IL140745A - Dry copying process for producing flat, single-dose active ingredient preparations - Google Patents

Dry copying process for producing flat, single-dose active ingredient preparations

Info

Publication number
IL140745A
IL140745A IL140745A IL14074500A IL140745A IL 140745 A IL140745 A IL 140745A IL 140745 A IL140745 A IL 140745A IL 14074500 A IL14074500 A IL 14074500A IL 140745 A IL140745 A IL 140745A
Authority
IL
Israel
Prior art keywords
active ingredient
roll
transferred
copying process
amount
Prior art date
Application number
IL140745A
Other languages
Hebrew (he)
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of IL140745A publication Critical patent/IL140745A/en

Links

Classifications

    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03GELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G13/00Electrographic processes using a charge pattern
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • GPHYSICS
    • G03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03GELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G9/00Developers
    • G03G9/08Developers with toner particles
    • G03G9/09Colouring agents for toner particles
    • G03G9/0926Colouring agents for toner particles characterised by physical or chemical properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Drying Of Solid Materials (AREA)
  • Coating Apparatus (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Storage Of Fruits Or Vegetables (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Color Printing (AREA)
  • Combination Of More Than One Step In Electrophotography (AREA)
  • Paper Feeding For Electrophotography (AREA)

Abstract

The invention relates to a method for dosing active agents in powder form onto a given surface. The method is characterised in that the active agent is transferred onto a roller in the form of an electrically charged powder, said roller having an opposite electric charge, in that the active agent transferred to the roller is then transferred onto a flat substrate with the opposite electric charge to the active agent and in that the active agent transferred onto the substrate is fixed by means of heat treatment.

Description

DVUDOJ ^UE] ΊΤ.1Π Ή'Ί-GTl "7 ID J1T1 K Π]Π UJ_r Ώ ^ η^ΠΠ DRY COPYING PROCESS FOR PRODUCING FLAT, SINGLE-DOSE ACTIVE INGREDIENT PREPARATIONS O Dry copying process for producing flat, single-dose active ingredient preparations Single-dose active ingredient preparations mean preparations which contain a predetermined amount of active substance in separate preparation units which can be handled individually.
An active ingredient for the purpose of this invention may be understood to be, for exam le, a medicinal substance, an insecticide, a pesticide, a reagent etc.
If an active substance means, for example, a medical active ingredient, such single-dose pharmaceutical forms are, for example, tablets, capsules, suppositories or transdermal therapeutic systems (TTS) .
Non-single-dose pharmaceutical forms would be, for example, sprays, syrups, ointments and drops, with which the actual dosage takes place only immediately before use.
In single-dose active ingredient preparations, the active ingredient is to be processed in an appropriate amount together with any excipients necessary to give the active ingredient preparations ready for use. This technology can be regarded as mature for the production of tablets and capsules. Modern tablet presses and capsule-filling machines guarantee a high"production rate and very accurate metering in the range 95-105% of the specification.
Transdermal therapeutic systems are still a relatively recent pharmaceutical form which is used externally in the form of a plaster 0:0. the skin and delivers the active ingredient through the skin to the body. Special metering techniques are used to produce these TTS, and further innovations in terms of new metering techniques are possible.
In one embodiment of these TTS, the active ingredient is contained directly in the adhesive and, during production, is metered together with the adhesive two-dimensionally onto a sheet.
This means that TTS are the only pharmaceutical form for which it is important to meter a medicinal active ingredient onto a predetermined area in a predetermined amount. Considering non-medicinal active ingredients such as, for example, insecticides, pesticides or reagents, two- dimensional preparations in the form of impregnated papers, sheets or boards have been known for a long time. However, the demands on the accuracy of metering in the area for . these applications are not great.
The present invention is based on the object of providing a method for metering active ingredients in powder form onto a predetermined are;-..
This object is achieved with use of the techniques known from the dry copying process by a method according to the features of main Claim 1.
It has emerged that this technique is capable of metering active ingredients in powder form onto an area with an accuracy sufficient for medicinal products. This is directly discernible with colour copying, in which each colour is metered separately, and major inaccuracies would result in wrong colours „ The dry copying process or- acerography functions in the manner described hereinafter.
A roll coated with a photoconductive material is provided with a positive electric charge and exposed through a suitable optical system to the original to be copied.
Through this procedure, the charge is at least partially removed wherever the conductivity of the photoconductive material increases due to the exposure.
In a next step, negatively charged coloured particles (toners) are applied to the roll, but these remain adherent only on the still charged areas of the roll in an amount depending on the size of the charge, and produce a visible image there.
Subsequently, the coloured particles (toners) are transferred to a positively charged paper or sheet and fixed there by a heat treatment.
A modern variant of the method is employed in so-called laser printers. In this case, the roll is directly exposed to a laser beam without original, and thus the image is traced under computer control directly on the roll.
Otherwise, the same technology is used for laser printers as for dry copiers .
The present invention is based on the use of these processes in order to transfer active ingredient particles, instead of the coloured pigments, to paper or, in general, sheets.
Experiments were carried out with a normal black/white copier to find the amounts of toner which can be transferred to sheet and the re x-oducibility thereof.
Coxrfmeroially available large polyester overhead sheets in the DIN A4 format are used as sheet. The original used was a dead-black sheet of paper, and the maximum degree of blackening was chosen for the copy. The results are recorded in the following table, Table 1 The results show that although only a comparatively small amount of toner was transferred, this was with an accuracy suitable for medicinal applications too.
In another experiment it was then found whether the amount can be increased by multiple metering.
The results are depicted in FIG. 1 and show that the transferred amount of toner is proportional to the number of copying procedures .
This result shows that although the amount transferred in one copying process is small, this disadvantage can, be overcome by multiple copying without the accuracy of metering suffering thereby.
The amount of toner or active ingredient transferred depends on the charged state of the copying roll and can be increased by applying a stronger charge than usual with copying machines.
If the active ingredient is metered without a special pattern it is possible to dispense entirely with the exposure step. In this case, the copying roll does not have to consist of photoconductive material.
If the metering is to take place in a pattern, the exposure step and the use of a copying roll coated with a photoconductive material, for example selenium, is necessary. The exposure can in this case take place via an original or else via a laser with computer control. The variability is, of course, greatest with computer- controlled laser exposure.
It is to be assumed that most active ingredients are colourless. From this viewpoint, it is worthwhile to admix an indicator dye to the active ingredient and excipient mixture in powder form. This dye then permits, after appropriate calibration, direct measurement by optical methods of the amount of active ingredient transferred, and automatic correction of any deviations from the specificatio .
The flat substrate onto which the active ingredient is transferred can moreover consist in principle of any materials as long as it is flexible and suitable for withstanding the fixing procedure. It is conceivable in this connection that the material will be employed in the form of sheets or will be supplied from a roll. This material is then cut into smaller pieces during further-processing and thus converted into the single-dose active ingredient preparation. An alternative possibility is for the material also to be perforated, in which case the dosage is predetermined by the perforation.

Claims (1)

1. CLAIMS Method for metering active ingredient in powder form onto a predetermined area, characterized in that the active ingredient is transferred as electrically charged powder to a roll with the opposite charge, the active ingredient transferred to the roll is transferred to a two-dimensional substrate with an electric charge opposite to the active ingredient, the active ingredient transferred to the substrate is fixed by means of a heat treatment. Method according to Claim 1, characterized in that excipients likewise in powder form are metered together with the active ingredient. Method according to Claim 2, characterized in that at least one excipient acts as fixative. Method according to Claim 2, characterized in that one excipient is coloured and is used for optical determination of the amount of active ingredient. Method according to Claim 1 to 4, characterized in that the roll is coated with a photoconducting material. Method according to Claim 1, characterized in that the charge on the roll and thus the amount and/or the pattern of active ingredient transfer is influenced by exposure of the loaded roll. Method according to Claim 6, characterised in that the exposure of the roll tft.kes place via a computer- controlled laser or conventionally via the optical imaging of an original.
IL140745A 1998-07-09 2000-01-04 Dry copying process for producing flat, single-dose active ingredient preparations IL140745A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19830650A DE19830650C1 (en) 1998-07-09 1998-07-09 Dry copying to give bonded active ingredients at a substrate surface for transdermal therapy
PCT/EP1999/004612 WO2000002533A2 (en) 1998-07-09 1999-07-02 Dry-copying method for producing flat, individually dosed preparations of active agents

Publications (1)

Publication Number Publication Date
IL140745A true IL140745A (en) 2007-05-15

Family

ID=7873429

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14074599A IL140745A0 (en) 1998-07-09 1999-07-02 Dry copying process for producing flat, single-dose active ingredient preparations
IL140745A IL140745A (en) 1998-07-09 2000-01-04 Dry copying process for producing flat, single-dose active ingredient preparations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL14074599A IL140745A0 (en) 1998-07-09 1999-07-02 Dry copying process for producing flat, single-dose active ingredient preparations

Country Status (14)

Country Link
EP (1) EP1094794B1 (en)
JP (1) JP4252215B2 (en)
KR (1) KR100517819B1 (en)
CN (1) CN1308524A (en)
AT (1) ATE256459T1 (en)
AU (1) AU750142B2 (en)
BR (1) BR9911961A (en)
CA (1) CA2336713A1 (en)
DE (2) DE19830650C1 (en)
DK (1) DK1094794T3 (en)
ES (1) ES2214035T3 (en)
HU (1) HUP0104919A2 (en)
IL (2) IL140745A0 (en)
WO (1) WO2000002533A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI121936B (en) * 2002-03-14 2011-06-15 Metso Paper Inc transfer of powdery particles

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2672800B1 (en) * 1991-02-15 1995-03-10 Dolisos Lab NOVEL THERAPEUTIC USE OF PYCNOGENOLS FOR THE PREPARATION OF DRUGS WITH ANTI-INFLAMMATORY ACTIVITY.
GB2253164B (en) * 1991-02-22 1994-10-05 Hoechst Uk Ltd Improvements in or relating to electrostatic coating of substrates of medicinal products
DE69220031T2 (en) * 1991-10-03 1997-09-04 Sony Corp METHOD FOR IMAGING
US5681255A (en) * 1993-05-21 1997-10-28 Ranpak Corp. Dispensing table and guide system for a cushioning conversion machine
TR199701324T1 (en) * 1995-05-09 1998-04-21 Colorcon Limited Electrostatic coating.
US5714007A (en) * 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US5858099A (en) * 1996-04-09 1999-01-12 Sarnoff Corporation Electrostatic chucks and a particle deposition apparatus therefor
GB9623634D0 (en) * 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use

Also Published As

Publication number Publication date
EP1094794B1 (en) 2003-12-17
AU4905599A (en) 2000-02-01
WO2000002533A2 (en) 2000-01-20
CN1308524A (en) 2001-08-15
AU750142B2 (en) 2002-07-11
HUP0104919A2 (en) 2002-04-29
DE19830650C1 (en) 1999-08-12
BR9911961A (en) 2001-03-27
KR100517819B1 (en) 2005-09-30
DK1094794T3 (en) 2004-03-29
DE59908117D1 (en) 2004-01-29
IL140745A0 (en) 2002-02-10
JP4252215B2 (en) 2009-04-08
EP1094794A2 (en) 2001-05-02
CA2336713A1 (en) 2000-01-20
ATE256459T1 (en) 2004-01-15
WO2000002533A3 (en) 2000-02-17
JP2002520266A (en) 2002-07-09
ES2214035T3 (en) 2004-09-01
KR20010074643A (en) 2001-08-04

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Legal Events

Date Code Title Description
MM9K Patent not in force due to non-payment of renewal fees