WO2000001826A3 - Variants stabilises d'inhibiteur de subtilisine de streptomyces - Google Patents

Variants stabilises d'inhibiteur de subtilisine de streptomyces Download PDF

Info

Publication number
WO2000001826A3
WO2000001826A3 PCT/US1999/015246 US9915246W WO0001826A3 WO 2000001826 A3 WO2000001826 A3 WO 2000001826A3 US 9915246 W US9915246 W US 9915246W WO 0001826 A3 WO0001826 A3 WO 0001826A3
Authority
WO
WIPO (PCT)
Prior art keywords
variants
ssi
personal care
present
subtilisin inhibitor
Prior art date
Application number
PCT/US1999/015246
Other languages
English (en)
Other versions
WO2000001826A2 (fr
Inventor
Charles Winston Saunders
Paul Elliott Correa
Yiping Sun
Mark Donald Bauer
Donn Nelton Rubingh
Original Assignee
Procter & Gamble
Charles Winston Saunders
Paul Elliott Correa
Yiping Sun
Mark Donald Bauer
Donn Nelton Rubingh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble, Charles Winston Saunders, Paul Elliott Correa, Yiping Sun, Mark Donald Bauer, Donn Nelton Rubingh filed Critical Procter & Gamble
Priority to CA002332564A priority Critical patent/CA2332564A1/fr
Priority to JP2000558216A priority patent/JP2004500007A/ja
Priority to BR9912519-6A priority patent/BR9912519A/pt
Priority to AU48623/99A priority patent/AU4862399A/en
Priority to EP99932287A priority patent/EP1093518A2/fr
Publication of WO2000001826A2 publication Critical patent/WO2000001826A2/fr
Publication of WO2000001826A3 publication Critical patent/WO2000001826A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/33—Amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3719—Polyamides or polyimides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38618—Protease or amylase in liquid compositions only

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Variants de l'inhibiteur de subtilisine de Streptomyces (SSI) et inhibiteurs ayant une homologie avec SSI. Ces variants sont utiles en conjonction avec des enzymes, en particulier des protéases, dans des compositions de nettoyage et des compositions d'hygiène personnelle. Lesdits variants comprennent une substitution d'acide aminé en position 63 correspondant à SSI. Ces variants présentent une stabilité protéolytique améliorée dans des compositions de nettoyage et des compositions d'hygiène personnelle. La présente invention concerne également des compositions de nettoyage et des compositions d'hygiène personnelle comportant lesdits variants, ainsi que des gènes codant ces variants.
PCT/US1999/015246 1998-06-26 1999-07-07 Variants stabilises d'inhibiteur de subtilisine de streptomyces WO2000001826A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002332564A CA2332564A1 (fr) 1998-06-26 1999-07-07 Variants stabilises d'inhibiteur de subtilisine de streptomyces
JP2000558216A JP2004500007A (ja) 1998-06-26 1999-07-07 ストレプトマイセス属のサブチリシンインヒビターの安定化変異体
BR9912519-6A BR9912519A (pt) 1998-06-26 1999-07-07 Variantes estabilizadas de inibidor de subtilisina de streptomyces
AU48623/99A AU4862399A (en) 1998-06-26 1999-07-07 Stabilized variants of (streptomyces) subtilisin inhibitor
EP99932287A EP1093518A2 (fr) 1998-06-26 1999-07-07 Variants stabilises d'inhibiteur de subtilisine de streptomyces

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9191198P 1998-06-26 1998-06-26
US60/091,911 1998-07-07

Publications (2)

Publication Number Publication Date
WO2000001826A2 WO2000001826A2 (fr) 2000-01-13
WO2000001826A3 true WO2000001826A3 (fr) 2000-04-06

Family

ID=22230265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015246 WO2000001826A2 (fr) 1998-06-26 1999-07-07 Variants stabilises d'inhibiteur de subtilisine de streptomyces

Country Status (8)

Country Link
EP (1) EP1093518A2 (fr)
JP (1) JP2004500007A (fr)
CN (1) CN1316000A (fr)
AR (1) AR020106A1 (fr)
AU (1) AU4862399A (fr)
BR (1) BR9912519A (fr)
CA (1) CA2332564A1 (fr)
WO (1) WO2000001826A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030037267A (ko) 2000-07-28 2003-05-12 헨켈 코만디트게젤샤프트 아우프 악티엔 바실러스속 ａ ７－７ (ｄｓｍ １２３６８) 에서 추출한신규한 아밀분해 효소 및 상기 신규한 아밀분해 효소를함유하는 세척 및 세정제
PL361363A1 (en) 2000-11-28 2004-10-04 Henkel Kommanditgesellschaft Auf Aktien Novel cyclodextrin glucanotransferase (cgtase), obtained from bacillus agaradherens (dsm 9948) and detergents and cleaning agents containing said novel cyclodextrin glucanotransferase
WO2003041667A2 (fr) * 2001-11-13 2003-05-22 The Procter & Gamble Company Compositions contenant des enzymes stabilisees a l'aide de certains osmoprotecteurs et methodes d'utilisation de ces compositions dans des soins d'hygiene personnelle
WO2003041680A1 (fr) * 2001-11-13 2003-05-22 The Procter & Gamble Company Compositions topiques contenant des enzymes stabilisees a l'aide d'inhibiteurs
DE10360805A1 (de) 2003-12-23 2005-07-28 Henkel Kgaa Neue Alkalische Protease und Wasch- und Reinigungsmittel, enthaltend diese neue Alkalische Protease
WO2008051491A2 (fr) 2006-10-20 2008-05-02 Danisco Us, Inc. Genencor Division Polyol oxydases
DE102007032111B4 (de) 2007-07-09 2017-07-20 Henkel Ag & Co. Kgaa Neue Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen
DE102007036756A1 (de) 2007-08-03 2009-02-05 Henkel Ag & Co. Kgaa Neue Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Proteasen
JP5953312B2 (ja) * 2011-10-12 2016-07-20 三洋化成工業株式会社 タンパク質性プロテアーゼインヒビター並びにこれを含有するタンパク質溶液及び洗剤組成物
DE102022205593A1 (de) * 2022-06-01 2023-12-07 Henkel Ag & Co. Kgaa Wasch- und reinigungsmittel mit verbesserter enzymstabilität

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998013387A1 (fr) * 1996-09-24 1998-04-02 The Procter & Gamble Company Inhibiteurs proteiniques stabilises de protease et leurs variants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998013387A1 (fr) * 1996-09-24 1998-04-02 The Procter & Gamble Company Inhibiteurs proteiniques stabilises de protease et leurs variants

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KOJIMA, SHUICHI ET AL: "Effects of deletion in the flexible loop of the protease inhibitor SSI ( Streptomyces subtilisin inhibitor ) on interactions with proteases.", PROTEIN ENGINEERING, (1993) VOL. 6, NO. 3, PP. 297-303., XP002128269 *
MITSUI Y ET AL: "CRYSTAL STRUCTURE OF A BACTERIAL PROTEIN PROTEINASE INHIBITOR STREPTOMYCES SUBTILISIN INHIBITOR AT 2.6 ANGSTROM RESOLUTION.", J MOL BIOL, (1979) 131 (4), 697-724., XP000867414 *

Also Published As

Publication number Publication date
EP1093518A2 (fr) 2001-04-25
WO2000001826A2 (fr) 2000-01-13
BR9912519A (pt) 2001-05-02
AR020106A1 (es) 2002-04-10
JP2004500007A (ja) 2004-01-08
AU4862399A (en) 2000-01-24
CN1316000A (zh) 2001-10-03
CA2332564A1 (fr) 2000-01-13

Similar Documents

Publication Publication Date Title
AU2002302564A1 (en) Alkaline protease variants and detergents and cleaning agents containing said alkaline protease variants
MX9605357A (es) Variantes de subtilisina bpn' que tiene absorcion reducida e hidrolisis incrementada.
WO2003038082A3 (fr) Nouveaux variants de protease alcaline et detergents et produits de lavage contenant ces nouveaux variants
HUP0100859A2 (hu) Tisztítókészítmények többszörös aminosav-szubsztitúciókat tartalmazó proteázvariánsokkal
AU8079794A (en) Protease-containing cleaning compositions
MX9605359A (es) Composiciones para la limpieza de telas que contienen variantes de subtilicina bpn.
WO1995030011A3 (fr) Variants de subtilisine 309 a adsorption reduite et a hydrolyse accrue
DK39093D0 (da) Enzym
HK1071766A1 (en) Novel alkaline protease from bacillus dsm 14392 and its use
WO1996028566A3 (fr) Variants de subtilisine carlsberg ayant un pouvoir d'adsorption minore et d'hydrolyse accru
AU2002340415A1 (en) Compositions containing enzymes stabilized with certain osmo-protectants and methods for using such compositions in personal care
CA2412961A1 (fr) Composition cosmetique comprenant des elastomeres de siloxane reticules emulsifiants et non emulsifiants
BR9909130A (pt) Variantes de protease de serina tendo substituições de amino-ácido
NO961067D0 (no) Subtilisin BPN' varianter med senket adsorpsjon og öket hydrolyse
ATE450606T1 (de) Mehrfachsubstituierte proteasevarianten
WO2001007578A3 (fr) Proteases variantes de la subtilisine par substitutions acide amine dans des regions definies de l'epitope
WO2000001826A3 (fr) Variants stabilises d'inhibiteur de subtilisine de streptomyces
WO2000001831A3 (fr) Proteases fusionnees avec des variants d'inhibiteur de subtilisine de streptomyces
WO1999005291A3 (fr) Metalloproteases decomposant l'aggrecan
AU2002365646A1 (en) Novel proteins with il-6 inhibiting activity
WO2001007575A3 (fr) Variants de protease subtilisine possedant des suppressions et des substitutions d'acides amines dans certaines regions de sites antigeniques
WO1995020663A3 (fr) VARIANTS THERMOSTABLES DE PROTEASES NEUTRES DE BACILLUS STEAROTHERMOPHILUS ET DE $i(BACILLUS THERMOPROTEOLYTICUS)
NO975188D0 (no) Anvendelse av mannanaser som slimregulerende midler
BR9711540A (pt) Inibidores de protease proteìnico estabilizados e variantes dos mesmos
AU2676801A (en) Xylosyltransferase and isoforms thereof

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99810458.2

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AT AU AZ BA BB BG BR BY CA CH CN CU CZ CZ DE DE DK DK EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 09720399

Country of ref document: US

ENP Entry into the national phase

Ref document number: 2332564

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/000302

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2000 558216

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1999932287

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999932287

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1999932287

Country of ref document: EP