WO1999065550A1 - Dispositif d'inhalation - Google Patents

Dispositif d'inhalation Download PDF

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Publication number
WO1999065550A1
WO1999065550A1 PCT/EP1999/004160 EP9904160W WO9965550A1 WO 1999065550 A1 WO1999065550 A1 WO 1999065550A1 EP 9904160 W EP9904160 W EP 9904160W WO 9965550 A1 WO9965550 A1 WO 9965550A1
Authority
WO
WIPO (PCT)
Prior art keywords
vortex
medicament
inhalation
particles
user
Prior art date
Application number
PCT/EP1999/004160
Other languages
English (en)
Inventor
Karl Holm
Original Assignee
Karl Holm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Holm filed Critical Karl Holm
Priority to AU45142/99A priority Critical patent/AU4514299A/en
Publication of WO1999065550A1 publication Critical patent/WO1999065550A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the present invention relates to an inhalation device for and a method of providing medicament for inhalation.
  • the medicament is introduced as an uncontrolled cloud, most of which is deposited in the oral cavity and throat, with only a small part reaching the destination in the lungs. It would therefore be of very great advantage if the medicament could be administered into the oral cavity as a controlled narrow jet or spot dosed to a small area, by means of which the dosing can be aimed directly towards the location in the neck region where the windpipe begins. In this way. scattering and the undesirable deposition of medicament in the throat and mouth are greatly reduced.
  • the present invention provides an inhalation device for providing medicament for inhalation, including a vortex generator for generating a vortex entraining particles of medicament in a gas for inhalation by a user
  • the present invention also provides a method of providing medicament for inhalation, comprising the step of generating a vortex entraining particles of medicament in a gas for inhalation by a user.
  • the principle underlying the present invention is the use of the physical concept of a vortex.
  • Such vortices include the smoke rings which are generated, for example, from the exhausts of diesel engines in certain fishing boats.
  • the particles which are entrained by the air movements associated with the smoke rings are transported in an unimpeded manner and in the same concentration. Formation of these vortices can take place in many ways, and, if the air in a vortex ring entrains particles of medicament, these particles will be carried along unimpeded and be concentrated in the annular air flow formed.
  • Figure 1 illustrates a component part of the vortex generator of an inhaler in accordance with a first embodiment of the present invention
  • Figure 3 illustrates a sectional view of the inhaler of the first embodiment of the present invention
  • Figure 5 illustrates a sectional view of an inhaler in accordance with a second embodiment of the present invention
  • FIG. 1 An example of a vortex generator for generating a concentrated moving ring of air/medicament of. for example, roughly 5 mm in diameter is shown in Figure 1
  • a round tube 1 (for example 30 mm in diameter) has a front plate 2 in which there is a hole 2a (for example 3 to 4 mm in diameter)
  • a flexible rubber diaphragm 3 is fixed as an end plate in the opposite end of the tube 1 This rubber diaphragm 3 can be pushed into the tube 1 , as shown by 3a
  • the tube 1 contains suspended particles of medicament 4
  • An external cylindrical shell is shown by 6
  • the shell 6 includes a mouthpiece with holes m the periphery shown by 7
  • a tube 8 contains particles of medicament 4. and an exit hole for the vortex rings 5 entraining medicament is shown by 9
  • An electric mini-motor 12 d ⁇ ves the tube 8 round and actuates a conical striker wheel 14
  • Batteries for operating the motor 14 are shown by 15
  • the tube 8 has a rear wall made of a flexible material, for example of rubber, shown by 16
  • 18 is a tube and 19 is a plunger connected to a connecting rod 20 and a piezoelectric crystal 21.
  • the cavity of the tube 18 contains medicament in the form of powder or vapour/droplets 22 suspended therein.
  • the plunger 19 in the tube 18 will be advanced in a sudden thrust with very great acceleration, with the air/medicament mixture 22 then being expelled as vortex rings 23 and moving forwards through the air.
  • Figure 6 illustrates modified plungers 24a, 24b, with conical and part-spherical tips, it being possible to use a number of different constructions to achieve the desired vortex ring.
  • Figure 6 also illustrates a modified tube 25, the tube 25 being provided with a rough internal surface 26 so as to achieve an improved efficiency in vortex formation. Generally, however, it is a sharp aperture opening that is used in vortex formation.
  • a piezoelectric crystal as the vibration generator, can be used in all embodiments, namely aperture opening or tube outlet, diaphragm or plunger.
  • FIGS. 7 to 9 illustrate an inhaler in accordance with a third embodiment of the present invention.
  • 27 represents a round pulse-pressure container
  • 28 represents a plunger which is connected to a push-rod 29.
  • the pressure container 27 is provided with a hinged cover 30 on which a plurality of, in this embodiment eight, fork pins 31 are mounted, around which a rubber or plastic balloon 32 containing medicament in the form of a powder can be fixed.
  • the fork pins 31 are made to rotate outwardly towards the periphery of the cover 30 by means known in the art from, for example, variable aperture openings, and guided in a rotary path 35 as shown in Figure 9.
  • the cover 30 has a central hole 36 through which vortex rings 34 are in use generated.
  • the cover 30 is opened and the fork pins 31 are, by means of rotation of the vanes 33, made to move inwardly towards the centre of the cover 30 to the position 31a as shown in Figure 9.
  • the balloon 32 has in the bottom thereof a separate pocket containing medicament in the form of a powder, and the balloon 32 is fitted on the fork pins 31 as shown in Figure 7.
  • the cover 30 is closed in on the container 27 and, by means of the vanes 33, the fork pins 31 are moved to the outer position 31b as shown in Figure 8.
  • Figure 9 shows the fork pins 31 in the outer position 31b, as they have been moved along the grooves 35 in the cover 30.
  • the balloon 32 will be dilated and the pocket containing medicament in the bottom of the balloon 32 will break so that the medicament will escape therefrom.
  • the particles of medicament will float around in the balloon 32.
  • the plunger 28 is actuated so as to thrust several times in a pulse-like manner, typically by an electronically-controlled piezoelectric crystal, motor hammer or solenoid hammer against the balloon 32, vortex rings 34 will be generated which exit the hole 36, which vortex rings 34 entrain particles containing medicament and move forwards.
  • the cover 30 of the container 27 is opened, the fork pins 31 are screwed back to inner position 31a by rotation of the vanes 33, and the balloon 32 and any medicament residue is removed.
  • the velocity and the compression of the air mass which forms the vortex ring can likewise be changed, by means of which the velocity, diameter and ring thickness of the vortex rings of air and medicament are also changed.
  • the aperture opening, through which the vortex rings are generated the diameter and velocity of the latter are likewise changed. Moving vortex rings of different diameter and with different velocity are obtained, or vortex rings in which only one parameter is changed. It is also possible to cause the vortex rings to collide and in this way change their behaviour, in terms of both diameter and velocity, as the vortex rings can be made to move in and out of one another.
  • lacquer powder can be transported in this manner in lacquering, or vortex transport can be used for volatile paints.
  • Another example is field spraying, the insecticide or herbicide sprayed reaching the surface of the field without great quantities evaporating as they do now.

Abstract

L'invention porte sur un dispositif d'inhalation et sur un procédé de fabrication de médicament à inhaler. Ce dispositif d'inhalation comprend un générateur de tourbillon entraînant des particules de médicament dans un gaz devant être inhalé par l'utilisateur.
PCT/EP1999/004160 1998-06-15 1999-06-15 Dispositif d'inhalation WO1999065550A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45142/99A AU4514299A (en) 1998-06-15 1999-06-15 Inhalation device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA199800785 1998-06-15
DK78598 1998-06-15
DKPA199800847 1998-06-30
DKPA199800847 1998-06-30

Publications (1)

Publication Number Publication Date
WO1999065550A1 true WO1999065550A1 (fr) 1999-12-23

Family

ID=26064656

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/004160 WO1999065550A1 (fr) 1998-06-15 1999-06-15 Dispositif d'inhalation

Country Status (2)

Country Link
AU (1) AU4514299A (fr)
WO (1) WO1999065550A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004071541A1 (fr) * 2003-02-06 2004-08-26 S. C. Johnson & Son Inc. Generateur de tourbillon pour la distribution de substances actives
US7779837B2 (en) 2004-02-24 2010-08-24 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US8261739B2 (en) 2004-12-09 2012-09-11 Cambridge Consultants Limited Dry powder inhalers
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US9402809B2 (en) 2006-03-16 2016-08-02 Niconovum Usa, Inc. Snuff composition
US9629832B2 (en) 2002-12-20 2017-04-25 Niconovum Usa, Inc. Physically and chemically stable nicotine-containing particulate material
US10238821B2 (en) 2016-10-11 2019-03-26 Microdose Therapeutx, Inc. Inhaler and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2788607A (en) * 1954-03-22 1957-04-16 Donald R Ward Smoke-ring signaling drum
US4090320A (en) * 1976-07-19 1978-05-23 Carmelo Loiacono Smoke ring box
US5483953A (en) * 1995-04-08 1996-01-16 The United States Of America As Represented By The Secretary Of The Navy Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient
US5823434A (en) * 1997-05-05 1998-10-20 The United States Of America As Represented By The Secretary Of The Navy Electromechanical driver for an aerosol dispensing apparatus which dispenses a medicated vapor into the lungs of a patient

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2788607A (en) * 1954-03-22 1957-04-16 Donald R Ward Smoke-ring signaling drum
US4090320A (en) * 1976-07-19 1978-05-23 Carmelo Loiacono Smoke ring box
US5483953A (en) * 1995-04-08 1996-01-16 The United States Of America As Represented By The Secretary Of The Navy Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient
US5823434A (en) * 1997-05-05 1998-10-20 The United States Of America As Represented By The Secretary Of The Navy Electromechanical driver for an aerosol dispensing apparatus which dispenses a medicated vapor into the lungs of a patient

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9629832B2 (en) 2002-12-20 2017-04-25 Niconovum Usa, Inc. Physically and chemically stable nicotine-containing particulate material
US7059544B2 (en) 2003-02-06 2006-06-13 S.C. Johnson & Son, Inc. Vortex generator for dispensing actives
WO2004071541A1 (fr) * 2003-02-06 2004-08-26 S. C. Johnson & Son Inc. Generateur de tourbillon pour la distribution de substances actives
US7779837B2 (en) 2004-02-24 2010-08-24 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US8322338B2 (en) 2004-02-24 2012-12-04 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US8261739B2 (en) 2004-12-09 2012-09-11 Cambridge Consultants Limited Dry powder inhalers
US10219999B2 (en) 2006-03-16 2019-03-05 Niconovum Usa, Inc. Snuff composition
US9402809B2 (en) 2006-03-16 2016-08-02 Niconovum Usa, Inc. Snuff composition
US11129792B2 (en) 2006-03-16 2021-09-28 Modoral Brands Inc. Snuff composition
US11547660B2 (en) 2006-03-16 2023-01-10 Niconovum Usa, Inc. Snuff composition
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US9974909B2 (en) 2010-01-05 2018-05-22 Microdose Therapeutx, Inc. Inhalation device and method
US10434267B2 (en) 2010-01-05 2019-10-08 Microdose Therapeutx, Inc. Inhalation device and method
US10238821B2 (en) 2016-10-11 2019-03-26 Microdose Therapeutx, Inc. Inhaler and methods of use thereof

Also Published As

Publication number Publication date
AU4514299A (en) 2000-01-05

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