WO2000001813A3 - Inhibiteurs de l'activation independante de l'androgene du recepteur d'androgene - Google Patents

Inhibiteurs de l'activation independante de l'androgene du recepteur d'androgene Download PDF

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Publication number
WO2000001813A3
WO2000001813A3 PCT/CA1999/000604 CA9900604W WO0001813A3 WO 2000001813 A3 WO2000001813 A3 WO 2000001813A3 CA 9900604 W CA9900604 W CA 9900604W WO 0001813 A3 WO0001813 A3 WO 0001813A3
Authority
WO
WIPO (PCT)
Prior art keywords
androgen
independent activation
androgen receptor
receptor
activation
Prior art date
Application number
PCT/CA1999/000604
Other languages
English (en)
Other versions
WO2000001813A2 (fr
Inventor
Marianne D Sadar
Nicholas Bruchovsky
Peter W Gout
Robert Snoek
Nasrin R Mawji
Original Assignee
Univ British Columbia
Marianne D Sadar
Nicholas Bruchovsky
Peter W Gout
Robert Snoek
Nasrin R Mawji
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia, Marianne D Sadar, Nicholas Bruchovsky, Peter W Gout, Robert Snoek, Nasrin R Mawji filed Critical Univ British Columbia
Priority to CA002302169A priority Critical patent/CA2302169A1/fr
Priority to AU44943/99A priority patent/AU4494399A/en
Publication of WO2000001813A2 publication Critical patent/WO2000001813A2/fr
Publication of WO2000001813A3 publication Critical patent/WO2000001813A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'activation indépendante de l'androgène du récepteur d'androgène est localisée dans la région comprenant les acides aminés 234-391 de la protéine du récepteur d'androgène humain. L'invention concerne des peptides dérivés et des acides nucléiques codant pour ces peptides. Ces peptides sont utiles comme domaines d'activation, comme inhibiteurs de l'activation indépendante des androgènes du récepteur d'androgène, et comme agents thérapeutiques pour des pathologies d'origine androgénique telles que le cancer de la prostate. L'invention concerne en outre des procédés permettant la sélection de composés affectant l'activation indépendante de l'androgène du récepteur d'androgène.
PCT/CA1999/000604 1998-06-30 1999-06-30 Inhibiteurs de l'activation independante de l'androgene du recepteur d'androgene WO2000001813A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002302169A CA2302169A1 (fr) 1998-06-30 1999-06-30 Inhibiteurs du phenomene d'activation ne dependant pas de l'androgene et ayant un effet sur le recepteur de l'androgene
AU44943/99A AU4494399A (en) 1998-06-30 1999-06-30 Inhibitors of androgen-independent activation of androgen receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9187198P 1998-06-30 1998-06-30
US60/091,871 1998-06-30

Publications (2)

Publication Number Publication Date
WO2000001813A2 WO2000001813A2 (fr) 2000-01-13
WO2000001813A3 true WO2000001813A3 (fr) 2000-04-13

Family

ID=22230037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000604 WO2000001813A2 (fr) 1998-06-30 1999-06-30 Inhibiteurs de l'activation independante de l'androgene du recepteur d'androgene

Country Status (3)

Country Link
AU (1) AU4494399A (fr)
CA (1) CA2302169A1 (fr)
WO (1) WO2000001813A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003018987A (ja) * 2001-06-25 2003-01-21 Okazaki National Research Institutes 遺伝子導入細胞及びそれを用いた撹乱物質の検出法
US20100189776A1 (en) * 2007-03-16 2010-07-29 Cancer Research Technology Ltd Anti-androgen peptides and uses thereof in cancer therapy
US20100291086A1 (en) * 2007-09-11 2010-11-18 Christopher Hovens Use of estrogen and androgen binding proteins in methods and compositions for treating gynaecological cancers
FR2938334A1 (fr) * 2008-11-13 2010-05-14 Galderma Res & Dev Modulateurs de l'adfp dans le traitement de l'acne, d'une dermatite seborrheique ou de l'hyperseborrhee
BRPI0913673A2 (pt) 2008-07-02 2015-10-13 British Columbia Cancer Agency uso de um composto, composição farmacêutica, e, método para modular a atividade do receptor de andrógeno
CN102131775B (zh) 2008-08-22 2015-12-16 不列颠哥伦比亚癌症局分支机构 雄激素受体n-末端活化的小分子抑制剂
EP2521707B1 (fr) 2010-01-06 2017-06-14 British Columbia Cancer Agency Branch Dérivés du bisphénol et leur utilisation en tant que modulateurs de l'activité du récepteur des androgènes
EP2693875A4 (fr) 2011-04-08 2014-10-22 British Columbia Cancer Agency Composés de bisphénol et leurs procédés d'utilisation
WO2013028572A1 (fr) 2011-08-19 2013-02-28 British Columbia Cancer Agency Branch Composés d'éthers de bisphénol fluorés et leurs procédés d'utilisation
GB2496135B (en) * 2011-11-01 2015-03-18 Valirx Plc Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis
US9365510B2 (en) 2012-04-16 2016-06-14 British Columbia Cancer Agency Branch Aziridine bisphenol ethers and related compounds and methods for their use
GB2513615A (en) 2013-05-01 2014-11-05 Cancer Rec Tech Ltd Medical use
CN105358522A (zh) 2013-05-10 2016-02-24 不列颠哥伦比亚癌症局分支机构 雄激素受体调节剂的酯衍生物及其使用方法
US9375496B2 (en) 2013-09-09 2016-06-28 British Columbia Cancer Agency Branch Halogenated compounds for cancer imaging and treatment and methods for their use
AU2015266654A1 (en) 2014-05-30 2016-12-01 British Columbia Cancer Agency Branch Androgen receptor modulators and methods for their use
ES2907708T3 (es) 2015-01-13 2022-04-26 British Columbia Cancer Agency Branch Compuestos heterocíclicos para obtención de imágenes y tratamiento del cáncer y métodos para su uso
WO2016141458A1 (fr) 2015-03-12 2016-09-15 British Columbia Cancer Agency Branch Dérivés d'éther de bisphénol et leurs procédés d'utilisation
US20170298033A1 (en) 2016-04-15 2017-10-19 The University Of British Columbia Bisphenol derivatives and their use as androgen receptor activity modulators
US20190345202A1 (en) * 2016-08-08 2019-11-14 Olipass Corporation Androgen receptor antisense oligonucleotides
US11485713B2 (en) 2018-05-25 2022-11-01 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
KR20210093886A (ko) 2018-10-18 2021-07-28 에싸 파마 아이엔씨. 안드로겐 수용체 조절제 및 그 사용 방법
EP4135675A4 (fr) 2020-04-17 2024-04-10 Essa Pharma, Inc. Formes solides d'un inhibiteur de récepteur des androgènes de domaine n-terminal et leurs utilisations
WO2023046283A1 (fr) 2021-09-22 2023-03-30 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Composés et leur utilisation dans une méthode de modulation de l'activité transcriptionnelle d'ar (récepteur des androgènes)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009791A1 (fr) * 1988-04-14 1989-10-19 University Of North Carolina At Chapel Hill Adn codant pour des proteines receptrices d'androgene
EP0577932A2 (fr) * 1992-05-08 1994-01-12 American Cyanamid Company Développement d'un "screening" basé en mécanisme pour identifier agonistes et antagonistes du récepteur d'androgène
WO1997030074A1 (fr) * 1996-02-16 1997-08-21 Cytogen Corporation Isolation et utilisation de peptides de liaison de sh3

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009791A1 (fr) * 1988-04-14 1989-10-19 University Of North Carolina At Chapel Hill Adn codant pour des proteines receptrices d'androgene
EP0577932A2 (fr) * 1992-05-08 1994-01-12 American Cyanamid Company Développement d'un "screening" basé en mécanisme pour identifier agonistes et antagonistes du récepteur d'androgène
WO1997030074A1 (fr) * 1996-02-16 1997-08-21 Cytogen Corporation Isolation et utilisation de peptides de liaison de sh3

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
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CULIG Z ET AL.,: "Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor", CANCER RESEARCH, vol. 54, 15 October 1994 (1994-10-15), pages 5474 - 5478, XP000867802 *
DE RUITER PE ET AL.,: "Synergism between androgens and protein kinase-C on androgen regulated gene expression", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 110, 1995, pages r1 - r6, XP000874779 *
JENSTER G ET AL.,: "Identification of two transcription activation units in the N-terminal domain of the human androgen receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 13, 31 March 1995 (1995-03-31), pages 7341 - 7346, XP000867758 *
JIA L D ET AL: "Androgenic up-regulation of androgen receptor cDNA expression in androgen-independent prostate cancer cells", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION,US,ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, vol. 61, no. 9, 1996, pages 531-539, XP004070285, ISSN: 0039-128X *
NAZARETH LV AND WEIGEL NL: "Activation of human androgen receptor through a protein kinase A signaling pathway", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, 1996, pages 19900 - 19907, XP002130095 *
SADAR MD: "Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, 12 March 1999 (1999-03-12), pages 7777 - 7783, XP002130097 *

Also Published As

Publication number Publication date
WO2000001813A2 (fr) 2000-01-13
AU4494399A (en) 2000-01-24
CA2302169A1 (fr) 2000-01-13

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