WO1999065523A1 - Immunotherapeutic composition and method for the treatment of prostate cancer - Google Patents

Immunotherapeutic composition and method for the treatment of prostate cancer Download PDF

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Publication number
WO1999065523A1
WO1999065523A1 PCT/IB1999/001115 IB9901115W WO9965523A1 WO 1999065523 A1 WO1999065523 A1 WO 1999065523A1 IB 9901115 W IB9901115 W IB 9901115W WO 9965523 A1 WO9965523 A1 WO 9965523A1
Authority
WO
WIPO (PCT)
Prior art keywords
psa
antigen
agent
bmding
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1999/001115
Other languages
English (en)
French (fr)
Inventor
Beatrice Leveugle
Ragupathy Madiyalakan
Antoine A. Noujaim
Birgit Schultes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALTAREX CORP
Altarex Inc
Original Assignee
ALTAREX CORP
Altarex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALTAREX CORP, Altarex Inc filed Critical ALTAREX CORP
Priority to CA002328504A priority Critical patent/CA2328504A1/en
Priority to AU41594/99A priority patent/AU768002B2/en
Priority to AT99925216T priority patent/ATE480566T1/de
Priority to DE69942742T priority patent/DE69942742D1/de
Priority to JP2000554401A priority patent/JP2002518347A/ja
Priority to EP99925216A priority patent/EP1085905B1/en
Priority to IL13970099A priority patent/IL139700A/xx
Publication of WO1999065523A1 publication Critical patent/WO1999065523A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Definitions

  • the present invention relates generally to the generation of cellular and humoral immune responses to prostate-specific antigen (PSA).
  • PSA prostate-specific antigen
  • the present invention also relates to a therapeutic composition that contains a monoclonal antibody that is useful in generating cellular and humoral immune responses to PSA.
  • Immunogenicity is the property of stimulating the immune system to generate a specific response. Thus, all immunogens are antigens, but not vice-versa. Although an irnmune system may recognize an antigen, it does not respond to the antigen unless the antigen is also immunogenic.
  • an antibody whose antigen combining site (paratope) interacts with an antigenic determinant on another antibody V region (idiotope) is called an anti- idiotypic antibody (Ab2).
  • an antibody includes an antigen binding site, and may include one or more antibody binding sites.
  • anti-idiotypic antibodies sometimes called Ab2 ⁇ and Ab2 ⁇ .
  • Ab2 ⁇ anti-idiotype antibody
  • the combining site perfecdy mimics the structure of the antigen epitope recognized by the Abl antibody. This type of anti-idiotype is said to represent the internal image of the antigen.
  • Administration may be more than once, preferably three times over a prolonged period.
  • the compositions of this invention may be used for patient's in a serious disease state, i.e., Ufe-threatening or potentially Ufe-threatening, excesses of the binding agent may be aclministered if desirable.
  • Actual methods and protocols for administering pharmaceutical compositions, including dilution techniques for injections of the present compositions, are well known or will be apparent to one skilled in the art. Some of these methods and protocols are described in Remington s Pharmaceutical Science, Mack Publishing Co. (1982).
  • Administration may also include ex vivo administration protocols, e.g., removing a portion of a patient's body fluid, contacting in vitro the body fluid with the therapeutic composition, and then returning the treated body fluid to the patient.
  • Second screening Hyb ⁇ doma clones secreting anti-PSA antibodies were first detected by ELISA on PSA coated plates (ELISA #1). We selected 80 positive clones from this first screening. Those clones are currently kept frozen m liquid nitrogen tank Second screening: The positive clones were further screened agamst PSA complexed to alpha anti-chymotrypsin (PSA-ACT) (ELISA #2); PSA non complexing to alpha anti- chymotrypsin (ELISA #4); Plasmatique kalhkrem (ELISA #5); and PSA peptide 139-163 (ELISA #6) The reactivity of the AR47 clones towards the different forms of PSA and towards kallikrem is reported in Example 2 The isotype of the antibodies secreted by AR47 clones is reported m Example 3.
  • AR 47.47 is directed towards a PSA epitope comprised between the sequence 139-163 of the PSA molecule.
  • the anti-PSA antibodies produced by AR 47.47 immunized mice can specifically interact with the PSA peptide 139-163, showing that at least part of the Ab3 produced are identical in term of specificity to AR 47.47.
  • Ab2 is a surrogate antigen capable of mimicking the PSA epitope recognized by the injected anti-PSA antibody.
  • a competitive inhibition assay was established to measure the serum level of Ab2. This assay was performed 5 days after the second injection. An inhibition was observed after incubation in the presence of mouse sera from mice immunized with anti-PSA antibody, but not when sera from mice immunized with control antibody or PBS were used.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/IB1999/001115 1998-06-15 1999-06-15 Immunotherapeutic composition and method for the treatment of prostate cancer Ceased WO1999065523A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002328504A CA2328504A1 (en) 1998-06-15 1999-06-15 Immunotherapeutic composition and method for the treatment of prostate cancer
AU41594/99A AU768002B2 (en) 1998-06-15 1999-06-15 Immunotherapeutic composition and method for the treatment of prostate cancer
AT99925216T ATE480566T1 (de) 1998-06-15 1999-06-15 Immuntherapeutische zusammensetzung und verfahren zur behandlung von prostatakrebs
DE69942742T DE69942742D1 (de) 1998-06-15 1999-06-15 Immuntherapeutische zusammensetzung und verfahren zur behandlung von prostatakrebs
JP2000554401A JP2002518347A (ja) 1998-06-15 1999-06-15 前立腺癌治療のための免疫療法組成物および方法
EP99925216A EP1085905B1 (en) 1998-06-15 1999-06-15 Immunotherapeutic composition and method for the treatment of prostate cancer
IL13970099A IL139700A (en) 1998-06-15 1999-06-15 Immunotherapeutic composition for the treatment of prostate cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8928198P 1998-06-15 1998-06-15
US60/089,281 1998-06-15

Publications (1)

Publication Number Publication Date
WO1999065523A1 true WO1999065523A1 (en) 1999-12-23

Family

ID=22216751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/001115 Ceased WO1999065523A1 (en) 1998-06-15 1999-06-15 Immunotherapeutic composition and method for the treatment of prostate cancer

Country Status (9)

Country Link
US (3) US6881405B2 (https=)
EP (1) EP1085905B1 (https=)
JP (1) JP2002518347A (https=)
AT (1) ATE480566T1 (https=)
AU (1) AU768002B2 (https=)
CA (1) CA2328504A1 (https=)
DE (1) DE69942742D1 (https=)
IL (1) IL139700A (https=)
WO (1) WO1999065523A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000041722A1 (de) * 1999-01-13 2000-07-20 Igeneon Krebs-Immuntherapie Forschungs- Und Entwicklungs-Ag Verwendung von antikörpern zur vakzinierung gegen krebs
WO2001085204A3 (en) * 2000-05-11 2002-08-22 Altarex Inc Therapeutic method and composition utilizing antigen-antibody complexation and presentation by dendritic cells
EP2331130A4 (en) * 2008-04-09 2012-11-07 Advanced Immune Therapeutics Inc IGE ANTIBODIES FOR THE TREATMENT OF CANCER

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8038994B2 (en) 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
US6881405B2 (en) * 1998-06-15 2005-04-19 Altarex Medical Corp. Reagents and methods for inducing an immune response to prostate specific antigen
JP2005522483A (ja) * 2002-04-11 2005-07-28 アルタレックス メディカル コーポレーション 結合剤及び腫瘍細胞をターゲティングする際のそれらの使用
US20050271649A1 (en) * 2002-10-17 2005-12-08 Schultes Birgit C Therapeutic adjuvant
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
GB0329146D0 (en) * 2003-12-16 2004-01-21 Glaxosmithkline Biolog Sa Vaccine
CA2523032A1 (en) 2005-10-07 2007-04-07 Immunovaccine Technologies Inc. Vaccines for cancer therapy
US20080095790A1 (en) * 2006-10-24 2008-04-24 Perambakam Supriya M Methods of Treating Prostate Cancer
CA2700808C (en) 2007-09-27 2017-11-14 Immunovaccine Technologies Inc. Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
ES2524699T3 (es) * 2008-06-05 2014-12-11 Immunovaccine Technologies Inc. Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba
GB0811567D0 (en) * 2008-06-24 2008-07-30 Cytosystems Ltd Assay
EP3912643B8 (en) 2009-02-13 2023-08-23 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
EP3009455A1 (en) 2009-09-16 2016-04-20 Immunomedics Inc. Class i anti-cea antibodies and uses thereof
ES2978177T3 (es) 2009-12-02 2024-09-06 Immunomedics Inc Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer
US9023802B2 (en) * 2009-12-14 2015-05-05 Immatics Biotechnologies Gmbh HLA-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof
AU2012250924B2 (en) 2011-05-02 2017-05-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
JP6240077B2 (ja) 2011-10-06 2017-11-29 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． Ｔｌｒ２を活性化するか、またはその活性を増加させるアジュバントを含むリポソーム組成物およびその使用
AU2013302696B9 (en) 2012-08-14 2018-08-09 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
SI2900277T1 (sl) 2012-12-13 2022-05-31 Immunomedics, Inc. Odmerki imunokonjugatov protiteles in SN-38 za boljšo učinkovitost in zmanjšano toksičnost
WO2015126548A1 (en) 2014-02-21 2015-08-27 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to trop-2 expressing cells
US9139649B2 (en) 2014-02-25 2015-09-22 Immunomedics, Inc. Humanized anti-CD22 antibody
WO2015200260A1 (en) 2014-06-24 2015-12-30 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
CN117138060A (zh) 2014-10-07 2023-12-01 免疫医疗公司 抗体-药物缀合物的新辅助剂用途
WO2016172427A1 (en) 2015-04-22 2016-10-27 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
EP4257134A3 (en) 2015-06-25 2024-01-24 Immunomedics, Inc. Combining anti-hla-dr or anti-trop-2 antibodies with microtubule inhibitors, parp inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
PL3316885T3 (pl) 2015-07-01 2021-12-06 Immunomedics, Inc. Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a
US20250073349A1 (en) 2021-05-10 2025-03-06 Kawasaki Institute Of Industrial Promotion Antibody having reduced binding affinity for antigen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0652014A1 (en) * 1993-11-10 1995-05-10 National Institute Of Immunology Treatment of prostatic hypertrophy
WO1997029199A2 (en) * 1996-02-06 1997-08-14 Abbott Laboratories Prostate specific antigen peptides and uses thereof
WO1998010292A1 (en) * 1996-09-06 1998-03-12 Centocor, Inc. Monoclonal antibodies specific for prostate specific antigen and methods of detecting prostate specific antigen

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865689A (en) 1972-11-09 1975-02-11 Hoffmann La Roche Method of producing carcinoembryonic antigens
US4446122A (en) 1979-12-28 1984-05-01 Research Corporation Purified human prostate antigen
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US5053224A (en) 1983-11-07 1991-10-01 Hilary Koprowski Induction of antibody response to solid tumors with anti-idiotype antibodies
DE3650139T2 (de) 1985-07-05 1995-03-09 Hutchinson Fred Cancer Res Verfahren zum reduzieren der immunogenizität und zum induzieren immunologischer toleranz.
EP0234122A3 (en) 1986-02-21 1989-03-22 Oncogen Limited Partnership Tumor therapy with biologically active anti-tumor antibodies
AU613590B2 (en) 1986-11-19 1991-08-08 Bristol-Myers Squibb Company Hybridomas producing monoclonal antibodies to new mucin epitopes
US5059680A (en) 1986-11-24 1991-10-22 Centocor, Inc. Method of isolating ca 125 antigen
US5683674A (en) 1987-01-07 1997-11-04 Imperial Cancer Research Technology Ltd. Antibody against human mucin core protein and method of preparing and using same
US4859449A (en) 1987-09-14 1989-08-22 Center For Molecular Medicine And Immunology Modified antibodies for enhanced hepatocyte clearance
GB8728856D0 (en) 1987-12-10 1988-01-27 Bradwell A R Tumour-locating agents & method of locating tumours
EP0491867B1 (en) 1989-09-15 1996-11-27 Genetic Systems Corporation Hybridoma ct43 producing a monoclonal antibody to a mucin epitope of colorectal cancer
US5165922A (en) 1990-05-22 1992-11-24 Bristol-Myers Squibb Company Synergistic tumor therapy with combinations of biologically active anti-tumor antibodies and chemotherapy
DE4133791A1 (de) 1991-10-11 1993-04-15 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte antigene, verfahren zu ihrer herstellung und ihre verwendung
US5773292A (en) 1995-06-05 1998-06-30 Cornell University Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood
GB9606228D0 (en) 1996-03-25 1996-05-29 Secr Defence Apparatus for matrix coating fibres with metal vapour
US6881405B2 (en) * 1998-06-15 2005-04-19 Altarex Medical Corp. Reagents and methods for inducing an immune response to prostate specific antigen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0652014A1 (en) * 1993-11-10 1995-05-10 National Institute Of Immunology Treatment of prostatic hypertrophy
WO1997029199A2 (en) * 1996-02-06 1997-08-14 Abbott Laboratories Prostate specific antigen peptides and uses thereof
WO1998010292A1 (en) * 1996-09-06 1998-03-12 Centocor, Inc. Monoclonal antibodies specific for prostate specific antigen and methods of detecting prostate specific antigen

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CORREALE P ET AL: "In vitro generation of human cytotoxic T lymphocytes specific for peptides derived from prostate-specific antigen.", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 89, no. 4, 19 February 1997 (1997-02-19), pages 293 - 300, XP002039189 *
LEVEUGLE B ET AL: "PSA-directed immunotherapy of prostate cancer.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 39, March 1998 (1998-03-01), pages 355, XP002117652 *
UEMURA H ET AL: "Generation of anti-idiotype antibodies related to PSA: posible tools for treatment of prostate cancer.", JOURNAL OF UROLOGY, vol. 153, no. SUPPL 4, 1995, pages 380A, XP002117650 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000041722A1 (de) * 1999-01-13 2000-07-20 Igeneon Krebs-Immuntherapie Forschungs- Und Entwicklungs-Ag Verwendung von antikörpern zur vakzinierung gegen krebs
EP1230932A3 (de) * 1999-01-13 2003-11-26 Igeneon Krebs-Immuntherapie Forschungs- und Entwicklungs-AG Verwendung von Antikörpern zur Vakzinierung gegen Krebs
US7691372B2 (en) 1999-01-13 2010-04-06 Igeneon Krebs-Immuntherapie Forschungs-und Entwickungs-AG Use of antibodies for the vaccination against cancer
US8444974B2 (en) 1999-01-13 2013-05-21 Igeneon Krebs-Immuntherapie Forschungs-Und Entwicklungs-Ag Use of antibodies for the vaccination against cancer
WO2001085204A3 (en) * 2000-05-11 2002-08-22 Altarex Inc Therapeutic method and composition utilizing antigen-antibody complexation and presentation by dendritic cells
WO2001085203A3 (en) * 2000-05-11 2002-08-22 Altarex Inc Therapeutic method and composition utilizing antigen-antibody complexation and presentation by dendritic cells
US6689355B2 (en) 2000-05-11 2004-02-10 Altarex Corp. Therapeutic method and composition utilizing antigen-antibody complexation and presentation by dendritic cells
EP2331130A4 (en) * 2008-04-09 2012-11-07 Advanced Immune Therapeutics Inc IGE ANTIBODIES FOR THE TREATMENT OF CANCER
US8697079B2 (en) 2008-04-09 2014-04-15 Quest Pharma Tech Inc. IgE antibodies for the treatment of cancer

Also Published As

Publication number Publication date
US20020136715A1 (en) 2002-09-26
ATE480566T1 (de) 2010-09-15
CA2328504A1 (en) 1999-12-23
US6881405B2 (en) 2005-04-19
AU768002B2 (en) 2003-11-27
IL139700A (en) 2005-09-25
EP1085905A1 (en) 2001-03-28
JP2002518347A (ja) 2002-06-25
US7579445B2 (en) 2009-08-25
US20090220493A1 (en) 2009-09-03
DE69942742D1 (de) 2010-10-21
AU4159499A (en) 2000-01-05
IL139700A0 (en) 2002-02-10
EP1085905B1 (en) 2010-09-08
US20050202018A1 (en) 2005-09-15

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