WO1999061599A3 - Synthase de polyketide narbonolide de recombinaison - Google Patents

Synthase de polyketide narbonolide de recombinaison Download PDF

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Publication number
WO1999061599A3
WO1999061599A3 PCT/US1999/011814 US9911814W WO9961599A3 WO 1999061599 A3 WO1999061599 A3 WO 1999061599A3 US 9911814 W US9911814 W US 9911814W WO 9961599 A3 WO9961599 A3 WO 9961599A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyketide synthase
narbonolide
recombinant
recombinant narbonolide
compounds
Prior art date
Application number
PCT/US1999/011814
Other languages
English (en)
Other versions
WO1999061599A2 (fr
Inventor
Gary Ashley
Melanie C Betlach
Mary Betlach
Robert Mcdaniel
Li Tang
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/141,908 external-priority patent/US6503741B1/en
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Priority to CA002328427A priority Critical patent/CA2328427A1/fr
Priority to NZ509006A priority patent/NZ509006A/en
Priority to EP99925954A priority patent/EP1082439A2/fr
Priority to JP2000550984A priority patent/JP2002516090A/ja
Priority to AU42137/99A priority patent/AU762399C/en
Publication of WO1999061599A2 publication Critical patent/WO1999061599A2/fr
Publication of WO1999061599A3 publication Critical patent/WO1999061599A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

L'invention porte sur des composés d'ADN de recombinaison qui codent tout ou partie de la synthase de polyketide narbonolide et qui sont utilisés pour exprimer des gènes de la synthase de polyketides de recombinaison dans des cellules hôtes pour la production de narbonolide et de dérivés de narbonolide, et de polyketides qui sont utiles comme antibiotiques et comme intermédiaires dans la synthèse de composés ayant une valeur pharmaceutique.
PCT/US1999/011814 1998-05-28 1999-05-27 Synthase de polyketide narbonolide de recombinaison WO1999061599A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002328427A CA2328427A1 (fr) 1998-05-28 1999-05-27 Synthase de polyketide narbonolide de recombinaison
NZ509006A NZ509006A (en) 1998-05-28 1999-05-27 Recombinant narbonolide polyketide synthase
EP99925954A EP1082439A2 (fr) 1998-05-28 1999-05-27 Synthase de polyketide narbonolide de recombinaison
JP2000550984A JP2002516090A (ja) 1998-05-28 1999-05-27 組換えナルボノライドポリケチドシンターゼ
AU42137/99A AU762399C (en) 1998-05-28 1999-05-27 Recombinant narbonolide polyketide synthase

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US8708098P 1998-05-28 1998-05-28
US09/141,908 US6503741B1 (en) 1998-05-28 1998-08-28 Polyketide synthase genes from Streptomyces venezuelae
US10088098P 1998-09-22 1998-09-22
US11913999P 1999-02-08 1999-02-08
US60/100,880 1999-02-08
US09/141,908 1999-02-08
US60/119,139 1999-02-08
US60/087,080 1999-02-08

Publications (2)

Publication Number Publication Date
WO1999061599A2 WO1999061599A2 (fr) 1999-12-02
WO1999061599A3 true WO1999061599A3 (fr) 2000-01-27

Family

ID=27492096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/011814 WO1999061599A2 (fr) 1998-05-28 1999-05-27 Synthase de polyketide narbonolide de recombinaison

Country Status (6)

Country Link
EP (1) EP1082439A2 (fr)
JP (1) JP2002516090A (fr)
AU (1) AU762399C (fr)
CA (1) CA2328427A1 (fr)
NZ (1) NZ509006A (fr)
WO (1) WO1999061599A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
EP1754700A3 (fr) 1999-01-27 2007-05-09 Kosan Biosciences, Inc. synthese de polycetides
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
JP2005529579A (ja) 2000-05-02 2005-10-06 コーサン バイオサイエンシーズ， インコーポレイテッド ポリケチドの生合成のための過剰産生宿主
WO2002059322A2 (fr) * 2000-10-17 2002-08-01 Cubist Pharmaceuticlas, Inc. Compositions et methodes liees a la famille de genes biosynthetiques de la daptomycine
ES2337134T3 (es) 2002-03-12 2010-04-21 Bristol-Myers Squibb Company Derivados de c3-ciano-epotilona.
JP2014508516A (ja) 2011-01-28 2014-04-10 アミリス， インコーポレイテッド ゲルに封入されたマイクロコロニーのスクリーニング
MX2013013065A (es) 2011-05-13 2013-12-02 Amyris Inc Metodos y composiciones para detectar la produccion microbiana de compuestos inmiscibles em agua.
CN104540949B (zh) 2012-08-07 2018-05-29 阿迈瑞斯公司 用于稳定乙酰-辅酶a衍生化合物生成的方法
KR102159691B1 (ko) 2013-03-15 2020-09-24 아미리스 인코퍼레이티드 아세틸-코엔자임 a 유래 화합물을 생산하기 위한 포스포케톨라제 및 포스포트랜스아세틸라제의 용도
EP3663392A1 (fr) 2013-08-07 2020-06-10 Amyris, Inc. Procédés pour stabiliser la production de composés dérivés de l'acétyl-coenzyme a
BR112017027970A2 (pt) 2015-06-25 2018-08-28 Amyris, Inc. degrons dependentes de maltose, promotores responsivos à maltose, construtos de estabilização, e seu uso na produção de compostos não catabólicos

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040968A1 (fr) * 1995-06-07 1996-12-19 The Leland Stanford Junior University Production de polyketides nouveaux par recombinaison
WO1998001546A2 (fr) * 1996-07-05 1998-01-15 Biotica Technology Limited Polyketides et leur synthese

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040968A1 (fr) * 1995-06-07 1996-12-19 The Leland Stanford Junior University Production de polyketides nouveaux par recombinaison
WO1998001546A2 (fr) * 1996-07-05 1998-01-15 Biotica Technology Limited Polyketides et leur synthese

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BROWN M J B ET AL: "A MUTANT GENERATED BY EXPRESSION OF AN ENGINEERED DEBS1 PROTEIN FROM THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE (PKS) IN STREPTOMYCES COELICOLOR PRODUCES THE TRIKETIDE AS A LACTONE, BUT THE MAJOR PRODUCT IS THE NOR-ANALOGUE DERIVED FROM ACETATE AS STARTER ACID", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS,GB,CHEMICAL SOCIETY. LETCHWORTH, no. 15, 1995, pages 1517-1518, XP002044729, ISSN: 0022-4936 *

Also Published As

Publication number Publication date
CA2328427A1 (fr) 1999-12-02
WO1999061599A2 (fr) 1999-12-02
AU4213799A (en) 1999-12-13
AU762399B2 (en) 2003-06-26
AU762399C (en) 2004-02-05
NZ509006A (en) 2003-09-26
EP1082439A2 (fr) 2001-03-14
JP2002516090A (ja) 2002-06-04

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