WO1999062520A1 - Inhibiteurs de vih integrase - Google Patents
Inhibiteurs de vih integrase Download PDFInfo
- Publication number
- WO1999062520A1 WO1999062520A1 PCT/US1999/012093 US9912093W WO9962520A1 WO 1999062520 A1 WO1999062520 A1 WO 1999062520A1 US 9912093 W US9912093 W US 9912093W WO 9962520 A1 WO9962520 A1 WO 9962520A1
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- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- phenyl
- substituted
- benzyl
- hydroxy
- Prior art date
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- 0 *c1cc(C2c3ccccc3CCC2)ccc1 Chemical compound *c1cc(C2c3ccccc3CCC2)ccc1 0.000 description 2
- JSRLURSZEMLAFO-UHFFFAOYSA-N Brc1cc(Br)ccc1 Chemical compound Brc1cc(Br)ccc1 JSRLURSZEMLAFO-UHFFFAOYSA-N 0.000 description 1
- WDEHEDLDICGIEG-UHFFFAOYSA-N CC(C)(C)OC(NCCCCCCOc1cc(C(CC(C(OC)=O)=O)=O)cc(OCc2ccccc2)c1)=O Chemical compound CC(C)(C)OC(NCCCCCCOc1cc(C(CC(C(OC)=O)=O)=O)cc(OCc2ccccc2)c1)=O WDEHEDLDICGIEG-UHFFFAOYSA-N 0.000 description 1
- MKNJWFYGHYWDER-UHFFFAOYSA-N CC(C)(C)OC(NCCCCCCOc1cc(OCc2ccccc2)cc(C(C)=O)c1)=O Chemical compound CC(C)(C)OC(NCCCCCCOc1cc(OCc2ccccc2)cc(C(C)=O)c1)=O MKNJWFYGHYWDER-UHFFFAOYSA-N 0.000 description 1
- PCEFZWSUUNLPTQ-UHFFFAOYSA-N CC(C)(C)OC(NCCCCCCOc1cc(OCc2ccccc2)cc(C(CC(C(O)=O)=O)=O)c1)=O Chemical compound CC(C)(C)OC(NCCCCCCOc1cc(OCc2ccccc2)cc(C(CC(C(O)=O)=O)=O)c1)=O PCEFZWSUUNLPTQ-UHFFFAOYSA-N 0.000 description 1
- FYMLPSAMLACNAE-UHFFFAOYSA-N CC(c1cc(Cc(nccc2)c2Cl)ccc1)=O Chemical compound CC(c1cc(Cc(nccc2)c2Cl)ccc1)=O FYMLPSAMLACNAE-UHFFFAOYSA-N 0.000 description 1
- GNUZSAXGHHPKER-UHFFFAOYSA-N CC(c1cc(Cc2nccnc2)cc(Cc2ccccc2)c1)=O Chemical compound CC(c1cc(Cc2nccnc2)cc(Cc2ccccc2)c1)=O GNUZSAXGHHPKER-UHFFFAOYSA-N 0.000 description 1
- IFGYBELSTQHXNL-UHFFFAOYSA-N CCCC1N(CCOc2cc(C(CC(C(O)=O)=O)=O)cc(OCc3ccccc3)c2)CCOC1 Chemical compound CCCC1N(CCOc2cc(C(CC(C(O)=O)=O)=O)cc(OCc3ccccc3)c2)CCOC1 IFGYBELSTQHXNL-UHFFFAOYSA-N 0.000 description 1
- NHSMEDZXIYDNST-UHFFFAOYSA-N CCOC(C(CC(c(cc1)ccc1N(Cc1ccccc1)Cc1ccccc1)=O)=O)=O Chemical compound CCOC(C(CC(c(cc1)ccc1N(Cc1ccccc1)Cc1ccccc1)=O)=O)=O NHSMEDZXIYDNST-UHFFFAOYSA-N 0.000 description 1
- WYZDCUGWXKHESN-UHFFFAOYSA-N CN(Cc1ccccc1)Cc1ccccc1 Chemical compound CN(Cc1ccccc1)Cc1ccccc1 WYZDCUGWXKHESN-UHFFFAOYSA-N 0.000 description 1
- UCNZQWDFHXKCND-UHFFFAOYSA-N COc(cc1)c(Cc2ccccc2)cc1C(CC(C(O)=O)=O)=O Chemical compound COc(cc1)c(Cc2ccccc2)cc1C(CC(C(O)=O)=O)=O UCNZQWDFHXKCND-UHFFFAOYSA-N 0.000 description 1
- TWFAAHUKBXUHQH-UHFFFAOYSA-N OC(C(CC(c1cc(C(CCC2)c3c2cccc3)ccc1)=O)=O)=O Chemical compound OC(C(CC(c1cc(C(CCC2)c3c2cccc3)ccc1)=O)=O)=O TWFAAHUKBXUHQH-UHFFFAOYSA-N 0.000 description 1
- HKIPZTAZTLJESD-UHFFFAOYSA-N OC(C(CC(c1cc(Cc2ccccc2)ccc1)=O)=O)=O Chemical compound OC(C(CC(c1cc(Cc2ccccc2)ccc1)=O)=O)=O HKIPZTAZTLJESD-UHFFFAOYSA-N 0.000 description 1
- QKKRXCANHYDXCU-UHFFFAOYSA-N OC(C(CC(c1cc(OCc(cc2)ccc2F)ccc1)=O)=O)=O Chemical compound OC(C(CC(c1cc(OCc(cc2)ccc2F)ccc1)=O)=O)=O QKKRXCANHYDXCU-UHFFFAOYSA-N 0.000 description 1
- ICUJZFWFILKTGH-UHFFFAOYSA-N Oc(c(Br)cc(Cc1ccccc1)c1)c1Br Chemical compound Oc(c(Br)cc(Cc1ccccc1)c1)c1Br ICUJZFWFILKTGH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
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- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
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- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000551776A JP2002516863A (ja) | 1998-06-03 | 1999-06-01 | Hivインテグラーゼ阻害薬 |
CA002333707A CA2333707A1 (fr) | 1998-06-03 | 1999-06-01 | Inhibiteurs de vih integrase |
EP99926094A EP1082121A4 (fr) | 1998-06-03 | 1999-06-01 | Inhibiteurs de vih integrase |
AU42254/99A AU4225499A (en) | 1998-06-03 | 1999-06-01 | Hiv integrase inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8782098P | 1998-06-03 | 1998-06-03 | |
US60/087,820 | 1998-06-03 | ||
GBGB9815175.6A GB9815175D0 (en) | 1998-07-13 | 1998-07-13 | HIV integrase inhibitors |
GB9815175.6 | 1998-07-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999062520A1 true WO1999062520A1 (fr) | 1999-12-09 |
Family
ID=26314024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/012093 WO1999062520A1 (fr) | 1998-06-03 | 1999-06-01 | Inhibiteurs de vih integrase |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1082121A4 (fr) |
AU (1) | AU4225499A (fr) |
CA (1) | CA2333707A1 (fr) |
WO (1) | WO1999062520A1 (fr) |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000039086A1 (fr) * | 1998-12-25 | 2000-07-06 | Shionogi & Co., Ltd. | Composes heterocycliques aromatiques possedant des activites inhibitrices de l'integrase du vih |
WO2001096283A2 (fr) * | 2000-06-16 | 2001-12-20 | Bristol-Myers Squibb Company | Inhibiteurs d'integrase du vih |
US6333323B1 (en) | 1998-03-26 | 2001-12-25 | Shionogi & Co., Ltd. | Indole derivatives with antiviral activity |
WO2002090336A1 (fr) * | 2001-05-09 | 2002-11-14 | Bayer Cropscience Ag | Arylcetones substituees |
US6492423B1 (en) | 1998-07-27 | 2002-12-10 | Istituto Di Ricerche Di Biologia Molecolare Pangeletti Spa | Diketoacid-derivatives as inhibitors of polymerases |
WO2003016266A1 (fr) * | 2001-08-16 | 2003-02-27 | Japan Tobacco Inc. | Composes $g(b)-cetoamides et leur utilisation medicinale |
WO2003035076A1 (fr) * | 2001-10-26 | 2003-05-01 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Inhibiteurs de l'integrase du vih a base de dihydroxypyrimidine carboxamide |
EP1463741A2 (fr) * | 2001-12-07 | 2004-10-06 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Composes destines a traiter l'infection au vih et le sida |
US6858602B2 (en) | 2001-06-12 | 2005-02-22 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
WO2005087759A1 (fr) | 2004-03-10 | 2005-09-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Quinolin-4-ones utilises comme inhibiteurs de l'integrase retrovirale pour le traitement du vih, du sida et du syndrome apparente au sida (arc) |
US7169780B2 (en) | 2001-10-26 | 2007-01-30 | Istitute Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase |
US7253180B2 (en) | 2002-10-16 | 2007-08-07 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
US7323460B2 (en) | 2002-03-15 | 2008-01-29 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors |
WO2008010953A3 (fr) * | 2006-07-19 | 2008-05-08 | Univ Georgia Res Found | Dicétoacides de pyridinone : inhibiteurs de la réplication du vih dans une thérapie combinée |
US7462721B2 (en) | 2003-09-19 | 2008-12-09 | Gilead Sciences, Inc. | Aza-quinolinol phosphonate integrase inhibitor compounds |
EP2033952A1 (fr) | 2001-03-01 | 2009-03-11 | Shionogi&Co., Ltd. | Composés d'hétéroaryle contenant de l'azote exerçant un effet inhibiteur sur l'intégrase du VIH |
EP2045242A1 (fr) | 2002-08-13 | 2009-04-08 | Shionogi&Co., Ltd. | Composants hétérocycliques disposant d'une activité inhibitoire contre l'intégrase du HIV |
WO2009094190A2 (fr) | 2008-01-25 | 2009-07-30 | Chimerix, Inc. | Méthodes de traitement d’infections virales |
WO2010047774A2 (fr) * | 2008-10-20 | 2010-04-29 | The Texas A & M University System | Inhibiteurs de la mycobacterium tuberculosis malate synthase, procédés de marquage et utilisations de ceux-ci |
US20110184028A1 (en) * | 2010-01-22 | 2011-07-28 | Brent Richard Stranix | Derivatives of pyridoxine for inhibiting hiv integrase |
US8008287B2 (en) | 2006-05-16 | 2011-08-30 | Gilead Sciences, Inc. | Integrase inhibitors |
EP2522670A1 (fr) | 2004-04-07 | 2012-11-14 | Takeda Pharmaceutical Company Limited | Antagonistes hétérocycliques des récépteurs du CRF |
CN103420894A (zh) * | 2012-05-22 | 2013-12-04 | 中国科学院上海药物研究所 | 丁-2-烯-1,4-二酮类化合物及其制备方法和用途 |
US8703801B2 (en) | 2009-12-07 | 2014-04-22 | University Of Georgia Research Foundation, Inc. | Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications |
EP3042894A1 (fr) | 2001-08-10 | 2016-07-13 | Shionogi & Co., Ltd. | Agent antiviral |
CN106905244A (zh) * | 2017-02-27 | 2017-06-30 | 武汉工程大学 | 二芳基嘧啶‑二酮酸类杂合型hiv‑1抑制剂及其制备方法 |
EP3216789A1 (fr) | 2010-02-12 | 2017-09-13 | Chimerix, Inc. | Procédés de traitement d'une infection virale |
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1999
- 1999-06-01 EP EP99926094A patent/EP1082121A4/fr not_active Withdrawn
- 1999-06-01 AU AU42254/99A patent/AU4225499A/en not_active Abandoned
- 1999-06-01 CA CA002333707A patent/CA2333707A1/fr not_active Abandoned
- 1999-06-01 WO PCT/US1999/012093 patent/WO1999062520A1/fr not_active Application Discontinuation
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US4336397A (en) * | 1980-12-29 | 1982-06-22 | Merck & Co., Inc. | 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis |
US4423063A (en) * | 1980-12-29 | 1983-12-27 | Merck & Co., Inc. | 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis |
EP0418845A1 (fr) * | 1989-09-22 | 1991-03-27 | Fujisawa Pharmaceutical Co., Ltd. | Dérivés de pyrazole, leur procédé de préparation et composition pharmaceutique les contenant |
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Cited By (64)
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---|---|---|---|---|
US6333323B1 (en) | 1998-03-26 | 2001-12-25 | Shionogi & Co., Ltd. | Indole derivatives with antiviral activity |
US6716605B2 (en) | 1998-03-26 | 2004-04-06 | Shionogi & Co., Ltd. | Indole derivatives having an antiviral activity |
US6506787B2 (en) | 1998-03-26 | 2003-01-14 | Shionogi & Co., Ltd. | Indole derivatives having an antiviral activity |
US6492423B1 (en) | 1998-07-27 | 2002-12-10 | Istituto Di Ricerche Di Biologia Molecolare Pangeletti Spa | Diketoacid-derivatives as inhibitors of polymerases |
US6620841B1 (en) | 1998-12-25 | 2003-09-16 | Shionogi & Co., Ltd. | Aromatic heterocycle compounds having HIV integrase inhibiting activities |
WO2000039086A1 (fr) * | 1998-12-25 | 2000-07-06 | Shionogi & Co., Ltd. | Composes heterocycliques aromatiques possedant des activites inhibitrices de l'integrase du vih |
US7098201B2 (en) | 1998-12-25 | 2006-08-29 | Shionogi & Co., Ltd. | Heteroaromatic derivatives having an inhibitory activity against HIV integrase |
US6645956B1 (en) | 1998-12-25 | 2003-11-11 | Shionogi & Co., Ltd. | Heteroaromatic derivatives having an inhibitory activity against HIV integrase |
WO2001096283A3 (fr) * | 2000-06-16 | 2002-05-02 | Bristol Myers Squibb Co | Inhibiteurs d'integrase du vih |
WO2001098248A3 (fr) * | 2000-06-16 | 2003-07-10 | Bristol Myers Squibb Co | Inhibiteurs d'integrase du vih |
WO2001098248A2 (fr) * | 2000-06-16 | 2001-12-27 | Bristol-Myers Squibb Company | Inhibiteurs d'integrase du vih |
WO2001096283A2 (fr) * | 2000-06-16 | 2001-12-20 | Bristol-Myers Squibb Company | Inhibiteurs d'integrase du vih |
EP2033952A1 (fr) | 2001-03-01 | 2009-03-11 | Shionogi&Co., Ltd. | Composés d'hétéroaryle contenant de l'azote exerçant un effet inhibiteur sur l'intégrase du VIH |
US7456133B2 (en) | 2001-05-09 | 2008-11-25 | Bayer Cropscience Ag | Substituted arylketones |
WO2002090336A1 (fr) * | 2001-05-09 | 2002-11-14 | Bayer Cropscience Ag | Arylcetones substituees |
US7112554B2 (en) | 2001-05-09 | 2006-09-26 | Bayer Cropscience Ag | Substituted arylketones |
US7012071B2 (en) * | 2001-06-12 | 2006-03-14 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US7101910B2 (en) | 2001-06-12 | 2006-09-05 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US6946491B2 (en) | 2001-06-12 | 2005-09-20 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US7329782B2 (en) | 2001-06-12 | 2008-02-12 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US7863475B2 (en) | 2001-06-12 | 2011-01-04 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US7041659B2 (en) | 2001-06-12 | 2006-05-09 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US7045541B2 (en) | 2001-06-12 | 2006-05-16 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US7547802B2 (en) | 2001-06-12 | 2009-06-16 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US6916848B2 (en) | 2001-06-12 | 2005-07-12 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US8604083B2 (en) | 2001-06-12 | 2013-12-10 | Wellstat Therapeutics Corporation | Method for the treatment of metabolic disorders |
US6858602B2 (en) | 2001-06-12 | 2005-02-22 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US8487000B2 (en) | 2001-06-12 | 2013-07-16 | Wellstat Therapertics Corporation | Compound for the treatment of metabolic disorders |
US6924314B2 (en) | 2001-06-12 | 2005-08-02 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US8552062B2 (en) | 2001-06-12 | 2013-10-08 | Wellstat Therapeutics Corporation | Methods for the treatment of metabolic disorders such as diabetes |
EP3042894A1 (fr) | 2001-08-10 | 2016-07-13 | Shionogi & Co., Ltd. | Agent antiviral |
US9572813B2 (en) | 2001-08-10 | 2017-02-21 | Shionogi & Co., Ltd. | Antiviral agent |
WO2003016266A1 (fr) * | 2001-08-16 | 2003-02-27 | Japan Tobacco Inc. | Composes $g(b)-cetoamides et leur utilisation medicinale |
WO2003035076A1 (fr) * | 2001-10-26 | 2003-05-01 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Inhibiteurs de l'integrase du vih a base de dihydroxypyrimidine carboxamide |
US7435734B2 (en) | 2001-10-26 | 2008-10-14 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase |
US7459452B2 (en) | 2001-10-26 | 2008-12-02 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase |
US7232819B2 (en) | 2001-10-26 | 2007-06-19 | Istituto Di Ricerche Di Biologia P. Angeletti S.P.A. | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase |
US7217713B2 (en) | 2001-10-26 | 2007-05-15 | Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase |
US7169780B2 (en) | 2001-10-26 | 2007-01-30 | Istitute Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase |
US7820660B2 (en) | 2001-10-26 | 2010-10-26 | Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase |
EP1463741A2 (fr) * | 2001-12-07 | 2004-10-06 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Composes destines a traiter l'infection au vih et le sida |
EP1463741A4 (fr) * | 2001-12-07 | 2006-07-05 | Us Gov Health & Human Serv | Composes destines a traiter l'infection au vih et le sida |
US7323460B2 (en) | 2002-03-15 | 2008-01-29 | Merck & Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors |
EP2045242A1 (fr) | 2002-08-13 | 2009-04-08 | Shionogi&Co., Ltd. | Composants hétérocycliques disposant d'une activité inhibitoire contre l'intégrase du HIV |
US7253180B2 (en) | 2002-10-16 | 2007-08-07 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
US7462721B2 (en) | 2003-09-19 | 2008-12-09 | Gilead Sciences, Inc. | Aza-quinolinol phosphonate integrase inhibitor compounds |
US7776883B2 (en) | 2004-03-10 | 2010-08-17 | The United States Of America As Represented By The Department Of Health And Human Services | Quinolin-4-ones as inhibitors of retroviral integrase for the treatment of HIV, AIDS and AIDS related complex (ARC) |
WO2005087759A1 (fr) | 2004-03-10 | 2005-09-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Quinolin-4-ones utilises comme inhibiteurs de l'integrase retrovirale pour le traitement du vih, du sida et du syndrome apparente au sida (arc) |
EP2522670A1 (fr) | 2004-04-07 | 2012-11-14 | Takeda Pharmaceutical Company Limited | Antagonistes hétérocycliques des récépteurs du CRF |
US8008287B2 (en) | 2006-05-16 | 2011-08-30 | Gilead Sciences, Inc. | Integrase inhibitors |
US7888375B2 (en) | 2006-07-19 | 2011-02-15 | The University Of Georgia Research Foundation, Inc | Pyridinone diketo acids: inhibitors of HIV replication |
WO2008010953A3 (fr) * | 2006-07-19 | 2008-05-08 | Univ Georgia Res Found | Dicétoacides de pyridinone : inhibiteurs de la réplication du vih dans une thérapie combinée |
EP3085377A1 (fr) | 2008-01-25 | 2016-10-26 | Chimerix, Inc. | Méthodes de traitement d'infections virales |
WO2009094190A2 (fr) | 2008-01-25 | 2009-07-30 | Chimerix, Inc. | Méthodes de traitement d’infections virales |
WO2010047774A2 (fr) * | 2008-10-20 | 2010-04-29 | The Texas A & M University System | Inhibiteurs de la mycobacterium tuberculosis malate synthase, procédés de marquage et utilisations de ceux-ci |
WO2010047774A3 (fr) * | 2008-10-20 | 2010-08-19 | The Texas A & M University System | Inhibiteurs de la mycobacterium tuberculosis malate synthase, procédés de marquage et utilisations de ceux-ci |
US8664255B2 (en) | 2008-10-20 | 2014-03-04 | The Texas A&M University System | Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof |
US8703801B2 (en) | 2009-12-07 | 2014-04-22 | University Of Georgia Research Foundation, Inc. | Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications |
US8664248B2 (en) | 2010-01-22 | 2014-03-04 | Taimed Biologics, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
US8283366B2 (en) * | 2010-01-22 | 2012-10-09 | Ambrilia Biopharma, Inc. | Derivatives of pyridoxine for inhibiting HIV integrase |
US20110184028A1 (en) * | 2010-01-22 | 2011-07-28 | Brent Richard Stranix | Derivatives of pyridoxine for inhibiting hiv integrase |
EP3216789A1 (fr) | 2010-02-12 | 2017-09-13 | Chimerix, Inc. | Procédés de traitement d'une infection virale |
CN103420894A (zh) * | 2012-05-22 | 2013-12-04 | 中国科学院上海药物研究所 | 丁-2-烯-1,4-二酮类化合物及其制备方法和用途 |
CN106905244A (zh) * | 2017-02-27 | 2017-06-30 | 武汉工程大学 | 二芳基嘧啶‑二酮酸类杂合型hiv‑1抑制剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1082121A4 (fr) | 2003-02-05 |
AU4225499A (en) | 1999-12-20 |
CA2333707A1 (fr) | 1999-12-09 |
EP1082121A1 (fr) | 2001-03-14 |
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JPH05148251A (ja) | 新規なチアゾール誘導体 |
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