WO1999065491A1 - Method of treatment - Google Patents
Method of treatment Download PDFInfo
- Publication number
- WO1999065491A1 WO1999065491A1 PCT/US1999/013623 US9913623W WO9965491A1 WO 1999065491 A1 WO1999065491 A1 WO 1999065491A1 US 9913623 W US9913623 W US 9913623W WO 9965491 A1 WO9965491 A1 WO 9965491A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- paroxetine
- core
- deposit
- use according
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to a method for promoting smoking cessation or reduction or preventing relapse smoking, and especially to the use of paroxetine in such treatment.
- paroxetine the (-) trans isomer of 4-(4 - fluorophenyl)-3-(3',4'-methylene-dioxyphenoxymethyl)-piperidine (see Example 2 of US-A-4007196).
- This compound is a Selective Serotonin Reuptake Inhibitor (SSRI).
- SSRI Selective Serotonin Reuptake Inhibitor
- the hydrochloride salt of paroxetine is approved for human use in therapy to treat inter alia depression, obsessive compulsive disorder (OCD) and panic.
- paroxetine hydrochloride is supplied as a crystalline hemihydrate (see EP-A-0223403 of Beecham Group).
- Various crystalline anhydrate forms are also known (see WO96/24595 of SmithKline Beecham pic).
- SSRI compounds such as fluoxetine and sertraline have been proposed for use in treating chemical dependency (see US 5130338) including nicotine withdrawal symptons (see US 4940585 and US 4999382).
- fluoxetine had favourable influences on factors associated with smoking cessation such as weight gain and alcohol consumption, it did not enhance smoking cessation rates (see Mizes et al, Psychopharmacol.Bull. 32, No.3, 491, 1996; Sullivan et al, J.Clin.Pharmacol. 29, No.9, 850, 1989).
- paroxetine has potential therapeutic utility as a medicament for promoting smoking cessation or reduction or preventing relapse smoking.
- the present invention provides a method for promoting smoking cessation or reduction or preventing relapse smoking, which method comprises administering an effective, non-toxic amount of paroxetine or a pharmaceutically acceptable salt or solvate there of, to human in need thereof.
- the present invention also provides the use of paroxetine or a pharmaceutically acceptable salt or solvate thereof in the manufacture of a medicament for use in promoting smoking cessation or reduction or preventing relapse smoking.
- Paroxetine used in the present invention is suitably in the form of the free base or a pharmaceutically acceptable salt thereof.
- a preferred pharmaceutically acceptable salt of paroxetine is crystalline hydrochloride.
- Suitable procedures for preparing paroxetine hydrochloride include those mentioned in US Patents 4009196, 4721723, 4902801, 4861893 and 5039803 and PCT/GB93/00721.
- Especially preferred is the hemi-hydrate, prepared as EP-A-0223403.
- a medicament, for use in promoting smoking cessation or reduction or preventing relapse smoking may be prepared by admixture of paroxetine or a pharmaceutically acceptable salt or solvate thereof with an appropriate carrier, which may contain a diluent, binder, filler, disintegrant, flavouring agent, colouring agent, lubricant or preservative in conventional manner.
- the medicament is in unit dosage form and in a form adapted for use in the medical or veterinarial fields.
- preparations may be in a pack form accompanied by written or printed instructions for use in promoting smoking cessation or reduction or preventing relapse smoking.
- the suitable dosage range for paroxetine or a pharmaceutically acceptable salt or solvate depends on the severity of the smoking disorders and on the condition of the patient. It will also depend, inter alia, upon the relation of potency to absorbability and the frequency and route of administration.
- Paroxetine or a pharmaceutically acceptable salt or solvate thereof may be formulated for administration by any route, and examples are oral, sub-lingual, rectal, topical, trans-dermal, parenteral, intravenous or intramuscular administration. Preparations may, if desired, be designed to give slow release of the paroxetine or a pharmaceutically acceptable salt or solvate thereof.
- the medicaments may additionally contain other active ingredients useful in methods of promoting smoking cessation or reduction or preventing relapse smoking, such as nicotine or a pharmaceutically acceptable derivative thereof.
- the medicaments may, for example, be in the form of tablets, capsules, sachets, vials, powders, granules, lozenges, reconstitutable powders, or liquid preparations, for example solutions or suspensions, or suppositories.
- the medicaments may contain conventional excipients such as binding agents, for example syrup, acacia, gelatin, sorbitol, tragacanth, or polyvinylpyrrolidone; fillers, for example lactose, sugar, maize-starch, calcium phosphate, sorbitol or glycerine; tabletting lubricants, for example magnesium stearate; disintegrants, for example starch, polyvinylpyrrolidone, sodium starch glycollate or microcrystalline cellulose; or pharmaceutically acceptable setting agents such as sodium lauryl sulphate.
- binding agents for example syrup, acacia, gelatin, sorbitol, tragacanth, or polyvinylpyrrolidone
- fillers for example lactose, sugar, maize-starch, calcium phosphate, sorbitol or glycerine
- tabletting lubricants for example magnesium stearate
- disintegrants for example starch, polyvinylpyrrolidon
- Solid medicaments may be obtained by conventional methods of blending, filling, tabletting or the like. Repeated blending operations may be used to distribute paroxetine or a salt or solvate thereof throughout those medicaments employing large quantities of fillers.
- any carrier suitable for formulating solid pharmaceutical compositions may be used, examples being magnesium stearate, starch, glucose, lactose, sucrose, rice flour and chalk. Tablets may be coated according to methods well known in normal pharmaceutical practice, in particular with an enteric coating.
- the medicament may also be in the form of an ingestible capsule, for example of gelatin containing paroxetine or a salt thereof if desired with a carrier or other excipients.
- Medicaments for oral administration as liquids may be in the form of, for example, emulsions, syrups, or elixirs, or may be presented as a dry product for reconstitution with water or other suitable vehicle before use.
- Such liquid medicaments may contain conventional additives such as suspending agents, for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethylcellulose, carboxymethylcellulose, aluminium stearate gel, hydrogenated edible fats; emulsifying agents, for example lecithin, sorbitan monooleate, or acacia; aqueous or non-aqueous vehicles, which include edible oils, for example almond oil, fractionated coconut oil, oily esters, for example esters of glycerine, or propylene glycol, or ethyl alcohol, glycerine, water or normal saline; preservatives, for example methyl or propyl p-hydroxybenzoate or sorbic acid; and if desired conventional flavouring
- Paroxetine or a pharmaceutically acceptable salt or solvate thereof may also be administered by a non-oral route.
- the medicaments may be formulated, for example for rectal administration as a suppository. They may also be formulated for presentation in an injectable form in an aqueous or non-aqueous solution, suspension or emulsion in a pharmaceutically acceptable liquid, e.g. sterile pyrogen-free water or a parenterally acceptable oil or a mixture of liquids.
- the liquid may contain bacteriostatic agents, anti-oxidants or other preservatives, buffers or solutes to render the solution isotonic with the blood, thickening agents, suspending agents or other pharmaceutically acceptable additives.
- Such forms will be presented in unit dose form such as ampoules or disposable injection devices or in multi-dose forms such as a bottle from which the appropriate dose may be withdrawn or a solid form or concentrate which can be used to prepare an injectable formulation.
- the effective dose of the paroxetine or pharmaceutically acceptable salt or solvate depends on the severity of the smoking disorders to be treated, the condition of the patient and on the frequency and route of administration.
- a unit dose will generally contain from 2 to 1000 mg and preferably will contain from 30 to 500 mg, in particular 20, 50, 100, 150, 200, 250, 300, 350, 400, 450, or 500 mg.
- the composition may be administered once or more times a day, for example 2, 3 or 4 times daily, and the total daily dose for a 70 kg adult will normally be in the range 100 to 3000 mg.
- the unit dose will contain from 2 to 20 mg of paroxetine (calculated as free base) and be administered in multiples, if desired, to give the preceding daily dose.
- the present invention is practised using a controlled release or delayed release formulation containing paroxetine or a pharmaceutically acceptable salt thereof.
- controlled release any formulation technique wherein release of the active substance from the dosage from is modified to occur at a slower rater than that from an immediate release product, such as a conventional swallow tablet or capsule.
- delayed release any formulation technique wherein release of the active substance from the dosage form is modified to occur at a later time than that from a conventional immediate release product.
- the subsequent release of active substance from a delayed release formulation may also be controlled as defined above. Examples of controlled release formulations which are suitable for incorporating paroxetine are described in:
- delayed release formulations which are suitable for incorporating paroxetine are described in: Remington's Pharmaceutical Sciences 16th Edition, Mack Publishing
- Such controlled release formulations are preferably formulated in a manner such that release of active substance such as paroxetine is effected predominantly during the passage through the stomach and the small intestine, and delayed release formulations are preferably formulated such that release of active substance such as paroxetine is avoided in the stomach and is effected predominantly during passage through the small intestine
- Said formulations are preferably formulated such that the release of the active substance is predominantly /2 to 3 hours post ingestion.
- Preferred formulations are ultimately enteric coated tablets or caplets, wax or polymer coated tablets or caplets or time-release matrices, or combinations thereof.
- a particular aspect of the invention involves use of a polymeric controlled release composition
- a polymeric controlled release composition comprising a reaction complex formed by the interaction of (1) a calcium polycarbophil component which is a water-swellable, but water insoluble, fibrous cross-linked carboxy-functional polymer, said polymer containing (a) a plurality of repeating units of which at least about 80% contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5% cross-linking agent substantially free from polyalkenyl polyether, said percentages being based upon the weights of unpolymerised repeating unit and cross-linking agent, respectively, with (2) water, in the presence of paroxetine.
- the amount of calcium polycarbophil present is from about 0.1 to about 99% by weight, for example about 10%.
- the amount of active agent present is from about 0.0001 to about 65% by weight, for example between about 5 and 20%.
- the amount of water present is from about 5 to about 200% by weight, for example between about 5 and 10%.
- the interaction is carried out at a pH of between about 3 and about 10, for example about 6 to 7.
- the calcium polycarbophil is originally present in the form of a calcium salt containing from about 5 to about 25% calcium.
- a further particular aspect involves use of a system for the controlled release of paroxetine, comprising (a) a deposit-core comprising an effective amount of paroxetine and having defined geometric form, and (b) a support-platform applied to said deposit-core, wherein said deposit-core contains paroxetine, and at least one member selected from the group consisting of (1) a polymeric material which swells on contact with water or aqueous liquids and a gellable polymeric material wherein the ratio of the said swellable polymeric material to said gellable polymeric material is in the range 1 :9 to 9: 1, and (2) a single polymeric material having both swelling and gelling properties, and wherein the support-platform is an elastic support, applied to said deposit-core so that it partially covers the surface of the deposit-core and follows changes due to hydration of the deposit-core and is slowly soluble and/or slowly gellable in aqueous fluids.
- the support-platform may comprise polymers such as hydroxypropylmethylcellulose, plasticizers such as a glyceride, binders such as polyvinylpyrrolidone, hydrophilic agents such as lactose and silica, and/or hydrophobic agents such as magnesium stearate and glycerides.
- the polymer(s) typically make up 30 to 90% by weight of the support-platform, for example about 35 to 40%.
- Plasticizer may make up at least 2% by weight of the support-platform, for example about 15 to 20%.
- Binder(s), hydrophilic agent(s) and hydrophobic agent(s) typically total up to about 50% by weight of the support- platform, for example about 40 to 50%.
- the present invention further provides a pharmaceutical composition for use in promoting smoking cessation or reduction or preventing relapse smoking which comprises an effective amount of paroxetine or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier.
- a pharmaceutical composition for use in promoting smoking cessation or reduction or preventing relapse smoking which comprises an effective amount of paroxetine or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable carrier.
- Such compositions may be prepared in the manner as hereinbefore described.
- the paroxetine product of the present invention may optionally be coadministered with a nicotine-containing smoking cessation aid such as a patch, gum, or inhalator.
- Tablet Coating (apply approximately 6-10% of tablet core weight) %w/w Hydroxypropylmethylcellulose Phthalate 90.0
- Tablet Coating (apply approximately 6-10% of tablet core weight) %w/w Cellulose Acetate Phthalate 90.0 Diethyl Phthalate 10.0
- Tablet Coating (apply approximately 5-12% of tablet core weight) %w/w
- Example 12 Enteric coated controlled release bilayer tablet
- Paroxetine hydrochloride hemihydrate 228.8 g Dibasic calcium phosphate dihydrate 2441.2 g Hydroxypropylmethyl cellulose 2910 150.0 g Sodium starch glycollate 150.0 g
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Addiction (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/719,378 US6300343B1 (en) | 1998-06-16 | 1999-06-16 | Method of treatment |
IL13994399A IL139943A0 (en) | 1998-06-16 | 1999-06-16 | Method of treatment |
BR9911150-0A BR9911150A (pt) | 1998-06-16 | 1999-06-16 | Método de tratamento |
SK1919-2000A SK19192000A3 (sk) | 1998-06-16 | 1999-06-16 | Použitie paroxetínu alebo jeho farmaceuticky prijateľnej soli alebo solvátu na podporu odvykania od fajčenia alebo na zníženie alebo prevenciu relapsu fajčenia |
APAP/P/2000/002002A AP2000002002A0 (en) | 1998-06-16 | 1999-06-16 | Method of treatment. |
PL99345261A PL345261A1 (en) | 1998-06-16 | 1999-06-16 | Method of treatment |
CA002335236A CA2335236A1 (en) | 1998-06-16 | 1999-06-16 | Method of treatment |
EA200100041A EA003584B1 (ru) | 1998-06-16 | 1999-06-16 | Способ стимуляции отказа от курения или его снижения или предупреждения возобновления курения и применение пароксетина или его фармацевтически приемлемых солей или сольватов для получения лекарственного средства |
NZ508532A NZ508532A (en) | 1998-06-16 | 1999-06-16 | Method for promoting smoking cessation or reduction or preventing relapse smoking |
AU46885/99A AU740749B2 (en) | 1998-06-16 | 1999-06-16 | Method of treatment |
EP99930327A EP1087766A4 (en) | 1998-06-16 | 1999-06-16 | TREATMENT METHOD |
JP2000554371A JP2002518330A (ja) | 1998-06-16 | 1999-06-16 | 処置方法 |
KR1020007014240A KR20010052895A (ko) | 1998-06-16 | 1999-06-16 | 치료 방법 |
NO20006383A NO20006383L (no) | 1998-06-16 | 2000-12-14 | Fremgangsmåte for behandling |
BG105127A BG105127A (en) | 1998-06-16 | 2001-01-08 | Method for treament of nicotine addiction |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9812941.4 | 1998-06-16 | ||
GBGB9812941.4A GB9812941D0 (en) | 1998-06-16 | 1998-06-16 | Method of treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999065491A1 true WO1999065491A1 (en) | 1999-12-23 |
Family
ID=10833832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/013623 WO1999065491A1 (en) | 1998-06-16 | 1999-06-16 | Method of treatment |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1087766A4 (ru) |
JP (1) | JP2002518330A (ru) |
KR (1) | KR20010052895A (ru) |
CN (1) | CN1305379A (ru) |
AP (1) | AP2000002002A0 (ru) |
AU (1) | AU740749B2 (ru) |
BG (1) | BG105127A (ru) |
BR (1) | BR9911150A (ru) |
CA (1) | CA2335236A1 (ru) |
CZ (1) | CZ20004698A3 (ru) |
EA (1) | EA003584B1 (ru) |
GB (1) | GB9812941D0 (ru) |
HU (1) | HUP0102507A3 (ru) |
IL (1) | IL139943A0 (ru) |
NO (1) | NO20006383L (ru) |
NZ (1) | NZ508532A (ru) |
PL (1) | PL345261A1 (ru) |
SK (1) | SK19192000A3 (ru) |
WO (1) | WO1999065491A1 (ru) |
ZA (1) | ZA200007396B (ru) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6645523B2 (en) * | 2000-08-28 | 2003-11-11 | Synthon Bct Technologies, Llc | Paroxetine compositions and processes for making the same |
EP1465601A2 (en) * | 2001-12-28 | 2004-10-13 | Teva Pharmaceutical Industries Ltd. | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
WO2006023347A1 (en) * | 2004-08-20 | 2006-03-02 | Alpharma, Inc. | Paroxetine formulations |
FR2926221A1 (fr) * | 2008-01-14 | 2009-07-17 | Tassin Thomas | Compositions permettant la reproduction artificielle des conditions pharmacologiques de la dependance aux drogues addictives telles que opiaces, psychostimulants, tabac et alcool, par la combinaison de nicotine et d'un ligand. |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4721723A (en) * | 1985-10-25 | 1988-01-26 | Beecham Group P.L.C. | Anti-depressant crystalline paroxetine hydrochloride hemihydrate |
US5371092A (en) * | 1990-11-24 | 1994-12-06 | Beecham Group, P.L.C. | Use of paroxetine for the treatment of senile dementia, bulimia, migraine or anorexia |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK283608B6 (sk) * | 1995-02-06 | 2003-10-07 | Smithkline Beecham Plc | Bezvodý hydrochlorid paroxetínu, spôsob jeho výroby a použitie |
GB9605828D0 (en) * | 1996-03-20 | 1996-05-22 | Smithkline Beecham Plc | Treatment method |
-
1998
- 1998-06-16 GB GBGB9812941.4A patent/GB9812941D0/en not_active Ceased
-
1999
- 1999-06-16 CA CA002335236A patent/CA2335236A1/en not_active Abandoned
- 1999-06-16 SK SK1919-2000A patent/SK19192000A3/sk unknown
- 1999-06-16 NZ NZ508532A patent/NZ508532A/en unknown
- 1999-06-16 CZ CZ20004698A patent/CZ20004698A3/cs unknown
- 1999-06-16 PL PL99345261A patent/PL345261A1/xx not_active Application Discontinuation
- 1999-06-16 HU HU0102507A patent/HUP0102507A3/hu unknown
- 1999-06-16 CN CN99807465A patent/CN1305379A/zh active Pending
- 1999-06-16 EP EP99930327A patent/EP1087766A4/en not_active Withdrawn
- 1999-06-16 KR KR1020007014240A patent/KR20010052895A/ko not_active Application Discontinuation
- 1999-06-16 BR BR9911150-0A patent/BR9911150A/pt not_active Application Discontinuation
- 1999-06-16 JP JP2000554371A patent/JP2002518330A/ja not_active Withdrawn
- 1999-06-16 WO PCT/US1999/013623 patent/WO1999065491A1/en not_active Application Discontinuation
- 1999-06-16 EA EA200100041A patent/EA003584B1/ru not_active IP Right Cessation
- 1999-06-16 IL IL13994399A patent/IL139943A0/xx unknown
- 1999-06-16 AP APAP/P/2000/002002A patent/AP2000002002A0/en unknown
- 1999-06-16 AU AU46885/99A patent/AU740749B2/en not_active Ceased
-
2000
- 2000-12-12 ZA ZA200007396A patent/ZA200007396B/xx unknown
- 2000-12-14 NO NO20006383A patent/NO20006383L/no unknown
-
2001
- 2001-01-08 BG BG105127A patent/BG105127A/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4721723A (en) * | 1985-10-25 | 1988-01-26 | Beecham Group P.L.C. | Anti-depressant crystalline paroxetine hydrochloride hemihydrate |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6645523B2 (en) * | 2000-08-28 | 2003-11-11 | Synthon Bct Technologies, Llc | Paroxetine compositions and processes for making the same |
EP1465601A2 (en) * | 2001-12-28 | 2004-10-13 | Teva Pharmaceutical Industries Ltd. | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
EP1465601A4 (en) * | 2001-12-28 | 2006-02-15 | Teva Pharma | STABLE PHARMACEUTICAL FORMULATION OF PAROXETINE ANHYDROUS HYDROCHLORIDE AND PREPARATION METHOD |
US7396542B2 (en) | 2001-12-28 | 2008-07-08 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
WO2006023347A1 (en) * | 2004-08-20 | 2006-03-02 | Alpharma, Inc. | Paroxetine formulations |
FR2926221A1 (fr) * | 2008-01-14 | 2009-07-17 | Tassin Thomas | Compositions permettant la reproduction artificielle des conditions pharmacologiques de la dependance aux drogues addictives telles que opiaces, psychostimulants, tabac et alcool, par la combinaison de nicotine et d'un ligand. |
Also Published As
Publication number | Publication date |
---|---|
NO20006383D0 (no) | 2000-12-14 |
NZ508532A (en) | 2003-08-29 |
IL139943A0 (en) | 2002-02-10 |
BG105127A (en) | 2001-11-30 |
SK19192000A3 (sk) | 2001-05-10 |
JP2002518330A (ja) | 2002-06-25 |
EP1087766A1 (en) | 2001-04-04 |
BR9911150A (pt) | 2001-03-06 |
HUP0102507A3 (en) | 2003-12-29 |
AU4688599A (en) | 2000-01-05 |
NO20006383L (no) | 2000-12-14 |
CA2335236A1 (en) | 1999-12-23 |
AU740749B2 (en) | 2001-11-15 |
PL345261A1 (en) | 2001-12-03 |
HUP0102507A2 (hu) | 2002-05-29 |
GB9812941D0 (en) | 1998-08-12 |
CN1305379A (zh) | 2001-07-25 |
EP1087766A4 (en) | 2001-11-21 |
EA003584B1 (ru) | 2003-06-26 |
ZA200007396B (en) | 2002-02-27 |
EA200100041A1 (ru) | 2001-06-25 |
AP2000002002A0 (en) | 2000-12-31 |
CZ20004698A3 (cs) | 2002-02-13 |
KR20010052895A (ko) | 2001-06-25 |
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