photoconductive material is provided with a positive electrical charge and exposed to the original to be copied via suitable optics. Through this process, the charge is at least partially removed where the conductivity of the photoconductive material increases due to the exposure.
In einem nächsten Schritt werden negativ geladene Farbpartikel (Toner) auf die Walze aufgebracht, die allerdings nur auf den noch geladenen Flächen der Walze in von der Größe der Ladung abhängigen Menge haften bleiben und dort ein sichtbares Bild entstehen lassen.In a next step, negatively charged color particles (toner) are applied to the roller, which, however, only adhere to the still charged areas of the roller in an amount dependent on the size of the load and create a visible image there.
Anschließend werden die Farbpartikel (Toner) auf ein positiv geladenes Papier oder Folie übertragen und dort durch eine Hitzebehandlung fixiert.The color particles (toner) are then transferred to a positively charged paper or film and fixed there by heat treatment.
Eine moderne Variante des Verfahrens wird bei den sogenannten Laserdruckern eingesetzt. Hier wird ohne Vorlage die Walze direkt mit einem Laserstrahl belichtet und damit das Bild computergesteuert direkt auf die Walze geschrieben. Ansonsten wird bei Laserprintern die gleiche Technik benutzt wie bei Trockenkopierern.A modern variant of the process is used in the so-called laser printers. Here, the roller is directly exposed to a laser beam without a template and the image is thus computer-controlled written directly on the roller. Otherwise, the same technology is used for laser printers as for dry copiers.
Die vorliegende Erfindung basiert auf der Verwendung dieser Prozesse, um statt der Farbpigmente Wirkstoffpartikel auf Papier bzw. allgemein Folien zu übertragen.The present invention is based on the use of these processes in order to transfer active substance particles onto paper or generally foils instead of the color pigments.
In Versuchen mit einem normalen Schwarzweißkopierer wurde ermittelt, welche Mengen an Toner auf Folie mit welcher Reproduzierbarkeit übertragen werden können.In experiments with a normal black and white copier, it was determined which amounts of toner can be transferred to film with which reproducibility.
Bei der verwendeten Folie handelt es sich um handelsübliche große Overhead-Folien aus Polyester im Format DIN A4. Als Vorlage wurde ein tiefschwarzer Bogen Papier verwendet und der stärkste Schwärzungsgrad für die Kopie gewählt. Die Ergebnisse sind in folgender Tabelle festgehalten.The film used is a large commercial polyester film in A4 format. A deep black sheet of paper was used as the template and the heaviest degree of blackening was selected for the copy. The results are shown in the following table.
Figure imgf000006_0001
Figure imgf000006_0001
Tabelle 1Table 1
Die Ergebnisse zeigen, daß zwar nur eine vergleichsweise kleine Menge an Toner übertragen wurde, dies jedoch mit einer auch für medizinische Anwendungen geeigneten Genauigkeit.The results show that only a comparatively small amount of toner was transferred, but with an accuracy that is also suitable for medical applications.
In einem weiteren Versuch wurde nun ermittelt, ob die Menge durch Mehrfachdosierung erhöht werden kann.In a further experiment it was determined whether the amount could be increased by multiple dosing.
Die Ergebnisse sind in FIG.l dargestellt und zeigen, daß die übertragene Menge Toner proportional der Anzahl der Kopiervorgänge ist.The results are shown in FIG. 1 and show that the amount of toner transferred is proportional to the number of copies.
Dieses Ergebnis zeigt, daß die in einem Kopierprozeß übertragene Menge zwar klein ist, dieser Nachteil jedoch durch mehrfaches Kopieren überwunden werden kann, ohne daß die Genauigkeit der Dosierung darunter leidet. Die Menge an übertragenem Toner bzw. Wirkstoff hängt von dem Ladungszustand der Kopierwalze ab und kann durch eine stärkere Aufladung über das bei Kopiergeräten übliche Maß gesteigert werden.This result shows that the amount transferred in a copying process is small, but this disadvantage can be overcome by copying several times without the accuracy of the dosage being impaired. The amount of toner or active ingredient transferred depends on the charge state of the copying roller and can be increased by a higher charge than is usual in copiers.
Wenn der Wirkstoff ohne spezielles Muster dosiert wird, kann auf den Belichtungsschnitt ganz verzichtet werden. In diesem Fall braucht die Kopierwalze nicht aus einem photoleitfähigen Material zu bestehen.If the active ingredient is dosed without a special pattern, the exposure cut can be dispensed with entirely. In this case, the copying roller need not be made of a photoconductive material.
Soll die Dosierung in einem Muster erfolgen, ist der Belichtungsschnitt und die Verwendung einer mit einem photo- leifähigen Material, z.B. Selen, beschichteten KopierwalZΘ notwendig. Die Belichtung kann dabei über ein Vorlage oder aber auch coputergesteuert über einen Laser erfolgen. Die größte Variabilität ist natürlich mit der computergesteuerten Laserbelichtung gegeben.If the dosage is to be done in a pattern, the exposure cut and the use of a photo-conductive material, e.g. Selenium, coated KopierwalZΘ necessary. The exposure can take place using a template or else computer-controlled using a laser. The greatest variability is of course with the computer-controlled laser exposure.
Es ist davon auszugehen, daß die meisten Wirkstoffe farblos sind. Unter diesem Aspekt ist es sinnvoll, der pulverförmi- gen Wirk- und Hilfsstoffmischung einen Indikatorfarbstoff beizumischen. Dieser Farbstoff erlaubt dann nach entsprechender Eichung, mit optischen Methoden direkt die Menge an übertragenem Wirkstoff zu messen und eventuellen Abweichungen vom Sollwert automatisch entgegenzusteuern.It can be assumed that most of the active ingredients are colorless. From this point of view, it makes sense to add an indicator dye to the powdered active and auxiliary mixture. After appropriate calibration, this dye then allows the amount of active substance transferred to be measured directly using optical methods and counteracts any deviations from the target value automatically.
Das flächige Substrat, auf das der Wirkstoff übertragen wird, kann dabei im Prinzip aus beliebigen Materialien bestehen, solange es flexibel und geeignet ist, den Fixiervorgang zu überstehen. Dabei ist denkbar, daß das Material in Form von Blättern eingesetzt wird oder von einer Rolle kommt. Dieses Material wird dann im Zuge der Weiterverarbeitung in kleinere Teile geschnitten und damit in die ein- zeldosierte WirkstoffZubereitung überführt. Alternativ kann das Material auch perforiert sein, wobei dann die Dosierung durch die Perforierung vorgegeben ist. The flat substrate to which the active substance is transferred can in principle consist of any materials, as long as it is flexible and suitable to survive the fixing process. It is conceivable that the material is used in the form of sheets or comes from a roll. This material is then cut into smaller parts in the course of further processing and thus transferred to the individually dosed active ingredient preparation. Alternatively, the material can also be perforated, in which case the dosage is predetermined by the perforation.

Claims

A N S P R U C H E EXPECTATIONS
1. Verfahren zur Dosierung von pulverför igen Wirkstoff auf eine vorgegebene Fläche, dadurch gekennzeichnet, daß1. A method for dosing pulverf ive active ingredient on a predetermined area, characterized in that
- der Wirkstoff als elektrisch geladenes Pulver auf eine entgegengesetzt geladene Walze übertragen,- transfer the active substance as an electrically charged powder to an oppositely charged roller,
- der auf die Walze übertragene Wirkstoff auf ein flächen- förmiges Substrat mit zum Wirkstoff entgegengesetzter elektrischer Ladung transferiert,the active substance transferred to the roller is transferred to a sheet-like substrate with an electric charge opposite to the active substance,
- der auf das Substrat übertragene Wirkstoff mittels einer Hitzebehandlung fixiert wird.- The active substance transferred to the substrate is fixed by means of a heat treatment.
2. Verfahren gemäß Anspruch 1, dadurch gekennzeichnet, daß zusammen mit dem Wirkstoff ebenfalls pulverförmige Hilfsstoffe dosiert werden.2. The method according to claim 1, characterized in that powdered excipients are also metered together with the active ingredient.
3. Verfahren gemäß Anspruch 2, dadurch gekennzeichnet, daß zumindest ein Hilfsstoff als Fixiermittel fungiert.3. The method according to claim 2, characterized in that at least one auxiliary acts as a fixing agent.
4. Verfahren gemäß Anspruch 2, dadurch gekennzeichnet, daß ein Hilfsstoff farbig ist und zur optischen Ermittlung der Wirkstoffmenge dient.4. The method according to claim 2, characterized in that an auxiliary is colored and is used for the optical determination of the amount of active ingredient.
5. Verfahren gemäß Anspruch 1 bis 4, dadurch gekennzeichnet, daß die Walze mit einem photoleitenden Material überzogen ist.5. The method according to claim 1 to 4, characterized in that the roller is coated with a photoconductive material.
6. Verfahren gemäß Anspruch 1, dadurch gekennzeichnet, daß die Ladung der Walze und damit die Menge und/oder das Muster der Wirkstoffübertragung durch eine Belichtung der geladenen Walze beeinflußt wird.6. The method according to claim 1, characterized in that the charge of the roller and thus the amount and / or the pattern of active ingredient transfer is influenced by an exposure of the loaded roller.
7. Verfahren gemäß Anspruch 6, dadurch gekennzeichnet, daß die Belichtung der Walze über einen computergesteuerten Laser oder konventionell über die optische Abbildung einer Vorlage geschieht. 7. The method according to claim 6, characterized in that the exposure of the roller via a computer-controlled Laser or conventional happens via the optical imaging of a template.
PCT/EP1999/004612 1998-07-09 1999-07-02 Dry-copying method for producing flat, individually dosed preparations of active agents WO2000002533A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP99932794A EP1094794B1 (en) 1998-07-09 1999-07-02 Dry-copying method for producing flat, individually dosed preparations of active agents
AT99932794T ATE256459T1 (en) 1998-07-09 1999-07-02 DRY COPYING PROCESS FOR PRODUCING PLAIN, SINGLE-DOSE ACTIVE INGREDIENT PREPARATIONS
HU0104919A HUP0104919A2 (en) 1998-07-09 1999-07-02 Dry-copying method for producing flat, individually dosed preparations of active agents
AU49055/99A AU750142B2 (en) 1998-07-09 1999-07-02 Dry-copying method for producing flat, individually dosed preparations of active agents
JP2000558794A JP4252215B2 (en) 1998-07-09 1999-07-02 Dry transfer method for producing flat unit dosage formulations of active ingredients
CA002336713A CA2336713A1 (en) 1998-07-09 1999-07-02 Dry-copying method for producing flat, individually dosed preparations of active agents
BR9911961-7A BR9911961A (en) 1998-07-09 1999-07-02 Process for dosing active substance in powder form on a given surface.
DK99932794T DK1094794T3 (en) 1998-07-09 1999-07-02 Dry copying process for the preparation of flat single dose active agent preparations
IL14074599A IL140745A0 (en) 1998-07-09 1999-07-02 Dry copying process for producing flat, single-dose active ingredient preparations
DE59908117T DE59908117D1 (en) 1998-07-09 1999-07-02 DRY COPING PROCESS FOR PRODUCING SINGLE, INDIVIDUALLY DRIED ACTIVE INGREDIENTS
IL140745A IL140745A (en) 1998-07-09 2000-01-04 Dry copying process for producing flat, single-dose active ingredient preparations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19830650.4 1998-07-09
DE19830650A DE19830650C1 (en) 1998-07-09 1998-07-09 Dry copying to give bonded active ingredients at a substrate surface for transdermal therapy

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09743231 A-371-Of-International 2001-02-28
US10/163,752 Continuation US6652903B2 (en) 1998-07-09 2002-06-06 Dry-copying method for producing flat, individually dosed preparations of active agents

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WO1992014451A1 (en) * 1991-02-22 1992-09-03 Hoechst Uk Limited Improvements in or relating to electrostatic coating of substrates of medicinal products
WO1996035516A1 (en) * 1995-05-09 1996-11-14 Colorcon Limited Electrostatic coating
WO1996039257A1 (en) * 1995-06-06 1996-12-12 Sarnoff Corporation Electrostatically depositing a medicament powder
WO1997038480A1 (en) * 1996-04-09 1997-10-16 Sarnoff Corporation Electrostatic chucks
WO1998020861A1 (en) * 1996-11-13 1998-05-22 Phoqus Limited Method and apparatus for the coating of substrates for pharmaceutical use

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DE69220031T2 (en) * 1991-10-03 1997-09-04 Sony Corp METHOD FOR IMAGING
US5681255A (en) * 1993-05-21 1997-10-28 Ranpak Corp. Dispensing table and guide system for a cushioning conversion machine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014451A1 (en) * 1991-02-22 1992-09-03 Hoechst Uk Limited Improvements in or relating to electrostatic coating of substrates of medicinal products
WO1996035516A1 (en) * 1995-05-09 1996-11-14 Colorcon Limited Electrostatic coating
WO1996039257A1 (en) * 1995-06-06 1996-12-12 Sarnoff Corporation Electrostatically depositing a medicament powder
WO1997038480A1 (en) * 1996-04-09 1997-10-16 Sarnoff Corporation Electrostatic chucks
WO1998020861A1 (en) * 1996-11-13 1998-05-22 Phoqus Limited Method and apparatus for the coating of substrates for pharmaceutical use

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IL140745A (en) 2007-05-15
IL140745A0 (en) 2002-02-10
CA2336713A1 (en) 2000-01-20
AU750142B2 (en) 2002-07-11
DE19830650C1 (en) 1999-08-12
WO2000002533A3 (en) 2000-02-17
KR100517819B1 (en) 2005-09-30
EP1094794A2 (en) 2001-05-02
EP1094794B1 (en) 2003-12-17
JP4252215B2 (en) 2009-04-08
DK1094794T3 (en) 2004-03-29
ES2214035T3 (en) 2004-09-01
DE59908117D1 (en) 2004-01-29
AU4905599A (en) 2000-02-01
ATE256459T1 (en) 2004-01-15
JP2002520266A (en) 2002-07-09
CN1308524A (en) 2001-08-15
HUP0104919A2 (en) 2002-04-29
KR20010074643A (en) 2001-08-04
BR9911961A (en) 2001-03-27

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