WO1999063982A1 - Traitement des blessures par inhibition d'adenosine diphosphate-ribosyl transferase - Google Patents

Traitement des blessures par inhibition d'adenosine diphosphate-ribosyl transferase Download PDF

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Publication number
WO1999063982A1
WO1999063982A1 PCT/US1999/013264 US9913264W WO9963982A1 WO 1999063982 A1 WO1999063982 A1 WO 1999063982A1 US 9913264 W US9913264 W US 9913264W WO 9963982 A1 WO9963982 A1 WO 9963982A1
Authority
WO
WIPO (PCT)
Prior art keywords
vitamin
wound healing
vegf
adenosine diphosphate
inhibitor
Prior art date
Application number
PCT/US1999/013264
Other languages
English (en)
Inventor
Samuel J. Leibovich
Original Assignee
University Of Medicine & Dentistry Of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Medicine & Dentistry Of New Jersey filed Critical University Of Medicine & Dentistry Of New Jersey
Priority to JP2000553051A priority Critical patent/JP2002517436A/ja
Priority to AU44383/99A priority patent/AU4438399A/en
Priority to CA002329160A priority patent/CA2329160A1/fr
Priority to EP99927490A priority patent/EP1085859A4/fr
Publication of WO1999063982A1 publication Critical patent/WO1999063982A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

L'invention concerne une méthode permettant de soigner une blessure chez un mammifère. Cette méthode consiste à utiliser une composition thérapeutique de régénération des blessures comprenant une quantité efficace du point de vue thérapeutique d'un inhibiteur de mono-adénosine diphosphate-ribosyl transférase, de manière à inhiber l'adénosine diphosphate-ribosylation du facteur de croissance de l'endothélium vasculaire. Cette méthode consiste également à mettre en contact la composition thérapeutique de régénération des blessures avec une blessure d'un mammifère. L'invention concerne également des compositions de régénération des blessures ainsi que des méthodes de préparation et d'utilisation de ces compositions et des produits pharmaceutiques dans lesquels ces compositions peuvent être utilisées. L'invention concerne en outre des compositions thérapeutiques de régénération des blessures cutanées utiles pour traiter et atténuer les effets de l'érythème fessier du nourrisson ainsi que des méthodes de préparation et d'utilisation de ces compositions.
PCT/US1999/013264 1998-06-11 1999-06-11 Traitement des blessures par inhibition d'adenosine diphosphate-ribosyl transferase WO1999063982A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000553051A JP2002517436A (ja) 1998-06-11 1999-06-11 アデノシン二リン酸リボシルトランスフェラーゼの阻害を介する創傷処置
AU44383/99A AU4438399A (en) 1998-06-11 1999-06-11 Wound treatment through inhibition of adenosine diphosphate ribosyl transferase
CA002329160A CA2329160A1 (fr) 1998-06-11 1999-06-11 Traitement des blessures par inhibition d'adenosine diphosphate-ribosyl transferase
EP99927490A EP1085859A4 (fr) 1998-06-11 1999-06-11 Traitement des blessures par inhibition d'adenosine diphosphate-ribosyl transferase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8892498P 1998-06-11 1998-06-11
US60/088,924 1998-06-11

Publications (1)

Publication Number Publication Date
WO1999063982A1 true WO1999063982A1 (fr) 1999-12-16

Family

ID=22214311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/013264 WO1999063982A1 (fr) 1998-06-11 1999-06-11 Traitement des blessures par inhibition d'adenosine diphosphate-ribosyl transferase

Country Status (5)

Country Link
EP (1) EP1085859A4 (fr)
JP (1) JP2002517436A (fr)
AU (1) AU4438399A (fr)
CA (1) CA2329160A1 (fr)
WO (1) WO1999063982A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6538030B2 (en) * 2000-09-20 2003-03-25 Yih-Lin Chung Treating radiation fibrosis
US20030139353A1 (en) * 2000-02-28 2003-07-24 Jackson John K. Compositions and methods for the treatment of inflammatory diseases
WO2003103623A1 (fr) * 2002-06-10 2003-12-18 Beiersdorf Ag Formulations cosmetiques ou dermatologiques pour soigner la peau avant ou apres une exposition au soleil ou le rasage
FR2885802A1 (fr) * 2005-05-17 2006-11-24 Oreal Utilisation cosmetique de la vitamine k pour ameliorer la fonction barriere de la peau
US7893244B2 (en) 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
US7893243B2 (en) 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
US8283382B2 (en) 2005-04-15 2012-10-09 Albert Einstein College Of Medicine Of Yeshiva University Vitamin K for prevention and treatment of skin rash secondary to anti-EGFR therapy
EP2712613A1 (fr) * 2012-09-28 2014-04-02 Pharmadab d.o.o. Vitamine K1 et ses utilisations
US8815953B2 (en) 2008-03-13 2014-08-26 Spectrum Pharmaceuticals, Inc. Formulations of vitamin K analogs for topical use
TWI578994B (zh) * 2014-03-27 2017-04-21 中央研究院 燒燙傷口癒合組合物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105336B2 (en) * 2002-10-07 2006-09-12 Biogaia Ab Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029770A (en) * 1974-03-26 1977-06-14 Caw Industries, Inc. Method of therapeutically treating damaged and/or infected tissue and relieving stress and shock in warm blooded animals

Family Cites Families (8)

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FR2074627A1 (en) * 1970-01-13 1971-10-08 Socres Ppsoriasis treatment compsn
US4289757A (en) * 1978-02-28 1981-09-15 The Upjohn Company Method for treating inflammation
US5602183A (en) * 1991-03-01 1997-02-11 Warner-Lambert Company Dermatological wound healing compositions and methods for preparing and using same
IT1253431B (it) * 1991-12-02 1995-08-08 Valetudo S R L Preparati farmaceutici per uso topico destinati al trattamento della psoriasi e della dermatite atopica
IT1265340B1 (it) * 1993-07-14 1996-11-22 Istituto Biochimico Italiano Sostanze inibenti l'adp-ribosilazione proteica atte alla prevenzione delle complicanze del diabete mellito.
US5677349A (en) * 1995-04-27 1997-10-14 Gilad; Gad M. Agmatine for the treatment of neurotrauma and neurodegenerative diseases
AU2804297A (en) * 1996-04-22 1997-11-12 Advanced Polymer Systems Inc. Method of and composition for treating disorders of the skin using vitamin k
CN1133417C (zh) * 1996-04-23 2004-01-07 普罗克特和甘保尔公司 维生素b3化合物调节皮肤外观的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029770A (en) * 1974-03-26 1977-06-14 Caw Industries, Inc. Method of therapeutically treating damaged and/or infected tissue and relieving stress and shock in warm blooded animals

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1085859A4 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030139353A1 (en) * 2000-02-28 2003-07-24 Jackson John K. Compositions and methods for the treatment of inflammatory diseases
US8883856B2 (en) * 2000-02-28 2014-11-11 John Jackson Compositions and methods for the treatment of inflammatory diseases using topoisomerase inhibitors
US6538030B2 (en) * 2000-09-20 2003-03-25 Yih-Lin Chung Treating radiation fibrosis
WO2003103623A1 (fr) * 2002-06-10 2003-12-18 Beiersdorf Ag Formulations cosmetiques ou dermatologiques pour soigner la peau avant ou apres une exposition au soleil ou le rasage
US7893244B2 (en) 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
US7893243B2 (en) 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
US8283382B2 (en) 2005-04-15 2012-10-09 Albert Einstein College Of Medicine Of Yeshiva University Vitamin K for prevention and treatment of skin rash secondary to anti-EGFR therapy
FR2885802A1 (fr) * 2005-05-17 2006-11-24 Oreal Utilisation cosmetique de la vitamine k pour ameliorer la fonction barriere de la peau
US8815953B2 (en) 2008-03-13 2014-08-26 Spectrum Pharmaceuticals, Inc. Formulations of vitamin K analogs for topical use
EP2712613A1 (fr) * 2012-09-28 2014-04-02 Pharmadab d.o.o. Vitamine K1 et ses utilisations
TWI578994B (zh) * 2014-03-27 2017-04-21 中央研究院 燒燙傷口癒合組合物

Also Published As

Publication number Publication date
AU4438399A (en) 1999-12-30
CA2329160A1 (fr) 1999-12-16
JP2002517436A (ja) 2002-06-18
EP1085859A1 (fr) 2001-03-28
EP1085859A4 (fr) 2003-02-26

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