WO1999054448A2 - Human nucleic acid sequences, increased expression thereof in uterus myoma tissue - Google Patents

Human nucleic acid sequences, increased expression thereof in uterus myoma tissue Download PDF

Info

Publication number
WO1999054448A2
WO1999054448A2 PCT/DE1999/001178 DE9901178W WO9954448A2 WO 1999054448 A2 WO1999054448 A2 WO 1999054448A2 DE 9901178 W DE9901178 W DE 9901178W WO 9954448 A2 WO9954448 A2 WO 9954448A2
Authority
WO
WIPO (PCT)
Prior art keywords
seq
undef
nucleic acid
sequences
prostate
Prior art date
Application number
PCT/DE1999/001178
Other languages
German (de)
French (fr)
Other versions
WO1999054448A3 (en
Inventor
Thomas Specht
Bernd Hinzmann
Armin Schmitt
Christian Pilarsky
Edgar Dahl
André ROSENTHAL
Original Assignee
Metagen Gesellschaft Für Genomforschung Mbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metagen Gesellschaft Für Genomforschung Mbh filed Critical Metagen Gesellschaft Für Genomforschung Mbh
Priority to JP2000544780A priority Critical patent/JP2002512024A/en
Priority to EP99927686A priority patent/EP1080188A2/en
Publication of WO1999054448A2 publication Critical patent/WO1999054448A2/en
Publication of WO1999054448A3 publication Critical patent/WO1999054448A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to human nucleic acid sequences (mRNA, cDNA, genomic sequences) of uterus myoma tissue, coding for genetic products or parts thereof, in addition to the use thereof. The invention also relates to the polypeptides obtained according to said sequences and to the use thereof.

Description

Menschliche Nukleinsäuresequenzen aus Uterusmyomgewebe Human nucleic acid sequences from uterine fibroid tissue
Die Erfindung betrifft menschliche Nukleinsäuresequenzen aus Uterusmyomgewebe, die für Genprodukte oder Teile davon kodieren, deren funktionale Gene, die mindestens ein biologisch aktives Polypeptid kodieren und deren Verwendung. Die Erfindung betrifft weiterhin die über die Sequenzen erhältlichen Polypeptide und deren Verwendung. Eine der Hauptkrebstodesursachen bei Frauen ist das Uterusmyom, für dessen Bekämpfung neue Therapien notwendig sind. Bisher verwendete Therapien, wie z.B. Chemotherapie, Hormontherapie oder chirugische Entfernung des Tumorgewebes, führen häufig nicht zu einer vollständigen Heilung. Das Phänomen Krebs geht häufig einher mit der Über- oder Unterexpression gewisser Gene in den entarteten Zellen, wobei noch unklar ist, ob diese veränderten Expressionsraten Ursache oder Folge der malignen Transformation sind. Die Identifikation solcher Gene wäre ein wesentlicher Schritt für die Entwicklung neuer Therapien gegen Krebs. Der spontanen Entstehung von Krebs geht häufig eine Vielzahl von Mutationen voraus. Diese können verschiedenste Auswirkungen auf das Expressionsmuster in dem betroffenen Gewebe haben, wie z.B. Unter- oder Überexpression, aber auch Expression verkürzter Gene. Mehrere solcher Veränderungen durch solche Mutationskaskaden können schließlich zu bösartigen Entartungen führen. Die Komplexität solcher Zusammenhänge erschwert die experimentelle Herangehensweise sehr.The invention relates to human nucleic acid sequences from uterine fibroid tissue which code for gene products or parts thereof, their functional genes, which code for at least one biologically active polypeptide, and their use. The invention further relates to the polypeptides obtainable via the sequences and their use. One of the main causes of cancer death in women is the uterine fibroid, for which new therapies are necessary to combat it. Therapies used so far, such as Chemotherapy, hormone therapy or surgical removal of the tumor tissue often do not lead to complete healing. The phenomenon of cancer is often associated with the over- or under-expression of certain genes in the degenerate cells, although it is still unclear whether these altered expression rates are the cause or the consequence of the malignant transformation. The identification of such genes would be an essential step in the development of new therapies for cancer. The spontaneous development of cancer is often preceded by a large number of mutations. These can have various effects on the expression pattern in the affected tissue, e.g. Under- or overexpression, but also expression of shortened genes. Several such changes through such cascade mutations can eventually lead to malignant degeneration. The complexity of such relationships makes the experimental approach very difficult.
Für die Suche nach Kandidatengenen, d.h. Genen, die im Vergleich zum Tumorgewebe im normalen Gewebe stärker exprimiert werden, wird eine Datenbank verwendet, die aus sogenanten ESTs besteht. ESTs (Expressed Sequence Tags) sind Sequenzen von cDNAs, d.h. revers transkribierten mRNAs, den Molekülen also, die die Expression von Genen widerspiegeln. Die EST-Sequenzen werden für normale und entartete Gewebe ermittelt. Solche Datenbanken werden von verschiedenen Betreibern z.T. kommerziell angeboten. Die ESTs der LifeSeq- Datenbank, die hier verwendet wird, sind in der Regel zwischen 150 und 350 Nukleotide lang. Sie repräsentieren ein für ein bestimmtes Gen unverkennbares Muster, obwohl dieses Gen normalerweise sehr viel länger ist ( > 2000 Nukleotide). Durch Vergleich der Expressionsmuster von normalen und Tumorgewebe können ESTs identifiziert werden, die für die Tumorentstehung und -proliferation wichtig sind. Es besteht jedoch folgendes Problem: Da durch unterschiedliche Konstruktionen der cDNA-Bibliotheken die gefundenen EST-Sequenzen zu unterschiedlichen Regionen eines unbekannten Gens gehören können, ergäbe sich in einem solchen Fall ein völlig falsches Verhältnis des Vorkommens dieser ESTs in dem jeweiligen Gewebe. Dieses würde erst bemerkt werden, wenn das vollständige Gen bekannt ist und somit die ESTs dem gleichen Gen zugeordnet werden können. Es wurde nun gefunden, daß diese Fehlermöglichkeit verringert werden kann, wenn zuvor sämtliche ESTs aus dem jeweiligen Gewebstyp assembliert werden, bevor die Expressionsmuster miteinander verglichen werden. Es wurden also überlappende ESTs ein und desselben Gens zu längeren Sequenzen zusammengefaßt (s. Fig. 1 , Fig. 2a und Fig.3). Durch diese Verlängerung und damit Abdeckung eines wesentlich größeren Genbereichs in jeder der jeweiligen Banken sollte der oben beschriebene Fehler weitgehenst vermieden werden. Da es hierzu keine bestehenden Softwareprodukte gab, wurden Programme für das Assemblieren von genomischen Abschnitten verwendet, die abgewandelt eingesetzt und durch eigene Programme ergänzt wurden. Ein Flowchart der Assemblierungsprozedur ist in Fig. 2b1 - 2b4 dargestellt. Es konnten nun die Nukleinsäure-Sequenzen Seq. ID No 1 bis Seq. ID No. 31 und Seq. ID 52 gefunden werden, die als Kandidatengene beim Uterusmyom eine Rolle spielen.A database consisting of so-called ESTs is used to search for candidate genes, ie genes that are more strongly expressed in normal tissue than tumor tissue. ESTs (Expressed Sequence Tags) are sequences of cDNAs, ie reverse-transcribed mRNAs, the molecules that reflect the expression of genes. The EST sequences are determined for normal and degenerate tissues. Various operators offer such databases commercially. The ESTs in the LifeSeq database used here are typically between 150 and 350 nucleotides long. They represent a pattern unmistakable for a specific gene, although this gene is usually much longer (> 2000 nucleotides). By comparing the expression patterns of normal and tumor tissue, ESTs can be identified that are important for tumor development and proliferation. However, there is the following problem: since, due to different constructions of the cDNA libraries, the EST sequences found can belong to different regions of an unknown gene, the result would be a completely wrong ratio of the occurrence of these ESTs in the respective tissue. This would only be noticed when the complete gene is known and the ESTs can thus be assigned to the same gene. It has now been found that this possibility of error can be reduced if all ESTs from the respective tissue type are assembled beforehand before the expression patterns are compared with one another. Overlapping ESTs of one and the same gene were thus combined into longer sequences (see FIG. 1, FIG. 2a and FIG. 3). By extending and thus covering a much larger gene range in each of the respective banks, the error described above should be avoided as far as possible. Since there were no existing software products for this purpose, programs for the assembly of genomic Sections used, which were used modified and supplemented by own programs. A flowchart of the assembly procedure is shown in Figures 2b1 - 2b4. The nucleic acid sequences Seq. ID No 1 to Seq. ID No. 31 and Seq. ID 52 can be found that play a role as candidate genes in uterine fibroids.
Von besonderem Interesse sind die Nukleinsäure-Sequenzen Seq. ID Nos. 14-18, 30, 31 , 52.The nucleic acid sequences Seq are of particular interest. ID Nos. 14-18, 30, 31, 52.
Die Erfindung betrifft somit Nukleinsäure-Sequenzen, die ein Genprodukt oder ein Teil davon kodieren, umfassend a) eine Nukleinsäure-Sequenz, ausgewählt aus der Gruppe der Nukleinsäure-Sequenzen Seq ID Nos. 14-18, 30, 31 , 52.The invention thus relates to nucleic acid sequences which encode a gene product or a part thereof, comprising a) a nucleic acid sequence selected from the group of the nucleic acid sequences Seq ID Nos. 14-18, 30, 31, 52.
b) eine allelische Variation der unter a) genannten Nukleinsäure-b) an allelic variation of the nucleic acid mentioned under a)
SequenzenSequences
oder c) eine Nukleinsäure-Sequenz, die komplementär zu den unter a) oder b) genannten Nukleinsäure-Sequenzen ist.or c) a nucleic acid sequence which is complementary to the nucleic acid sequences mentioned under a) or b).
Die Erfindung betrifft weiterhin eine Nukleinsäure-Sequenz gemäß einer der Sequenzen Seq ID Nos 14-18, 30, 31 oder eine komplementäre oder allelische Variante davon und die Nukleinsäure-Sequenzen davon, die eine 90%ige bis 95% ige Homologie zu einer humanen Nukleinsäure-Sequenz aufweisen.The invention further relates to a nucleic acid sequence according to one of the sequences Seq ID Nos 14-18, 30, 31 or a complementary or allelic variant thereof and the nucleic acid sequences thereof which have a 90% to 95% homology to a human nucleic acid Sequence.
Die Erfindung betrifft auch die Nukleinsäure-Sequenzen Seq. ID No. 1 bis Seq. ID No. 31 und und Seq. ID 52, die im Uterusmyom erhöht exprimiert sind.The invention also relates to the nucleic acid sequences Seq. ID No. 1 to Seq. ID No. 31 and and Seq. ID 52, which are expressed increased in the uterine fibroid.
Die Erfindung betrifft ferner Nukleinsäure-Sequenzen, umfassend einen Teil der oben genannten Nukleinsäure-Sequenzen, in solch einer ausreichenden Größe, daß sie mit den Sequenzen Seq. ID Nos 14-18, 30, 31 , 52 hybridisieren.The invention further relates to nucleic acid sequences comprising a part of the above-mentioned nucleic acid sequences, in such a sufficient size that they can be combined with the sequences Seq. Hybridize ID Nos 14-18, 30, 31, 52.
Die erfindungsgemäßen Nukleinsäure-Sequenzen weisen im allgemeinen eine Länge von mindestens 50 bis 4500 bp, vorzugsweise eine Länge von mindestens 150 bis 4000 bp, insbesondere eine Länge von 450 bis 3500 bp auf. Mit den erfindungsgemäßen Teilsequenzen Seq. ID Nos. 14-18, 30, 31 , 52 können gemäß gängiger Verfahrenspraxis auch Expressionskassetten konstruiert werden, wobei auf der Kassette mindestens eine der erfindungsgemäßen Nukleinsäure- Sequenzen zusammen mit mindestens einer dem Fachmann allgemein bekannten Kontroll- oder regulatorischen Sequenz, wie z. B. einem geeigneten Promotor, kombiniert wird. Die erfindungsgemäßen Sequenzen können in sense oder antisense Orientierung eingefügt sein. In der Literatur sind ist eine große Anzahl von Expressionskassetten bzw. Vektoren und Promotoren bekannt, die verwendet werden können.The nucleic acid sequences according to the invention generally have a length of at least 50 to 4500 bp, preferably a length of at least 150 to 4000 bp, in particular a length of 450 to 3500 bp. With the partial sequences Seq. ID Nos. 14-18, 30, 31, 52, expression cassettes can also be constructed in accordance with current process practice, with at least one of the nucleic acid sequences according to the invention together with at least one control or regulatory sequence known to the person skilled in the art, such as eg B. a suitable promoter is combined. The sequences according to the invention can be inserted in sense or antisense orientation. A large number of expression cassettes or vectors and promoters are known in the literature which can be used.
Unter Expressionskassetten bzw. Vektoren sind zu verstehen: 1. bakterielle, wie z. B., phagescript, pBs, φX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene), pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia), 2. eukaryontische, wie z. B. pWLneo, pSV2cat, pOG44, pXT1 , pSG (Stratagene), pSVK3, pBPV, pMSG, pSVL (Pharmacia).Expression cassettes or vectors are to be understood: 1. bacterial, such as. B., phagescript, pBs, φX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene), pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia), like eukaryont, 2nd eukaryont. B. pWLneo, pSV2cat, pOG44, pXT1, pSG (Stratagene), pSVK3, pBPV, pMSG, pSVL (Pharmacia).
Unter Kontroll- oder regulatorischer Sequenz sind geignete Promotoren zu verstehen. Hierbei sind zwei bevorzugte Vektoren der pKK232-8 und der PCM7 Vektor. Im einzelnen sind folgende Promotoren gemeint: lad, lacZ, T3, T7, gpt, lambda PR, trc, CMV, HSV Thymidin-Kinase, SV40, LTRs aus Retrovirus und Maus Metallothionein-I.Suitable control or regulatory sequence means suitable promoters. Two preferred vectors are the pKK232-8 and the PCM7 vector. The following promoters are specifically meant: lad, lacZ, T3, T7, gpt, lambda PR, trc, CMV, HSV thymidine kinase, SV40, LTRs from retrovirus and mouse metallothionein-I.
Die auf der Expressionskassette befindlichen DNA-Sequenzen können ein Fusionsprotein kodieren, das ein bekanntes Protein und ein biologisch aktives Polypeptid-Fragment umfaßt.The DNA sequences on the expression cassette can encode a fusion protein which comprises a known protein and a biologically active polypeptide fragment.
Die Expressionskassetten sind ebenfalls Gegenstand der vorliegenden Erfindung.The expression cassettes are also the subject of the present invention.
Die erfindungsgemäßen Nukleinsäure-Fragmente können zur Herstellung von Vollängen-Genen verwendet werden. Die erhältlichen Gene sind ebenfalls Gegenstand der vorliegenden Erfindung.The nucleic acid fragments according to the invention can be used to produce full-length genes. The available genes are also the subject of the present invention.
Die Erfindung betrifft auch die Verwendung der erfindungsgemäßen Nukleinsäure- Sequenzen, sowie die aus der Verwendung erhältlichen Gen-Fragmente. Die erfindungsgemäßen Nukleinsäure-Sequenzen können mit geeigneten Vektoren in Wirtszellen gebracht werden, in denen als heterologer Teil die auf den Nukleinsäure-Fragmenten enthaltene genetischen Information befindet, die exprimiert wird. Die die Nukleinsäure-Fragmente enthaltenden Wirtszellen sind ebenfalls Gegenstand der vorliegenden Erfindung.The invention also relates to the use of the nucleic acid sequences according to the invention and the gene fragments obtainable from the use. The nucleic acid sequences according to the invention can be brought into host cells with suitable vectors, in which the heterologous part contains the genetic information contained on the nucleic acid fragments which is expressed. The host cells containing the nucleic acid fragments are also the subject of the present invention.
Geeignete Wirtszellen sind z. B. prokaryontische Zellsysteme wie E. coli oder eukaryontische Zellsysteme wie tierische oder humane Zellen oder Hefen.Suitable host cells are e.g. B. prokaryotic cell systems such as E. coli or eukaryotic cell systems such as animal or human cells or yeasts.
Die erfindungsgemäßen Nukleinsäure-Sequenzen können in sense oder antisense Form verwendet werden.The nucleic acid sequences according to the invention can be used in sense or antisense form.
Die Herstellung der Polypeptide oder deren Fragment erfolgt durch Kultivierung der Wirtszellen gemäß gängiger Kultivierungsmethoden und anschließender Isolierung und Aufreinigung der Peptide bzw. Fragmente, ebenfalls mittels gängiger Verfahren. Die Erfindung betrifft ferner Nukleinsäure-Sequenzen, die mindestens eine Teilsequenz eines biologisch aktiven Polypeptids kodieren. Ferner betrifft die vorliegende Erfindung Polypeptid-Teilsequenzen, sogenannte ORF (open-reading-frame)-Peptide, gemäß den Sequenzprotokollen ORF ID Nos 32 - 51 und ORF ID Nos 53-55. Die Erfindung betrifft ferner die Polypeptid-Sequenzen, die mindestens eine 80%ige Homologie, insbesondere eine 90%ige Homologie zu den erfindungsgemäßen Polypeptid-Teilsequenzen der ORF. ID Nos. 32-51 und ORF ID Nos 53-55 aufweisen. Die Erfindung betrifft auch Antikörper, die gegen ein Polypeptid oder Fragment davon gerichtet sind, weiche von den erfindungsgemäßen Nukleinsäuren der Sequenzen Seq. ID No. 1-31 und Seq.lD No. 52 kodiert werden.The polypeptides or their fragments are produced by cultivating the host cells in accordance with common cultivation methods and then isolating and purifying the peptides or fragments, likewise by means of conventional methods. The invention further relates to nucleic acid sequences which encode at least a partial sequence of a biologically active polypeptide. Furthermore, the present invention relates to partial polypeptide sequences, so-called ORF (open reading frame) peptides, according to the sequence protocols ORF ID Nos 32-51 and ORF ID Nos 53-55. The invention further relates to the polypeptide sequences which have at least 80% homology, in particular 90% homology, to the polypeptide partial sequences of the ORF according to the invention. ID Nos. 32-51 and ORF ID Nos 53-55. The invention also relates to antibodies which are directed against a polypeptide or fragment thereof which are of the nucleic acids of the sequences Seq. ID No. 1-31 and Seq.lD No. 52 can be encoded.
Unter Antikörper sind insbesondere monoklonale Antikörper zu verstehen.Antibodies are to be understood in particular as monoclonal antibodies.
Die erfindungsgemäßen Antikörper können u.a. durch ein Phage Display Verfahren identifiziert werden. Auch diese Antikörper sind Gegenstand der Erfindung.The antibodies of the invention can include can be identified by a phage display method. These antibodies are also the subject of the invention.
Die erfindungsgemäßen Polypeptid-Teilsequenzen können in einem Phage Display Verfahren verwendet werden. Die mit diesem Verfahren identifizierten Polypeptide, die an die erfindungsgemäßen Polypeptid-Teilsequenzen binden, sind auch Gegenstand der Erfindung.The partial polypeptide sequences according to the invention can be used in a phage display method. The polypeptides identified by this method which bind to the partial polypeptide sequences according to the invention are also the subject of the invention.
Ebenso können die erfindungsgemäßen Nukleinsäure-Sequenzen in einem Phage Display Verfahren verwendet werden.The nucleic acid sequences according to the invention can also be used in a phage display method.
Die erfindungsgemäßen Polypeptide der Sequenzen Seq. ID Nos. 32 - 51 und Seq. ID Nos 53-55 können auch als Tool zum Auffinden von Wirkstoffen gegen das Uterusmyom verwendet werden, was ebenfalls Gegenstand der vorliegenden Erfindung ist.The polypeptides according to the invention of the sequences Seq. ID Nos. 32-51 and Seq. ID Nos 53-55 can also be used as a tool for finding active substances against the uterine fibroid, which is also the subject of the present invention.
Ebenfalls Gegenstand der vorliegenden Erfindung ist die Verwendung der Nukleinsäure-Sequenzen gemäß den Sequenzen Seq. ID No. 1 bis Seq. ID No. 31 und Seq. ID 52 zur Expression von Polypeptiden, die als Tools zum Auffinden von Wirkstoffen gegen das Uterusmyom verwendet werden können.The present invention also relates to the use of the nucleic acid sequences according to the sequences Seq. ID No. 1 to Seq. ID No. 31 and Seq. ID 52 for the expression of polypeptides that can be used as tools for finding active substances against the uterine fibroid.
Die Erfindung betrifft auch die Verwendung der gefundenen Polypeptid- Teilsequenzen Seq. ID No. 32 bis Seq. ID No. 51 und Seq. ID Nos 53-55 als Arzneimittel in der Gentherapie zur Behandlung gegen das Uterusmyom, bzw. zur Herstellung eines Arzneimittels zur Behandlung gegen das Uterusmyom.The invention also relates to the use of the polypeptide partial sequences Seq found. ID No. 32 to Seq. ID No. 51 and Seq. ID Nos 53-55 as a drug in gene therapy for the treatment of the uterine fibroid, or for the manufacture of a drug for the treatment of the uterine fibroid.
Die Erfindung betrifft auch Arzneimittel, die mindestens eine Polypeptid-Teilsequenz Seq.. ID No. 32 bis 51 und Seq. ID Nos 53-55 enthalten. Die gefundenen erfindungsgemäßen Nukleinsäure-Sequenzen können auch genomische oder mRNA-Sequenzen sein.The invention also relates to pharmaceutical compositions which contain at least one polypeptide partial sequence Seq. ID No. 32 to 51 and Seq. ID Nos 53-55 included. The nucleic acid sequences according to the invention found can also be genomic or mRNA sequences.
Die Erfindung betrifft auch genomische Gene, ihre Exon- und Intronstruktur und deren Spleißvarianten, erhältlich aus den cDNAs der Sequenzen Seq. ID No. 1-31 , 52, sowie deren Verwendung zusammen mit geeigneten regulativen Elementen, wie geeigneten Promotoren und/ oder Enhancern. Mit den erfindungsgemäßen Nukleinsäuren (cDNA-Sequenzen) Seq. ID. No. 1-31 , 52 werden genomische BAC-, PAC- und Cosmid-Bibliotheken gescreent und über komplementäre Basenpaarung (Hybridisierung) spezifisch humane Klone isoliert. Die so isolierten BAC-, PAC- und Cosmid-Klone werden mit Hilfe der Fluoreszenz-in-situ- Hybridisation auf Metaphasenchromosomen hybridisiert und entsprechende Chromosomenabschnitte identifiziert, auf denen die entsprechenden genomischen Gene liegen. BAC-, PAC- und Cosmid-Klone werden sequenziert, um die entsprechenden genomischen Gene in ihrer vollständigen Struktur (Promotoren, Enhancer, Silencer, Exons und Introns) aufzuklären. BAC-, PAC- und Cosmid-Klone können als eigenständige Moleküle für den Gentransfer eingesetzt werden (s. Fig. 5).The invention also relates to genomic genes, their exon and intron structure and their splice variants, obtainable from the cDNAs of the sequences Seq. ID No. 1-31, 52, and their use together with suitable regulatory elements, such as suitable promoters and / or enhancers. With the nucleic acids (cDNA sequences) according to the invention Seq. ID. No. 1-31, 52 genomic BAC, PAC and cosmid libraries are screened and specifically human clones are isolated via complementary base pairing (hybridization). The BAC, PAC and cosmid clones isolated in this way are hybridized with the aid of fluorescence in situ hybridization to metaphase chromosomes and corresponding chromosome sections on which the corresponding genomic genes lie are identified. BAC, PAC and cosmid clones are sequenced in order to elucidate the corresponding genomic genes in their complete structure (promoters, enhancers, silencers, exons and introns). BAC, PAC and cosmid clones can be used as independent molecules for gene transfer (see FIG. 5).
Die Erfindung betrifft auch BAC-, PAC- und Cosmid-Klone, enthaltend funktionelle Gene und ihre chromosomale Lokalisation, entsprechend den Sequenzen Seq. ID. No. 1-31 , 52 zur Verwendung als Vehikel zum Gentransfer. The invention also relates to BAC, PAC and cosmid clones containing functional genes and their chromosomal localization, according to the sequences Seq. ID. No. 1-31, 52 for use as a vehicle for gene transfer.
Bedeutungen von Fachbegriffen und AbkürzungenMeanings of technical terms and abbreviations
Nukleinsäuren= Unter Nukleinsäuren sind in der voliegenden Erfindung zu verstehen: mRNA, partielle cDNA, vollängen cDNA und genomische Gene (Chromosomen).Nucleic acids = nucleic acids are to be understood in the full invention: mRNA, partial cDNA, full length cDNA and genomic genes (chromosomes).
ORF = Open Reading Frame, eine definierte Abfolge von Aminosäuren, die von der cDNA-Sequenz abgeleitet werden kann. Contig = eine Menge von DNA-Sequenzen, die aufgrund sehr großer Ähnlichkeiten zu einer Sequenz zusammengefaßt werden können (Consensus)ORF = Open Reading Frame, a defined sequence of amino acids that can be derived from the cDNA sequence. Contig = a set of DNA sequences that can be combined into one sequence due to their very similarities (consensus)
Singieton= ein Contig, der nur eine Sequenz enthältSingieton = a contig that contains only one sequence
Modul = Domäne eines Proteins mit einer definierten Sequenz, die eine strukturelle Einheit darstellt und in unterschiedlichen Proteinen vorkommt N = wahlweise das Nukleotid A, T, G oder C X = wahlweise eine der 20 natürlich vorkommenden AminosäurenModule = domain of a protein with a defined sequence, which represents a structural unit and occurs in different proteins N = optionally the nucleotide A, T, G or C X = optionally one of the 20 naturally occurring amino acids
Erklärung zu den Alignmentparametern minimal initial match= minimaler anfänglicher Identitätsbereich maximum pads per read= maximale Anzahl von Insertionen maximum percent mismatch= maximale Abweichung in %Explanation of the alignment parameters minimal initial match = minimum initial identity range maximum pads per read = maximum number of insertions maximum percent mismatch = maximum deviation in%
Erklärung der AbbildungenExplanation of the pictures
Fig. 1 zeigt die systematische Gen-Suche in der Incyte LifeSeq Datenbank.Fig. 1 shows the systematic gene search in the Incyte LifeSeq database.
Fig. 2a zeigt das Prinzip der EST-Assemblierung Fig. 2b1-2b4 zeigt das gesamte Prinzip der EST-Assemblierung Fig. 3 zeigt die in silico Subtraktion der Genexpression in verschiedenen GewebenFig. 2a shows the principle of EST assembly. Fig. 2b1-2b4 shows the entire principle of EST assembly. Fig. 3 shows in silico subtraction of gene expression in different tissues
Fig. 4a zeigt die Bestimmung der gewebsspezifischen Expression über elektronischen Northern.4a shows the determination of the tissue-specific expression via electronic Northern.
Fig. 4b zeigt den elektronischen Northern Fig. 5 zeigt die Isolierung von genomischen BAC- und PAC-Klonen. Die nachfolgenden Beispiele erläutern die Herstellung der erfindungsgemäßen Nukleinsäure-Sequenzen, ohne die Erfindung auf diese Beispiele und Nukleinsäure- Sequenzen zu beschränken.Fig. 4b shows the electronic Northern. Fig. 5 shows the isolation of genomic BAC and PAC clones. The following examples explain the preparation of the nucleic acid sequences according to the invention without restricting the invention to these examples and nucleic acid sequences.
Beispiel 1example 1
Suche nach Tumor-bezogenen KandidatengenenSearch for tumor-related candidate genes
Zuerst wurden sämtliche ESTs des entsprechenden Gewebes aus der LifeSeq- Datenbank (vom Oktober 1997) extrahiert. Diese wurden dann mittels des Programms GAP4 des Staden-Pakets mit den Parametern 0% mismatch, 8 pads per read und einem minimalen match von 20 assembliert. Die nicht in die GAP4- Datenbank aufgenommenen Sequenzen (Fails) wurden erst bei 1 % mismatch und dann nochmals bei 2% mismatch mit der Datenbank assembliert. Aus den Contigs der Datenbank, die aus mehr als einer Sequenz bestanden, wurden Consensussequenzen errechnet. Die Singletons der Datenbank, die nur aus einer Sequenz bestanden, wurden mit den nicht in die GAP4-Datenbank aufgenommenen Sequenzen bei 2% mismatch erneut assembliert. Wiederum wurden für die Contigs die Consensussequenzen ermittelt. Alle übrigen ESTs wurden bei 4% mismatch erneut assembliert. Die Consensussequenzen wurden abermals extrahiert und mit den vorherigen Consensussequenzen sowie den Singletons und den nicht in die Datenbank aufgenommenen Sequenzen abschließend bei 4% mismatch assembliert. Die Consensussequenzen wurden gebildet und mit den Singletons und Fails als Ausgangsbasis für die Gewebsvergleiche verwendet. Durch diese Prozedur konnte sichergestellt werden, daß unter den verwendeten Parametern sämtliche Sequenzen von einander unabhängige Genbereiche darstellten. Fig. 2b1-2b4 veranschaulicht die Verlängerung der Uterusmyomgewebe ESTs.First, all ESTs of the corresponding tissue were extracted from the LifeSeq database (from October 1997). These were then assembled using the program GAP4 of the Staden package with the parameters 0% mismatch, 8 pads per read and a minimum match of 20. The sequences (failures) not included in the GAP4 database were assembled with the database first at 1% mismatch and then again at 2% mismatch. Consensus sequences were calculated from the database contigs, which consisted of more than one sequence. The singletons of the database, which consisted of only one sequence, were reassembled with the sequences not included in the GAP4 database at 2% mismatch. Again, the consensus sequences were determined for the contigs. All other ESTs were reassembled at 4% mismatch. The consensus sequences were extracted again and finally assembled with the previous consensus sequences as well as the singletons and the sequences not included in the database at 4% mismatch. The consensus sequences were formed and used with the singletons and failures as the basis for the tissue comparisons. This procedure ensured that, under the parameters used, all sequences represented mutually independent gene regions. 2b1-2b4 illustrates the extension of the uterine fibroid tissue ESTs.
Die so assemblierten Sequenzen der jeweiligen Gewebe wurden anschließend mittels des gleichen Programms miteinander verglichen (Fig. 3). Hierzu wurden erst alle Sequenzen des ersten Gewebes in die Datenbank eingegeben. (Daher war es wichtig, daß diese voneinander unabhängig waren.)The sequences of the respective tissues assembled in this way were then compared using the same program (FIG. 3). For this purpose, all sequences of the first tissue were first entered in the database. (It was therefore important that they were independent of each other.)
Dann wurden alle Sequenzen des zweiten Gewebes mit allen des ersten verglichen. Das Ergebnis waren Sequenzen, die für das erste bzw. das zweite Gewebe spezifisch waren, sowie welche, die in beiden vorkamen. Bei Letzteren wurde das Verhältnis der Häufigkeit des Vorkommens in den jeweiligen Geweben ausgewertet. Sämtliche, die Auswertung der assemblierten Sequenzen betreffenden Programme, wurden selbst entwickelt.Then all sequences of the second tissue were compared to all of the first. The result was sequences that were specific for the first and second tissues as well as those that occurred in both. In the latter, the ratio of the frequency of occurrence in the respective tissues was evaluated. All programs related to the evaluation of the assembled sequences were developed in-house.
Alle Sequenzen, die mehr als viermal in jeweils einem der verglichenen Gewebe vorkamen, sowie alle, die mindestens fünfmal so häufig in einem der beiden Gewebe vorkamen wurden weiter untersucht. Diese Sequenzen wurden einem elektronischen Northern (s. Beispiel 2.1) unterzogen, wodurch die Verteilung in sämtlichen Tumor- und Normal-Geweben untersucht wurde (s. Fig. 4a und Fig. 4b). Die relevanten Kandidaten wurden dann mit Hilfe sämtlicher Incyte ESTs und allen ESTs öffentlicher Datenbanken verlängert (s. Beispiel 3). Anschließend wurden die Sequenzen und ihre Übersetzung in mögliche Proteine mit allen Nukleotid- und Proteindatenbanken verglichen, sowie auf mögliche, für Proteine kodierende Regionen untersucht. Beispiel 2All sequences that occurred more than four times in one of the compared tissues as well as all that occurred at least five times as frequently in one of the two tissues were examined further. These sequences were subjected to an electronic Northern (see Example 2.1), whereby the distribution in all tumor and normal tissues was examined (see FIGS. 4a and 4b). The relevant candidates were then extended using all Incyte ESTs and all ESTs in public databases (see Example 3). The sequences and their translation into possible proteins were then compared with all nucleotide and protein databases and examined for possible regions coding for proteins. Example 2
Algorithmus zur Identifikation und Verlängerung von partiellen cDNA- Sequenzen mit verändertem ExpressionsmusterAlgorithm for the identification and extension of partial cDNA sequences with a changed expression pattern
Im folgenden soll ein Algorithmus zur Auffindung über- oder unterexprimierter Gene erläutert werden. Die einzelnen Schritte sind der besseren Übersicht halber auch in einem Flußdiagramm zusammengefaßt (s. Fig. 4b).An algorithm for finding over- or underexpressed genes will be explained below. For the sake of clarity, the individual steps are also summarized in a flow chart (see FIG. 4b).
2.1 Elektronischer Northern-Blot2.1 Electronic Northern blot
Zu einer partiellen DNA-Sequenz S, z. B. einem einzelnen EST oder einem Contig von ESTs, werden mittels eines Standardprogramms zur Homolgiesuche, z. B. BLAST (Altschul, S. F., Gish W., Miller, W., Myers, E. W. und Lipman, D. J. (1990) J. Mol. Bio!., 215, 403-410), BLAST2 (Altschul, S. F., Madden, T. L, Schäffer, A. A., Zhang, J., Zhang, Z., Miller, W. und Lipman, D. J. (1997) Nucleic Acids Research 25 3389-3402) oder FASTA (Pearson, W. R. und Lipman, D. J. (1988) Proc. Natl. Acad. Sei. USA 85 2444-2448), die homologen Sequenzen in verschiedenen nach Geweben geordneten (privaten oder öffentlichen) EST-Bibliotheken bestimmt. Die dadurch ermittelten (relativen oder absoluten) Gewebe-spezifischen Vorkommenshäufigkeiten dieser Partial-Sequenz S werden als elektronischer Northern-Blot bezeichnet.To a partial DNA sequence S, e.g. B. a single EST or a contig of ESTs are using a standard program for homology search, z. B. BLAST (Altschul, SF, Gish W., Miller, W., Myers, EW and Lipman, DJ (1990) J. Mol. Bio!., 215, 403-410), BLAST2 (Altschul, SF, Madden, T. L, Schäffer, AA, Zhang, J., Zhang, Z., Miller, W. and Lipman, DJ (1997) Nucleic Acids Research 25 3389-3402) or FASTA (Pearson, WR and Lipman, DJ (1988) Proc. Natl. Acad. Sci. USA 85 2444-2448), which determines homologous sequences in various EST libraries ordered by tissue (private or public). The (relative or absolute) tissue-specific occurrence frequencies of this partial sequence S determined in this way are referred to as electronic Northern blot.
2.1.12.1.1
Analog der unter 2.1 beschriebenen Verfahrensweise wurde die Sequenz Seq. ID No. 30 gefunden, die häufiger im Uterusmyomgewebe als im Normalgewebe vorkommt.Analogous to the procedure described under 2.1, the sequence Seq. ID No. 30 found that occurs more frequently in uterine fibroid tissue than in normal tissue.
Das Ergebnis ist wie folgt: Elektronischer Northern für SEQ. ID. NO: 30The result is as follows: Electronic Northern for SEQ. ID. NO: 30
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufιgkeιt %Haeuflgkeit N/T T/N% Haeufιgkeιt% Frequency N / T T / N
Blase 0.0078 0.0000 undef 0.0000Bubble 0.0078 0.0000 undef 0.0000
Brust 0.0013 0.0000 undef 0.0000Breast 0.0013 0.0000 undef 0.0000
Duenndarm 0.0092 0.0000 undef 0.0000Small intestine 0.0092 0.0000 undef 0.0000
Eierstock 0.0000 0.0000 undef undefOvary 0.0000 0.0000 undef undef
Endokrines Gewebe 0.0034 0.0000 undef 0.0000Endocrine tissue 0.0034 0.0000 undef 0.0000
Gastromtestmal 0.0019 0.0000 undef 0.0000Gastrom test times 0.0019 0.0000 undef 0.0000
Gehirn 0.0000 0.0000 undef undefBrain 0.0000 0.0000 undef undef
Haematopoetisch 0.0000 0.0000 undef undefHaematopoetic 0.0000 0.0000 undef undef
Haut 0.0000 0.0000 undef undefSkin 0.0000 0.0000 undef undef
Hepatisch 0.0000 0.0000 undef undefHepatic 0.0000 0.0000 undef undef
Herz 0.0011 0.0000 undef 0.0000Heart 0.0011 0.0000 undef 0.0000
Hoden 0.0000 0.0000 undef undefTesticles 0.0000 0.0000 undef undef
Lunge 0.0010 0.0000 undef 0.0000Lungs 0.0010 0.0000 undef 0.0000
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0000 0.0000 undef undefMusculoskeletal 0.0000 0.0000 undef undef
Niere 0.0000 0.0000 undef undefKidney 0.0000 0.0000 undef undef
Pankreas 0.0000 0.0000 undef undef Penis 0.0000 0,.0000 undef undefPancreas 0.0000 0.0000 undef undef Penis 0.0000 0, .0000 undef undef
Prostata 0.0109 0. .0021 5.11810.1954Prostate 0.0109 0.0021 5.11810.1954
Uterus Endometriu 0.0000 0. .0000 undef undefUterine endometrium 0.0000 0. .0000 undef undef
Uterus Myometrium 0.0000 0. ,0340 0.0000 undefUterine myometrium 0.0000 0., 0340 0.0000 undef
Uterus_allgemem 0.0102 0. ,0000 undef 0.0000Uterus_general 0.0102 0., 0000 undef 0.0000
Brust-Hyperplasie 0.0000Breast hyperplasia 0.0000
Prostata-Hyperplasie 0.0000Prostate hyperplasia 0.0000
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0000 eisse Blutkoerperchen 0.0000Sensory organs 0.0000 ice blood 0.0000
Zervix 0.0000Cervix 0.0000
FOETUS %HaeuflgkeitFOETUS% frequency
Entwicklung 0.0000Development 0.0000
Gastrointenstmal 0.0000Gastrointest time 0.0000
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0000Cardiac blood vessels 0.0000
Lunge 0.0000Lungs 0.0000
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0000Kidney 0.0000
Placenta 0.0000Placenta 0.0000
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeuflgkeit% Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0000Fetal 0.0000
Gastromtestmal 0.0000Gastro test times 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0000Skin muscle 0.0000
Hoden 0.0000Testicles 0.0000
Lunge 0.0000Lungs 0.0000
Nerven 0.0000Nerves 0.0000
Prostata 0.0068Prostate 0.0068
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0000Uterus n 0.0000
2.1.22.1.2
Analog der unter 2.1 beschriebenen Verfahrensweise wurde die Sequenz Seq. ID No. 31 gefunden, die .häufiger im Uterusmyomgewebe als im Normalgewebe vorkommt.Analogous to the procedure described under 2.1, the sequence Seq. ID No. 31 found that occurs more frequently in uterine fibroid tissue than in normal tissue.
Das Ergebnis ist wie folgt: Elektronischer Northern für SEQ. ID. NO: 31The result is as follows: Electronic Northern for SEQ. ID. NO: 31
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeuflgkeit %Haeuflgki Bit N/T T/N% Frequency% frequency bit N / T T / N
Blase 0.0000 0.0051 0.0000 undefBubble 0.0000 0.0051 0.0000 undef
Brust 0.0038 0.0019 2.04160.4898Breast 0.0038 0.0019 2.04160.4898
Duenndarm 0.0031 0.0000 undef 0.0000Small intestine 0.0031 0.0000 undef 0.0000
Eierstock 0.0030 0.0104 0.28783.4745Ovary 0.0030 0.0104 0.28783.4745
Endokrines Gewebe 0.0034 0.0100 0.33962.9444Endocrine tissue 0.0034 0.0100 0.33962.9444
Gastrointestinal 0.0057 0.0046 1.24250.8048Gastrointestinal 0.0057 0.0046 1.24250.8048
Gehirn 0.0111 0.0051 2.15990.4630Brain 0.0111 0.0051 2.15990.4630
Haematopoetisch 0.0040 0.0000 undef 0.0000Haematopoetic 0.0040 0.0000 undef 0.0000
Haut 0.0000 0.0000 undef undefSkin 0.0000 0.0000 undef undef
Hepatisch 0.0048 0.0000 undef 0.0000Hepatic 0.0048 0.0000 undef 0.0000
Herz 0.0095 0.0000 undef 0.0000Heart 0.0095 0.0000 undef 0.0000
Hoden 0.0058 0.0000 undef 0.0000Testicles 0.0058 0.0000 undef 0.0000
Lunge 0.0042 0.0102 0.40642.4605Lungs 0.0042 0.0102 0.40642.4605
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0034 0.0060 0.57111.7510Musculoskeletal 0.0034 0.0060 0.57111.7510
Niere 0.0163 0.0068 2.37910.4203Kidney 0.0163 0.0068 2.37910.4203
Pankreas 0.0017 0.0000 undef 0.0000Pancreas 0.0017 0.0000 undef 0.0000
Penis 0.0090 0.0000 undef 0.0000Penis 0.0090 0.0000 undef 0.0000
Prostata 0.0022 0.0021 1.02360.9769Prostate 0.0022 0.0021 1.02360.9769
Uterus Endometrium 0.0135 0.0000 undef 0.0000Uterine endometrium 0.0135 0.0000 undef 0.0000
Uterus Myorαetnum 0.0000 0.0340 0.0000 undefUterine Myorαetnum 0.0000 0.0340 0.0000 undef
Uterus_allgemeιn 0.0000 0.0000 undef undefUterus_allgemeιn 0.0000 0.0000 undef undef
Brust-Hyperplasie 0.0224Breast hyperplasia 0.0224
Prostata-hyperplasie 0.0030Prostate hyperplasia 0.0030
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0061White blood cells 0.0061
Zervix 0.0213Cervix 0.0213
FOETUS HaeuflgkeitFOETUS frequency
Entwicklung 0.0000Development 0.0000
Gastromtenstmal 0.0028Gastromtenstmal 0.0028
Gehirn 0.0125Brain 0.0125
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0036Heart blood vessels 0.0036
Lunge 0.0036Lungs 0.0036
Nebenniere 0.0254Adrenal gland 0.0254
Niere 0.0062Kidney 0.0062
Placenta 0.0303Placenta 0.0303
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0126Sensory organs 0.0126
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeuflgkeit% Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0000Fetal 0.0000
Gastrointestinal 0.0000Gastrointestinal 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0000Skin muscle 0.0000
Hoden 0.0000Testicles 0.0000
Lunge 0.0082Lungs 0.0082
Nerven 0.0000Nerves 0.0000
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0000 In analoger Verfahrensweise wurden auch folgende Northerns gefunden: Elektronischer Northern für SEQ. ID. NO: 1Uterus n 0.0000 The following Northerns were also found in an analogous procedure: Electronic Northern for SEQ. ID. NO: 1
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeuflgkeit %Haeuflgkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0468 0.0562 0.83211.2018Bubble 0.0468 0.0562 0.83211.2018
Brust 0.0576 0.0752 0.76561.3062Breast 0.0576 0.0752 0.76561.3062
Duenndarm 0.0766 0.0662 1.15860.8631Small intestine 0.0766 0.0662 1.15860.8631
Eierstock 0.0509 0.0650 0.78291.2774Ovary 0.0509 0.0650 0.78291.2774
Endokπnes_Gewebe 0.0596 0.0702 0.84911.1778Endokπnes_Gewebe 0.0596 0.0702 0.84911.1778
Gastrointestinal 0.0690 0.1203 0.57351.7438Gastrointestinal 0.0690 0.1203 0.57351.7438
Gehirn 0.0850 0.0873 0.97411.0266Brain 0.0850 0.0873 0.97411.0266
Haematopoetisch 0.0722 0.0379 1.90560.5248Haematopoetic 0.0722 0.0379 1.90560.5248
Haut 0.0918 0.0000 undef 0.0000Skin 0.0918 0.0000 undef 0.0000
Hepatisch 0.0143 0.1100 0.12987.7066Hepatic 0.0143 0.1100 0.12987.7066
Herz 0.1123 0.0275 4.08620.2447Heart 0.1123 0.0275 4.08620.2447
Hoden 0.0518 0.0819 0.63251.5809Testis 0.0518 0.0819 0.63251.5809
Lunge 0.1080 0.0879 1.22870.8138Lungs 0.1080 0.0879 1.22870.8138
Magen-Speiseroenre 0.0676 0.0307 2.20590.4533Gastric food tube 0.0676 0.0307 2.20590.4533
Muskel-Skelett 0.0737 0.0780 0.94451.0587Musculoskeletal system 0.0737 0.0780 0.94451.0587
Niere 0.0407 0.0890 0.45752.1857Kidney 0.0407 0.0890 0.45752.1857
Pankreas 0.0463 0.0552 0.83761.1939Pancreas 0.0463 0.0552 0.83761.1939
Penis 0.0449 0.0000 undef 0.0000Penis 0.0449 0.0000 undef 0.0000
Prostata 0.0436 0.0554 0.78741.2700Prostate 0.0436 0.0554 0.78741.2700
Uterus_Endometnum 0.0338 0.0000 undef 0.0000Uterus_Endometnum 0.0338 0.0000 undef 0.0000
Uterus_Myometrιum 0.0534 0.1426 0.37412.6732Uterus_Myometrιum 0.0534 0.1426 0.37412.6732
Uterus_allgemem 0.0255 0.0000 undef 0.0000Uterus_general 0.0255 0.0000 undef 0.0000
Brust-Hyperplasie 0.0863Breast hyperplasia 0.0863
Prostata-Hyperplasie 0.0535Prostate hyperplasia 0.0535
Samenblase 0.0890Seminal vesicle 0.0890
Sinnesorgane 0.0588 eιsse_Blutkoerperchen 0.0772Sensory organs 0.0588 eιsse_Blutkoerperchen 0.0772
Zervix 0.1171Cervix 0.1171
FOETUSFETUS
%Haeu lgkeit% Freight
Entwicklung 0.0139Development 0.0139
Gast romtenst mal 0.0583Guest romtenst times 0.0583
Gehirn 0.0500Brain 0.0500
Haematopoetisch 0.0590Haematopoetic 0.0590
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0462Cardiac blood vessels 0.0462
Lunge 0.0578Lungs 0.0578
Nebenniere 0.0254Adrenal gland 0.0254
Niere 0.0679Kidney 0.0679
Placenta 0.0545Placenta 0.0545
Prostata 0.2493Prostate 0.2493
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeιt% Haeufιgkeιt
Brust 0.0204Breast 0.0204
Eιerstock_n 0.1595Eιerstock_n 0.1595
Eιerstock_t 0.0051Eιerstock_t 0.0051
Endokrιnes_Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0256Fetal 0.0256
Gastrointestinal 0.0488Gastrointestinal 0.0488
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0227Skin muscle 0.0227
Hoden 0.0154Testicles 0.0154
Lunge 0.0082Lungs 0.0082
Nerven 0.0191Nerves 0.0191
Prostata 0.0068Prostate 0.0068
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0000 Elektronischer Northern für SEQ. ID. NO: 2Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 2
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeuflgkeit %Haeuflgkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0039 0.0102 0.38142.6222Bubble 0.0039 0.0102 0.38142.6222
Brust 0.0128 0.0038 3.40260.2939Breast 0.0128 0.0038 3.40260.2939
Duenndarm 0.0031 0.0165 0.18545.3946Small intestine 0.0031 0.0165 0.18545.3946
Eierstock 0.0000 0.0000 undef undefOvary 0.0000 0.0000 undef undef
Endokrines Gewebe 0.0017 0.0075 0.22644.4166Endocrine tissue 0.0017 0.0075 0.22644.4166
Gastrointestinal 0.0019 0.0093 0.20714.8289Gastrointestinal 0.0019 0.0093 0.20714.8289
Gehirn 0.0022 0.0103 0.21604.6299Brain 0.0022 0.0103 0.21604.6299
Haematopoetisch 0.0040 0.0000 undef 0.0000Haematopoetic 0.0040 0.0000 undef 0.0000
Haut 0.0000 0.0000 undef undefSkin 0.0000 0.0000 undef undef
Hepatisch 0.0000 0.0065 0.0000 undefHepatic 0.0000 0.0065 0.0000 undef
Herz 0.0011 0.0137 0.077112.9706Heart 0.0011 0.0137 0.077112.9706
Hoden 0.0058 0.0000 undef 0.0000Testicles 0.0058 0.0000 undef 0.0000
Lunge 0.0021 0.0082 0.25403.9367Lungs 0.0021 0.0082 0.25403.9367
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0000 0.0120 0.0000 undefMusculoskeletal 0.0000 0.0120 0.0000 undef
Niere 0.0054 0.0000 undef 0.0000Kidney 0.0054 0.0000 undef 0.0000
Pankreas 0.0000 0.0055 0.0000 undefPancreas 0.0000 0.0055 0.0000 undef
Penis 0.0030 0.0000 undef 0.0000Penis 0.0030 0.0000 undef 0.0000
Prostata 0.0000 0.0021 0.0000 undefProstate 0.0000 0.0021 0.0000 undef
Uterus Endometπum 0.0000 0.0528 0.0000 undefUterus Endometπum 0.0000 0.0528 0.0000 undef
Uterus Myometπum 0.0000 0.0408 0.0000 undefUterus Myometπum 0.0000 0.0408 0.0000 undef
Uterus allgemein 0.0051 0.0954 0.053418.7357General uterus 0.0051 0.0954 0.053418.7357
Brust-Hyperplasie 0.0064Breast hyperplasia 0.0064
Prostata-Hyperplasie 0.0000Prostate hyperplasia 0.0000
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0009White blood cells 0.0009
Zervix 0.0000Cervix 0.0000
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0974Development 0.0974
Gastromtenst al 0.0333Gastromtenst al 0.0333
Gehirn 0.0063Brain 0.0063
Haematopoetisch 0.0157Haematopoetic 0.0157
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0249Heart blood vessels 0.0249
Lunge 0.0325Lungs 0.0325
Nebenniere 0.0761Adrenal gland 0.0761
Niere 0.0618Kidney 0.0618
Placenta 0.0727Placenta 0.0727
Prostata 0.0249Prostate 0.0249
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0384Fetal 0.0384
Gastrointestinal 0.0122Gastrointestinal 0.0122
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0259Skin muscle 0.0259
Hoden 0.0000Testicles 0.0000
Lunge 0.0328Lungs 0.0328
Nerven 0.0171Nerves 0.0171
Prostata 0.0137Prostate 0.0137
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0083 Elektronischer Northern für SEQ. ID. NO: 3Uterus n 0.0083 Electronic Northern for SEQ. ID. NO: 3
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufιgkeιt N/T T/N% Frequency% frequency N / T T / N
Blase 0.0000 0.0000 undef undefBubble 0.0000 0.0000 undef undef
Brust 0.0000 0.0000 undef undefBreast 0.0000 0.0000 undef undef
Duenndarm 0.0000 0.0000 undef undefSmall intestine 0.0000 0.0000 undef undef
Eierstock 0.0000 0.0000 undef undefOvary 0.0000 0.0000 undef undef
Endokrines Gewebe 0.0000 0.1103 0.0000 undefEndocrine tissue 0.0000 0.1103 0.0000 undef
Gastrointestinal 0.0000 0.0000 undef undefGastrointestinal 0.0000 0.0000 undef undef
Gehirn 0.0140 0.0010 13.6792 0.0731Brain 0.0140 0.0010 13.6792 0.0731
Haematopoetisch 0.0000 0.0000 undef undefHaematopoetic 0.0000 0.0000 undef undef
Haut 0.0000 0.0000 undef undefSkin 0.0000 0.0000 undef undef
Hepatisch 0.0000 0.0000 undef undefHepatic 0.0000 0.0000 undef undef
Herz 0.0000 0.0000 undef undefHeart 0.0000 0.0000 undef undef
Hoden 0.0000 0.0000 undef undefTesticles 0.0000 0.0000 undef undef
Lunge 0.0000 0.0000 undef undefLung 0.0000 0.0000 undef undef
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0000 0.0000 undef undefMusculoskeletal 0.0000 0.0000 undef undef
Niere 0.0000 0.0000 undef undefKidney 0.0000 0.0000 undef undef
Pankreas 0.0000 0.0000 undef undefPancreas 0.0000 0.0000 undef undef
Penis 0.0000 0.0000 undef undefPenis 0.0000 0.0000 undef undef
Prostata 0.0000 0.0000 undef undefProstate 0.0000 0.0000 undef undef
Uterus Endometrium 0.0000 0.0000 undef undefUterine endometrium 0.0000 0.0000 undef undef
Uterus Myometrium 0.0000 0.0815 0.0000 undefUterine myometrium 0.0000 0.0815 0.0000 undef
Uterus allgemein 0.0000 0.0000 undef undefGeneral uterus 0.0000 0.0000 undef undef
Brust-Hyperplasie 0.0000Breast hyperplasia 0.0000
Prostata-Hyperplasie 0.0030Prostate hyperplasia 0.0030
Samenblase 0.0000Seminal vesicle 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0000White blood cells 0.0000
Zervix 0.0000Cervix 0.0000
FOETUS .HaeufigkeitFOETUS
Entwicklung 0.0000Development 0.0000
Gastromtenst al 0.0028Gastromtenst al 0.0028
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0000Cardiac blood vessels 0.0000
Lunge 0.0000Lungs 0.0000
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0000Kidney 0.0000
Placenta 0.0000Placenta 0.0000
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
IHaeufigkeitFrequent
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0000Fetal 0.0000
Gastrointestinal 0.0000Gastrointestinal 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0000Skin muscle 0.0000
Hoden 0.0000Testicles 0.0000
Lunge 0.0000Lungs 0.0000
Nerven 0.0090Nerves 0.0090
Prostata 0.0137Prostate 0.0137
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0000 Elektronischer Northern für SEQ. ID. NO: 4Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 4
NORMAL TUMOR VerhaeltmsseNORMAL TUMOR BEHAVIOR
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0078 0.0077 1.01700.9833Bubble 0.0078 0.0077 1.01700.9833
Brust 0.0026 0.0038 0.68051.4694Breast 0.0026 0.0038 0.68051.4694
Duenndarm 0.0031 0.0165 0.18545.3946Small intestine 0.0031 0.0165 0.18545.3946
Eierstock 0.0060 0.0026 2.30250.4343Ovary 0.0060 0.0026 2.30250.4343
Endokrines Gewebe 0.0000 0.0000 undef undefEndocrine tissue 0.0000 0.0000 undef undef
Gastrointestinal 0.0000 0.0046 0.0000 undefGastrointestinal 0.0000 0.0046 0.0000 undef
Gehirn 0.0007 0.0031 0.24004.1669Brain 0.0007 0.0031 0.24004.1669
Haematopoetisch 0.0000 0.0000 undef undefHaematopoetic 0.0000 0.0000 undef undef
Haut 0.0000 0.1695 0.0000 undefSkin 0.0000 0.1695 0.0000 undef
Hepatisch 0.0000 0.0065 0.0000 undefHepatic 0.0000 0.0065 0.0000 undef
Herz 0.0095 0.0412 0.23134.3235Heart 0.0095 0.0412 0.23134.3235
Hoden 0.0000 0.0000 undef undefTesticles 0.0000 0.0000 undef undef
Lunge 0.0021 0.0041 0.50801.9684Lungs 0.0021 0.0041 0.50801.9684
Magen-Speiseroehre 0.0000 0.0077 0.0000 undefGastro-ear of ear 0.0000 0.0077 0.0000 undef
Muskel-Skelett 0.0017 0.0120 0.14287.0040Musculoskeletal system 0.0017 0.0120 0.14287.0040
Niere 0.0027 0.0000 undef 0.0000Kidney 0.0027 0.0000 undef 0.0000
Pankreas 0.0033 0.0055 0.59831.6714Pancreas 0.0033 0.0055 0.59831.6714
Penis 0.0030 0.0000 undef 0.0000Penis 0.0030 0.0000 undef 0.0000
Prostata 0.0000 0.0021 0.0000 undefProstate 0.0000 0.0021 0.0000 undef
Uterus Endometrium 0.0068 0.0000 undef 0.0000Uterine endometrium 0.0068 0.0000 undef 0.0000
Uterus Myometπum 0.0152 0.0883 0.17275.7919Uterus Myometπum 0.0152 0.0883 0.17275.7919
Uterus allgemein 0.0051 0.0000 undef 0.0000General uterus 0.0051 0.0000 undef 0.0000
Brust-Hyperplasie 0.0032Breast hyperplasia 0.0032
Prostata-Hyperplasie 0.0030Prostate hyperplasia 0.0030
Samenblase 0.0000Seminal vesicle 0.0000
Sinnesorgane 0.0118Sensory organs 0.0118
'eisse Blutkoerperchen 0.0000'' blood corpuscles 0.0000
Zervix 0.0000Cervix 0.0000
FOETUS %HaeufιgkeιtFOETUS% Haeufιgkeιt
Entwicklung 0.0278Development 0.0278
Gastromtenstmal 0.0139Gastromtenstmal 0.0139
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0213Cardiac blood vessels 0.0213
Lunge 0.0253Lungs 0.0253
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0185Kidney 0.0185
Placenta 0.0061Placenta 0.0061
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeuf igkeit% Frequency
Brust 0 . 0068Breast 0. 0068
Eιerstock_n 0 . 0000Eιerstock_n 0. 0000
Eιerstock_t 0 . 0000Eιerstock_t 0. 0000
Endoknnes_Gewebe 0 . 0000Endoknnes_Gewebe 0. 0000
Foetal 0. 0093Fetal 0.0093
Gastrointestinal 0 . 0122Gastrointestinal 0. 0122
Haematopoetisch 0 . 0000Haematopoetic 0. 0000
Haut-Muskel 0 . 0130Skin muscle 0. 0130
Hoden 0 . 0000Testicles 0. 0000
Lunge 0. 0000Lungs 0.0000
Nerven 0 . 0000Nerves 0. 0000
Prostata 0 . 0000Prostate 0. 0000
Sinnesorgane 0 . 0000Sensory organs 0. 0000
Uterus n 0 . 0000 Elektronischer Northern für SEQ. ID. NO: 5Uterus n 0. 0000 Electronic Northern for SEQ. ID. NO: 5
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0390 0.0332 1.17340.8522Bubble 0.0390 0.0332 1.17340.8522
Brust 0.0345 0.0414 0.83521.1973Breast 0.0345 0.0414 0.83521.1973
Duenndarm 0.0399 0.0662 0.60241.6599Small intestine 0.0399 0.0662 0.60241.6599
Eierstock 0.0359 0.0546 0.65791.5201Ovary 0.0359 0.0546 0.65791.5201
Endokrines Gewebe 0.0528 0.0351 1.50400.6649Endocrine tissue 0.0528 0.0351 1.50400.6649
Gastrointestinal 0.0172 0.0185 0.93191.0731Gastrointestinal 0.0172 0.0185 0.93191.0731
Gehirn 0.0214 0.0359 0.59651.6763Brain 0.0214 0.0359 0.59651.6763
Haematopoetisch 0.0294 0.0379 0.77631.2881Haematopoetic 0.0294 0.0379 0.77631.2881
Haut 0.0257 0.1695 0.15166.5954Skin 0.0257 0.1695 0.15166.5954
Hepatisch 0.0476 0.0323 1.47060.6800Hepatic 0.0476 0.0323 1.47060.6800
Herz 0.0276 0.0000 undef 0.0000Heart 0.0276 0.0000 undef 0.0000
Hoden 0.0633 0.0234 2.70590.3696Testis 0.0633 0.0234 2.70590.3696
Lunge 0.0312 0.0266 1.17240.8530Lungs 0.0312 0.0266 1.17240.8530
Magen-Speiseroehre 0.0387 0.0153 2.52110.3967Stomach-ear of ear 0.0387 0.0153 2.52110.3967
Muskel-Skelett 0.0308 0.0360 0.85671.1673Musculoskeletal system 0.0308 0.0360 0.85671.1673
Niere 0.0326 0.0548 0.59481.6813Kidney 0.0326 0.0548 0.59481.6813
Pankreas 0.0132 0.0221 0.59831.6714Pancreas 0.0132 0.0221 0.59831.6714
Penis 0.0479 0.0000 undef 0.0000Penis 0.0479 0.0000 undef 0.0000
Prostata 0.0153 0.0319 0.47772.0934Prostate 0.0153 0.0319 0.47772.0934
Uterus Endometπum 0.0473 0.0528 0.89621.1158Uterine endometer 0.0473 0.0528 0.89621.1158
Uterus Myometrium 0.0305 0.1019 0.29933.3415Uterine myometrium 0.0305 0.1019 0.29933.3415
Uterus allgemein 0.0560 0.1908 0.29363.4065General uterus 0.0560 0.1908 0.29363.4065
Brust-Hyperplasie 0.0448Breast hyperplasia 0.0448
Pros ata-Hyperplasie 0.0446Pros ata hyperplasia 0.0446
Samenblase 0.1513Bubble 0.1513
Sinnesorgane 0.0235Sensory organs 0.0235
Weisse Blutkoerperchen 0.0061White blood cells 0.0061
Zervix 0.0426Cervix 0.0426
FOETUS %HaeufιgkeιtFOETUS% Haeufιgkeιt
Entwicklung 0.0974Development 0.0974
Gastromtenst al 0.0222Gastromtenst al 0.0222
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0197Haematopoetic 0.0197
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0356Cardiac blood vessels 0.0356
Lunge 0.0325Lungs 0.0325
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0185Kidney 0.0185
Placenta 0.0909Placenta 0.0909
Prostata 0.1496Prostate 0.1496
Sinnesorgane 0.0126Sensory organs 0.0126
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKEN %HaeufιgkeιtSTANDARDIZED / SUBTRACTED LIBRARIES% Haeufιgkeιt
Brust 0, .0136Breast 0, .0136
Eierstock n 0, .0000Ovary n 0, .0000
Eierstock t 0, .0051Ovary t 0, .0051
Indokrmes Gewebe 0, .0000Indocrm tissue 0, .0000
Foetal 0, ,0099Fetal 0, 0099
Gastrointestinal 0, .0122Gastrointestinal 0, .0122
Haematopoetisch 0. ,0000Haematopoetic 0. 0000
Haut-Muskel 0, .0324Skin muscle 0, .0324
Hoden 0, ,0231Testicles 0, 0231
Lunge 0. ,0328Lungs 0., 0328
Nerven 0, .0131Nerves 0, .0131
Prostata 0. ,0068Prostate 0, 0068
Sinnesorgane 0. .0077Sensory organs 0 .0077
Uterus n 0. ,0208 Elektronischer Northern für SEQ. ID. NO: 6Uterus n 0, 0208 Electronic Northern for SEQ. ID. NO: 6
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0429 0.1278 0.33562.9798Bubble 0.0429 0.1278 0.33562.9798
Brust 0.1036 0.1203 0.86131.1610Breast 0.1036 0.1203 0.86131.1610
Duenndarm 0.0215 0.0992 0.21634.6240Small intestine 0.0215 0.0992 0.21634.6240
Eierstock 0.0599 0.0702 0.85281.1726Ovary 0.0599 0.0702 0.85281.1726
Endokrines Gewebe 0.0783 0.0426 1.83800.5441Endocrine tissue 0.0783 0.0426 1.83800.5441
Gastrointestinal 0.0249 0.0786 0.31673.1574Gastrointestinal 0.0249 0.0786 0.31673.1574
Gehirn 0.0429 0.1284 0.33412.9935Brain 0.0429 0.1284 0.33412.9935
Haematopoetisch 0.0227 0.1136 0.20005.0008Haematopoetic 0.0227 0.1136 0.20005.0008
Haut 0.0844 0.1695 0.49822.0073Skin 0.0844 0.1695 0.49822.0073
Hepatisch 0.0523 0.0712 0.73531.3600Hepatic 0.0523 0.0712 0.73531.3600
Herz 0.0922 0.1649 0.55901.7890Heart 0.0922 0.1649 0.55901.7890
Hoden 0.0460 0.0585 0.78721.2704Testis 0.0460 0.0585 0.78721.2704
Lunge 0.0447 0.0797 0.56011.7853Lungs 0.0447 0.0797 0.56011.7853
Magen-Speiseroehre 0.0000 0.0537 0.0000 undefGastro-ear of ear 0.0000 0.0537 0.0000 undef
Muskel-Skelett 0.1490 0.1380 1.08010.9258Musculoskeletal 0.1490 0.1380 1.08010.9258
Niere 0.0489 0.0479 1.01960.9808Kidney 0.0489 0.0479 1.01960.9808
Pankreas 0.0149 0.1049 0.14177.0571Pancreas 0.0149 0.1049 0.14177.0571
Penis 0.0509 0.1333 0.38192.6187Penis 0.0509 0.1333 0.38192.6187
Prostata 0.0196 0.0319 0.61421.6282Prostate 0.0196 0.0319 0.61421.6282
Uterus Endometrium 0.0676 0.1583 0.42682.3432Uterine endometrium 0.0676 0.1583 0.42682.3432
Uterus Myometrium 0.0381 0.3260 0.11698.5541Uterine myometrium 0.0381 0.3260 0.11698.5541
Uterus allgemein 0.0560 0.0000 undef 0.0000General uterus 0.0560 0.0000 undef 0.0000
Brust-Hyperplasie 0.0863Breast hyperplasia 0.0863
Prostata-Hyperplasie 0.0297Prostate hyperplasia 0.0297
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0353 lsse Blutkoerperchen 0.0078Sensory organs 0.0353 release blood cells 0.0078
Zervix 0.0213Cervix 0.0213
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.1670Development 0.1670
Gastromtenstmal 0.1444Gastromtenstmal 0.1444
Gehirn 0.0125Brain 0.0125
Haematopoetisch 0.0629Haematopoetic 0.0629
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0889Cardiac blood vessels 0.0889
Lunge 0.0759Lungs 0.0759
Nebenniere 0.2535Adrenal gland 0.2535
Niere 0.1112Kidney 0.1112
Placenta 0.1091Placenta 0.1091
Prostata 0.1247Prostate 0.1247
Sinnesorgane 0.1004Sensory organs 0.1004
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKEN %HaeufigkeitSTANDARDIZED / SUBTRACTED LIBRARIES% Frequency
Brust 0. ,0476Breast 0, 0476
Eierstock n 0. .1595Ovary n0. .1595
Eierstock t 0. ,0203Ovary t0.0203
,ndokrιnes Gewebe 0. ,0000, ndocrιnes tissue 0., 0000
Foetal 0. .0379Fetal 0 .0379
Gastrointestinal 0. .0122Gastrointestinal 0 .0122
Haematopoetisch 0. ,0000Haematopoetic 0. 0000
Haut-Muskel 0, ,0486Skin muscle 0, .0486
Hoden 0. ,0077Testicles 0. 0077
Lunge 0, .0164Lungs 0, .0164
Nerven 0. ,0251Nerves 0, 0251
Prostata 0, .0068Prostate 0, .0068
Sinnesorgane 0, .0155Sensory organs 0, .0155
Uterus n 0, .0167 Elektronischer Northern für SEQ. ID. NO: 7Uterus n 0, .0167 Electronic Northern for SEQ. ID. NO: 7
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N Blase 0.0117 0.0051 2.2882 0.4370% Frequency% Frequency N / T T / N Bubble 0.0117 0.0051 2.2882 0.4370
Brust 0.0128 0.0075 1.7013 0.5878Breast 0.0128 0.0075 1.7013 0.5878
Duenndarm 0.0153 0.0331 0.4634 2.1579Small intestine 0.0153 0.0331 0.4634 2.1579
Eierstock 0.0150 0.0104 1.4391 0.6949Ovary 0.0150 0.0104 1.4391 0.6949
Endokrmes_Gewebe 0.0085 0.0050 1.6981 0.5889 Gastrointestinal 0.0096 0.0278 0.34512.8974Endocrine tissue 0.0085 0.0050 1.6981 0.5889 Gastrointestinal 0.0096 0.0278 0.34512.8974
Gehirn 0.0059 0.0113 0.5236 1.9098Brain 0.0059 0.0113 0.5236 1.9098
Haematopoetisch 0.0254 0.0000 undef 0.0000Haematopoetic 0.0254 0.0000 undef 0.0000
Haut 0.0257 0.0000 undef 0.0000Skin 0.0257 0.0000 undef 0.0000
Hepatisch 0.0143 0.0194 0.7353 1.3600 Herz 0.0106 0.0000 undef 0.0000Hepatic 0.0143 0.0194 0.7353 1.3600 heart 0.0106 0.0000 undef 0.0000
Hoden 0.0058 0.0234 0.2460 4.0652Testicles 0.0058 0.0234 0.2460 4.0652
Lunge 0.0104 0.0245 0.4234 2.3620Lungs 0.0104 0.0245 0.4234 2.3620
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0051 0.0360 0.1428 7.0040 Niere 0.0244 0.0068 3.5687 0.2802Musculoskeletal 0.0051 0.0360 0.1428 7.0040 Kidney 0.0244 0.0068 3.5687 0.2802
Pankreas 0.0083 0.0000 undef 0.0000Pancreas 0.0083 0.0000 undef 0.0000
Penis 0.0180 0.0000 undef 0.0000Penis 0.0180 0.0000 undef 0.0000
Prostata 0.0218 0.0064 3.4121 0.2931Prostate 0.0218 0.0064 3.4121 0.2931
Uterus_Endometrιum 0.0135 0.0000 undef 0.0000 Uterus_Myometrιum 0.0000 0.0408 0.0000 undefUterus_Endometrιum 0.0135 0.0000 undef 0.0000 Uterus_Myometrιum 0.0000 0.0408 0.0000 undef
Uterus_allgemem 0.0000 0.0000 undef undefUterus_general 0.0000 0.0000 undef undef
Brust-Hyperplasie 0.0192Breast hyperplasia 0.0192
Prostata-Hyperplasie 0.0030Prostate hyperplasia 0.0030
Samenblase 0.0089 Sinnesorgane 0.0235Seminal vesicle 0.0089 sensory organs 0.0235
Weιsse_Blutkoerperchen 0.0208Weιsse_Blutkoerperchen 0.0208
Zervix 0.0213Cervix 0.0213
FOETUSFETUS
%Haeuf igkeit% Frequency
Entwicklung 0 . 0278Development 0. 0278
Gastromtenstmal 0. 0083Gastromtenstmal 0. 0083
Gehirn 0 . 0125Brain 0. 0125
Haematopoetisch 0 . 0000Haematopoetic 0. 0000
Haut 0 . 0000Skin 0. 0000
Hepatisch 0 . 0000Hepatic 0. 0000
Herz-Blutgefaesse 0 . 0071Cardiac blood vessels 0. 0071
Lunge 0 . 0036Lungs 0. 0036
Nebenniere 0 . 0000Adrenal gland 0. 0000
Niere 0. 0309Kidney 0. 0309
Placenta 0 . 0061Placenta 0. 0061
Prostata 0 . 0249Prostate 0. 0249
Sinnesorgane 0 . 0000Sensory organs 0. 0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0000Breast 0.0000
Eιerstock_n 0.0000Eιerstock_n 0.0000
Eιerstock_t 0.0101Eιerstock_t 0.0101
Endokrmes_Gewebe 0245Endokrmes_Gewebe 0245
Foetal 0093Fetal 0093
Gastrointestinal 0122Gastrointestinal 0122
Haematopoetisch 0342Haematopoetic 0342
Haut-Muskel 0097Skin muscle 0097
Hoden 0154Testis 0154
Lunge 0082Lungs 0082
Nerven 0.0080Nerves 0.0080
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0042 Elektronischer Northern für SEQ. ID. NO: 8Uterus n 0.0042 Electronic Northern for SEQ. ID. NO: 8
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufιgkeit %Haeufιgkeιt N/T T/N% Haeufιgkeit% Haeufιgkeιt N / T T / N
Blase 0.0312 0.0460 0.67801.4750Bubble 0.0312 0.0460 0.67801.4750
Brust 0.0192 0.0282 0.68051.4694Breast 0.0192 0.0282 0.68051.4694
Duenndarm 0.0368 0.0000 undef 0.0000Small intestine 0.0368 0.0000 undef 0.0000
Eierstock 0.0210 0.0364 0.57561.7372Ovary 0.0210 0.0364 0.57561.7372
Endokrines Gewebe 0.0290 0.0326 0.88821.1258Endocrine tissue 0.0290 0.0326 0.88821.1258
Gastrointestinal 0.0460 0.0231 1.98800.5030Gastrointestinal 0.0460 0.0231 1.98800.5030
Gehirn 0.0532 0.0585 0.90941.0996Brain 0.0532 0.0585 0.90941.0996
Haematopoetisch 0.0361 0.0379 0.95281.0496Haematopoetic 0.0361 0.0379 0.95281.0496
Haut 0.0367 0.0000 undef 0.0000Skin 0.0367 0.0000 undef 0.0000
Hepatisch 0.0048 0.0647 0.073513.5999Hepatic 0.0048 0.0647 0.073513.5999
Herz 0.0699 0.0412 1.69610.5896Heart 0.0699 0.0412 1.69610.5896
Hoden 0.0288 0.4210 0.068314.6349Testis 0.0288 0.4210 0.068314.6349
Lunge 0.0343 0.0368 0.93141.0737Lungs 0.0343 0.0368 0.93141.0737
Magen-Speiseroehre 0.0773 0.0230 3.36140.2975Gastric ear of ear 0.0773 0.0230 3.36140.2975
Muskel-Skelett 0.0497 0.0660 0.75281.3283Musculoskeletal system 0.0497 0.0660 0.75281.3283
Niere 0.0353 0.1575 0.22414.4619Kidney 0.0353 0.1575 0.22414.4619
Pankreas 0.0165 0.0939 0.17605.6828Pancreas 0.0165 0.0939 0.17605.6828
Penis 0.0299 0.0267 1.12320.8903Penis 0.0299 0.0267 1.12320.8903
Prostata 0.0196 0.0298 0.65801.5197Prostate 0.0196 0.0298 0.65801.5197
Uterus Endometrium 0.0270 0.1583 0.17075.8579Uterine endometrium 0.0270 0.1583 0.17075.8579
Uterus Myometrium 0.0229 0.0679 0.33672.9702Uterine myometrium 0.0229 0.0679 0.33672.9702
Uterus allgemein 0.0051 0.0954 0.053418.7357General uterus 0.0051 0.0954 0.053418.7357
Brust-Hyperplasie 0.0192Breast hyperplasia 0.0192
Prostata-Hyperplasie 0.0505Prostate hyperplasia 0.0505
Samenblase 0.0890Seminal vesicle 0.0890
Sinnesorgane 0.0353Sensory organs 0.0353
Weisse Blutkoerperchen 0.0399White blood cells 0.0399
Zervix 0.0319Cervix 0.0319
FOETUS %HaeufιgkeitFOETUS% frequency
Entwicklung 0.0417Development 0.0417
Gastromtenstmal 0.0333Gastromtenstmal 0.0333
Gehirn 0.0313Brain 0.0313
Haematopoetisch 0.0197Haematopoetic 0.0197
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0783Cardiac blood vessels 0.0783
Lunge 0.0217Lungs 0.0217
Nebenniere 0.0507Adrenal gland 0.0507
Niere 0.0309Kidney 0.0309
Placenta 0.0727Placenta 0.0727
Prostata 0.0997Prostate 0.0997
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeit% Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0152Ovary t 0.0152
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0082Fetal 0.0082
Gastrointestinal 0.0244Gastrointestinal 0.0244
Haematopoetisch 0.0057Haematopoietic 0.0057
Haut-Muskel 0.0032Skin muscle 0.0032
Hoden 0.0077Testicles 0.0077
Lunge 0.0082Lungs 0.0082
Nerven 0.0141Nerves 0.0141
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0310Sensory organs 0.0310
Uterus n 0.0125 Elektronischer Northern für SEQ. ID. NO: 9Uterus n 0.0125 Electronic Northern for SEQ. ID. NO: 9
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufιgkιeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0468 0.0204 2.28820.4370Bubble 0.0468 0.0204 2.28820.4370
Brust 0.0205 0.0451 0.45372.2042Breast 0.0205 0.0451 0.45372.2042
Duenndarm 0.0307 0.0331 0.92681.0789Small intestine 0.0307 0.0331 0.92681.0789
Eierstock 0.0539 0.0468 1.15130.8686Ovary 0.0539 0.0468 1.15130.8686
Endokrines Gewebe 0.0562 0.0527 1.06740.9369Endocrine tissue 0.0562 0.0527 1.06740.9369
Gastrointestinal 0.0249 0.0324 0.76921.3001Gastrointestinal 0.0249 0.0324 0.76921.3001
Gehirn 0.0333 0.0318 1.04510.9568Brain 0.0333 0.0318 1.04510.9568
Haematopoetisch 0.0388 0.0379 1.02340.9772Haematopoetic 0.0388 0.0379 1.02340.9772
Haut 0.0257 0.1695 0.15166.5954Skin 0.0257 0.1695 0.15166.5954
Hepatisch 0.0095 0.0259 0.36762.7200Hepatic 0.0095 0.0259 0.36762.7200
Herz 0.0540 0.0000 undef 0.0000Heart 0.0540 0.0000 undef 0.0000
Hoden 0.0173 0.0702 0.24604.0652Testis 0.0173 0.0702 0.24604.0652
Lunge 0.0291 0.0491 0.59271.6872Lungs 0.0291 0.0491 0.59271.6872
Magen-Speiseroehre 0.0000 0.0230 0.0000 undefGastro-ear of ear 0.0000 0.0230 0.0000 undef
Muskel-Skelett 0.0206 0.1140 0.18035.5448Musculoskeletal system 0.0206 0.1140 0.18035.5448
Niere 0.0733 0.0274 2.67650.3736Kidney 0.0733 0.0274 2.67650.3736
Pankreas 0.0264 0.0331 0.79771.2536Pancreas 0.0264 0.0331 0.79771.2536
Penis 0.0269 0.0533 0.50541.9786Penis 0.0269 0.0533 0.50541.9786
Prostata 0.0501 0.0341 1.47150.6796Prostate 0.0501 0.0341 1.47150.6796
Uterus Endometriu 0.0541 0.2639 0.20494.8816Endometrial uterus 0.0541 0.2639 0.20494.8816
Uterus Myometrium 0.0152 0.0611 0.24944.0097Uterine myometrium 0.0152 0.0611 0.24944.0097
Uterus_allgemem 0.0204 0.0000 undef 0.0000Uterus_general 0.0204 0.0000 undef 0.0000
Brust-Hyperplasie 0.0512Breast hyperplasia 0.0512
Prostata-Hyperplasie 0.0386Prostate hyperplasia 0.0386
Samenblase 0.0623Seminal vesicle 0.0623
Sinnesorgane 0.0470 ιsse_Blutkoerperchen 0.0286Sensory organs 0.0470 ιsse_Blutkoerperchen 0.0286
Zervix 0.0426Cervix 0.0426
FOETUS %HaeufιgkeιtFOETUS% Haeufιgkeιt
Entwicklung 0.0557Development 0.0557
Gastromtenstmal 0.0666Gastromtenstmal 0.0666
Gehirn 0.0626Brain 0.0626
Haematopoetisch 0.0786Haematopoetic 0.0786
Haut 0.0000Skin 0.0000
Hepatisch 0.0260Hepatic 0.0260
Herz-Blutgefaesse 0.0818Cardiac blood vessels 0.0818
Lunge 0.0867Lungs 0.0867
Nebenniere 0.0761Adrenal gland 0.0761
Niere 0.0432Kidney 0.0432
Placenta 0.0606Placenta 0.0606
Prostata 0.0249Prostate 0.0249
Sinnesorgane 0.0628Sensory organs 0.0628
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0068Breast 0.0068
Eierstock 0.1595Ovary 0.1595
Eierstock t 0.0051Ovary t 0.0051
Endokrines Gewebe 0.0245Endocrine tissue 0.0245
Foetal 0.0256Fetal 0.0256
Gastrointestinal 0.0732Gastrointestinal 0.0732
Haematopoetisch 0.0057Haematopoietic 0.0057
Haut-Muskel 0.0551Skin muscle 0.0551
Hoden 0.0309Testis 0.0309
Lunge 0.0737Lungs 0.0737
Nerven 0.0231Nerves 0.0231
Prostata 0.0137Prostate 0.0137
Sinnesorgane 0.0310Sensory organs 0.0310
Uterus n 0.0333 Elektronischer Northern für SEQ. ID. NO: 10Uterus n 0.0333 Electronic Northern for SEQ. ID. NO: 10
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeu lgkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.1131 0.1431 0.79001 .2659Bubble 0.1131 0.1431 0.79001 .2659
Brust 0.1356 0.1692 0.80151 .2476Breast 0.1356 0.1692 0.80151 .2476
Duenndarm 0.1962 0.0165 11.8636 0.0843Small intestine 0.1962 0.0165 11.8636 0.0843
Eierstock 0.1827 0.2446 0.74711. .3385Ovary 0.1827 0.2446 0.74711. .3385
Endokrines Gewebe 0.1090 0.1329 0.82021 .2192Endocrine tissue 0.1090 0.1329 0.82021 .2192
Gastrointestinal 0.1878 0.2590 0.72481, .3797Gastrointestinal 0.1878 0.2590 0.72481, .3797
Gehirn 0.1035 0.1325 0.78141, .2798Brain 0.1035 0.1325 0.78141, .2798
Haematopoetisch 0.2700 0.1894 1.42570, ,7014Haematopoetic 0.2700 0.1894 1.42570,, 7014
Haut 0.1358 0.0847 1.60280, .6239Skin 0.1358 0.0847 1.60280, .6239
Hepatisch 0.0428 0.1812 0.23634, .2311Hepatic 0.0428 0.1812 0.23634, .2311
Herz 0.2586 0.0137 18.8118 0.0532Heart 0.2586 0.0137 18.8118 0.0532
Hoden 0.0633 0.1403 0.45102. .2174Testis 0.0633 0.1403 0.45102. .2174
Lunge 0.3231 0.2229 1.44950. .6899Lungs 0.3231 0.2229 1.44950. .6899
Magen-Speiseroehre 0.1643 0.2147 0.76531. ,3066Gastric ear of ear 0.1643 0.2147 0.76531. , 3066
Muskel-Skelett 0.1970 0.0960 2.05240, .4872Musculoskeletal 0.1970 0.0960 2.05240, .4872
Niere 0.1222 0.2328 0.52481. ,9055Kidney 0.1222 0.2328 0.52481. , 9055
Pankreas 0.0876 0.1767 0.49552. ,0183Pancreas 0.0876 0.1767 0.49552. , 0183
Penis 0.1407 0.1600 0.87981. 1366Penis 0.1407 0.1600 0.87981. 1366
Prostata 0.1003 0.0766 1.30800. ,7645Prostate 0.1003 0.0766 1.30800. , 7645
Uterus_Endometrιum 0.1824 0.0528 3.45690. 2893Uterine endometrium 0.1824 0.0528 3.45690. 2893
Uterus Myometrium 0.1677 0.3804 0.44092. 2681Uterine myometrium 0.1677 0.3804 0.44092. 2681
Uterus allgemein 0.2292 0.0000 undef 0. 0000General uterus 0.2292 0.0000 undef 0. 0000
Brust-Hyperplasie 0.0735Breast hyperplasia 0.0735
Prostata-Hyperplasie 0.0684Prostate hyperplasia 0.0684
Samenblase 0.1335Seminal vesicle 0.1335
Sinnesorgane 0.0470Sensory organs 0.0470
Weιsse_Blutkoerperchen 0.2749Weιsse_Blutkoerperchen 0.2749
Zervix 0.0958Cervix 0.0958
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0139Development 0.0139
Gastromtenstmal 0.0639Gastromtenstmal 0.0639
Gehirn 0.1063Brain 0.1063
Haematopoetisch 0.1258Haematopoietic 0.1258
Haut 0.2513Skin 0.2513
Hepatisch 0.0260Hepatic 0.0260
Herz-Blutgefaesse 0.0712Cardiac blood vessels 0.0712
Lunge 0.1517Lungs 0.1517
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0988Kidney 0.0988
Placenta 0.0909Placenta 0.0909
Prostata 0.1745Prostate 0.1745
Sinnesorgane 0.0377Sensory organs 0.0377
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0136Breast 0.0136
Eierstock n 0.3190Ovary n 0.3190
Eierstock t 0.0709Ovary t 0.0709
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0326Fetal 0.0326
Gastrointestinal 0.1464Gastrointestinal 0.1464
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.1328Skin muscle 0.1328
Hoden 0.0154Testicles 0.0154
Lunge 0.2211Lungs 0.2211
Nerven 0.0311Nerves 0.0311
Prostata 0.0410Prostate 0.0410
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0333 Elektronischer Northern für SEQ. ID. NO: 11Uterus n 0.0333 Electronic Northern for SEQ. ID. NO: 11
NORMAL TUMOR Verhaeltnisse %Haeufιgkeιt %Haeufιgkeιt N/T T/NNORMAL TUMOR Ratios% Haeufιgkeιt% Haeufιgkeιt N / T T / N
Blase 0.0156 0, .0051 3.05090.3278Bubble 0.0156 0 .0051 3.05090.3278
Brust 0.0064 0. .0113 0.56711.7633Breast 0.0064 0..0113 0.56711.7633
Duenndarm 0.0031 0, .0000 undef 0.0000Small intestine 0.0031 0, .0000 undef 0.0000
Eierstock 0.0240 0, .0234 1.02330.9772Ovary 0.0240 0 .0234 1.02330.9772
Endokrines Gewebe 0.0068 0, .0100 0.67921.4722Endocrine tissue 0.0068 0 .0100 0.67921.4722
Gastrointestinal 0.0096 0, .0046 2.07080.4829Gastrointestinal 0.0096 0, .0046 2.07080.4829
Gehirn 0.0022 0, .0257 0.086411.5747Brain 0.0022 0, .0257 0.086411.5747
Haematopoetisch 0.0147 0, .0000 undef 0.0000Haematopoetic 0.0147 0, .0000 undef 0.0000
Haut 0.0110 0, .0000 undef 0.0000Skin 0.0110 0, .0000 undef 0.0000
Hepatisch 0.0238 0, .0065 3.67650.2720Hepatic 0.0238 0 .0065 3.67650.2720
Herz 0.0276 0, .0275 1.00230.9977Heart 0.0276 0, .0275 1.00230.9977
Hoden 0.0000 0, .0117 0.0000 undefTesticles 0.0000 0, .0117 0.0000 undef
Lunge 0.0083 0, .0245 0.33872.9526Lungs 0.0083 0, .0245 0.33872.9526
Magen-Speiseroehre 0.0000 0, .0077 0.0000 undefStomach-ear of ear 0.0000 0, .0077 0.0000 undef
Muskel-Skelett 0.0086 0. .0060 1.42780.7004Musculoskeletal system 0.0086 0. .0060 1.42780.7004
Niere 0.0081 0, .0616 0.13227.5658Kidney 0.0081 0, .0616 0.13227.5658
Pankreas 0.0165 0. .0000 undef 0.0000Pancreas 0.0165 0. .0000 undef 0.0000
Penis 0.0120 0, .0267 0.44932.2259Penis 0.0120 0, .0267 0.44932.2259
Prostata 0.0065 0, .0085 0.76771.3026Prostate 0.0065 0, .0085 0.76771.3026
Uterus Endometrium 0.0270 0, ,0000 undef 0.0000Uterine endometrium 0.0270 0, .0000 undef 0.0000
Uterus Myometrium 0.0076 0, .0951 0.080212.4748Uterine myometrium 0.0076 0 .0951 0.080212.4748
Uterus allgemein 0.0968 0. .0000 undef 0.0000General uterus 0.0968 0. .0000 undef 0.0000
Brust-Hyperplasie 0.0096Breast hyperplasia 0.0096
Prostata-Hyperplasie 0.0089Prostate hyperplasia 0.0089
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0706Sensory organs 0.0706
Weιsse_Blutkoerperchen 0.0000White blood body 0.0000
Zervix 0.0106Cervix 0.0106
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0139Development 0.0139
Gastromtenstmal 0.0278Gastromtenstmal 0.0278
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0708Haematopoetic 0.0708
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0320Cardiac blood vessels 0.0320
Lunge 0.0036Lungs 0.0036
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0124Kidney 0.0124
Placenta 0.2121Placenta 0.2121
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0233Fetal 0.0233
Gastrointestinal 0.0244Gastrointestinal 0.0244
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0648Skin muscle 0.0648
Hoden 0.0000Testicles 0.0000
Lunge 0.0164Lungs 0.0164
Nerven 0.0010Nerves 0.0010
Prostata 0.0068Prostate 0.0068
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0083 Elektronischer Northern für SEQ. ID. NO: 12Uterus n 0.0083 Electronic Northern for SEQ. ID. NO: 12
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeuf_ .gkeit %Haeufιgkιeit N/T T/N% Haeuf_ .gkeit% Haeufιgkιeit N / T T / N
Blase 0.0351 0.3093 0.11358.8135Bubble 0.0351 0.3093 0.11358.8135
Brust 0.0269 0.0470 0.57161.7493Breast 0.0269 0.0470 0.57161.7493
Duenndarm 0.0092 0.0662 0.13907.1929Small intestine 0.0092 0.0662 0.13907.1929
Eierstock 0.0569 0.0182 3.12480.3200Ovary 0.0569 0.0182 3.12480.3200
Endokrines Gewebe 0.0528 0.0502 1.05280.9498Endocrine tissue 0.0528 0.0502 1.05280.9498
Gastrointestinal 0.0019 0.0093 0.20714.8289Gastrointestinal 0.0019 0.0093 0.20714.8289
Gehirn 0.0022 0.0873 0.025439.3541Brain 0.0022 0.0873 0.025439.3541
Haematopoetisch 0.0147 0.0000 undef 0.0000Haematopoetic 0.0147 0.0000 undef 0.0000
Haut 0.0220 0.5085 0.043323.0839Skin 0.0220 0.5085 0.043323.0839
Hepatisch 0.0285 0.0582 0.49022.0400Hepatic 0.0285 0.0582 0.49022.0400
Herz 0.0191 0.0000 undef 0.0000Heart 0.0191 0.0000 undef 0.0000
Hoden 0.0115 0.0000 undef 0.0000Testicles 0.0115 0.0000 undef 0.0000
Lunge 0.0114 0.0061 1.86280.5368Lungs 0.0114 0.0061 1.86280.5368
Magen-Speiseroehre 0.0193 0.0077 2.52110.3967Stomach-ear of ear 0.0193 0.0077 2.52110.3967
Muskel-Skelett 0.0771 0.0540 1.42780.7004Musculoskeletal system 0.0771 0.0540 1.42780.7004
Niere 0.0489 0.0137 3.56870.2802Kidney 0.0489 0.0137 3.56870.2802
Pankreas 0.0264 0.0442 0.59831.6714Pancreas 0.0264 0.0442 0.59831.6714
Penis 0.0090 0.1066 0.084211.8713Penis 0.0090 0.1066 0.084211.8713
Prostata 0.0000 0.0064 0.0000 undefProstate 0.0000 0.0064 0.0000 undef
Uterus Endometrium 0.0743 0.0000 undef 0.0000Uterine endometrium 0.0743 0.0000 undef 0.0000
Uterus Myometrium 0.0381 0.1494 0.25513.9206Uterine myometrium 0.0381 0.1494 0.25513.9206
Uterus allgemein 0.0153 0.0954 0.16016.2452General uterus 0.0153 0.0954 0.16016.2452
Brust-Hyperplasie 0.0096Breast hyperplasia 0.0096
Prostata-Hyperplasie 0.0059Prostate hyperplasia 0.0059
Samenblase 0.0000Seminal vesicle 0.0000
Sinnesorgane 0.0118Sensory organs 0.0118
Weιsse_Blutkoerperchen 0.0000White blood body 0.0000
Zervix 0.0000Cervix 0.0000
FOETUS %HaeufιgkeitFOETUS% frequency
Entwicklung 0.0696Development 0.0696
Gastromtenstmal 0.4387Gastromtenstmal 0.4387
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.2713Haematopoetic 0.2713
Haut 0.0000Skin 0.0000
Hepatisch 1.6121Hepatic 1.6121
Herz-Blutgefaesse 0.0605Cardiac blood vessels 0.0605
Lunge 0.1770Lungs 0.1770
Nebenniere 1.1663Adrenal gland 1.1663
Niere 0.8092Kidney 0.8092
Placenta 0.7635Placenta 0.7635
Prostata 0.0499Prostate 0.0499
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
.Haeufigkeit.Frequency
Brust 0.0612Breast 0.0612
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.1114Ovary t 0.1114
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.4665Fetal 0.4665
Gastrointestinal 0.0000Gastrointestinal 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0000Skin muscle 0.0000
Hoden 0.0000Testicles 0.0000
Lunge 0.0000Lungs 0.0000
Nerven 0.0030Nerves 0.0030
Prostata 0.0068Prostate 0.0068
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0291 Elektronischer Northern für SEQ. ID. NO: 13Uterus n 0.0291 Electronic Northern for SEQ. ID. NO: 13
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0078 0.0204 0.38142.6222Bubble 0.0078 0.0204 0.38142.6222
Brust 0.0256 0.0432 0.59181.6899Breast 0.0256 0.0432 0.59181.6899
Duenndarm 0.0000 0.0000 undef undefSmall intestine 0.0000 0.0000 undef undef
Eierstock 0.0060 0.0078 0.76751.3029Ovary 0.0060 0.0078 0.76751.3029
Endokrines Gewebe 0.0000 0.0050 0.0000 undefEndocrine tissue 0.0000 0.0050 0.0000 undef
Gastrointestinal 0.0000 0.0000 undef undefGastrointestinal 0.0000 0.0000 undef undef
Gehirn 0.0074 0.0216 0.34282.9168Brain 0.0074 0.0216 0.34282.9168
Haematopoetisch 0.0013 0.0000 undef 0.0000Haematopoetic 0.0013 0.0000 undef 0.0000
Haut 0.0073 0.0000 undef 0.0000Skin 0.0073 0.0000 undef 0.0000
Hepatisch 0.0000 0.0000 undef undefHepatic 0.0000 0.0000 undef undef
Herz 0.0021 0.0000 undef 0.0000Heart 0.0021 0.0000 undef 0.0000
Hoden 0.0115 0.0468 0.24604.0652Testicles 0.0115 0.0468 0.24604.0652
Lunge 0.0031 0.0082 0.38102.6245Lungs 0.0031 0.0082 0.38102.6245
Magen-Speiseroehre 0.0580 0.0000 undef 0.0000Stomach-ear of ear 0.0580 0.0000 undef 0.0000
Muskel-Skelett 0.0000 0.0300 0.0000 undefMusculoskeletal 0.0000 0.0300 0.0000 undef
Niere 0.0027 0.0000 undef 0.0000Kidney 0.0027 0.0000 undef 0.0000
Pankreas 0.0033 0.0276 0.11978.3571Pancreas 0.0033 0.0276 0.11978.3571
Penis 0.0210 0.1066 0.19665.0877Penis 0.0210 0.1066 0.19665.0877
Prostata 0.0022 0.0043 0.51181.9538Prostate 0.0022 0.0043 0.51181.9538
Uterus Endometrium 0.0135 0.0000 undef 0.0000Uterine endometrium 0.0135 0.0000 undef 0.0000
Uterus Myometrium 0.0305 0.0883 0.34532.8959Uterine myometrium 0.0305 0.0883 0.34532.8959
Uterus allgemein 0.0102 0.0000 undef 0.0000General uterus 0.0102 0.0000 undef 0.0000
Brust-Hyperplasie 0.0160Breast hyperplasia 0.0160
Prostata-Hyperplasie 0.0059Prostate hyperplasia 0.0059
Samenblase 0.0356Seminal vesicle 0.0356
Sinnesorgane 0.0000 lsse Blutkoerperchen 0.0035Sensory organs 0.0000 blood corpuscles 0.0035
Zervix 0.0639Cervix 0.0639
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0000Development 0.0000
Gastromtenstmal 0.0028Gastromtenstmal 0.0028
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0000Cardiac blood vessels 0.0000
Lunge 0.0145Lungs 0.0145
Nebenniere 0.0761Adrenal gland 0.0761
Niere 0.0247Kidney 0.0247
Placenta 0.0061Placenta 0.0061
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0408Breast 0.0408
Eierstöcken 0.0000Eierstöck e n 0.0000
Eιerstock_t 0.1266Eιerstock_t 0.1266
Endokrmes_Gewebe 0.0000Endokrmes_Gewebe 0.0000
Foetal 0.0047Fetal 0.0047
Gastrointestinal 0.0000Gastrointestinal 0.0000
Haematopoetisch 0.0057Haematopoietic 0.0057
Haut-Muskel 0.0032Skin muscle 0.0032
Hoden 0.0000Testicles 0.0000
Lunge 0.0000Lungs 0.0000
Nerven 0.0030Nerves 0.0030
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0208 Elektronischer Northern für SEQ. ID. NO: 14Uterus n 0.0208 Electronic Northern for SEQ. ID. NO: 14
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufι .gkea t %Haeufιgkιeit N/T T/N% Haeufι .gkea t% Haeufιgkιeit N / T T / N
Blase 0.0195 0.0051 3.81360.2622Bubble 0.0195 0.0051 3.81360.2622
Brust 0.0051 0.0132 0.38892.5715Breast 0.0051 0.0132 0.38892.5715
Duenndarm 0.0061 0.0000 undef 0.0000Small intestine 0.0061 0.0000 undef 0.0000
Eierstock 0.0150 0.0130 1.15130.8686Ovary 0.0150 0.0130 1.15130.8686
Endokrines Gewebe 0.0153 0.0150 1.01890.9815Endocrine tissue 0.0153 0.0150 1.01890.9815
Gastromtestmal 0.0115 0.0000 undef 0.0000Gastrom test times 0.0115 0.0000 undef 0.0000
Gehirn 0.0133 0.0133 0.99691.0031Brain 0.0133 0.0133 0.99691.0031
Haematopoetisch 0.0174 0.0000 undef 0.0000Haematopoetic 0.0174 0.0000 undef 0.0000
Haut 0.0147 0.0000 undef 0.0000Skin 0.0147 0.0000 undef 0.0000
Hepatisch 0.0000 0.0194 0.0000 undefHepatic 0.0000 0.0194 0.0000 undef
Herz 0.0265 0.0000 undef 0.0000Heart 0.0265 0.0000 undef 0.0000
Hoden 0.0058 0.0000 undef 0.0000Testicles 0.0058 0.0000 undef 0.0000
Lunge 0.0042 0.0164 0.25403.9367Lungs 0.0042 0.0164 0.25403.9367
Magen-Speiseroehre 0.0000 0.0077 0.0000 undefGastro-ear of ear 0.0000 0.0077 0.0000 undef
Muskel-Skelett 0.0069 0.0540 0.12697.8795Musculoskeletal system 0.0069 0.0540 0.12697.8795
Niere 0.0217 0.0274 0.79301.2610Kidney 0.0217 0.0274 0.79301.2610
Pankreas 0.0165 0.0055 2.99150.3343Pancreas 0.0165 0.0055 2.99150.3343
Penis 0.0090 0.0000 undef 0.0000Penis 0.0090 0.0000 undef 0.0000
Prostata 0.0087 0.0170 0.51181.9538Prostate 0.0087 0.0170 0.51181.9538
Uterus Endometrium 0.0338 0.2111 0.16006.2484Uterine endometrium 0.0338 0.2111 0.16006.2484
Uterus Myometrium 0.0076 0.0475 0.16036.2374Uterine myometrium 0.0076 0.0475 0.16036.2374
Uterus allgemein 0.0000 0.0000 undef undefGeneral uterus 0.0000 0.0000 undef undef
Brust-Hyperplasie 0.0320Breast hyperplasia 0.0320
Prostata-Hyperplasie 0.0238Prostate hyperplasia 0.0238
Samenblase 0.0267Seminal vesicle 0.0267
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0069White blood cells 0.0069
Zervix 0.0213Cervix 0.0213
FOETUS %HaeufιgkeitFOETUS% frequency
Entwicklung 0.0417Development 0.0417
Gastromtenstmal 0.0139Gastromtenstmal 0.0139
Gehirn 0.0125Brain 0.0125
Haematopoetisch 0.0157Haematopoetic 0.0157
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0427Cardiac blood vessels 0.0427
Lunge 0.0253Lungs 0.0253
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0124Kidney 0.0124
Placenta 0.0121Placenta 0.0121
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0126Sensory organs 0.0126
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeit% Frequency
Brust 0.0068Breast 0.0068
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0051Ovary t 0.0051
Endokrines Gewebe 0.0245Endocrine tissue 0.0245
Foetal 0.0035Fetal 0.0035
Gastrointestinal 0.0244Gastrointestinal 0.0244
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0 . 0065Skin muscle 0. 0065
Hoden 0 . 0000Testicles 0. 0000
Lunge 0 . 0082Lungs 0. 0082
Nerven 0 . 0050Nerves 0. 0050
Prostata 0 . 0137Prostate 0. 0137
Sinnesorgane 0 . 0155Sensory organs 0. 0155
Uterus n 0 . 0042 Elektronischer Northern für SEQ. ID. NO: 15Uterus n 0. 0042 Electronic Northern for SEQ. ID. NO: 15
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufιgkeit %Haeuflgkeit N/T T/N% Frequency% frequency N / D T / N
Blase 0.0078 0.0102 0.76271.3111Bubble 0.0078 0.0102 0.76271.3111
Brust 0.0026 0.0150 0.17015.8778Breast 0.0026 0.0150 0.17015.8778
Duenndarm 0.0184 0.0496 0.37072.6973Small intestine 0.0184 0.0496 0.37072.6973
Eierstock 0.0000 0.0052 0.0000 undefOvary 0.0000 0.0052 0.0000 undef
Endokrines Gewebe 0.0000 0.0025 0.0000 undefEndocrine tissue 0.0000 0.0025 0.0000 undef
Gastrointestinal 0.0000 0.0093 0.0000 undefGastrointestinal 0.0000 0.0093 0.0000 undef
Gehirn 0.0007 0.0072 0.10299.7228Brain 0.0007 0.0072 0.10299.7228
Haematopoetisch 0.0000 0.0000 undef undefHaematopoetic 0.0000 0.0000 undef undef
Haut 0.0037 0.0000 undef 0.0000Skin 0.0037 0.0000 undef 0.0000
Hepatisch 0.0000 0.0000 undef undefHepatic 0.0000 0.0000 undef undef
Herz 0.0032 0.0000 undef 0.0000Heart 0.0032 0.0000 undef 0.0000
Hoden 0.0058 0.0000 undef 0.0000Testicles 0.0058 0.0000 undef 0.0000
Lunge 0.0021 0.0041 0.50801.9684Lungs 0.0021 0.0041 0.50801.9684
Magen-Speiseroehre 0.0000 0.0307 0.0000 undefGastro-ear of ear 0.0000 0.0307 0.0000 undef
Muskel-Skelett 0.0086 0.0240 0.35692.8016Musculoskeletal 0.0086 0.0240 0.35692.8016
Niere 0.0027 0.0000 undef 0.0000Kidney 0.0027 0.0000 undef 0.0000
Pankreas 0.0000 0.0055 0.0000 undefPancreas 0.0000 0.0055 0.0000 undef
Penis 0.0240 0.0000 undef 0.0000Penis 0.0240 0.0000 undef 0.0000
Prostata 0.0065 0.0021 3.07090.3256Prostate 0.0065 0.0021 3.07090.3256
Uterus Endometrium 0.0000 0.0000 undef undefUterine endometrium 0.0000 0.0000 undef undef
Uterus Myometrium 0.0000 0.0340 0.0000 undefUterine myometrium 0.0000 0.0340 0.0000 undef
Uterus allgemein 0.0000 0.0000 undef undefGeneral uterus 0.0000 0.0000 undef undef
Brust-Hyperplasie 0.0096Breast hyperplasia 0.0096
Prostata-Hyperplasie 0.0000Prostate hyperplasia 0.0000
Samenblase 0.0000Seminal vesicle 0.0000
Sinnesorgane 0.0118Sensory organs 0.0118
Weisse Blutkoerperchen 0.0000White blood cells 0.0000
Zervix 0.0000Cervix 0.0000
FOETUS %HaeufιgkeitFOETUS% frequency
Entwicklung 0.0139Development 0.0139
Gastromtenstmal 0.0000Gastromtenstmal 0.0000
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0039Haematopoietic 0.0039
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0036Heart blood vessels 0.0036
Lunge 0.0036Lungs 0.0036
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0000Kidney 0.0000
Placenta 0.0000Placenta 0.0000
Prostata 0.0249Prostate 0.0249
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeit% Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0000Fetal 0.0000
Gastrointestinal 0.0000Gastrointestinal 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0000Skin muscle 0.0000
Hoden 0.0000Testicles 0.0000
Lunge 0.0000Lungs 0.0000
Nerven 0.0020Nerves 0.0020
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0125 Elektronischer Northern für SEQ. ID. NO: 16Uterus n 0.0125 Electronic Northern for SEQ. ID. NO: 16
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeuf_ .gkeit %Haeufigkeit N/T T/N% Frequency ..% frequency N / D T / N
Blase 0.0039 0.0153 0.25423.9333Bubble 0.0039 0.0153 0.25423.9333
Brust 0.0077 0.0038 2.04160.4898Breast 0.0077 0.0038 2.04160.4898
Duenndarm 0.0123 0.0000 undef 0.0000Small intestine 0.0123 0.0000 undef 0.0000
Eierstock 0.0060 0.0026 2.30250.4343Ovary 0.0060 0.0026 2.30250.4343
Endokrines Gewebe 0.0119 0.0251 0.47552.1032Endocrine tissue 0.0119 0.0251 0.47552.1032
Gastromtestmal 0.0096 0.0139 0.69031.4487Gastro test times 0.0096 0.0139 0.69031.4487
Gehirn 0.0163 0.0246 0.66001.5152Brain 0.0163 0.0246 0.66001.5152
Haematopoetisch 0.0040 0.0000 undef 0.0000Haematopoetic 0.0040 0.0000 undef 0.0000
Haut 0.0110 0.0000 undef 0.0000Skin 0.0110 0.0000 undef 0.0000
Hepatisch 0.0095 0.0065 1.47060.6800Hepatic 0.0095 0.0065 1.47060.6800
Herz 0.0180 0.0000 undef 0.0000Heart 0.0180 0.0000 undef 0.0000
Hoden 0.0000 0.0117 0.0000 undefTesticles 0.0000 0.0117 0.0000 undef
Lunge 0.0135 0.0082 1.65110.6057Lungs 0.0135 0.0082 1.65110.6057
Magen-Speiseroehre 0.0000 0.0153 0.0000 undefGastro-ear of ear 0.0000 0.0153 0.0000 undef
Muskel-Skelett 0.0069 0.0060 1.14220.8755Musculoskeletal 0.0069 0.0060 1.14220.8755
Niere 0.0000 0.0000 undef undefKidney 0.0000 0.0000 undef undef
Pankreas 0.0033 0.0276 0.11978.3571Pancreas 0.0033 0.0276 0.11978.3571
Penis 0.0090 0.0267 0.33692.9678Penis 0.0090 0.0267 0.33692.9678
Prostata 0.0196 0.0128 1.53540.6513Prostate 0.0196 0.0128 1.53540.6513
Uterus Endometnum 0.0068 0.0000 undef 0.0000Uterus endometnum 0.0068 0.0000 undef 0.0000
Uterus_Myometπum 0.0000 0.0408 0.0000 undefUterus_Myometπum 0.0000 0.0408 0.0000 undef
Uterus allgemein 0.0357 0.0000 undef 0.0000General uterus 0.0357 0.0000 undef 0.0000
Brust-Hyperplasie 0.0128Breast hyperplasia 0.0128
Prostata-Hyperplasie 0.0089Prostate hyperplasia 0.0089
Samenblase 0.0267Seminal vesicle 0.0267
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0000White blood cells 0.0000
Zervix 0.0000Cervix 0.0000
FOETUS %HaeufιgkeitFOETUS% frequency
Entwicklung 0.0000Development 0.0000
Gastromtenstmal 0.0000Gastromtenstmal 0.0000
Gehirn 0.0375Brain 0.0375
Haematopoetisch 0.0039Haematopoietic 0.0039
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0071Cardiac blood vessels 0.0071
Lunge 0.0036Lungs 0.0036
Nebenniere 0.0507Adrenal gland 0.0507
Niere 0.0124Kidney 0.0124
Placenta 0.0061Placenta 0.0061
Prostata 0.0249Prostate 0.0249
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeit% Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0012Fetal 0.0012
Gastrointestinal 0.0122Gastrointestinal 0.0122
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0097Skin muscle 0.0097
Hoden 0.0000Testicles 0.0000
Lunge 0.0082Lungs 0.0082
Nerven 0.0050Nerves 0.0050
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0083 Elektronischer Northern für SEQ. ID. NO: 17Uterus n 0.0083 Electronic Northern for SEQ. ID. NO: 17
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeu igkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0195 0.0179 1.08960.9178Bubble 0.0195 0.0179 1.08960.9178
Brust 0.0307 0.0338 0.90741.1021Breast 0.0307 0.0338 0.90741.1021
Duenndarm 0.0184 0.0165 1.11220.8991Small intestine 0.0184 0.0165 1.11220.8991
Eierstock 0.0509 0.0286 1.77920.5620Ovary 0.0509 0.0286 1.77920.5620
Endokrines Gewebe 0.0375 0.0301 1.24530.8030Endocrine tissue 0.0375 0.0301 1.24530.8030
Gastrointestinal 0.0153 0.0093 1.65670.6036Gastrointestinal 0.0153 0.0093 1.65670.6036
Gehirn 0.0222 0.0452 0.49092.0372Brain 0.0222 0.0452 0.49092.0372
Haematopoetisch 0.0160 0.0000 undef 0.0000Haematopoetic 0.0160 0.0000 undef 0.0000
Haut 0.0661 0.0000 undef 0.0000Skin 0.0661 0.0000 undef 0.0000
Hepatisch 0.0143 0.0518 0.27573.6266Hepatic 0.0143 0.0518 0.27573.6266
Herz 0.0636 0.0000 undef 0.0000Heart 0.0636 0.0000 undef 0.0000
Hoden 0.0173 0.0117 1.47590.6775Testis 0.0173 0.0117 1.47590.6775
Lunge 0.0177 0.0532 0.33223.0104Lungs 0.0177 0.0532 0.33223.0104
Magen-Speiseroehre 0.0483 0.0000 undef 0.0000Gastric ear of ear 0.0483 0.0000 undef 0.0000
Muskel-Skelett 0.0137 0.0960 0.14287.0040Musculoskeletal system 0.0137 0.0960 0.14287.0040
Niere 0.0217 0.0685 0.31723.1524Kidney 0.0217 0.0685 0.31723.1524
Pankreas 0.0264 0.0055 4.78640.2089Pancreas 0.0264 0.0055 4.78640.2089
Penis 0.0449 0.0000 undef 0.0000Penis 0.0449 0.0000 undef 0.0000
Prostata 0.0283 0.0341 0.83171.2024Prostate 0.0283 0.0341 0.83171.2024
Uterus Endometrium 0.0135 0.0000 undef 0.0000Uterine endometrium 0.0135 0.0000 undef 0.0000
Uterus Myometrium 0.0229 0.0679 0.33672.9702Uterine myometrium 0.0229 0.0679 0.33672.9702
Uterus allgemein 0.0051 0.0000 undef 0.0000General uterus 0.0051 0.0000 undef 0.0000
Brust-Hyperplasie 0.0671Breast hyperplasia 0.0671
Prostata-Hyperplasie 0.0476Prostate hyperplasia 0.0476
Samenblase 0.0356Seminal vesicle 0.0356
Sinnesorgane 0.0353Sensory organs 0.0353
Weisse Blutkoerperchen 0.0121White blood cells 0.0121
Zervix 0.0532Cervix 0.0532
FOETUS HaeufigkeitFOETUS frequency
Entwicklung 0.0557Development 0.0557
Gastromtenstmal 0.0278Gastromtenstmal 0.0278
Gehirn 0.0688Brain 0.0688
Haematopoetisch 0.0275Haematopoetic 0.0275
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0534Cardiac blood vessels 0.0534
Lunge 0.0831Lungs 0.0831
Nebenniere 0.1014Adrenal gland 0.1014
Niere 0.0741Kidney 0.0741
Placenta 0.0182Placenta 0.0182
Prostata 0.1247Prostate 0.1247
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eιerstock_t 0.0203Eιerstock_t 0.0203
Endokrines Gewebe 0.0490Endocrine tissue 0.0490
Foetal 0.0169Fetal 0.0169
Gastrointestinal 0 . 0122Gastrointestinal 0. 0122
Haematopoetisch 0. 0000Haematopoetic 0. 0000
Haut-Muskel 0 . 0259Skin muscle 0. 0259
Hoden 0. 0000Testicles 0.0000
Lunge 0. 0082Lungs 0. 0082
Nerven 0. 0050Nerves 0050
Prostata 0 . 0068Prostate 0. 0068
Sinnesorgane 0. 0000Sensory organs 0. 0000
Uterus n 0 . 0167 Elektronischer Northern für SEQ. ID. NO: 18Uterus n 0. 0167 Electronic Northern for SEQ. ID. NO: 18
NORMAL TUMOR Verhaelt nisseNORMAL TUMOR Behavior
%Haeuf igkeit %Haeuf igkeit N/T T/N% Frequency% frequency N / D T / N
Blase 0.0195 0, .0179 1.08960.9178Bubble 0.0195 0, .0179 1.08960.9178
Brust 0.0371 0, .0357 1.03870.9627Breast 0.0371 0 .0357 1.03870.9627
Duenndarm 0.0245 0, ,0331 0.74151.3487Small intestine 0.0245 0, .0331 0.74151.3487
Eierstock 0.0479 0, .0390 1.22800.8143Ovary 0.0479 0 .0390 1.22800.8143
Endokrines Gewebe 0.0358 0, .0326 1.09720.9114Endocrine tissue 0.0358 0 .0326 1.09720.9114
Gast romtest mal 0.0153 0, .0093 1.65670.6036Guest romtest times 0.0153 0, .0093 1.65670.6036
Gehirn 0.0229 0, .0524 0.43762.2851Brain 0.0229 0, .0524 0.43762.2851
Haematopoetisch 0.0147 0, .0000 undef 0.0000Haematopoetic 0.0147 0, .0000 undef 0.0000
Haut 0.0587 0, .0000 undef 0.0000Skin 0.0587 0, .0000 undef 0.0000
Hepatisch 0.0143 0, .0518 0.2757 3.6266Hepatic 0.0143 0.0518 0.2757 3.6266
Herz 0.0593 0, .0000 undef 0.0000Heart 0.0593 0, .0000 undef 0.0000
Hoden 0.0115 0, .0117 0.98391.0163Testes 0.0115 0 .0117 0.98391.0163
Lunge 0.0145 0, .0491 0.2964 3.3743Lungs 0.0145 0 .0491 0.2964 3.3743
Magen-Speiseroehre 0.0290 0, ,0000 undef 0.0000Gastric ear of ear 0.0290 0, .0000 undef 0.0000
Muskel-Skelett 0.0120 0, .1140 0.10529.5055Musculoskeletal 0.0120 0, .1140 0.10529.5055
Niere 0.0299 0, .0616 0.48462.0634Kidney 0.0299 0, .0616 0.48462.0634
Pankreas 0.0281 0, .0055 5.08550.1966Pancreas 0.0281 0 .0055 5.08550.1966
Penis 0.0449 0, .0000 undef 0.0000Penis 0.0449 0, .0000 undef 0.0000
Prostata 0.0349 0, .0319 1.09190.9159Prostate 0.0349 0 .0319 1.09190.9159
Uterus Endometπum 0.0203 0, .0000 undef 0.0000Uterine endometer 0.0203 0, .0000 undef 0.0000
Uterus Myometrium 0.0152 0, .0679 0.22454.4553Uterine myometrium 0.0152 0 .0679 0.22454.4553
Uterus_allgemem 0.0051 0, .0000 undef 0.0000Uterus_general 0.0051 0, .0000 undef 0.0000
Brust -Hyperplasie 0.0576Breast hyperplasia 0.0576
Prostata-Hyperplasie 0.0446Prostate hyperplasia 0.0446
Samenblase 0.0356Seminal vesicle 0.0356
Sinnesorgane 0.0235Sensory organs 0.0235
Weisse BlutKoerperchen 0.0130White blood corpuscles 0.0130
Zervix 0.0532Cervix 0.0532
FOETUS %Haeuf igkeitFOETUS% frequency
Entwicklung 0.0417Development 0.0417
Gastromtenstmal 0.0333Gastromtenstmal 0.0333
Gehirn 0.0688Brain 0.0688
Haematopoetisch 0.0275Haematopoetic 0.0275
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0427Cardiac blood vessels 0.0427
Lunge 0.0867Lungs 0.0867
Nebenniere 0.1268Adrenal gland 0.1268
Niere 0.0741Kidney 0.0741
Placenta 0.0182Placenta 0.0182
Prostata 0.1247Prostate 0.1247
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0000Breast 0.0000
Eierstock 0.0000Ovary 0.0000
Eιerstock_t 0.0253Eιerstock_t 0.0253
Endokrmes_Gewebe 0.0245Endocrmes_Tissue 0.0245
Foetal 0.0326Fetal 0.0326
Gastrointestinal 0.0122Gastrointestinal 0.0122
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0518Skin muscle 0.0518
Hoden 0.0000Testicles 0.0000
Lunge 0.0082Lungs 0.0082
Nerven 0.0090Nerves 0.0090
Prostata 0.0137Prostate 0.0137
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0208 Elektronischer Northern für SEQ. ID. NO: 19Uterus n 0.0208 Electronic Northern for SEQ. ID. NO: 19
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufι .gkeit %Haeufιgkι Bit N/T T/N% Haeufι .gkeit% Haeufιgkι Bit N / T T / N
Blase 0.0351 0.0332 1.05610.9469Bubble 0.0351 0.0332 1.05610.9469
Brust 0.0269 0.0376 0.71461.3995Breast 0.0269 0.0376 0.71461.3995
Duenndarm 0.0337 0.0992 0.33982.9425Small intestine 0.0337 0.0992 0.33982.9425
Eierstock 0.0240 0.0312 0.76751.3029Ovary 0.0240 0.0312 0.76751.3029
Endokrιnes_Gewebe 0.0409 0.0075 5.43400.1840Endocrine tissue 0.0409 0.0075 5.43400.1840
Gastrointestinal 0.0268 0.0971 0.27613.6217Gastrointestinal 0.0268 0.0971 0.27613.6217
Gehirn 0.0059 0.0113 0.52361.9098Brain 0.0059 0.0113 0.52361.9098
Haematopoetisch 0.0013 0.2273 0.0059170.0273Haematopoetic 0.0013 0.2273 0.0059170.0273
Haut 0.0330 0.0000 undef 0.0000Skin 0.0330 0.0000 undef 0.0000
Hepatisch 0.0095 0.0388 0.24514.0800Hepatic 0.0095 0.0388 0.24514.0800
Herz 0.0223 0.0000 undef 0.0000Heart 0.0223 0.0000 undef 0.0000
Hoden 0.0173 0.0351 0.49202.0326Testis 0.0173 0.0351 0.49202.0326
Lunge 0.0395 0.0900 0.43882.2792Lungs 0.0395 0.0900 0.43882.2792
Magen-Speiseroehre 0.0000 0.0077 0.0000 undefGastro-ear of ear 0.0000 0.0077 0.0000 undef
Muskel-Skelett 0.0857 0.1920 0.44622.2413Musculoskeletal system 0.0857 0.1920 0.44622.2413
Niere 0.0136 0.0205 0.66091.5132Kidney 0.0136 0.0205 0.66091.5132
Pankreas 0.0198 0.0221 0.89741.1143Pancreas 0.0198 0.0221 0.89741.1143
Penis 0.0629 0.0800 0.78621.2719Penis 0.0629 0.0800 0.78621.2719
Prostata 0.0087 0.0106 0.81891.2211Prostate 0.0087 0.0106 0.81891.2211
Uterus Endometπum 0.0676 0.0000 undef 0.0000Uterine endometrium 0.0676 0.0000 undef 0.0000
Uterus Myometrium 0.0686 0.1630 0.42082.3761Uterine myometrium 0.0686 0.1630 0.42082.3761
Uterus allgemein 0.0153 0.0000 undef 0.0000General uterus 0.0153 0.0000 undef 0.0000
Brust-Hyperplasie 0.0735Breast hyperplasia 0.0735
Prostata-Hyperplasie 0.0416Prostate hyperplasia 0.0416
Samenblase 0.0000Seminal vesicle 0.0000
Sinnesorgane 0.0235Sensory organs 0.0235
'eisse Blutkoerperchen 0.0000'' blood corpuscles 0.0000
Zervix 0.0426Cervix 0.0426
FOETUS %HaeufιgkeitFOETUS% frequency
Entwicklung 0.1113Development 0.1113
Gastromtenstmal 0.0056Gastromtenstmal 0.0056
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0039Haematopoietic 0.0039
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0356Cardiac blood vessels 0.0356
Lunge 0.0289Lungs 0.0289
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0062Kidney 0.0062
Placenta 0.1333Placenta 0.1333
Prostata 0.0249Prostate 0.0249
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeit% Frequency
Brust 0.0204Breast 0.0204
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0111Fetal 0.0111
Gastrointestinal 0.0244Gastrointestinal 0.0244
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0065Skin muscle 0.0065
Hoden 0.0000Testicles 0.0000
Lunge 0.0000Lungs 0.0000
Nerven 0.0000Nerves 0.0000
Prostata 0.0068Prostate 0.0068
Sinnesorgane 0.0077Sensory organs 0.0077
Uterus n 0.0125 Elektronischer Northern für SEQ. ID. NO: 20Uterus n 0.0125 Electronic Northern for SEQ. ID. NO: 20
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0858 0. .1048 0.81851 .2217Bubble 0.0858 0..1048 0.81851 .2217
Brust 0.1036 0, .1729 0.59921. .6690Breast 0.1036 0, .1729 0.59921. .6690
Duenndarm 0.1226 0, .1158 1.05930 .9441Small intestine 0.1226 0, .1158 1.05930 .9441
Eierstock 0.0958 0, .1197 0.80091, .2486Ovary 0.0958 0, .1197 0.80091, .2486
Endokrines Gewebe 0.0954 0, .1128 0.84531. .1830Endocrine tissue 0.0954 0, .1128 0.84531. .1830
Gastrointestinal 0.0900 0, .1573 0.57251, .7466Gastrointestinal 0.0900 0, .1573 0.57251, .7466
Gehirn 0.0658 0. .0924 0.71201. .4046Brain 0.0658 0. .0924 0.71201. .4046
Haematopoetisch 0.1109 0, .0758 1.46450, .6828Haematopoietic 0.1109 0, .0758 1.46450, .6828
Haut 0.0918 0, .0000 undef 0. .0000Skin 0.0918 0, .0000 undef 0. .0000
Hepatisch 0.0333 0, ,0906 0.36762, .7200Hepatic 0.0333 0.0906 0.367627200
Herz 0.2120 0. .0412 5.13980, .1946Heart 0.2120 0. .0412 5.13980, .1946
Hoden 0.0690 0. .3625 0.19045, .2509Testis 0.0690 0. .3625 0.19045, .2509
Lunge 0.0696 0. .1186 0.58691, .7040Lungs 0.0696 0. .1186 0.58691, .7040
Magen-Speiseroehre 0.0483 0, .0460 1.05040, .9520Stomach-ear of ear 0.0483 0 .0460 1.05040, .9520
Muskel-Skelett 0.0702 0. ,2820 0.24914, .0145Musculoskeletal system 0.0702 0., 2820 0.24914, .0145
Niere 0.0652 0, .1027 0.63441, ,5762Kidney 0.0652 0 .1027 0.63441., 5762
Pankreas 0.1140 0. .1270 0.89741. .1143Pancreas 0.1140 0. .1270 0.89741. .1143
Penis 0.1018 0. ,0000 undef 0. ,0000Penis 0.1018 0., 0000 undef 0., 0000
Prostata 0.1090 0. ,1277 0.85301. ,1723Prostate 0.1090 0., 1277 0.85301. , 1723
Uterus Endometrium 0.1149 0. ,0000 undef 0. ,0000Uterine endometrium 0.1149 0., 0000 undef 0., 0000
Uterus Myometrium 0.0686 0, .2106 0.32583. ,0692Uterine myometrium 0.0686 0, .2106 0.32583. , 0692
Uterus allgemein 0.0458 0. ,1908 0.24024. ,1635General uterus 0.0458 0., 1908 0.24024. , 1635
Brust-Hyperplasie 0.1279Breast hyperplasia 0.1279
Prostata-Hyperplasie 0.1159Prostate hyperplasia 0.1159
Samenblase 0.1157Bubble 0.1157
Sinnesorgane 0.1059 ιsse_Blutkoerperchen 0.0832Sensory organs 0.1059 ιsse_Blutkoerperchen 0.0832
Zervix 0.1278Cervix 0.1278
FOETUS %HaeufιgkeιtFOETUS% Haeufιgkeιt
Entwicklung 0.0557Development 0.0557
Gastromtenstmal 0.2471Gastromtenstmal 0.2471
Gehirn 0.2189Brain 0.2189
Haematopoetisch 0.1612Haematopoietic 0.1612
Haut 0.0000Skin 0.0000
Hepatisch 0.1560Hepatic 0.1560
Herz-Blutgefaesse 0.2633Cardiac blood vessels 0.2633
Lunge 0.1012Lungs 0.1012
Nebenniere 0.1014Adrenal gland 0.1014
Niere 0.1112Kidney 0.1112
Placenta 0.0848Placenta 0.0848
Prostata 0.3740Prostate 0.3740
Sinnesorgane 0.0126Sensory organs 0.0126
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0136Breast 0.0136
Eιerstock_n 0.1595Eιerstock_n 0.1595
Eιerstock_t 0.0658Eιerstock_t 0.0658
Endokrmes_Gewebe 0000Endokrmes_Gewebe 0000
Foetal 0216Fetal 0216
Gastrointestinal 0732Gastrointestinal 0732
Haematopoetisch 0057Haematopoetic 0057
Haut-Muskel 0259Skin muscle 0259
Hoden 0.0000Testicles 0.0000
Lunge 0.1638Lungs 0.1638
Nerven 0.0211Nerves 0.0211
Prostata 0.0205Prostate 0.0205
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0333 Elektronischer Northern für SEQ. ID. NO: 21Uterus n 0.0333 Electronic Northern for SEQ. ID. NO: 21
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0273 0.0102 2.66950.3746Bubble 0.0273 0.0102 2.66950.3746
Brust 0.0051 0.0019 2.72210.3674Breast 0.0051 0.0019 2.72210.3674
Duenndarm 0.0276 0.0000 undef 0.0000Small intestine 0.0276 0.0000 undef 0.0000
Eierstock 0.0180 0.0000 undef 0.0000Ovary 0.0180 0.0000 undef 0.0000
Endokrines Gewebe 0.0136 0.0000 undef 0.0000Endocrine tissue 0.0136 0.0000 undef 0.0000
Gastrointestinal 0.0134 0.0046 2.89920.3449Gastrointestinal 0.0134 0.0046 2.89920.3449
Gehirn 0.0015 0.0164 0.090011.1117Brain 0.0015 0.0164 0.090011.1117
Haematopoetisch 0.0053 0.0000 undef 0.0000Haematopoetic 0.0053 0.0000 undef 0.0000
Haut 0.0147 0.0000 undef 0.0000Skin 0.0147 0.0000 undef 0.0000
Hepatisch 0.0048 0.0000 undef 0.0000Hepatic 0.0048 0.0000 undef 0.0000
Herz 0.0106 0.0412 0.25703.8912Heart 0.0106 0.0412 0.25703.8912
Hoden 0.0000 0.0117 0.0000 undefTesticles 0.0000 0.0117 0.0000 undef
Lunge 0.0052 0.0102 0.50801.9684Lungs 0.0052 0.0102 0.50801.9684
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0223 0.0060 3.71220.2694Musculoskeletal system 0.0223 0.0060 3.71220.2694
Niere 0.0081 0.0000 undef 0.0000Kidney 0.0081 0.0000 undef 0.0000
Pankreas 0.0033 0.0276 0.11978.3571Pancreas 0.0033 0.0276 0.11978.3571
Penis 0.0030 0.0267 0.11238.9035Penis 0.0030 0.0267 0.11238.9035
Prostata 0.0022 0.0043 0.51181.9538Prostate 0.0022 0.0043 0.51181.9538
Uterus Endometrium 0.0135 0.0000 undef 0.0000Uterine endometrium 0.0135 0.0000 undef 0.0000
Uterus Myometrium 0.0381 0.1019 0.37412.6732Uterine myometrium 0.0381 0.1019 0.37412.6732
Uterus allgemein 0.0102 0.0000 undef 0.0000General uterus 0.0102 0.0000 undef 0.0000
Brust-Hyperplasie 0.0032Breast hyperplasia 0.0032
Prostata-Hyperplasie 0.0000Prostate hyperplasia 0.0000
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0130White blood cells 0.0130
Zervix 0.0106Cervix 0.0106
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0000Development 0.0000
Gastromtenstmal 0.0111Gastromtenstmal 0.0111
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0157Haematopoetic 0.0157
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0107Cardiac blood vessels 0.0107
Lunge 0.0000Lungs 0.0000
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0247Kidney 0.0247
Placenta 0.0000Placenta 0.0000
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0204Breast 0.0204
Eierstock n 0.0000Ovary n 0.0000
Eιerstock_t 0.0101Eιerstock_t 0.0101
Endokrmes_Gewebe 0490Endokrmes_Gewebe 0490
Foetal 0093Fetal 0093
Gastrointestinal 0122Gastrointestinal 0122
Haematopoetisch 0057Haematopoetic 0057
Haut-Muskel 0421Skin muscle 0421
Hoden 0.0154Testicles 0.0154
Lunge 0.0000Lungs 0.0000
Nerven 0.0010Nerves 0.0010
Prostata 0.0274Prostate 0.0274
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0000 Elektronischer Northern für SEQ. ID. NO: 22Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 22
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufιgkeιt N/T T/N% Frequency% frequency N / T T / N
Blase 0.0000 0.0102 0.0000 undefBubble 0.0000 0.0102 0.0000 undef
Brust 0.0064 0.0207 0.30933.2328Breast 0.0064 0.0207 0.30933.2328
Duenndarm 0.0153 0.0662 0.23174.3157Small intestine 0.0153 0.0662 0.23174.3157
Eierstock 0.0180 0.0156 1.15130.8686Ovary 0.0180 0.0156 1.15130.8686
Endokrines Gewebe 0.0204 0.0351 0.58221.7176Endocrine tissue 0.0204 0.0351 0.58221.7176
Gastromtestmal 0.0153 0.0231 0.66271.5090Gastric test times 0.0153 0.0231 0.66271.5090
Gehirn 0.0510 0.0257 1.98710.5032Brain 0.0510 0.0257 1.98710.5032
Haematopoetisch 0.0134 0.0000 undef 0.0000Haematopoetic 0.0134 0.0000 undef 0.0000
Haut 0.0367 0.0000 undef 0.0000Skin 0.0367 0.0000 undef 0.0000
Hepatisch 0.0095 0.0000 undef 0.0000Hepatic 0.0095 0.0000 undef 0.0000
Herz 0.0466 0.0000 undef 0.0000Heart 0.0466 0.0000 undef 0.0000
Hoden 0.0000 0.0117 0.0000 undefTesticles 0.0000 0.0117 0.0000 undef
Lunge 0.0249 0.0348 0.71721.3943Lungs 0.0249 0.0348 0.71721.3943
Magen-Speiseroehre 0.0193 0.0077 2.52110.3967Stomach-ear of ear 0.0193 0.0077 2.52110.3967
Muskel-Skelett 0.0377 0.0300 1.25640.7959Musculoskeletal system 0.0377 0.0300 1.25640.7959
Niere 0.0244 0.0274 0.89221.1209Kidney 0.0244 0.0274 0.89221.1209
Pankreas 0.0083 0.0166 0.49862.0057Pancreas 0.0083 0.0166 0.49862.0057
Penis 0.0329 0.0267 1.23550.8094Penis 0.0329 0.0267 1.23550.8094
Prostata 0.0131 0.0149 0.87741.1397Prostate 0.0131 0.0149 0.87741.1397
Uterus Endometrium 0.0338 0.0000 undef 0.0000Uterine endometrium 0.0338 0.0000 undef 0.0000
Uterus Myometrium 0.0000 0.0340 0.0000 undefUterine myometrium 0.0000 0.0340 0.0000 undef
Uterus allgemein 0.0153 0.0000 undef 0.0000General uterus 0.0153 0.0000 undef 0.0000
Brust-Hyperplasie 0.0256Breast hyperplasia 0.0256
Prostata-Hyperplasie 0.0238Prostate hyperplasia 0.0238
Samenblase 0.0000Seminal vesicle 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Weιsse_Blutkoerperchen 0.0069Weιsse_Blutkoerperchen 0.0069
Zervix 0.0213Cervix 0.0213
FOETUS %HaeufιgkeitFOETUS% frequency
Entwicklung 0.0139Development 0.0139
Gastromtenstmal 0.0194Gastromtenstmal 0.0194
Gehirn 0.0125Brain 0.0125
Haematopoetisch 0.0039Haematopoietic 0.0039
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0320Cardiac blood vessels 0.0320
Lunge 0.0434Lungs 0.0434
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0124Kidney 0.0124
Placenta 0.0061Placenta 0.0061
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0251Sensory organs 0.0251
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeit% Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0 . 3190Ovary n 0. 3190
Eιerstock_t 0. 0000Eιerstock_t 0. 0000
Endokrmes_Gewebe 0 . 0000Endocrm tissue 0. 0000
Foetal 0 . 0373Fetal 0. 0373
Gastrointestinal 0 . 0000Gastrointestinal 0. 0000
Haematopoetisch 0 . 0114Haematopoetic 0. 0114
Haut-Muskel 0 . 0680Skin muscle 0. 0680
Hoden 0.0231Testicles 0.0231
Lunge 0 . 0000Lungs 0. 0000
Nerven 0 . 0211Nerves 0. 0211
Prostata 0 . 0205Prostate 0. 0205
Sinnesorgane 0 . 0077Sensory organs 0. 0077
Uterus n 0 . 0458 Elektronischer Northern für SEQ. ID. NO: 23Uterus n 0. 0458 Electronic Northern for SEQ. ID. NO: 23
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufιgkeιt N/T T/N% Frequency% frequency N / T T / N
Blase 0.0741 0.0639 1.15930.8626Bubble 0.0741 0.0639 1.15930.8626
Brust 0.0691 0.0827 0.83521.1973Breast 0.0691 0.0827 0.83521.1973
Duenndarm 0.0245 0.0496 0.49432.0230Small intestine 0.0245 0.0496 0.49432.0230
Eierstock 0.0689 0.0494 1.39360.7176Ovary 0.0689 0.0494 1.39360.7176
Endokrines Gewebe 0.2487 0.5191 0.47912.0873Endocrine tissue 0.2487 0.5191 0.47912.0873
Gastrointestinal 0.0421 0.0879 0.47962.0852Gastrointestinal 0.0421 0.0879 0.47962.0852
Gehirn 0.1700 0.1037 1.63950.6099Brain 0.1700 0.1037 1.63950.6099
Haematopoetisch 0.0695 0.0758 0.91751.0899Haematopoetic 0.0695 0.0758 0.91751.0899
Haut 0.0367 0.4237 0.086611.5419Skin 0.0367 0.4237 0.086611.5419
Hepatisch 0.0143 0.0388 0.36762.7200Hepatic 0.0143 0.0388 0.36762.7200
Herz 0.0668 0.1375 0.48572.0588Heart 0.0668 0.1375 0.48572.0588
Hoden 0.0460 0.0468 0.98391.0163Testis 0.0460 0.0468 0.98391.0163
Lunge 0.0592 0.0470 1.25900.7943Lungs 0.0592 0.0470 1.25900.7943
Magen-Speiseroehre 0.1160 0.0690 1.68070.5950Stomach-ear of ear 0.1160 0.0690 1.68070.5950
Muskel-Skelett 0.0754 0.0960 0.78531.2735Musculoskeletal system 0.0754 0.0960 0.78531.2735
Niere 0.0706 0.0479 1.47280.6790Kidney 0.0706 0.0479 1.47280.6790
Pankreas 0.0677 0.0552 1.22650.8153Pancreas 0.0677 0.0552 1.22650.8153
Penis 0.0988 0.0267 3.70640.2698Penis 0.0988 0.0267 3.70640.2698
Prostata 0.0697 0.0660 1.05660.9464Prostate 0.0697 0.0660 1.05660.9464
Uterus Endometrium 0.0608 0.0000 undef 0.0000Uterine endometrium 0.0608 0.0000 undef 0.0000
Uterus Myometrium 0.0152 0.0611 0.24944.0097Uterine myometrium 0.0152 0.0611 0.24944.0097
Uterus allgemein 0.1120 0.0000 undef 0.0000General uterus 0.1120 0.0000 undef 0.0000
Brust-Hyperplasie 0.0480Breast hyperplasia 0.0480
Prostata-Hyperplasie 0. .0565Prostate hyperplasia 0 .0565
Samenblase 0. .0445Seminal vesicle 0 .0445
Sinnesorgane 0. .0823Sensory organs 0 .0823
Weisse Blutkoerperchen 0, .0824White blood cells 0, .0824
Zervix 0. .0852Cervix 0. .0852
FOETUSFETUS
%Haeufigkeit%Frequency
Entwicklung 0.1113Development 0.1113
Gastromtenstmal 0.0805Gastromtenstmal 0.0805
Gehirn 0.1376Brain 0.1376
Haematopoetisch 0.1140Haematopoietic 0.1140
Haut 0.0000Skin 0.0000
Hepatisch 0.0520Hepatic 0.0520
Herz-Blutgefaesse 0.0996Cardiac blood vessels 0.0996
Lunge 0.1951Lungs 0.1951
Nebenniere 0.1268Adrenal gland 0.1268
Niere 0.1359Kidney 0.1359
Placenta 0.1030Placenta 0.1030
Prostata 0.0748Prostate 0.0748
Sinnesorgane 0.0879Sensory organs 0.0879
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0544Breast 0.0544
Eιerstock_n 0.0000Eιerstock_n 0.0000
Eιerstock_t 0.0203Eιerstock_t 0.0203
Endoknnes_Gewebe 0.0245Endoknnes_Gewebe 0.0245
Foetal 0.0309Fetal 0.0309
Gastrointestinal 0.0610Gastrointestinal 0.0610
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0356Skin muscle 0.0356
Hoden 0.0077Testicles 0.0077
Lunge 0.0655Lungs 0.0655
Nerven 0.0783Nerves 0.0783
Prostata 0.0547Prostate 0.0547
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0083 Elektronischer Northern für SEQ. ID. NO: 24Uterus n 0.0083 Electronic Northern for SEQ. ID. NO: 24
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0546 0.0332 1.64280.6087Bubble 0.0546 0.0332 1.64280.6087
Brust 0.0269 0.0320 0.84071.1896Breast 0.0269 0.0320 0.84071.1896
Duenndarm 0.0276 0.0000 undef 0.0000Small intestine 0.0276 0.0000 undef 0.0000
Eierstock 0.0479 0.0546 0.87711.1401Ovary 0.0479 0.0546 0.87711.1401
Endokrmes_Gewebe 0.0324 0.0176 1.84370.5424Endocrmes_Tissue 0.0324 0.0176 1.84370.5424
Gastrointestinal 0.0211 0.0463 0.45562.1950Gastrointestinal 0.0211 0.0463 0.45562.1950
Gehirn 0.0229 0.0277 0.82661.2097Brain 0.0229 0.0277 0.82661.2097
Haematopoetisch 0.0348 0.0379 0.91751.0899Haematopoetic 0.0348 0.0379 0.91751.0899
Haut 0.0184 0.0000 undef 0.0000Skin 0.0184 0.0000 undef 0.0000
Hepatisch 0.0190 0.0000 undef 0.0000Hepatic 0.0190 0.0000 undef 0.0000
Herz 0.0477 0.0000 undef 0.0000Heart 0.0477 0.0000 undef 0.0000
Hoden 0.0230 0.1169 0.19685.0816Testicles 0.0230 0.1169 0.19685.0816
Lunge 0.0156 0.0307 0.50801.9684Lungs 0.0156 0.0307 0.50801.9684
Magen-Speiseroehre 0.0000 0.0460 0.0000 undefGastro-ear of ear 0.0000 0.0460 0.0000 undef
Muskel-Skelett 0.0120 0.0480 0.24994.0023Musculoskeletal 0.0120 0.0480 0.24994.0023
Niere 0.0163 0.0068 2.37910.4203Kidney 0.0163 0.0068 2.37910.4203
Pankreas 0.0182 0.0331 0.54841.8234Pancreas 0.0182 0.0331 0.54841.8234
Penis 0.0180 0.0800 0.22464.4517Penis 0.0180 0.0800 0.22464.4517
Prostata 0.0174 0.0170 1.02360.9769Prostate 0.0174 0.0170 1.02360.9769
Uterus Endometrium 0.0541 0.0000 undef 0.0000Uterine endometrium 0.0541 0.0000 undef 0.0000
Uterus_Myometrιum 0.0229 0.0679 0.33672.9702Uterus_Myometrιum 0.0229 0.0679 0.33672.9702
Uterus_allgemem 0.0102 0.0000 undef 0.0000Uterus_general 0.0102 0.0000 undef 0.0000
Brust-Hyperplasie 0.0576Breast hyperplasia 0.0576
Prostata-Hyperplasie 0.0208Prostate hyperplasia 0.0208
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0118Sensory organs 0.0118
Weisse Blutkoerperchen 0.0277White blood cells 0.0277
Zervix 0.0213Cervix 0.0213
FOETUSFETUS
%Haeufigkeit%Frequency
Entwicklung 0.0278Development 0.0278
Gastromtenstmal 0.0639Gastromtenstmal 0.0639
Gehirn 0.0438Brain 0.0438
Haematopoetisch 0.0275Haematopoetic 0.0275
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0925Cardiac blood vessels 0.0925
Lunge 0.0831Lungs 0.0831
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0803Kidney 0.0803
Placenta 0.0667Placenta 0.0667
Prostata 0.0249Prostate 0.0249
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeιt% Haeufιgkeιt
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eιerstock_t 0.0000Eιerstock_t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0006Fetal 0.0006
Gastrointestinal 0.0122Gastrointestinal 0.0122
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0000Skin muscle 0.0000
Hoden 0.0077Testicles 0.0077
Lunge 0.0000Lungs 0.0000
Nerven 0.0040Nerves 0.0040
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0000 Elektronischer Northern für SEQ. ID. NO: 25Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 25
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufιgkeιt N/T T/N% Frequency% frequency N / T T / N
Blase 0.0429 0.0486 0.88321.1323Bubble 0.0429 0.0486 0.88321.1323
Brust 0.0435 0.0771 0.56431.7720Breast 0.0435 0.0771 0.56431.7720
Duenndarm 0.0307 0.0000 undef 0.0000Small intestine 0.0307 0.0000 undef 0.0000
Eierstock 0.0389 0.0833 0.46772.1381Ovary 0.0389 0.0833 0.46772.1381
Endokrines Gewebe 0.0460 0.0301 1.52830.6543Endocrine tissue 0.0460 0.0301 1.52830.6543
Gastrointestinal 0.0287 0.0971 0.29583.3803Gastrointestinal 0.0287 0.0971 0.29583.3803
Gehirn 0.0347 0.0534 0.65071.5367Brain 0.0347 0.0534 0.65071.5367
Haematopoetisch 0.0869 0.0000 undef 0.0000Haematopoetic 0.0869 0.0000 undef 0.0000
Haut 0.0551 0.0847 0.64981.5389Skin 0.0551 0.0847 0.64981.5389
Hepatisch 0.0143 0.0194 0.73531.3600Hepatic 0.0143 0.0194 0.73531.3600
Herz 0.0466 0.0137 3.39230.2948Heart 0.0466 0.0137 3.39230.2948
Hoden 0.0173 0.0935 0.18455.4203Testis 0.0173 0.0935 0.18455.4203
Lunge 0.0457 0.0613 0.74511.3421Lungs 0.0457 0.0613 0.74511.3421
Magen-Speiseroehre 0.0290 0.0153 1.89080.5289Gastric esophagus 0.0290 0.0153 1.89080.5289
Muskel-Skelett 0.0223 0.1140 0.19545.1183Musculoskeletal system 0.0223 0.1140 0.19545.1183
Niere 0.0407 0.0137 2.97390.3363Kidney 0.0407 0.0137 2.97390.3363
Pankreas 0.0314 0.0442 0.71051.4075Pancreas 0.0314 0.0442 0.71051.4075
Penis 0.0779 0.0533 1.46010.6849Penis 0.0779 0.0533 1.46010.6849
Prostata 0.0458 0.0617 0.74121.3491Prostate 0.0458 0.0617 0.74121.3491
Uterus_Endometnum 0.0473 0.0000 undef 0.0000Uterus_Endometnum 0.0473 0.0000 undef 0.0000
Uterus Myometrium 0.0305 0.1087 0.28063.5642Uterine myometrium 0.0305 0.1087 0.28063.5642
Uterus_allgemem 0.0357 0.0954 0.37362.6765Uterus_general 0.0357 0.0954 0.37362.6765
Brust-Hyperplasie 0.0256Breast hyperplasia 0.0256
Prostata-Hyperplasie 0.0803Prostate hyperplasia 0.0803
Samenblase 0.0801Seminal vesicle 0.0801
Sinnesorgane 0.0118Sensory organs 0.0118
Weisse Blutkoerperchen 0.0494White blood cells 0.0494
Zervix 0.0426Cervix 0.0426
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0417Development 0.0417
Gastromtenstmal 0.0611Gastromtenstmal 0.0611
Gehirn 0.0626Brain 0.0626
Haematopoetisch 0.0708Haematopoetic 0.0708
Haut 0.0000Skin 0.0000
Hepatisch 0.0260Hepatic 0.0260
Herz-Blutgefaesse 0.0534Cardiac blood vessels 0.0534
Lunge 0.0542Lungs 0.0542
Nebenniere 0.0761Adrenal gland 0.0761
Niere 0.0988Kidney 0.0988
Placenta 0.0303Placenta 0.0303
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0251Sensory organs 0.0251
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKEN %Haeu igkeitSTANDARDIZED / SUBTRACTED LIBRARIES% Frequency
Brust 0. ,0204Breast 0, 0204
Eierstock n 0, .1595Ovary n 0, .1595
Eierstock t 0. ,0101Ovary t 0., 0101
Endokrines Gewebe 0. .0000Endocrine tissue 0 .0000
Foetal 0. ,0332Fetal 0. 0332
Gastromtestmal 0. .0000Gastrointestinal test 0 .0000
Haematopoetisch 0, .0000Haematopoetic 0 .0000
Haut-Muskel 0. ,0194Skin muscle 0, 0194
Hoden 0, .0077Testicles 0, .0077
Lunge 0, .0328Lungs 0, .0328
Nerven 0, .0161Nerves 0, .0161
Prostata 0, .0068Prostate 0, .0068
Sinnesorgane 0, .0000Sensory organs 0, .0000
Uterus n 0, .0291 Elektronischer Northern für SEQ. ID. NO: 26Uterus n 0, .0291 Electronic Northern for SEQ. ID. NO: 26
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufι .gkeit %Haeuflgkeit N/T T/N% Frequency% frequency N / D T / N
Blase 0.0000 0.0000 undef undefBubble 0.0000 0.0000 undef undef
Brust 0.0000 0.0000 undef undefBreast 0.0000 0.0000 undef undef
Duenndarm 0.0000 0.0000 undef undefSmall intestine 0.0000 0.0000 undef undef
Eierstock 0.0000 0.0000 undef undefOvary 0.0000 0.0000 undef undef
Endokrmes_Gewebe 3.0675 0.0000 undef 0.0000Endokrmes_Gewebe 3.0675 0.0000 undef 0.0000
Gastromtestmal 0.0000 0.0000 undef undefGastrom test times 0.0000 0.0000 undef undef
Gehirn 0.0015 0.0000 undef 0.0000Brain 0.0015 0.0000 undef 0.0000
Haematopoetisch 0.0000 0.0000 undef undefHaematopoetic 0.0000 0.0000 undef undef
Haut 0.0000 0.0000 undef undefSkin 0.0000 0.0000 undef undef
Hepatisch 0.0000 0.0000 undef undefHepatic 0.0000 0.0000 undef undef
Herz 0.0000 0.0000 undef undefHeart 0.0000 0.0000 undef undef
Hoden 0.0000 0.0000 undef undefTesticles 0.0000 0.0000 undef undef
Lunge 0.0000 0.0000 undef undefLung 0.0000 0.0000 undef undef
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0000 0.0000 undef undefMusculoskeletal 0.0000 0.0000 undef undef
Niere 0.0000 0.0000 undef undefKidney 0.0000 0.0000 undef undef
Pankreas 0.0000 0.0000 undef undefPancreas 0.0000 0.0000 undef undef
Penis 0.0000 0.0000 undef undefPenis 0.0000 0.0000 undef undef
Prostata 0.0000 0.0000 undef undefProstate 0.0000 0.0000 undef undef
Uterus Endometrium 0.0000 0.0000 undef undefUterine endometrium 0.0000 0.0000 undef undef
Uterus Myometrium 0.0000 0.0340 0.0000 undefUterine myometrium 0.0000 0.0340 0.0000 undef
Uterus allgemein 0.0000 0.0000 undef undefGeneral uterus 0.0000 0.0000 undef undef
Brust-Hyperplasie 0.0000Breast hyperplasia 0.0000
Prostata-Hyperplasie 0.0000Prostate hyperplasia 0.0000
Samenblase 0.0000Seminal vesicle 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0000White blood cells 0.0000
Zervix 0.0000Cervix 0.0000
FOETUS %HaeufιgkeitFOETUS% frequency
Entwicklung 0.0000Development 0.0000
Gastromtenstmal 0.0028Gastromtenstmal 0.0028
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0000Cardiac blood vessels 0.0000
Lunge 0.0000Lungs 0.0000
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0000Kidney 0.0000
Placenta 0.0061Placenta 0.0061
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeit% Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0070Fetal 0.0070
Gastromtestmal 0.0000Gastro test times 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0000Skin muscle 0.0000
Hoden 0.0000Testicles 0.0000
Lunge 0.0000Lungs 0.0000
Nerven 0.0000Nerves 0.0000
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0155Sensory organs 0.0155
Uterus n 0.0250 Elektronischer Northern für SEQ. ID. NO: 27Uterus n 0.0250 Electronic Northern for SEQ. ID. NO: 27
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeuflgkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0039 0.0230 0.16955.8999Bubble 0.0039 0.0230 0.16955.8999
Brust 0.0179 0.0395 0.45372.2042Breast 0.0179 0.0395 0.45372.2042
Duenndarm 0.0061 0.0000 undef 0.0000Small intestine 0.0061 0.0000 undef 0.0000
Eierstock 0.0300 0.0130 2.30250.4343Ovary 0.0300 0.0130 2.30250.4343
Endokrmes_Gewebe 0.0068 0.0251 0.27173.6805Endocrmes_Tissue 0.0068 0.0251 0.27173.6805
Gastrointestinal 0.0077 0.0093 0.82831.2072Gastrointestinal 0.0077 0.0093 0.82831.2072
Gehirn 0.0015 0.0092 0.16006.2504Brain 0.0015 0.0092 0.16006.2504
Haematopoetisch 0.0053 0.0000 undef 0.0000Haematopoetic 0.0053 0.0000 undef 0.0000
Haut 0.0000 0.0000 undef undefSkin 0.0000 0.0000 undef undef
Hepatisch 0.0000 0.0194 0.0000 undefHepatic 0.0000 0.0194 0.0000 undef
Herz 0.0032 0.0000 undef 0.0000Heart 0.0032 0.0000 undef 0.0000
Hoden 0.0000 0.0000 undef undefTesticles 0.0000 0.0000 undef undef
Lunge 0.0083 0.0368 0.22584.4288Lungs 0.0083 0.0368 0.22584.4288
Magen-Speiseroehre 0.0290 0.0230 1.26050.7933Gastric ear of ear 0.0290 0.0230 1.26050.7933
Muskel-Skelett 0.0000 0.0060 0.0000 undefMusculoskeletal 0.0000 0.0060 0.0000 undef
Niere 0.0136 0.0068 1.98260.5044Kidney 0.0136 0.0068 1.98260.5044
Pankreas 0.0000 0.0276 0.0000 undefPancreas 0.0000 0.0276 0.0000 undef
Penis 0.0030 0.0000 undef 0.0000Penis 0.0030 0.0000 undef 0.0000
Prostata 0.0065 0.0128 0.51181.9538Prostate 0.0065 0.0128 0.51181.9538
Uterus Endometrium 0.0473 0.0000 undef 0.0000Uterine endometrium 0.0473 0.0000 undef 0.0000
Uterus Myometrium 0.0000 0.0340 0.0000 undefUterine myometrium 0.0000 0.0340 0.0000 undef
Uterus allgemein 0.0051 0.0000 undef 0.0000General uterus 0.0051 0.0000 undef 0.0000
Brust-Hyperplasie 0.0000Breast hyperplasia 0.0000
Prostata-Hyperplasie 0.0030Prostate hyperplasia 0.0030
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0000White blood cells 0.0000
Zervix 0.0213Cervix 0.0213
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0139Development 0.0139
Gastromtenstmal 0.0278Gastromtenstmal 0.0278
Gehirn 0.0125Brain 0.0125
Haematopoetisch 0.0079Haematopoietic 0.0079
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0320Cardiac blood vessels 0.0320
Lunge 0.0289Lungs 0.0289
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0185Kidney 0.0185
Placenta 0.0000Placenta 0.0000
Prostata 0.0997Prostate 0.0997
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit%Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0304Ovary t 0.0304
Endokrmes_Gewebe 0.0245Endocrmes_Tissue 0.0245
Foetal 0.0029Fetal 0.0029
Gastrointestinal 0.0122Gastrointestinal 0.0122
Haematopoetisch 0.0114Haematopoietic 0.0114
Haut-Muskel 0.0097Skin muscle 0.0097
Hoden 0.0000Testicles 0.0000
Lunge 0.0164Lungs 0.0164
Nerven 0.0020Nerves 0.0020
Prostata 0.0068Prostate 0.0068
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0000 Elektronischer Northern für SEQ. ID. NO: 28Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 28
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0195 0, .0383 0.50851.9666Bubble 0.0195 0 .0383 0.50851.9666
Brust 0.0256 0. .0714 0.35822.7919Breast 0.0256 0. .0714 0.35822.7919
Duenndarm 0.0552 0, .0331 1.66830.5994Small intestine 0.0552 0 .0331 1.66830.5994
Eierstock 0.0270 0, .0468 0.57561.7372Ovary 0.0270 0 .0468 0.57561.7372
Endokrines Gewebe 0.0477 0, .0451 1.05660.9464Endocrine tissue 0.0477 0 .0451 1.05660.9464
Gastrointestinal 0.0326 0, .0324 1.00580.9942Gastrointestinal 0.0326 0, .0324 1.00580.9942
Gehirn 0.0503 0, .0277 1.81320.5515Brain 0.0503 0, .0277 1.81320.5515
Haematopoetisch 0.0201 0, .1894 0.10599.4460Haematopoetic 0.0201 0, .1894 0.10599.4460
Haut 0.0367 0, .2542 0.14446.9252Skin 0.0367 0, .2542 0.14446.9252
Hepatisch 0.0476 0, .0388 1.22550.8160Hepatic 0.0476 0 .0388 1.22550.8160
Herz 0.0699 0. .0550 1.27210.7861Heart 0.0699 0. .0550 1.27210.7861
Hoden 0.0173 0, .1403 0.12308.1305Testis 0.0173 0 .1403 0.12308.1305
Lunge 0.0395 0, .0818 0.48262.0720Lungs 0.0395 0 .0818 0.48262.0720
Magen-Speiseroehre 0.0676 0. .0613 1.10300.9066Stomach-ear of ear 0.0676 0. .0613 1.10300.9066
Muskel-Skelett 0.0394 0, .0300 1.31350.7613Musculoskeletal system 0.0394 0 .0300 1.31350.7613
Niere 0.0462 0, .0616 0.74901.3351Kidney 0.0462 0 .0616 0.74901.3351
Pankreas 0.0347 0. ,0607 0.57111.7510Pancreas 0.0347 0. 0607 0.57111.7510
Penis 0.0509 0. .1600 0.31823.1424Penis 0.0509 0..1600 0.31823.1424
Prostata 0.0327 0, .0149 2.19350.4559Prostate 0.0327 0 .0149 2.19350.4559
Uterus Endometrium 0.0000 0. ,0000 undef undefUterine endometrium 0.0000 0., 0000 undef undef
Uterus Myometrium 0.0076 0. .0543 0.14037.1284Uterine myometrium 0.0076 0. .0543 0.14037.1284
Uterus allgemein 0.0357 0, ,0000 undef 0.0000General uterus 0.0357 0, .0000 undef 0.0000
Brust-Hyperplasie 0.0192Breast hyperplasia 0.0192
Prostata-Hyperplasie 0.0565Prostate hyperplasia 0.0565
Samenblase 0.0445Seminal vesicle 0.0445
Sinnesorgane 0.0941Sensory organs 0.0941
Weisse Blutkoerperchen 0.0390White blood cells 0.0390
Zervix 0.0319Cervix 0.0319
FOETUS %HaeufιgkeιtFOETUS% Haeufιgkeιt
Entwicklung 0.0557Development 0.0557
Gastromtenstmal 0.0194Gastromtenstmal 0.0194
Gehirn 0.0188Brain 0.0188
Haematopoetisch 0.0197Haematopoetic 0.0197
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0320Cardiac blood vessels 0.0320
Lunge 0.0325Lungs 0.0325
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0371Kidney 0.0371
Placenta 0.0242Placenta 0.0242
Prostata 0.0997Prostate 0.0997
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKEN %Haeuf igkeitSTANDARDIZED / SUBTRACTED LIBRARIES%
Brust 0. .0340Breast 0 .0340
Eierstock n 0. ,0000Ovary n 0., 0000
Eierstock t 0. ,0101Ovary t 0., 0101
Indokrmes Gewebe 0, .0000Indocrm tissue 0, .0000
Foetal 0. ,0396Fetal 0, 0396
Gastrointestinal 0, .0244Gastrointestinal 0, .0244
Haematopoetisch 0, .0000Haematopoetic 0 .0000
Haut-Muskel 0. .0778Skin muscle 0 .0778
Hoden 0, .0000Testes 0, .0000
Lunge 0, .0000Lungs 0, .0000
Nerven 0, .0231Nerves 0, .0231
Prostata 0, .0479Prostate 0, .0479
Sinnesorgane 0, .0697Sensory organs 0, .0697
Uterus n 0, .0291 Elektronischer Northern für SEQ. ID. NO: 29Uterus n 0, .0291 Electronic Northern for SEQ. ID. NO: 29
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufιgkeιt N/T T/N% Frequency% frequency N / T T / N
Blase 0.0663 0.0358 1.85230.5399Bubble 0.0663 0.0358 1.85230.5399
Brust 0.0512 0.0489 1.04700.9551Breast 0.0512 0.0489 1.04700.9551
Duenndarm 0.0368 0.0496 0.74151.3487Small intestine 0.0368 0.0496 0.74151.3487
Eierstock 0.0779 0.0728 1.06900.9354Ovary 0.0779 0.0728 1.06900.9354
Endokrines Gewebe 0.0562 0.0326 1.72420.5800Endocrine tissue 0.0562 0.0326 1.72420.5800
Gastrointestinal 0.0345 0.0370 0.93191.0731Gastrointestinal 0.0345 0.0370 0.93191.0731
Gehirn 0.0392 0.0524 0.74821.3366Brain 0.0392 0.0524 0.74821.3366
Haematopoetisch 0.0602 0.0379 1.58800.6297Haematopoetic 0.0602 0.0379 1.58800.6297
Haut 0.0587 0.0000 undef 0.0000Skin 0.0587 0.0000 undef 0.0000
Hepatisch 0.0095 0.0647 0.14716.7999Hepatic 0.0095 0.0647 0.14716.7999
Herz 0.0583 0.0550 1.06010.9433Heart 0.0583 0.0550 1.06010.9433
Hoden 0.0173 0.1520 0.11358.8080Testis 0.0173 0.1520 0.11358.8080
Lunge 0.0208 0.0491 0.42342.3620Lungs 0.0208 0.0491 0.42342.3620
Magen-Speiseroehre 0.0387 0.0460 0.84041.1900Stomach-ear of ear 0.0387 0.0460 0.84041.1900
Muskel-Skelett 0.0360 0.0420 0.85671.1673Musculoskeletal system 0.0360 0.0420 0.85671.1673
Niere 0.0380 0.0616 0.61681.6213Kidney 0.0380 0.0616 0.61681.6213
Pankreas 0.0314 0.0884 0.35522.8150Pancreas 0.0314 0.0884 0.35522.8150
Penis 0.0689 0.0267 2.58330.3871Penis 0.0689 0.0267 2.58330.3871
Prostata 0.0436 0.0490 0.89011.1235Prostate 0.0436 0.0490 0.89011.1235
Uterus Endometrium 0.0541 0.0000 undef 0.0000Uterine endometrium 0.0541 0.0000 undef 0.0000
Uterus Myometrium 0.0381 0.1155 0.33013.0296Uterine myometrium 0.0381 0.1155 0.33013.0296
Uterus_allgemem 0.0815 0.0000 undef 0.0000Uterus_general 0.0815 0.0000 undef 0.0000
Brust-Hyperplasie 0.0831Breast hyperplasia 0.0831
Prostata-Hyperplasie 0.0446Prostate hyperplasia 0.0446
Samenblase 0.0801Seminal vesicle 0.0801
Sinnesorgane 0.0353 ιsse_Blutkoerperchen 0.0520Sensory organs 0.0353 ιsse_Blutkoerperchen 0.0520
Zervix 0.0532Cervix 0.0532
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0000Development 0.0000
Gastromtenstmal 0.0389Gastromtenstmal 0.0389
Gehirn 0.0188Brain 0.0188
Haematopoetisch 0.0472Haematopoetic 0.0472
Haut 0.0000Skin 0.0000
Hepatisch 0.0260Hepatic 0.0260
Herz-Blutgefaesse 0.0498Cardiac blood vessels 0.0498
Lunge 0.0614Lungs 0.0614
Nebenniere 0.0254Adrenal gland 0.0254
Niere 0.0741Kidney 0.0741
Placenta 0.0364Placenta 0.0364
Prostata 0.0499Prostate 0.0499
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKEN Haeuf igkeitSTANDARDIZED / SUBTRACTED LIBRARIES Frequently
Brust 0. 0000Breast 0. 0000
Eierstock n 0 . 1595Ovary n 0. 1595
Eιerstock_t 0 . 0203Eιerstock_t 0. 0203
Endokrmes_Gewebe 0. 0000Endokrmes_Gewebe 0. 0000
Foetal 0. 0093Fetal 0.0093
Gastrointestinal 0 . 0366Gastrointestinal 0. 0366
Haematopoetisch 0 . 0000Haematopoetic 0. 0000
Haut-Muskel 0. 0130Skin muscle 0. 0130
Hoden 0 . 0000Testicles 0. 0000
Lunge 0 . 0164Lungs 0. 0164
Nerven 0. 0120Nerves 0. 0120
Prostata 0. 0205Prostate 0.0205
Sinnesorgane 0 . 0000Sensory organs 0. 0000
Uterus n 0 . 0208 Elektronischer Northern für SEQ. ID. NO: 30Uterus n 0. 0208 Electronic Northern for SEQ. ID. NO: 30
NORMAL TUMOR VerhaeiltnisseNORMAL TUMOR RELATIONSHIPS
%Haeufιgkeit %Haeuflgkeüt N/T T/N% Frequency% frequency N / D T / N
Blase 0.0078 0.0000 undef 0.0000Bubble 0.0078 0.0000 undef 0.0000
Brust 0.0013 0.0000 undef 0.0000Breast 0.0013 0.0000 undef 0.0000
Duenndarm 0.0092 0.0000 undef 0.0000Small intestine 0.0092 0.0000 undef 0.0000
Eierstock 0.0000 0.0000 undef undefOvary 0.0000 0.0000 undef undef
Endokrines Gewebe 0.0034 0.0000 undef 0.0000Endocrine tissue 0.0034 0.0000 undef 0.0000
Gastrointestinal 0.0019 0.0000 undef 0.0000Gastrointestinal 0.0019 0.0000 undef 0.0000
Gehirn 0.0000 0.0000 undef undefBrain 0.0000 0.0000 undef undef
Haematopoetisch 0.0000 0.0000 undef undefHaematopoetic 0.0000 0.0000 undef undef
Haut 0.0000 0.0000 undef undefSkin 0.0000 0.0000 undef undef
Hepatisch 0.0000 0.0000 undef undefHepatic 0.0000 0.0000 undef undef
Herz 0.0011 0.0000 undef 0.0000Heart 0.0011 0.0000 undef 0.0000
Hoden 0.0000 0.0000 undef undefTesticles 0.0000 0.0000 undef undef
Lunge 0.0010 0.0000 undef 0.0000Lungs 0.0010 0.0000 undef 0.0000
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0000 0.0000 undef undefMusculoskeletal 0.0000 0.0000 undef undef
Niere 0.0000 0.0000 undef undefKidney 0.0000 0.0000 undef undef
Pankreas 0.0000 0.0000 undef undefPancreas 0.0000 0.0000 undef undef
Penis 0.0000 0.0000 undef undefPenis 0.0000 0.0000 undef undef
Prostata 0.0109 0.0021 5.1181 0.1954Prostate 0.0109 0.0021 5.1181 0.1954
Uterus Endometrium 0.0000 0.0000 undef undefUterine endometrium 0.0000 0.0000 undef undef
Uterus Myometrium 0.0000 0.0340 0.0000 undefUterine myometrium 0.0000 0.0340 0.0000 undef
Uterus allgemein 0.0102 0.0000 undef 0.0000General uterus 0.0102 0.0000 undef 0.0000
Brust-Hyperplasie 0.0000Breast hyperplasia 0.0000
Prostata-Hyperplasie 0.0000Prostate hyperplasia 0.0000
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0000White blood cells 0.0000
Zervix 0.0000Cervix 0.0000
FOETUS %HaeuflgkeitFOETUS% frequency
Entwicklung 0.0000Development 0.0000
Gastromtenstmal 0.0000Gastromtenstmal 0.0000
Gehirn 0.0000Brain 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0000Cardiac blood vessels 0.0000
Lunge 0.0000Lungs 0.0000
Nebenniere 0.0000Adrenal gland 0.0000
Niere 0.0000Kidney 0.0000
Placenta 0.0000Placenta 0.0000
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0000Sensory organs 0.0000
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufιgkeit% Frequency
Brust 0.0000Breast 0.0000
Eierstock n 0.0000Ovary n 0.0000
Eierstock t 0.0000Ovary t 0.0000
Endokrines Gewebe 0.0000Endocrine tissue 0.0000
Foetal 0.0000Fetal 0.0000
Gastrointestinal 0.0000Gastrointestinal 0.0000
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0000Skin muscle 0.0000
Hoden 0.0000Testicles 0.0000
Lunge 0.0000Lungs 0.0000
Nerven 0.0000Nerves 0.0000
Prostata 0.0068Prostate 0.0068
Sinnesorgane 0.0000Sensory organs 0.0000
Uterus n 0.0000 Elektronischer Northern für SEQ. ID. NO: 31Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 31
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
Blase 0.0000 0.0051 0.0000 undefBubble 0.0000 0.0051 0.0000 undef
Brust 0.0038 0.0019 2.04160.4898Breast 0.0038 0.0019 2.04160.4898
Duenndarm 0.0031 0.0000 undef 0.0000Small intestine 0.0031 0.0000 undef 0.0000
Eierstock 0.0030 0.0104 0.28783.4745Ovary 0.0030 0.0104 0.28783.4745
Endokrines Gewebe 0.0034 0.0100 0.33962.9444Endocrine tissue 0.0034 0.0100 0.33962.9444
Gastrointestinal 0.0057 0.0046 1.24250.8048Gastrointestinal 0.0057 0.0046 1.24250.8048
Gehirn 0.0111 0.0051 2.15990.4630Brain 0.0111 0.0051 2.15990.4630
Haematopoetisch 0.0040 0.0000 undef 0.0000Haematopoetic 0.0040 0.0000 undef 0.0000
Haut 0.0000 0.0000 undef undefSkin 0.0000 0.0000 undef undef
Hepatisch 0.0048 0.0000 undef 0.0000Hepatic 0.0048 0.0000 undef 0.0000
Herz 0.0095 0.0000 undef 0.0000Heart 0.0095 0.0000 undef 0.0000
Hoden 0.0058 0.0000 undef 0.0000Testicles 0.0058 0.0000 undef 0.0000
Lunge 0.0042 0.0102 0.40642.4605Lungs 0.0042 0.0102 0.40642.4605
Magen-Speiseroehre 0.0000 0.0000 undef undefStomach-ear of ear 0.0000 0.0000 undef undef
Muskel-Skelett 0.0034 0.0060 0.57111.7510Musculoskeletal 0.0034 0.0060 0.57111.7510
Niere 0.0163 0.0068 2.37910.4203Kidney 0.0163 0.0068 2.37910.4203
Pankreas 0.0017 0.0000 undef 0.0000Pancreas 0.0017 0.0000 undef 0.0000
Penis 0.0090 0.0000 undef 0.0000Penis 0.0090 0.0000 undef 0.0000
Prostata 0.0022 0.0021 1.02360.9769Prostate 0.0022 0.0021 1.02360.9769
Uterus Endometrium 0.0135 0.0000 undef 0.0000Uterine endometrium 0.0135 0.0000 undef 0.0000
Uterus Myometrium 0.0000 0.0340 0.0000 undefUterine myometrium 0.0000 0.0340 0.0000 undef
Uterus allgemein 0.0000 0.0000 undef undefGeneral uterus 0.0000 0.0000 undef undef
Brust-Hyperplasie 0.0224Breast hyperplasia 0.0224
Prostata-Hyperplasie 0.0030Prostate hyperplasia 0.0030
Samenblase 0.0089Seminal vesicle 0.0089
Sinnesorgane 0.0000Sensory organs 0.0000
Weisse Blutkoerperchen 0.0061White blood cells 0.0061
Zervix 0.0213Cervix 0.0213
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0000Development 0.0000
Gastromtenstmal 0.0028Gastromtenstmal 0.0028
Gehirn 0.0125Brain 0.0125
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut 0.0000Skin 0.0000
Hepatisch 0.0000Hepatic 0.0000
Herz-Blutgefaesse 0.0036Heart blood vessels 0.0036
Lunge 0.0036Lungs 0.0036
Nebenniere 0.0254Adrenal gland 0.0254
Niere 0.0062Kidney 0.0062
Placenta 0.0303Placenta 0.0303
Prostata 0.0000Prostate 0.0000
Sinnesorgane 0.0126Sensory organs 0.0126
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKEN %HaeufigkeitSTANDARDIZED / SUBTRACTED LIBRARIES% Frequency
Brust 0, .0000Breast 0, .0000
Eierstock n 0. ,0000Ovary n 0., 0000
Eierstock t 0, .0000 indoknnes Gewebe 0, .0000Ovary t 0, .0000 indoknnes tissue 0, .0000
Foetal 0, .0000Fetal 0, .0000
Gastrointestinal 0, .0000Gastrointestinal 0, .0000
Haematopoetisch 0, .0000Haematopoetic 0 .0000
Haut-Muskel 0, .0000Skin muscle 0, .0000
Hoden 0, .0000Testes 0, .0000
Lunge 0, .0082Lungs 0, .0082
Nerven 0, .0000Nerves 0, .0000
Prostata 0, .0000Prostate 0, .0000
Sinnesorgane 0, .0000Sensory organs 0, .0000
Uterus n 0, .0000 Elektronischer Northern für SEQ. ID. NO: 52Uterus n 0 .0000 Electronic Northern for SEQ. ID. NO: 52
NORMAL TUMOR VerhaeltnisseNORMAL TUMOR conditions
%Haeufigkeit %Haeufigkeit N/T T/N% Frequency% frequency N / T T / N
B Lymphom 0.0599 0.0543 1.10370.9060B Lymphoma 0.0599 0.0543 1.10370.9060
Blase 0.0507 0.0282 1.79790.5562Bubble 0.0507 0.0282 1.79790.5562
Brust 0.0326 0.0450 0.72401.3811Breast 0.0326 0.0450 0.72401.3811
Dickdarm 0.0268 0.0313 0.85631.1679Colon 0.0268 0.0313 0.85631.1679
Duenndarm 0.0439 0.0426 1.03060.9703Small intestine 0.0439 0.0426 1.03060.9703
Eierstock 0.0564 0.0453 1.24430.8037Ovary 0.0564 0.0453 1.24430.8037
Endokrines Gewebe 0.0642 0.0530 1.21130.8255Endocrine tissue 0.0642 0.0530 1.21130.8255
Gehirn 0.0380 0.0379 1.00220.9978Brain 0.0380 0.0379 1.00220.9978
Haut 0.0330 0.0789 0.41902.3868Skin 0.0330 0.0789 0.41902.3868
Hepatisch 0.0093 0.0508 0.18315.4614Hepatic 0.0093 0.0508 0.18315.4614
Herz 0.0589 0.0000 undef 0.0000Heart 0.0589 0.0000 undef 0.0000
Hoden 0.0482 0.0533 0.90471.1054Testis 0.0482 0.0533 0.90471.1054
Lunge 0.0389 0.0499 0.77961.2828Lungs 0.0389 0.0499 0.77961.2828
Magen-Speiseroehre 0.0072 0.0256 0.28333.5296Stomach-ear of ear 0.0072 0.0256 0.28333.5296
Muskel-Skelett 0.0240 0.0702 0.34182.9256Musculoskeletal system 0.0240 0.0702 0.34182.9256
Niere 0.0694 0.0289 2.39840.4169Kidney 0.0694 0.0289 2.39840.4169
Pankreas 0.0297 0.0331 0.89741.1143Pancreas 0.0297 0.0331 0.89741.1143
Prostata 0.0443 0.0287 1.54570.6470Prostate 0.0443 0.0287 1.54570.6470
T Lymphom 0.0505 0.1643 0.30743.2533T lymphoma 0.0505 0.1643 0.30743.2533
Uterus 0.0325 0.0690 0.47152.1210Uterus 0.0325 0.0690 0.47152.1210
Weisse Blutkoerperchen 0.0363 0.0304 1.19480.8370White blood cells 0.0363 0.0304 1.19480.8370
Haematopoetisch 0.0495Haematopoetic 0.0495
Penis 0.0322Penis 0.0322
Samenblase 0.0493Seminal vesicle 0.0493
Sinnesorgane 0.0470Sensory organs 0.0470
FOETUS %HaeufigkeitFOETUS% frequency
Entwicklung 0.0696Development 0.0696
Gastromtenstmal 0.0750Gastromtenstmal 0.0750
Gehirn 0.0876Brain 0.0876
Haematopoetisch 0.0904Haematopoetic 0.0904
Haut 0.0000Skin 0.0000
Hepatisch 0.0260Hepatic 0.0260
Herz-Blutgefaesse 0.0854Cardiac blood vessels 0.0854
Lunge 0.0867Lungs 0.0867
Nebenniere 0.0761Adrenal gland 0.0761
Niere 0.0556Kidney 0.0556
Placenta 0.0606Placenta 0.0606
Prostata 0.0499Prostate 0.0499
Sinnesorgane 0.0628Sensory organs 0.0628
NORMIERTE/SUBTRAHIERTE BIBLIOTHEKENNORMALIZED / SUBTRACTED LIBRARIES
%Haeufigkeit Brust 0.0068% Frequency breast 0.0068
Brust_t 0.0000Breast_t 0.0000
Dιckdarm_t 0000Dιckdarm_t 0000
Eierstock n 1595Ovary n 1595
Eιerstock_t 0101 Endokrmes_Gewebe 0245Eιerstock_t 0101 Endokrmes_Gewebe 0245
Foetal 0284Foetal 0284
Gastrointestinal 0732Gastrointestinal 0732
Haematopoetisch 0.0000Haematopoietic 0.0000
Haut-Muskel 0.0616 Hoden n 0.0293Skin muscle 0.0616 testicles n 0.0293
Hoden_t 0.0000Testicle_t 0.0000
Lunge n .0195Lungs n. 0195
Lunge_t .0000Lung_t .0000
Nerven .0261 Nιere_t .0000Nerves .0261 Nιere_t .0000
Ovar_Uterus ,0293Ovarian Uterus, 0293
Prostata 0.0121Prostate 0.0121
Sinnesorgane 0.0310Sensory organs 0.0310
Weιsse_Blutkoerperchen 0.0000 2.2 Fisher-TestWhite blood body 0.0000 2.2 Fisher test
Um zu entscheiden, ob eine Partial-Sequenz S eines Gens in einer Bibliothek für Normal-Gewebe signifikant häufiger oder seltener vorkommt als in einer Bibliothek für entartetes Gewebe, wird Fishers Exakter Test, ein statistisches Standardverfahren (Hays, W. L, (1991 ) Statistics, Harcourt Brace College Publishers, Fort Worth), durchgeführt.In order to decide whether a partial sequence S of a gene occurs significantly more frequently or less frequently in a library for normal tissues than in a library for degenerate tissues, Fisher's exact test, a standard statistical method (Hays, W. L, (1991) Statistics, Harcourt Brace College Publishers, Fort Worth).
Die Null-Hypothese lautet: die beiden Bibliotheken können bezüglich der Häufigkeit zu S homologer Sequenzen nicht unterschieden werden. Falls die Null-Hypothese mit hinreichend hoher Sicherheit abgelehnt werden kann, wird das zu S gehörende Gen als interessanter Kandidat für ein Krebs-Gen akzeptiert, und es wird im nächsten Schritt versucht, eine Verlängerung seiner Sequenz zu erreichen.The null hypothesis is that the two libraries cannot be distinguished in terms of the frequency of sequences homologous to S. If the null hypothesis can be rejected with sufficient certainty, the gene belonging to S will be accepted as an interesting candidate for a cancer gene and the next step will be to try to extend its sequence.
Beispiel 3Example 3
Automatische Verlängerung der Partial-SequenzAutomatic extension of the partial sequence
Die automatische Verlängerung der Partial-Sequenz S vollzieht sich in drei Schritten:The automatic extension of the partial sequence S takes place in three steps:
1. Ermittlung aller zu S homologen Sequenzen aus der Gesamtmenge der zur Verfügung stehenden Sequenzen mit Hilfe von BLAST1. Determination of all sequences homologous to S from the total amount of available sequences using BLAST
2. Assemblierung dieser Sequenzen mittels des Standardprogramms GAP4 (Bonfield, J. K., Smith, K. F., und Staden R. (1995), Nucleic Acids Research 23 4992-4999) (Contig-Bildung).2. Assemble these sequences using the standard program GAP4 (Bonfield, J.K., Smith, K.F., and Staden R. (1995), Nucleic Acids Research 23 4992-4999) (Contig formation).
3. Berechnung einer Konsens-Sequenz C aus den assemblierten Sequenzen3. Calculation of a consensus sequence C from the assembled sequences
Die Konsens-Sequenz C wird im allgemeinen länger sein als die Ausgangssequenz S. Ihr elektronischer Northern-Blot wird demzufolge von dem für S abweichen. Ein erneuter Fisher-Test entscheidet, ob die Altemativ-Hypothese der Abweichung von einer gleichmäßigen Expression in beiden Bibliotheken aufrechterhalten werden kann. Ist dies der Fall, wird versucht, C in gleicher Weise wie S zu verlängern. Diese Iteration wird mit der jeweils erhaltenen Konsensus-Sequenzen Cj (/': Index der Iteration) fortgesetzt, bis die Altemativ-Hypothese verworfen wird (if Ho Exit; Abbruchkriterium I) oder bis keine automatische Verlängerung mehr möglich ist (while Cj > Cj-f, Abbruchkriterium II).The consensus sequence C will generally be longer than the starting sequence S. Your electronic Northern blot will therefore differ from that for S. A renewed Fisher test decides whether the alternative hypothesis of the deviation from a uniform expression can be maintained in both libraries. If this is the case, an attempt is made to extend C in the same way as S. This iteration is continued with the respectively obtained consensus sequences Cj (/ ' : index of the iteration) until the alternative hypothesis is rejected (if Ho Exit; termination criterion I) or until automatic extension is no longer possible (while Cj> Cj- f, termination criterion II).
Im Fall des Abbruchkriteriums II bekommt man mit der nach der letzten Iteration vorliegenden Konsens-Sequenz eine komplette oder annähernd komplette Sequenz eines Gens, das mit hoher statistischer Sicherheit mit Krebs in Zusammenhang gebracht werden kann.In the case of termination criterion II, the consensus sequence after the last iteration provides a complete or almost complete sequence of a gene that can be associated with cancer with a high degree of statistical certainty.
Analog der oben beschriebenen Beispiele konnten die in der Tabelle I beschriebenen Nukleinsäure-Sequenzen aus Uterusmyomgewebe gefunden werden. Ferner konnten zu den einzelnen Nukleinsäure-Sequenzen die Peptidsequenzen (ORF's) bestimmt werden, die in der Tabelle II aufgelistet sind, wobei wenigen Nukleinsäure-Sequenzen kein Peptid zugeordnet werden kann und einigen Nukleinsäure-Sequenzen mehr als ein Peptid zugeordnet werden kann. Wie bereits oben erwähnt, sind sowohl die ermittelten Nukleinsäure-Sequenzen, als auch die den Nukleinsäure-Sequenzen zugeordneten Peptid-Sequenzen Gegenstand der vorliegenden Erfindung.Analogously to the examples described above, the nucleic acid sequences described in Table I from uterine fibroid tissue could be found. It was also possible to determine the peptide sequences (ORF's) for the individual nucleic acid sequences which are listed in Table II, it being possible for a few nucleic acid sequences to be unable to assign a peptide and for some nucleic acid sequences to be able to assign more than one peptide. As already mentioned above, both the nucleic acid sequences determined and the peptide sequences assigned to the nucleic acid sequences are the subject of the present invention.
Beispiel 4Example 4
Kartierung der Nukleinsäure-Sequenzen auf dem humanen GenomMapping of nucleic acid sequences on the human genome
Die Kartierung der humanen Gene erfolgte unter Verwendung des Stanford G3 Hybrid-Panels (Stewart et al., 1997), der von Research Genetics, Huntsville, Alabama vertrieben wird. Dieses Panel besteht aus 83 verschiedenen genomischen DNAs von Mensch-Hamster Hybridzellinien und erlaubt eine Auflösung von 500 Kilobasen. Die Hybridzellinien wurden durch Fusion von bestrahlten diploiden menschlichen Zellen mit Zellen des Chinesischen Hamsters gewonnen. Das Rückhaltemuster der humanen Chromosomenfragmente wird mittels genspezifischer Primer in einer Polymerase-Kettenreaktion bestimmt und mit Hilfe der vom Stanford RH Server verfügbaren Software analysiert (http://www.stanford.edu/RH/rhserver_ form2.html). Dieses Programm bestimmt den STS-Marker, der am nächsten zum gesuchten Gen liegt. Die entsprechende zytogenetische Bande wurde unter Verwendung des "Mapview" -Programms der Genome Database (GDB), (http://gdbwww.dkfz-heidelberg.de) bestimmt.Human genes were mapped using the Stanford G3 hybrid panel (Stewart et al., 1997), which is sold by Research Genetics, Huntsville, Alabama. This panel consists of 83 different genomic DNAs from human-hamster hybrid cell lines and allows a resolution of 500 kilobases. The hybrid cell lines were obtained by fusion of irradiated diploid human cells with Chinese hamster cells. The retention pattern of the human chromosome fragments is determined using a gene-specific primer in a polymerase chain reaction and analyzed using the software available from the Stanford RH server (http://www.stanford.edu/RH/rhserver_form2.html). This program determines the STS marker that is closest to the gene you are looking for. The corresponding cytogenetic band was determined using the "Mapview" program from the Genome Database (GDB), (http://gdbwww.dkfz-heidelberg.de).
Neben dem kartieren von Genen auf dem menschlichen Cromosomensatz durch verschiedene experimentelle Methoden ist es möglich die Lage von Genen auf diesem durch bioinformatische Methoden zu bestimmen. Dazu wurde das bekannte Programm e-PCR eingesetzt (Schuler GD (1998) Electronic PCR: bridging the gap between genome mapping and genome sequencing. Trends Biotechnol 16; 456-459, Schuler GD (1997). Sequence mapping by electronic PCR. Genome Res 7; 541- 550). Die dabei eingesetzte Datenbank entspricht nicht mehr der in der Literatur angegebenen, sonder ist eine Weiterentwicklung, welche Daten der öffentlichen Datenbank RHdb (http://www.ebi.ac.uk/RHdb/index.html) einschließt. Analog zu der Kartierung durch die Hybrid-Panels erfolgte eine Auswertung der Ergebnisse mit der obengenannten Software und der Software des Whitehead-Institutes (http://carbon.wi. mit.edu:8000/cgi-bin/contig/rhmapper.pl). In addition to mapping genes on the human cromosome set using various experimental methods, it is possible to determine the location of genes on this using bioinformatic methods. The well-known program e-PCR was used for this (Schuler GD (1998) Electronic PCR: bridging the gap between genome mapping and genome sequencing. Trends Biotechnol 16; 456-459, Schuler GD (1997). Sequence mapping by electronic PCR. Genome Res 7; 541-550). The database used no longer corresponds to the one specified in the literature, but is a further development, which includes data from the public database RHdb (http://www.ebi.ac.uk/RHdb/index.html). Analogous to the mapping by the hybrid panels, the results were evaluated using the software mentioned above and the software from the Whitehead Institute (http: //carbon.wi. Mit.edu:8000/cgi-bin/contig/rhmapper.pl) .
TABELLE ITABLE I
Figure imgf000047_0001
Figure imgf000047_0001
Figure imgf000048_0001
Figure imgf000048_0001
Legende zu den Modulen:Legend for the modules:
Pfam: Protein families database of alignments and HMMs (pfam@sanger.ac.uk) PROSITE: The PROSITE database, its Status in 1999. Nucleic Acids Res. 27: 215-219 (http://www.expasy.ch/sprot/prosite.html) Pfam: Protein families database of alignments and HMMs (pfam@sanger.ac.uk) PROSITE: The PROSITE database, its Status in 1999. Nucleic Acids Res. 27: 215-219 (http://www.expasy.ch/sprot /prosite.html)
Figure imgf000049_0001
Figure imgf000049_0001
33 3433 34
15 3515 35
36 3736 37
16 3816 38
3939
17 4017 40
Figure imgf000049_0002
50 51
Figure imgf000049_0002
50 51
Die erfinderischen Nukleinsäure-Sequenzen Seq. ID No. 1 bis Seq. ID No. 31 der ermittelten Kandidatengene und die ermittelten Aminosäure-Sequenzen Seq. ID No 32 bis Seq. ID No. 51 werden in dem nachfolgenden Sequ protokoll beschrieben.The inventive nucleic acid sequences Seq. ID No. 1 to Seq. ID No. 31 of the determined candidate genes and the determined amino acid sequences Seq. ID No 32 to Seq. ID No. 51 are described in the following Sequ protocol.
SequenzprotokollSequence listing
(1 ) ALLGEMEINE INFORMATION:
Figure imgf000050_0002
(i) ANMELDER:(1) GENERAL INFORMATION:
Figure imgf000050_0002
(i) APPLICANT:
(A) NAME: metaGen - Gesellschaft für Genomforschung mbH(A) NAME: metaGen - Gesellschaft für Genomforschung mbH
(B) STRASSE: Ihnestrasse 63(B) STREET: Ihnestrasse 63
(C) STADT: Berlin
Figure imgf000050_0003
(C) CITY: Berlin
Figure imgf000050_0003
(E) LAND: Deutschland
Figure imgf000050_0001
Figure imgf000050_0004
(F) POST CODE (ZIP): D-14195(E) COUNTRY: Germany
Figure imgf000050_0001
Figure imgf000050_0004
(F) POST CODE (ZIP): D-14195
(G) TELEFON: (030)-8413 1673 (H) TELEFAX: (030)-8413 1674(G) TELEPHONE: (030) -8413 1673 (H) TELEFAX: (030) -8413 1674
(ii) TITEL DER ERFINDUNG: Menschliche Nukleinsäure-Sequenzen aus
Figure imgf000050_0005
(ii) TITLE OF THE INVENTION: Human nucleic acid sequences from
Figure imgf000050_0005
UterusmyomgewebeUterine fibroid tissue
(iii) Anzahl der Sequenzen: 55
Figure imgf000050_0006
(iii) Number of sequences: 55
Figure imgf000050_0006
(iv) COMPUTER READABLE FORM:(iv) COMPUTER READABLE FORM:
(A) MEDIUM TYPE: Floppy disk(A) MEDIUM TYPE: floppy disk
(B) COMPUTER: IBM PC compatible(B) COMPUTER: IBM PC compatible
(C) OPERATING SYSTEM: PC-DOS/MS-DOS (D) SOFTWARE: Patentin Release #1.0, Version #1.25 (EPO)(C) OPERATING SYSTEM: PC-DOS / MS-DOS (D) SOFTWARE: Patentin Release # 1.0, Version # 1.25 (EPO)
(2) INFORMATION ÜBER SEQ ID NO: 1 :(2) INFORMATION ABOUT SEQ ID NO: 1:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 779 Basenpaare (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 779 base pairs
(A) BIBLIOTHEK: cDNA library (xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO:1(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1
agcgagcagc ggcggcggcg cggagagacg cagcggaggt tttcctggtt tcggacccca 60 gcggccggat ggtgaaatcc tccctgcagc ggatcctcaa tagccactgc ttcgccagagl20 agaaggaagg ggataaaccc agcgccacca tccacgccag ccgcaccatg ccgctcctaalδO gcctgcacag ccgcggcggc agcagcagtg agagttccag ggtctccctc cactgctgta240 gtaacccggg tccggggcct cggtggtgct cctgatgccc ctcacccacc cctgaagatc300 ccaggtgggc gagggaatag tcaaagggac cacaatcttt cagctaactt attctactcc360 gatgatcggc tgaatgtaac agaggaacta acgtccaacg acaagacgag gattctcaac420 gtccagtcca ggctcacaga cgccaaacgc attaactggc gaacagtgct gagtggcggc480 actgctctac atcgagatcc cgggcggcgc gctgcccgag gggagcaagg acagctttgc540 agttctcctg ggagttcgct gaggagcagc tgcgaggccg accatgtctt aatttgcttcδOO cacaagaacc ccgaggacag agccgccttg ctccgaacct tcagcttttt cgggcttgag660 attttgagac cggggcatcc cctttgttcc ccaagagacc cgacgcttgc ttcatgggcc720 tacaagtttc gagagagagt ctttggggag aggaagaagg attaggggcc gcgtcgggt 779agcgagcagc ggcggcggcg cggagagacg cagcggaggt tttcctggtt tcggacccca 60 gcggccggat ggtgaaatcc tccctgcagc ggatcctcaa tagccactgc ttcgccagagl20 agaaggaagg ggataaaccc agcgccacca tccacgccag ccgcaccatg ccgctcctaalδO gcctgcacag ccgcggcggc agcagcagtg agagttccag ggtctccctc cactgctgta240 gtaacccggg tccggggcct cggtggtgct cctgatgccc ctcacccacc cctgaagatc300 ccaggtgggc gagggaatag tcaaagggac cacaatcttt cagctaactt attctactcc360 gatgatcggc tgaatgtaac agaggaacta acgtccaacg acaagacgag gattctcaac420 gtccagtcca ggctcacaga cgccaaacgc attaactggc gaacagtgct gagtggcggc480 actgctctac atcgagatcc cgggcggcgc gctgcccgag gggagcaagg acagctttgc540 agttctcctg ggagttcgct gaggagcagc tgcgaggccg accatgtctt aatttgcttcδOO cacaagaacc ccgaggacag agccgccttg ctccgaacct tcagcttttt cgggcttgag660 attttgagac cggggcatcc cctttgttcc ccaagagacc cgacgcttgc ttcatgggcc720 tacaagtttc gagagagagt ctttggggag aggaagaagg attaggggcc gcgtcgggt 779
(2) INFORMATION ÜBER SEQ ID NO: 2:(2) INFORMATION ABOUT SEQ ID NO: 2:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 2310 Basenpaare(A) LENGTH: 2310 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(C) ORGAN:(C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO:2(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2
gttctccgaa acatggagtc ctgtaggcaa ggtcttacct gaatcaggat gagggagtgg 60 tgggtccagg tggggctgct ggccgtgccc ctgcttgctg cgtacctgca catcccaccc 120 cctcagcgct cccctgccct tcactcatgg aagtcttcag gcaagttttt cacttacaag 180 ggactgcgta tcttctacca agactctgtg ggtgtggttg gaagtccaga gatagttgtg 240 cttttacacg gttttccaac atccagctac gactggtaca agatttggga aggtctgacc 300 ttgaggtttc atcgggtgat tgcccttgat ttcttaggct ttggcttcag tgacaaaccg 360 agaccacatc actattccat atttgagcag gccagcatcg tggaagcgct tttgcggcat 420 ctggggctcc agaaccgcag gatcaacctt ctttctcatg actatggaga tattgttgct 480 caggagcttc tctacaggta caagcagaat cgatctggtc ggcttaccat aaagagtctc 540 tgtctgtcaa atggaggtat ctttcctgag actcaccgtc cactccttct ccaaaagcta 600 ctcaaagatg gaggtgtgct gtcacccatc ctcacacgac tgatgaactt ctttgtattc 660 tctcgaggtc tcaccccagt ctttgggccg tatactcggc cctctgagag tgagctgtgg 720 gacatgtggg cagggatccg caacaatgac gggaacttag tcattgacag tctcttacag 780 tacatcaatc agaggaagaa gttcagaagg cgctgggtgg gagctcttgc ctctgtaact 840 atccccattc attttatcta tgggccattg gatcctgtaa atccctatcc agagtttttg 900 gagctgtaca ggaaaacgct gccgcggtcc acagtgtcga ttctggatga ccacattagc 960 cactatccac agctagagga tcccatgggc ttcttgaatg catatatggg cttcatcaacl020 tccttctgag ctggaaagag tagcttccct gtattacctc ccctactccc ttatgtgttgl080 tgtattccac ttaggaagaa atgcccaaaa gaggtcctgg ccatcaaaca taattctctcll40 acaaagtcca ctttactcaa attggtgaac agtgtatagg aagaagccag caggagctctl200 gactaaggtt gacataatag tccacctccc attactttga tatctgatca aatgtatagal260 cttggctttg ttttttgtgc tattaggaaa ttctgatgag cattactatt cactgatgcal320 gaaagacgtt cttttgcata aaagactttt tttaacactt tggacttctc tgaaatatttl380 agaagtgcta atttctggcc cacccccaac aggaattcta tagtaagggg gaggagaaggl440 ggggctcctt ccctctcctc gaatgacgtt atgggcacat gccttttaaa agttctttaal500 gcaacacaga gctgagtcct ctttgtcata cctttggatt tagtgtttca tcagctgtttl560 ttagttataa acattttgtt aaaatagata ttggtttaaa tgatacagta ttttaggtatl620 gatttaagac tatgatttac ctatacatta tatatatttt ataaagatac taaaccagcal680 tacccttact ctgccagagt agtgaagcta attaaacacg tttggtttct gaataaattgl740 aactaaatcc aaactatttc ctaaaatcac aggacattaa ggaccaatag catctgtgcclδOO agagatgtac tgttattagc tgggaagacc aattctaaca gcaaataaca gtctgagactl860 cctcatacct cagtggttag aagcatgtct ctcttgagct acagtagagg ggaagggattl920 gttgtgtagt caagtcacca tgctgaatgt acactgattc ctttatgatg actgcttaacl980 tccccactgc ctgtcccaga gaggctttcc aatgtagctc agtaattcct gttactttac2040 agacaggaaa gttccagaaa ctttaagaac aaactctgaa agacctatga gcaaatggtg2100 ctgaatactt tttttttaaa gccacatttc attgtcttag tcaaagcagg attattaagt2160 gattatttaa aattcgtttt tttaaattag caacttcaag tataacaact ttgaaactgg2220 aataagtgtt tattttctat taataaaaat gaattgtgac aaaaaaaaaa aaaggcttcg2280 gcttttgaag tctatgtgtg gggggggggt 2310gttctccgaa acatggagtc ctgtaggcaa ggtcttacct gaatcaggat gagggagtgg 60 tgggtccagg tggggctgct ggccgtgccc ctgcttgctg cgtacctgca catcccaccc 120 cctcagcgct cccctgccct tcactcatgg aagtcttcag gcaagttttt cacttacaag 180 ggactgcgta tcttctacca agactctgtg ggtgtggttg gaagtccaga gatagttgtg 240 cttttacacg gttttccaac atccagctac gactggtaca agatttggga aggtctgacc 300 ttgaggtttc atcgggtgat tgcccttgat ttcttaggct ttggcttcag tgacaaaccg 360 agaccacatc actattccat atttgagcag gccagcatcg tggaagcgct tttgcggcat 420 ctggggctcc agaaccgcag gatcaacctt ctttctcatg actatggaga tattgttgct 480 caggagcttc tctacaggta caagcagaat cgatctggtc ggcttaccat aaagagtctc 540 tgtctgtcaa atggaggtat ctttcctgag actcaccgtc cactccttct ccaaaagcta 600 ctcaaagatg gaggtgtgct gtcacccatc ctcacacgac tgatgaactt ctttgtattc 660 tctcgaggtc tcaccccagt ctttgggccg tatactcggc cctctgagag tgagctgtgg 720 gacatgtggg cagggatccg caacaatgac gggaacttag tcattgacag tctcttacag 780 tacatcaatc agaggaagaa gttcagaagg cgctgggtgg gagctcttgc ctctgtaact 840 atccccattc attttatcta tgggccattg gatcctgtaa atccctatcc agagtttttg 900 gagctgtaca ggaaaacgct gccgcggtcc acagtgtcga ttctggatga ccacattagc 960 cactatccac agctagagga tcccatgggc ttcttgaatg catatatggg cttcatcaacl020 tccttctgag ctggaaagag tagcttccct gtattacctc ccctactccc ttatgtgttgl080 tgtattccac ttaggaagaa atgcccaaaa gaggtcctgg ccatcaaaca taattctctcll40 acaaagtcca ctttactcaa attggtgaac agtgtatagg aagaagccag caggagctctl200 gactaaggtt gacataatag tccacctccc attactttga tatctgatca aatgtatagal260 cttggctttg ttttttgtgc tattaggaaa ttctgatgag cattactatt cactgatgcal320 gaaagacgtt cttttgcata aaagactttt tttaacactt tggacttctc tgaaatatttl380 agaagtgcta atttctggcc cacccccaac aggaattcta tagtaagggg gaggagaaggl440 ggggctcctt ccctctcctc gaatgacgtt atgggcacat gccttttaaa agttctttaal500 gcaacacaga gctgagtcct ctttgtcata cctttggatt tagtgtttca tcagctgtttl560 ttagttataa acattttgtt aaaatagata ttggtttaaa tgatacagta ttttaggtatl620 gatttaagac tatgattta c ctatacatta tatatatttt ataaagatac taaaccagcal680 tacccttact ctgccagagt agtgaagcta attaaacacg tttggtttct gaataaattgl740 aactaaatcc aaactatttc ctaaaatcac aggacattaa ggaccaatag catctgtgcclδOO agagatgtac tgttattagc tgggaagacc aattctaaca gcaaataaca gtctgagactl860 cctcatacct cagtggttag aagcatgtct ctcttgagct acagtagagg ggaagggattl920 gttgtgtagt caagtcacca tgctgaatgt acactgattc ctttatgatg actgcttaacl980 tccccactgc ctgtcccaga gaggctttcc aatgtagctc agtaattcct gttactttac2040 agacaggaaa gttccagaaa ctttaagaac aaactctgaa agacctatga gcaaatggtg2100 ctgaatactt tttttttaaa gccacatttc attgtcttag tcaaagcagg attattaagt2160 gattatttaa aattcgtttt tttaaattag caacttcaag tataacaact ttgaaactgg2220 aataagtgtt tattttctat taataaaaat gaattgtgac aaaaaaaaaaa aaaggctttggg2280gctgt10g
(2) INFORMATION ÜBER SEQ ID NO: 3:(2) INFORMATION ABOUT SEQ ID NO: 3:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 854 Basenpaare(A) LENGTH: 854 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(C) ORGAN:(C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO:3(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3
ctgcacgggg gctcgggctc actataaaag gtgggagcgc gtggtgcccc agcaacgacg 60 agtttcagaa cgatggagag ctcccgcgtg aggctgctgc ccctcctggg cgccgccctgl20 ctgctgatgc tacctctgtt gggtacccgt gcccaggagg acgccgagct ccagccccgal80 gccctggaca tctactctgc cgtggatgat gcctcccacg agaaggagct gatcgaagcg240 ctgcaagaag tcttgaagaa gctcaagagt aaacgtgttc ccatctatga gaagaagtat300 ggccaagtcc ccatgtgtga cgccggtgag cagtgtgcag tgaggaaagg ggcaaggatc360 gggaagctgt gtgactgtcc ccgaggaacc tcctgcaatt ccttcctcct gaagtgctta420 tgaaggggcg tccattctcc tccatacatc cccatccctc tactttcccc agaggaccac480 accttcctcc ctggagtttg gcttaagcaa cagataaagt ttttattttc ctctgaaggg540 aaagggctct tttcctgctg tttcaaaaat aaaagaacac attagatgtt actgtgtgaa600 gaataatgcc ttgtatggtg ttgatacgtg tgtgaagtat tcttatttta tttgtctgac660 aaactcttgt gtacctttgt gtaaagaagg gaagctttgt ttgaaaattg tatttttgta720 tgtggcatgg cagaatgaaa attagatcta gctaatctcg gtagatgtca ttacaacctg780 gaaaataaat caccctaagt gacacaaatt gaagcatgta caaattatac ataataaagt840 gtttttaata attg 854ctgcacgggg gctcgggctc actataaaag gtgggagcgc gtggtgcccc agcaacgacg 60 agtttcagaa cgatggagag ctcccgcgtg aggctgctgc ccctcctggg cgccgccctgl20 ctgctgatgc tacctctgtt gggtacccgt gcccaggagg acgccgagct ccagccccgal80 gccctggaca tctactctgc cgtggatgat gcctcccacg agaaggagct gatcgaagcg240 ctgcaagaag tcttgaagaa gctcaagagt aaacgtgttc ccatctatga gaagaagtat300 ggccaagtcc ccatgtgtga cgccggtgag cagtgtgcag tgaggaaagg ggcaaggatc360 gggaagctgt gtgactgtcc ccgaggaacc tcctgcaatt ccttcctcct gaagtgctta420 tgaaggggcg tccattctcc tccatacatc cccatccctc tactttcccc agaggaccac480 accttcctcc ctggagtttg gcttaagcaa cagataaagt ttttattttc ctctgaaggg540 aaagggctct tttcctgctg tttcaaaaat aaaagaacac attagatgtt actgtgtgaa600 gaataatgcc ttgtatggtg ttgatacgtg tgtgaagtat tcttatttta tttgtctgac660 aaactcttgt gtacctttgt gtaaagaagg gaagctttgt ttgaaaattg tatttttgta720 tgtggcatgg cagaatgaaa attagatcta gctaatctcg gtagatgtca ttacaacctg780 gaaaataaat caccctaagt gacacaaatt gaagcatgta caaattatac ataataaagt840 gtttttaata attg 854
(2) INFORMATION ÜBER SEQ ID NO: 4: (i) SEQUENZ CHARAKTERISTIK:(2) INFORMATION ABOUT SEQ ID NO: 4: (i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1112 Basenpaare(A) LENGTH: 1112 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library (xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 4(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4
cgccagcccc gtcgggggcc cggaggggac tcggagcggg ccaaggggcg gctccggcgg 60 gcggactcgg agcgggcggc ggagtgaccc ggacagctgt cctctctgac accaccccgg 120 cctgcctctt tgttgccatg agagctgcct acctcttcct gctattcctg cctgcaggct 180 tgctggctca gggccagtat gacctggacc cgctgccgcc gttccctgac cacgtccagt 240 acacccacta tagcgaccag atcgacaacc cagactacta tgattatcaa gaggtgactc 300 ctcggccctc cgaggaacag ttccagttcc agtcccagca gcaagtccaa caggaagtca 360 tcccagcccc aaccccagaa ccaggaaatg cagagctgga gcccacagag cctgggcctc 420 ttgactgccg tgaggaacag tacccgtgca cccgcctcta ctccatacac aggccttgca 480 aacagtgtct caacgaggtc tgcttctaca gcctccgccg tgtgtacgtc attaacaagg 540 agatctgtgt tcgtacagtg tgtgcccatg aggagctcct ccgagctgac ctctgtcggg 600 acaagttctc caaatgtggc gtgatggcca gcagcggcct gtgccaatcc gtggcggcct 660 cctgtgccag gagctgtggg agctgctagg gtggtgctgg catcctgagt cctggccctc 720 ctgggatctg gggccctcgg gccctgcctg acctggtgct tttttcccca tccccatgtt 780 ccttttattc tgtaaaaagt tagtggactg cagccctggg ggttgcaggc tgcggtgcct 840 caggcccctc cttcagcctg tggccacctc tggggcacga tgggggctcc ccactgccca 900 gtctgcccct cgggttgggg gagtatccca ggcctctctg tgggaccctg ggccctgacg 960 ggccttctca gcccgttttg aggacagaca gtcccccgag gtaggctaca tccccccaccl020 ccagctggtc tgcttggatt tcctacagcc cccgtgggca tggaccacct ttattttatal080 caaaattaaa aacaagtttt tacaaaaaaa aa 1112 (2) INFORMATION ÜBER SEQ ID NO: 5:cgccagcccc gtcgggggcc cggaggggac tcggagcggg ccaaggggcg gctccggcgg 60 gcggactcgg agcgggcggc ggagtgaccc ggacagctgt cctctctgac accaccccgg 120 cctgcctctt tgttgccatg agagctgcct acctcttcct gctattcctg cctgcaggct 180 tgctggctca gggccagtat gacctggacc cgctgccgcc gttccctgac cacgtccagt 240 acacccacta tagcgaccag atcgacaacc cagactacta tgattatcaa gaggtgactc 300 ctcggccctc cgaggaacag ttccagttcc agtcccagca gcaagtccaa caggaagtca 360 tcccagcccc aaccccagaa ccaggaaatg cagagctgga gcccacagag cctgggcctc 420 ttgactgccg tgaggaacag tacccgtgca cccgcctcta ctccatacac aggccttgca 480 aacagtgtct caacgaggtc tgcttctaca gcctccgccg tgtgtacgtc attaacaagg 540 agatctgtgt tcgtacagtg tgtgcccatg aggagctcct ccgagctgac ctctgtcggg 600 acaagttctc caaatgtggc gtgatggcca gcagcggcct gtgccaatcc gtggcggcct 660 cctgtgccag gagctgtggg agctgctagg gtggtgctgg catcctgagt cctggccctc 720 ctgggatctg gggccctcgg gccctgcctg acctggtgct tttttcccca tccccatgtt 780 ccttttattc tgtaaaaagt tagtggactg cagccctggg ggttgcaggc tgcggtgcct 840 caggcccctc cttcagcctg tggccacctc tggggcacga tgggggctcc ccactgccca 900 gtctgcccct cgggttgggg gagtatccca ggcctctctg tgggaccctg ggccctgacg 960 ggccttctca gcccgttttg aggacagaca gtcccccgag gtaggctaca tccccccaccl020 ccagctggtc tgcttggatt tcctacagcc cccgtgggca tggaccacct ttattttatal080 caaaattaaa aacaagtttt tacaaaaaaa aa 1112 (2) INFORMATION ABOUT SEQ ID NO: 5:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 1051 Basenpaare (B) TYP: Nukleinsäure(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1051 base pairs (B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(C) ORGAN: (vii) SONSTIGE HERKUNFT:(C) ORGAN: (vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 5(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5
gcgcaggcgc gaagaagctg gcaggggcac gagccggggg cgggtttgaa gacgcgtcgt 60 tgggttttgg aggccgtgaa acagccgttt gagtttggct gcgggtggag aacgtttgtc 120 aggggcccgg ccaagaagga ggcccgcctg ttacgatggt gtccatgagt ttcaagcgga 180 accgcagtga ccggttctac agcacccggt gctgcggctg ttgccatgtc cgcaccggga 240 cgatcatcct ggggacctgg tacatggtag taaacctatt gatggcaatt ttgctgactg 300 tggaagtgac tcatccaaac tccatgccag ctgtcaacat tcagtatgaa gtcatcggta 360 attactattc gtctgagaga atggctgata atgcctgtgt tctttttgcc gtctctgttc 420 ttatgtttat aatcagttca atgctggttt atggagcaat ttcttatcaa gtgggttggc 480 tgattccatt cttctgttac cgactttttg acttcgtcct cagttgcctg gttgctatta 540 gttctctcac ctatttgcca agaatcaaag aatatctgga tcaactacct gattttccct 600 acaaagatga cctcctggcc ttggactcca gctgcctcct gttcattgtt cttgtgttct 660 ttgccttatt catcattttt aaggcttatc taattaactg tgtttggaac tgctataaat 720 acatcaacaa ccgaaacgtg ccggagattg ctgtgtaccc tgcctttgaa gcacctcctc 780 agtacgtttt gccaacctat gaaatggccg tgaaaatgcc tgaaaaagaa ccaccacctc 840 cttacttacc tgcctgaaga aattctgcct ttgacaataa atcctatacc agctttttgt 900 ttgtttatgt tacagaatgc tgcaattcag ggctcttcaa acttgtttag atataaaata 960 tggtggccct ttggttttaa agcaatttat tttccaaaac actaagggag cctttttggal020 catctggtta aacggccttt ttgggttttt t 1051gcgcaggcgc gaagaagctg gcaggggcac gagccggggg cgggtttgaa gacgcgtcgt 60 tgggttttgg aggccgtgaa acagccgttt gagtttggct gcgggtggag aacgtttgtc 120 aggggcccgg ccaagaagga ggcccgcctg ttacgatggt gtccatgagt ttcaagcgga 180 accgcagtga ccggttctac agcacccggt gctgcggctg ttgccatgtc cgcaccggga 240 cgatcatcct ggggacctgg tacatggtag taaacctatt gatggcaatt ttgctgactg 300 tggaagtgac tcatccaaac tccatgccag ctgtcaacat tcagtatgaa gtcatcggta 360 attactattc gtctgagaga atggctgata atgcctgtgt tctttttgcc gtctctgttc 420 ttatgtttat aatcagttca atgctggttt atggagcaat ttcttatcaa gtgggttggc 480 tgattccatt cttctgttac cgactttttg acttcgtcct cagttgcctg gttgctatta 540 gttctctcac ctatttgcca agaatcaaag aatatctgga tcaactacct gattttccct 600 acaaagatga cctcctggcc ttggactcca gctgcctcct gttcattgtt cttgtgttct 660 ttgccttatt catcattttt aaggcttatc taattaactg tgtttggaac tgctataaat 720 acatcaacaa ccgaaacgtg ccggagattg ctgtgtaccc tgcctttgaa gcacctcctc 780 agtacgtttt gccaacctat gaaatggccg tgaaaatgcc tgaaaaagaa ccaccacctc 840 cttacttacc tgcctgaaga aattctgcct ttgacaataa atcctatacc agctttttgt 900 ttgtttatgt tacagaatgc tgcaattcag ggctcttcaa acttgtttag atataaaata 960 tggtggccct ttggttttaa agcaatttat tttccaaaac actaagggttacctctggttt20 cctctgggtt0 cctctgggtt20 cctctgggtt20 cctctgggtt0 cctctggttt20
(2) INFORMATION ÜBER SEQ ID NO: 6:(2) INFORMATION ABOUT SEQ ID NO: 6:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1516 Basenpaare(A) LENGTH: 1516 base pairs
(B) TYP: Nukleinsäure (C) STRANG: einzel(B) TYPE: nucleic acid (C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 6(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6
gttgtcctca tccctctcat acagggtgac caggacgttc ttgagccagt cccgcatgcg 60 cagggggaag aagatccatg agaaggagaa gcgcctggag gcaggagacc accccgtgga 120 gctgctggcc cgggacttcg agaagaacta taacatgtac atcttccctg tacactggca 180 gttcggccag ctggaccagc accccattga cgggtacctc tcccacaccg agctggctcc 240 actgcgtgct cccctcatcc ccatggagca ttgcaccacc cgctttttcg agacctgtga 300 cctggacaat gacaagtaca tcgccctgga tgagtgggcc ggctgcttcg gcatcaagca 360 gaaggatatc gacaaggatc ttgtgatcta aatccactcc ttccacagta ccggattctc 420 tctttaaccc tccccttcgt gtttccccca atgtttaaaa tgtttggatg gtttgttgtt 480 ctgcctggag acaaggtgct aacatagatt taagtgaata cattaacggt gctaaaaatg 540 aaaattctaa cccaagaaca tgacattctt agctgtaact taactattaa ggccttttcc 600 acacgcatta atagtcccat ttttctcttg ccatttgtag ctttgcccat tgtcttattg 660 ggcacatggg gtggacacgg atctgctggg ctctgcctta aacacacatt gcagcttcaa 720 cttttctctt tagtgttctg tttgaaacta atacttaccg agtcagactt tgtgttcatt 760 tcatttcagg gtcttggctg cctgtgggct tccccaggtg gcctggaggt gggcaaaggg 840 aagtaacaga cacacgatgt tgtcaaggat ggttttggga ctagaggctc agtggtggga 900 gagatccctg cagaacccac caaccagaac gtggtttgcc tgaggctgta actgagagaa 960 agattctggg gctgtgttat gaaaatatag acattctcac ataagcccag ttcatcaccal020 tttcctcctt tacctttcag tgcagtttct tttcacatta ggctgttggt tcaaacttttlOδO gggagcacgg actgtcagtt ctctgggaag tggtcagcgc atcctgcagg gcttctcctcll40 ctctgtcttt tggagaacca gggctcttct caggggctct agggactgcc aggctgtttcl200 agccaggaag gccaaaatca agagtgagat gtagaaagtt gtaaaataga aaaagtggagl260 ttggtgaatc ggttgttctt tcctcacatt tggatgattg tcataaggtt tttagcatgtl320 tcctcctttt ctccaccctc cccttttttc ccccaagaat acagagaaaa ctcaaagttal380 atggggaggg tcggatccta caggcctgag aatcggtcaa ctccaagcat ttcatggaaal440 aggcggcttc ctaattaatc ctacaaaccc ccacccagga tggtgagggg tttcaccaat!500 tcctccaaaa ataaaa 1516gttgtcctca tccctctcat acagggtgac caggacgttc ttgagccagt cccgcatgcg 60 cagggggaag aagatccatg agaaggagaa gcgcctggag gcaggagacc accccgtgga 120 gctgctggcc cgggacttcg agaagaacta taacatgtac atcttccctg tacactggca 180 gttcggccag ctggaccagc accccattga cgggtacctc tcccacaccg agctggctcc 240 actgcgtgct cccctcatcc ccatggagca ttgcaccacc cgctttttcg agacctgtga 300 cctggacaat gacaagtaca tcgccctgga tgagtgggcc ggctgcttcg gcatcaagca 360 gaaggatatc gacaaggatc ttgtgatcta aatccactcc ttccacagta ccggattctc 420 tctttaaccc tccccttcgt gtttccccca atgtttaaaa tgtttggatg gtttgttgtt 480 ctgcctggag acaaggtgct aacatagatt taagtgaata cattaacggt gctaaaaatg 540 aaaattctaa cccaagaaca tgacattctt agctgtaact taactattaa ggccttttcc 600 acacgcatta atagtcccat ttttctcttg ccatttgtag ctttgcccat tgtcttattg 660 ggcacatggg gtggacacgg atctgctggg ctctgcctta aacacacatt gcagcttcaa 720 cttttctctt tagtgttctg tttgaaacta atacttaccg agtcagactt tgtgttcatt 760 tcatttcagg gtcttggctg cctgtgggct tccccaggtg gcctggaggt gggcaaaggg 840 aagtaacaga cacacgatgt tgtcaaggat ggttttggga ctagaggctc agtggtggga 900 gagatccctg cagaacccac caaccagaac gtggtttgcc tgaggctgta actgagagaa 960 agattctggg gctgtgttat gaaaatatag acattctcac ataagcccag ttcatcaccal020 tttcctcctt tacctttcag tgcagtttct tttcacatta ggctgttggt tcaaacttttlOδO gggagcacgg actgtcagtt ctctgggaag tggtcagcgc atcctgcagg gcttctcctcll40 ctctgtcttt tggagaacca gggctcttct caggggctct agggactgcc aggctgtttcl200 agccaggaag gccaaaatca agagtgagat gtagaaagtt gtaaaataga aaaagtggagl260 ttggtgaatc ggttgttctt tcctcacatt tggatgattg tcataaggtt tttagcatgtl320 tcctcctttt ctccaccctc cccttttttc ccccaagaat acagagaaaa ctcaaagttal380 atggggaggg tcggatccta caggcctgag aatcggtcaa ctccaagcat ttcatggaaal440 aggcggcttc ctaattaatc ctacaaaccc tcacccaggaaa ta 500g
(2) INFORMATION ÜBER SEQ ID NO: 7:(2) INFORMATION ABOUT SEQ ID NO: 7:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 2367 Basenpaare(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2367 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN (vi) HERKUNFT:(iii) ANTI-SENSE: NO (vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 7(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7
cgccgggact cttggcgggt gaaggtgtgt gtcagctttt gcgtcactcg agccctgggc 60 gctgcttgct aaagagccga gcacgcgggt ctgtcatcat gtcgcgttac gggcggtacg 120 gaggagaaac caaggtgtat gttggtaacc tgggaactgg cgctggcaaa ggagagttag 180 aaagggcttt cagttattat ggtcctttaa gaactgtatg gattgcgaga aatcctccag 240 gatttgcctt tgtggaattc gaagatccta gagatgcaga agatgcagta cgaggactgg 300 atggaaaggt gatttgtggc tcccgagtga gggttgaact atcgacaggc atgcctcgga 360 gatcacgttt tgatagacca cctgcccgac gtccctttga tccaaatgat agatgctatg 420 agtgtggcga aaagggacat tatgcttatg attgtcatcg ttacagccgg cgaagaagaa 480 gcaggtcacg gtctagatca cattctcgat ccagaggaag gcgatactct cgctcacgca 540 gcaggagcag gggacgaagg tcaaggtcag catctcctcg acgatcaaga tctatctctc 600 ttcgtagatc aagatcagct tcactcagaa gatctaggtc tggttctata aaaggatcga 660 ggtatttcca atccccgtcg aggtcaagat caagatccag gtctatttca cgaccaagaa 720 gcagccgatc aaagtccaga tctccatctc caaaaagaag tcgttcccca tcaggaagtc 780 ctcgcagaag tgcaagtcct gaaagaatgg actgaagctc tcaagttcac cctttaggga 640 aaagttattt tgtttacatt attataaggg atttgtgatg tctgtaaagt gtaacctagg 900 aaagataatt caaccatcta atcaaaatgg atctggatta ctatgtaaat tcacagcagt 960 aagataatat aaattttgtt gaatgtatta acatcatatg gtctgaaaat gtgggtttttl020 atttggcaca tttaaataaa atgtttctaa ctagattttt gatttgtgtt caatattaacl080 acttcttaat ttgatatatt tgagagtcag acattataat tgttaacctt attcatacatll40 acctacattc agaattgaaa ggtgttggtt aagtcttgaa catcactatt ctatgcataal200 aacttggcca ggatcttaag ggactttgaa aattccatct tacccttgta gctctgggtal260 agatgacctg agtcccttat gatacagcct gaatgcatca tgacagatcc ttaagttagcl320 taatccgttt gaagttggtg ttagtaggta ttgtatgatc agtggtgaag caagtaggacl380 cactgatgtg tctaaatgag catgacagga actaaacgaa actgattaaa tgtatgagaal440 atagaaactg atttctggat gatctttata ctaattgcag ctttcaggct actaggtggcl500 atagtgttaa ttaggactcc ccaagatatg gggagttcta ctctcaatgg tcttgtttctl560 ttgctttcta cattagttaa ccagttttat accaaaaaat gcatgtttga ggaattgtctl620 gaaattggga caaaacacct tcatgtaaac cagctttgca aaattttcca gcccagatacl680 tcttcatcta ttcaaatgga ttgtcttatt ctgagcaaag acctgttgtt aatcttcaagl740 ctaggttttg cagttcccaa ccacaacatt cttctatttt gccaggctgg tgcaaagtaalδOO ttaaagatgt caatcagaaa tgtcaatgag actaaagtgg ttttgtaaat ctcagctatal860 tttagcaaca ctccatgtag ctaatatttt ttggtagcat ctggtagacc ttagaatgttl920 acatagccag taggttcttt attcaaattt taagtatctt aagaatagta gggcagtaacl980 agttactttt gagagttttc tggtcaagct tttaccaggc attctctagc cttggtacaa2040 aaaaaaaaaa aacctgctgg ttgcgcagat acctaggctt gtccatttta tgcatttcag2100 caaagtcatt ggatactatt gcaacttggg aatactggtc tgcatcaagt ttattcggta2160 gtttgaccgc tagtatgttg gaagttattt ggattgtttt tggaattttg actggctgaa2220 ttatggttgg tataaagtta tgtgtataac tggcaggctt atttatctgt tgcacttggt2260 tagctttaat tgttctgtat tatttaaaga taagtttact caacaataaa tctgcagaga2340 ttgaacaaat aaaaaaaaaa aaaaaaa 2367cgccgggact cttggcgggt gaaggtgtgt gtcagctttt gcgtcactcg agccctgggc 60 gctgcttgct aaagagccga gcacgcgggt ctgtcatcat gtcgcgttac gggcggtacg 120 gaggagaaac caaggtgtat gttggtaacc tgggaactgg cgctggcaaa ggagagttag 180 aaagggcttt cagttattat ggtcctttaa gaactgtatg gattgcgaga aatcctccag 240 gatttgcctt tgtggaattc gaagatccta gagatgcaga agatgcagta cgaggactgg 300 atggaaaggt gatttgtggc tcccgagtga gggttgaact atcgacaggc atgcctcgga 360 gatcacgttt tgatagacca cctgcccgac gtccctttga tccaaatgat agatgctatg 420 agtgtggcga aaagggacat tatgcttatg attgtcatcg ttacagccgg cgaagaagaa 480 gcaggtcacg gtctagatca cattctcgat ccagaggaag gcgatactct cgctcacgca 540 gcaggagcag gggacgaagg tcaaggtcag catctcctcg acgatcaaga tctatctctc 600 ttcgtagatc aagatcagct tcactcagaa gatctaggtc tggttctata aaaggatcga 660 ggtatttcca atccccgtcg aggtcaagat caagatccag gtctatttca cgaccaagaa 720 gcagccgatc aaagtccaga tctccatctc caaaaagaag tcgttcccca tcaggaagtc 780 ctcgcagaag tgcaagtcct gaaagaatgg actgaagctc tcaagttcac cctttaggga 640 aaagttattt tgtttacatt attataaggg atttgtgatg tctgtaaagt gtaacctagg 900 aaagataatt caaccatcta atcaaaatgg atctggatta ctatgtaaat tcacagcagt 960 aagataatat aaattttgtt gaatgtatta acatcatatg gtctgaaaat gtgggtttttl020 atttggcaca tttaaataaa atgtttctaa ctagattttt gatttgtgtt caatattaacl080 acttcttaat ttgatatatt tgagagtcag acattataat tgttaacctt attcatacatll40 acctacattc agaattgaaa ggtgttggtt aagtcttgaa catcactatt ctatgcataal200 aacttggcca ggatcttaag ggactttgaa aattccatct tacccttgta gctctgggtal260 agatgacctg agtcccttat gatacagcct gaatgcatca tgacagatcc ttaagttagcl320 taatccgttt gaagttggtg ttagtaggta ttgtatgatc agtggtgaag caagtaggacl380 cactgatgtg tctaaatgag catgacagga actaaacgaa actgattaaa tgtatgagaal440 atagaaactg atttctggat gatctttata ctaattgcag ctttcaggct actaggtggcl500 atagtgttaa ttaggactcc ccaagatatg gggagttcta ctctcaatgg tcttgtttctl560 ttgctttcta cattagttaa ccagttttat accaaaaaat gcatgtttga ggaattgtctl620 gaaattggga caaaacacct tcatgtaaac cagctttgca aaattttcca gcccagatacl680 tcttcatcta ttcaaatgga ttgtcttatt ctgagcaa ag acctgttgtt aatcttcaagl740 ctaggttttg cagttcccaa ccacaacatt cttctatttt gccaggctgg tgcaaagtaalδOO ttaaagatgt caatcagaaa tgtcaatgag actaaagtgg ttttgtaaat ctcagctatal860 tttagcaaca ctccatgtag ctaatatttt ttggtagcat ctggtagacc ttagaatgttl920 acatagccag taggttcttt attcaaattt taagtatctt aagaatagta gggcagtaacl980 agttactttt gagagttttc tggtcaagct tttaccaggc attctctagc cttggtacaa2040 aaaaaaaaaa aacctgctgg ttgcgcagat acctaggctt gtccatttta tgcatttcag2100 caaagtcatt ggatactatt gcaacttggg aatactggtc tgcatcaagt ttattcggta2160 gtttgaccgc tagtatgttg gaagttattt ggattgtttt tggaattttg actggctgaa2220 ttatggttgg tataaagtta tgtgtataac tggcaggctt atttatctgt tgcacttggt2260 tagctttaat tgttctgtat tatttaaaga taagtttact caacaataaa tctgcagaga2340 ttgaacaaat aaaaaaaaaaa67aaaaaaaa67a
(2) INFORMATION ÜBER SEQ ID NO: 8:(2) INFORMATION ABOUT SEQ ID NO: 8:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 568 Basenpaare(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 568 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear (ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(C) STRAND: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(C) ORGAN:(C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 8(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8
ctcgagccgt gggcagtggc cgcgaatgcg cggagacact gaccttcagc gcctcggctc 60 cagcgccatg gcgccctcca ggaagttctt cgttggggga aactggaaga tgaacgggcgl20 gaagcagagt ctgggggagc tcatcggcac tctgaacgcg gccaaggtgc cggccgacaclδO cgaggtggtt tgtgctcccc ctactgccta tatcgacttc gcccggcaga agctagatcc240 caagattgct gtggctgcgc agaactgcta caaagtgact aatggggctt ttactgggga300 gatcagccct ggcatgatca aagactgcgg agccacgtgg gtggtcctgg ggcactcaga360 gagaaggcat gtctttgggg agtcagatga gctgattggg cagaaagtgg cccatgctct420 ggcagaggga ctcggagtaa tcgcctgcat tggggagaag ctagatgaaa gggaagctgg480 catcactgag aatgttgttt tcgagcagac aaaggtcatc ggggatgact tgaaggactg540 gatcaagttc gtcctggcct gttggcct 568ctcgagccgt gggcagtggc cgcgaatgcg cggagacact gaccttcagc gcctcggctc 60 cagcgccatg gcgccctcca ggaagttctt cgttggggga aactggaaga tgaacgggcgl20 gaagcagagt ctgggggagc tcatcggcac tctgaacgcg gccaaggtgc cggccgacaclδO cgaggtggtt tgtgctcccc ctactgccta tatcgacttc gcccggcaga agctagatcc240 caagattgct gtggctgcgc agaactgcta caaagtgact aatggggctt ttactgggga300 gatcagccct ggcatgatca aagactgcgg agccacgtgg gtggtcctgg ggcactcaga360 gagaaggcat gtctttgggg agtcagatga gctgattggg cagaaagtgg cccatgctct420 ggcagaggga ctcggagtaa tcgcctgcat tggggagaag ctagatgaaa gggaagctgg480 catcactgag aatgttgttt tcgagcagac aaaggtcatc ggggatgact tgaaggactg540 gatcaagttc gtcctggcct gttggcct 568
(2) INFORMATION ÜBER SEQ ID NO: 9:(2) INFORMATION ABOUT SEQ ID NO: 9:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1775 Basenpaare(A) LENGTH: 1775 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(C) ORGAN:(C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 9(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9
ctcgggggcc attttgtgaa gagacgaaga ctgagcggtt gtggccgcgt tgccgacctc 60 cagcagcagt cggcttctct acgcagaacc cgggagtagg agactcagaa tcgaatctct 120 tctccctccc cttcttgtga gatttttttg atcttcagct acattttcgg ctttgtgaga 180 aaccttacca tcaaacacga tggccagcaa cgttaccaac aagacagatc ctcgctccat 240 gaactcccgt gtattcattg ggaatctcaa cactcttgtg gtcaagaaat ctgatgtgga 300 ggcaatcttt tcgaagtatg gcaaaattgt gggctgctct gttcataagg gctttgcctt 360 cgttcagtat gttaatgaga gaaatgcccg ggctgctgta gcaggagagg atggcagaat 420 gattgctggc caggttttag atattaacct ggctgcagag ccaaaagtga accgaggaaa 480 agcaggtgtg aaacgatctg cagcggagat gtacggctcc tcttttgact tggactatga 540 ctttcaacgg gactattatg ataggatgta cagttaccca gcacgtgtac ctcctcctcc 600 tcctattgct cgggctgtag tgccctcgaa acgtcagcgt gtatcaggaa acacttcacg 660 aaggggcaaa agtggcttca attctaagag tggacagcgg ggatcttcca agtctggaaa 720 gttgaaagga gatgaccttc aggccattaa gaaggagctg acccagataa aacaaaaagt 780 ggattctctc ctggaaaacc tggaaaaaat tgaaaaggaa cagagcaaac aagcagtaga 840 gatgaagaat gataagtcag aagaggagca gagcagcagc tccgtgaaga aagatgagac 900 taatgtgaag atggagtctg aggggggtgc agatgactct gctgaggagg gggacctact 960 ggatgatgat gataatgaag atcgggggga tgaccagctg gagttgatca aggatgatgal020 aaaagaggct gaggaaggag aggatgacag agacagcgcc aatggcgagg atgactcttalOδO agcacatagt ggggtttaga aatcttatcc cattatttct ttacctaggc gcttgtctaall40 gatcaaattt ttcaccagat cctctcccct agtatcttca gcacatgctc actgttctccl200 ccatccttgt ccttcccatg ttcattaatt catattgccc cgcgcctagt cccattttcal260 cttcctttga cgctcctagt agttttgtta agtcttaccc tgtaattttt gcttttaattl320 ttgatacctc tttatgactt aacaataaaa aggatgtatg gtttttatca actgtctccal3δ0 aaataatctc ttgttatgca gggagtacag ttcttttcat tcatacataa gttcagtagtl440 tgcttcccta actgcaaagg caatctcatt tagttgagta gctcttgaaa gcagctttgal500 gttagaagta tgtgtgttac accctcacat tagtgtgctg tgtggggcag ttcaacacaal560 atgtaacaat gtatttttgt gaatgagagt tggcatgtca aatgcatcct ctagaaaaatl620 aattagtgtt atagtcttaa gatttgtttt ctaaagttga tactgtgggt tatttttgtglδδO aacagcctga tgtttgggac cttttttcct caaaataaac aagtccttat taaaccaggal740 atttggagaa aaaaaaaaaa aaaaaaaaaa aaaaa 1775ctcgggggcc attttgtgaa gagacgaaga ctgagcggtt gtggccgcgt tgccgacctc 60 cagcagcagt cggcttctct acgcagaacc cgggagtagg agactcagaa tcgaatctct 120 tctccctccc cttcttgtga gatttttttg atcttcagct acattttcgg ctttgtgaga 180 aaccttacca tcaaacacga tggccagcaa cgttaccaac aagacagatc ctcgctccat 240 gaactcccgt gtattcattg ggaatctcaa cactcttgtg gtcaagaaat ctgatgtgga 300 ggcaatcttt tcgaagtatg gcaaaattgt gggctgctct gttcataagg gctttgcctt 360 cgttcagtat gttaatgaga gaaatgcccg ggctgctgta gcaggagagg atggcagaat 420 gattgctggc caggttttag atattaacct ggctgcagag ccaaaagtga accgaggaaa 480 agcaggtgtg aaacgatctg cagcggagat gtacggctcc tcttttgact tggactatga 540 ctttcaacgg gactattatg ataggatgta cagttaccca gcacgtgtac ctcctcctcc 600 tcctattgct cgggctgtag tgccctcgaa acgtcagcgt gtatcaggaa acacttcacg 660 aaggggcaaa agtggcttca attctaagag tggacagcgg ggatcttcca agtctggaaa 720 gttgaaagga gatgaccttc aggccattaa gaaggagctg acccagataa aacaaaaagt 780 ggattctctc ctggaaaacc tggaaaaaat tgaaaaggaa cagagcaaac aagcagtaga 840 gatgaagaat gataagtcag aagaggagca gagcagcagc tccgtgaaga aagatgagac 900 taatgtgaag atggagtct g aggggggtgc agatgactct gctgaggagg gggacctact 960 ggatgatgat gataatgaag atcgggggga tgaccagctg gagttgatca aggatgatgal020 aaaagaggct gaggaaggag aggatgacag agacagcgcc aatggcgagg atgactcttalOδO agcacatagt ggggtttaga aatcttatcc cattatttct ttacctaggc gcttgtctaall40 gatcaaattt ttcaccagat cctctcccct agtatcttca gcacatgctc actgttctccl200 ccatccttgt ccttcccatg ttcattaatt catattgccc cgcgcctagt cccattttcal260 cttcctttga cgctcctagt agttttgtta agtcttaccc tgtaattttt gcttttaattl320 ttgatacctc tttatgactt aacaataaaa aggatgtatg gtttttatca actgtctccal3δ0 aaataatctc ttgttatgca gggagtacag ttcttttcat tcatacataa gttcagtagtl440 tgcttcccta actgcaaagg caatctcatt tagttgagta gctcttgaaa gcagctttgal500 gttagaagta tgtgtgttac accctcacat tagtgtgctg tgtggggcag ttcaacacaal560 atgtaacaat gtatttttgt gaatgagagt tggcatgtca aatgcatcct ctagaaaaatl620 aattagtgtt atagtcttaa gatttgtttt ctaaagttga tactgtgggt tatttttgtglδδO aacagcctga tgtttgggac cttttttcct caaaataaac aagtccttat taaaccaggal740 atttggagaa aaaaaaaaaa aaaaaaaaaa aaa aa 1775
(2) INFORMATION ÜBER SEQ ID NO: 10:(2) INFORMATION ABOUT SEQ ID NO: 10:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 509 Basenpaare (B) TYP: Nukleinsäure(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 509 base pairs (B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN: (vii) SONSTIGE HERKUNFT:(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO:10(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10
caggtcgagt ggccactgcg cagaccagac ttcgctcgta ctcgtgcgcc tcgcttcgct 60 tttcctccgc aaccatgtct gacaaacccg atatggctga gatcgagaaa ttcgataagtl20 cgaaactgaa gaagacagag acgcaagaga aaaatccact gccttccaaa gaaacgattglδO aacaggagaa gcaagcaggc gaatcgtaat gaggcgtgcg ccgccaatat gcactgtaca240 ttccacaagc attgccttct tattttactt cttttagctg tttaactttg taagatgcaa300 agaggttgga tcaagtttaa atgactgtgc tgcccctttc acatcaaagg gactacttga360 acaacggaag ggccgcggcc tacctttccc atctgtctat ctatctggct ggcagggaag420 ggaagagttg caggttggtg aggaagaagt ggggtggaag aagttggatg ggccgccagt480 aaaacttggg taaaccgaac ttggccaag 509caggtcgagt ggccactgcg cagaccagac ttcgctcgta ctcgtgcgcc tcgcttcgct 60 tttcctccgc aaccatgtct gacaaacccg atatggctga gatcgagaaa ttcgataagtl20 cgaaactgaa gaagaccaa actatacaaga gaaccccaga aacaggagaa gcaagcaggc gaatcgtaat gaggcgtgcg ccgccaatat gcactgtaca240 ttccacaagc attgccttct tattttactt cttttagctg tttaactttg taagatgcaa300 agaggttgga tcaagtttaa atgactgtgc tgcccctttc acatcaaagg gactacttga360 acaacggaag ggccgcggcc tacctttccc atctgtctat ctatctggct ggcagggaag420 ggaagagttg caggttggtg aggaagaagt ggggtggaag aagttggatg ggccgccagt480 aaaacttggg taaaccgaac ttggccaag 509
(2) INFORMATION ÜBER SEQ ID NO: 1 1 : (i) SEQUENZ CHARAKTERISTIK:(2) INFORMATION ABOUT SEQ ID NO: 1 1: (i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 2191 Basenpaare(A) LENGTH: 2191 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library (xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 1 1(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1 1
actgagcgag ggccagccgt gcggcatcta caccgagcgc tgtggctccg gccttcgctg 60 ccagccgtcg cccgacgagg cgcgaccgct gcaggcgctg ctggacggcc gcgggctctg 120 cgtcaacgct agtgccgtca gccgcctgcg cgcctacctg ctgccagcgc cgccagctcc 180 aggaaatgct agtgagtcgg aggaagaccg cagcgccggc agtgtggaga gcccgtccgt 240 ctccagcacg caccgggtgt ctgatcccaa gttccacccc ctccattcaa agataatcat 300 catcaagaaa gggcatgcta aagacagcca gcgctacaaa gttgactacg agtctcagag 360 cacagatacc cagaacttct cctccgagtc caagcgggag acagaatatg gtccctgccg 420 tagagaaatg gaagacacac tgaatcacct gaagttcctc aatgtgctga gtcccagggg 460 tgtacacatt cccaactgtg acaagaaggg attttataag aaaaagcagt gtcgcccttc 540 caaaggcagg aagcggggct tctgctggtg tgtggataag tatgggcagc ctctcccagg 600 ctacaccacc aaggggaagg aggacgtgca ctgctacagc atgcagagca agtagacgcc 660 tgccgcaagg ttaatgtgga gctcaaatat gccttatttt gcacaaaaga ctgccaagga 720 catgaccagc agctggctac agcctcgatt tatatttctg tttgtggtga actgattttt 760 tttaaaccaa agtttagaaa gaggtttttg aaatgcctat ggtttctttg aatggtaaac 840 ttgagcatct tttcactttc cagtagtcag caaagagcag tttgaatttt cttgtcgctt 900 cctatcaaaa tattcagaga ctcgagcaca gcacccagac ttcatgcgcc cgtggaatgc 960 tcaccacatg ttggtcgaag cggccgacca ctgactttgt gacttaggcg gctgtgttgcl020 ctatgtagag aacacgcttc acccccactc cccgtacagt gcgcacaggc tttatcgagal080 ataggaaaac ctttaaaccc cggtcatccg gacatcccaa cgcatgctcc tggagctcacll40 agccttctgt ggtgtcattt ctgaaacaag ggcgtggatc cctcaaccaa gaagaatgttl200 tatgtcttca agtgacctgt actgcttggg gactattgga gaaaataagg tggagtcctal260 cttgtttaaa aaatatgtat ctaagaatgt tctagggcac tctgggaacc tataaaggcal320 ggtatttcgg gccctcctct tcaggaatct tcctgaagac atggcccagt cgaaggcccal380 ggatggcttt tgctgcggcc ccgtggggta ggagggacag agagacaggg agagtcagccl440 tccacattca gaggcatcac aagtaatggc acaattcttc ggatgactgc agaaaatagtl500 gttttgtagt tcaacaactc aagacgaagc ttatttctga ggataagctc tttaaaggcal560 aagctttatt ttcatctctc atcttttgtc ctccttagca caatgtaaaa aagaatagtal620 atatcagaac aggaaggagg aatggcttgc tggggagccc atccaggaca ctgggagcacl680 atagagattc acccatgttt gttgaactta gagtcattct catgcttttc tttataattcl740 acacatatat gcagagaaga tatgttcttg ttaacattgt atacaacata gccccaaatalδOO tagtaagatc tatactagat aatcctagat gaaatgttag agatgctata tgatacaactl860 gtggccatga ctgaggaaag gagctcacgc ccagagactg ggctgctctc ccggaggccal920 aacccaagaa ggtctggcaa agtcaggctc agggagactc tgccctgctg cagacctcggl980 tgtggacaca cgctgcatag agctctcctt gaaaacagag gggtctcaag acattctgcc2040 tacctattag cttttcttta tttttttaac tttttggggg gaaaagtatt tttgagaagt2100 ttgtcttgca atgtatttat aaatagtaaa taaagttttt accattaaaa aaaaaaggag2160 taaaaagaaa aaaaagggcg gccgccgact a 2191actgagcgag ggccagccgt gcggcatcta caccgagcgc tgtggctccg gccttcgctg 60 ccagccgtcg cccgacgagg cgcgaccgct gcaggcgctg ctggacggcc gcgggctctg 120 cgtcaacgct agtgccgtca gccgcctgcg cgcctacctg ctgccagcgc cgccagctcc 180 aggaaatgct agtgagtcgg aggaagaccg cagcgccggc agtgtggaga gcccgtccgt 240 ctccagcacg caccgggtgt ctgatcccaa gttccacccc ctccattcaa agataatcat 300 catcaagaaa gggcatgcta aagacagcca gcgctacaaa gttgactacg agtctcagag 360 cacagatacc cagaacttct cctccgagtc caagcgggag acagaatatg gtccctgccg 420 tagagaaatg gaagacacac tgaatcacct gaagttcctc aatgtgctga gtcccagggg 460 tgtacacatt cccaactgtg acaagaaggg attttataag aaaaagcagt gtcgcccttc 540 caaaggcagg aagcggggct tctgctggtg tgtggataag tatgggcagc ctctcccagg 600 ctacaccacc aaggggaagg aggacgtgca ctgctacagc atgcagagca agtagacgcc 660 tgccgcaagg ttaatgtgga gctcaaatat gccttatttt gcacaaaaga ctgccaagga 720 catgaccagc agctggctac agcctcgatt tatatttctg tttgtggtga actgattttt 760 tttaaaccaa agtttagaaa gaggtttttg aaatgcctat ggtttctttg aatggtaaac 840 ttgagcatct tttcactttc cagtagtcag caaagagcag tttgaatttt cttgtcgctt 900 cctatcaaaa tattcagaga ctcgagcaca gcacccagac ttcatgcgcc cgtggaatgc 960 tcaccacatg ttggtcgaag cggccgacca ctgactttgt gacttaggcg gctgtgttgcl020 ctatgtagag aacacgcttc acccccactc cccgtacagt gcgcacaggc tttatcgagal080 ataggaaaac ctttaaaccc cggtcatccg gacatcccaa cgcatgctcc tggagctcacll40 agccttctgt ggtgtcattt ctgaaacaag ggcgtggatc cctcaaccaa gaagaatgttl200 tatgtcttca agtgacctgt actgcttggg gactattgga gaaaataagg tggagtcctal260 cttgtttaaa aaatatgtat ctaagaatgt tctagggcac tctgggaacc tataaaggcal320 ggtatttcgg gccctcctct tcaggaatct tcctgaagac atggcccagt cgaaggcccal380 ggatggcttt tgctgcggcc ccgtggggta ggagggacag agagacaggg agagtcagccl440 tccacattca gaggcatcac aagtaatggc acaattcttcca ga ga gtc tca ga ga gtc aagctttatt ttcatctctc atcttttgtc ctccttagca caatgtaaaa aagaatagtal620 atatcagaac aggaaggagg aatggcttgc tggggagccc atccaggaca ctgggagcacl680 atagagattc acccatgttt gttgaactta gagtcattct catgcttttc tttataattcl740 acacatatat gcagagaaga tatgttcttg ttaacattgt atacaacata gccccaaatalδOO tagtaagatc tatactagat aatcctagat gaaatgttag agatgctata tgatacaactl860 gtggccatga ctgaggaaag gagctcacgc ccagagactg ggctgctctc ccggaggccal920 aacccaagaa ggtctggcaa agtcaggctc agggagactc tgccctgctg cagacctcggl980 tgtggacaca cgctgcatag agctctcctt gaaaacagag gggtctcaag acattctgcc2040 tacctattag cttttcttta tttttttaac tttttggggg gaaaagtatt tttgagaagt2100 ttgtcttgca atgtatttat aaatagtaaa taaagttttt accattaaaa aaaaaaggag2160 taaaaagaaa aaaaagggcg gccgccgact a 2191
(2) INFORMATION ÜBER SEQ ID NO: 12:(2) INFORMATION ABOUT SEQ ID NO: 12:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1769 Basenpaare(A) LENGTH: 1769 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(C) ORGAN:(C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 12(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12
attatttaca tttcaaaata attcccctta atcgttttac tcctaagttc attaccattg 60 ttggcccacc ttaggttcca ccacttggtt gttaccccag ccctgggttc aaacagggac 120 atggcaaggg gacacaggac agaggggtcc ccagctgcca cctcacccac cgcaattcat 180 ttagtagcag gcacaggggc agctccggca cggctttctc aggcctatgc cggagcctcg 240 agggctggag agcgggaaga caggcagtgc tcggggagtt gcagcaggac gtcaccagga 300 gggcgaacgg ccacgggagg ggggccccgg gacattgcgc agcaaggagg ctgcaggggc 360 tcggcctgcg ggcgccggtc ccacgaggca ctgcggccca gggtctggtg cggagagggc 420 ccacagtgga cttggtgacg ctgtatgccc tcaccgctca gcccctgggg ctggcttggc 480 agacagtaca gcatccaggg gagtcaaggg catggggcga gaccagacta ggcgaggcgg 540 gcggggcgga gtgaatgagc tctcaggagg gaggatggtg caggcagggg tgaggagcgc 600 agggggcggc gagcgggagg cactggcctc cagagcccgt ggccaaggcg ggcctcgcgg 660 gcggcgacgg agccgggatc ggtgcctcag cgttcgggct ggagacgagg ccaggtctcc 720 agctggggtg gacgtgccca ccagctgccg aaggcaagac gccaggtccg gtggacgtga 780 caagcaggac atgacatggt ccggtgtgac ggcgaggaca gaggaggcgc gtccggcctt 840 cctgaacacc ttaggctggt ggggctgcgg caagaagcgg gtctgtttct ttacttcctc 900 cacggagtcg gcacactatg gctgccctct gggctcccag aacccacaac atgaaagaaa 960 tggtgctacc cagctcaagc ctgggccttt gaatccggac acaaaaccct ctagcttggal020 aatgaatatg ctgcacttta caaccactgc actacctgac tcaggaatcg gctctggaagl080 gtgaagctag aggaaccaga cctcatcagc ccaacatcaa agacaccatc ggaacagcagll40 cgcccgcagc acccaccccg caccggcgac tccatcttca tggccacccc ctgcggcggal200 cggttgacca ccagccacca catcatccca gagctgagct cctccagcgg gatgacgccgl260 tccccaccac ctccctcttc ttctttttca tccttctgtc tctttgtttc tgagctttccl320 tgtctttcct tttttctgag agattcaaag cctccacgac tctgtttccc ccgtcccttcl380 tgaatttaat ttgcactaag tcatttgcac tggttggagt tgtggagacg gccttgagtcl440 tcagtacgag tgtgcgtgag tgtgagccac cttggcaagt gcctgtgcag ggcccggccgl500 ccctccatct gggccgggtg actgggcgcc ggctgtgtgc ccgaggcctc accctgccctl560 cgcctagtct ggaagctccg accgacatca cggagcagcc ttcaagcatt ccattacgccl620 ccatctcgct ctgtgcccct ccccaccagg gcttcagcag gagccctgga ctcatcatcal680 ataaacactg ttacagcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaal740 aaaaaaaaaa aaaaaaaaaa aaaaaaaag 1769attatttaca tttcaaaata attcccctta atcgttttac tcctaagttc attaccattg 60 ttggcccacc ttaggttcca ccacttggtt gttaccccag ccctgggttc aaacagggac 120 atggcaaggg gacacaggac agaggggtcc ccagctgcca cctcacccac cgcaattcat 180 ttagtagcag gcacaggggc agctccggca cggctttctc aggcctatgc cggagcctcg 240 agggctggag agcgggaaga caggcagtgc tcggggagtt gcagcaggac gtcaccagga 300 gggcgaacgg ccacgggagg ggggccccgg gacattgcgc agcaaggagg ctgcaggggc 360 tcggcctgcg ggcgccggtc ccacgaggca ctgcggccca gggtctggtg cggagagggc 420 ccacagtgga cttggtgacg ctgtatgccc tcaccgctca gcccctgggg ctggcttggc 480 agacagtaca gcatccaggg gagtcaaggg catggggcga gaccagacta ggcgaggcgg 540 gcggggcgga gtgaatgagc tctcaggagg gaggatggtg caggcagggg tgaggagcgc 600 agggggcggc gagcgggagg cactggcctc cagagcccgt ggccaaggcg ggcctcgcgg 660 gcggcgacgg agccgggatc ggtgcctcag cgttcgggct ggagacgagg ccaggtctcc 720 agctggggtg gacgtgccca ccagctgccg aaggcaagac gccaggtccg gtggacgtga 780 caagcaggac atgacatggt ccggtgtgac ggcgaggaca gaggaggcgc gtccggcctt 840 cctgaacacc ttaggctggt ggggctgcgg caagaagcgg gtctgtttct ttacttcctc 900 cacggagtcg gcacactatg gctgccctct gggctcccag aacccacaac atgaaagaaa 960 tggtgctacc cagctcaagc ctgggccttt gaatccggac acaaaaccct ctagcttggal020 aatgaatatg ctgcacttta caaccactgc actacctgac tcaggaatcg gctctggaagl080 gtgaagctag aggaaccaga cctcatcagc ccaacatcaa agacaccatc ggaacagcagll40 cgcccgcagc acccaccccg caccggcgac tccatcttca tggccacccc ctgcggcggal200 cggttgacca ccagccacca catcatccca gagctgagct cctccagcgg gatgacgccgl260 tccccaccac ctccctcttc ttctttttca tccttctgtc tctttgtttc tgagctttccl320 tgtctttcct tttttctgag agattcaaag cctccacgac tctgtttccc ccgtcccttcl380 tgaatttaat ttgcactaag tcatttgcac tggttggagt tgtggagacg gccttgagtcl440 tcagtacgag tgtgcgtgag tgtgagccac cttggcaagt gcctgtgcag ggcccggccgl500 ccctccatct gggccgggtg actgggcgcc ggctgtgtgc ccgaggcctc accctgccctl560 cgcctagtct ggaagctccg accgacatca cggagcagcc ttcaagcatt ccattacgccl620 ccatctcgct ctgtgcccct ccccaccagg gcttcagcag gagccctgga ctcatcatcal680 ataaacactg ttacagcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaal740 aaaaaaaaaa aaaaaaaaaa aaaaaaaag 1769
(2) INFORMATION ÜBER SEQ ID NO: 13: (i) SEQUENZ CHARAKTERISTIK:(2) INFORMATION ABOUT SEQ ID NO: 13: (i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1026 Basenpaare(A) LENGTH: 1026 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library (xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 13(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13
aaaagctgtc cgcgcgggga gcccagggcc agctttgggg ttgtccctgg acttgtcttg 60 gttccagaac ctgacgaccc ggcgacggcg acgtctcttt tgactaaaag acagtgtcca 120 gtgctccagc ctaggagtct acggggaccg cctcccgcgc cgccaccatg cccaacttct 180 ctggcaactg gaaaatcatc cgatcggaaa acttcgagga attgctcaaa gtgctggggg 240 tgaatgtgat gctgaggaag attgctgtgg ctgcagcgtc caagccagca gtggagatca 300 aacaggaggg agacactttc tacatcaaaa cctccaccac cgtgcgcacc acagagatta 360 acttcaaggt tggggaggag tttgaggagc agactgtgga tgggaggccc tgtaagagcc 420 tggtgaaatg ggagagtgag aataaaatgg tctgtgagca gaagctcctg aagggagagg 480 gccccaagac ctcgtggacc agagaactga ccaacgatgg ggaactgatc ctgaccatga 540 cggcggatga cgttgtgtgc accagggtct acgtccgaga gtgagtggcc acaggtagaa 600 ccgcggccga agcccaccac tggccatgct caccgccctg cttcactgcc ccctccgtcc 660 caccccctcc ttctaggata gcgctcccct taccccagtc acttctgggg gtcactggga 720 tgcctcttgc agggtcttgc tttctttgac ctcttctctc ctcccctaca ccaacaaaga 780 ggaatggctg caagagccca gatcacccat tccgggttca ctccccgcct ccccaagtca 840 gcagtcctag ccccaaacca gcccagagca gggtctctct aaaggggact tgagggcctg 900 agcaggaaag actggccctc tagcttctac cctttgtccc tgtagcctat acagtttaga 960 atatttattt gttaatttta ttaaaatgct ttaaaaaaat aaaaaaaaaa aaaaaaaaaal020 aaaaaa 1026 (2) INFORMATION ÜBER SEQ ID NO: 14:aaaagctgtc cgcgcgggga gcccagggcc agctttgggg ttgtccctgg acttgtcttg 60 gttccagaac ctgacgaccc ggcgacggcg acgtctcttt tgactaaaag acagtgtcca 120 gtgctccagc ctaggagtct acggggaccg cctcccgcgc cgccaccatg cccaacttct 180 ctggcaactg gaaaatcatc cgatcggaaa acttcgagga attgctcaaa gtgctggggg 240 tgaatgtgat gctgaggaag attgctgtgg ctgcagcgtc caagccagca gtggagatca 300 aacaggaggg agacactttc tacatcaaaa cctccaccac cgtgcgcacc acagagatta 360 acttcaaggt tggggaggag tttgaggagc agactgtgga tgggaggccc tgtaagagcc 420 tggtgaaatg ggagagtgag aataaaatgg tctgtgagca gaagctcctg aagggagagg 480 gccccaagac ctcgtggacc agagaactga ccaacgatgg ggaactgatc ctgaccatga 540 cggcggatga cgttgtgtgc accagggtct acgtccgaga gtgagtggcc acaggtagaa 600 ccgcggccga agcccaccac tggccatgct caccgccctg cttcactgcc ccctccgtcc 660 caccccctcc ttctaggata gcgctcccct taccccagtc acttctgggg gtcactggga 720 tgcctcttgc agggtcttgc tttctttgac ctcttctctc ctcccctaca ccaacaaaga 780 ggaatggctg caagagccca gatcacccat tccgggttca ctccccgcct ccccaagtca 840 gcagtcctag ccccaaacca gcccagagca gggtctctct aaaggggact tgagggcctg 900 agcaggaaag actggccctc tagcttctac cctttgtccc tgtagcctat acagtttaga 960 atatttattt gttaatttta ttaaaatatct ttaaaaaaaat aaaaaaaa20aaaaaaaaaaaaaaaaa20a (2) INFORMATION ABOUT SEQ ID NO: 14:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 676 Basenpaare (B) TYP: Nukleinsäure(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 676 base pairs (B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN: (vii) SONSTIGE HERKUNFT:(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 14(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14
ggccattttg tgaagagacg aagactgagc ggttgtggcc gcgttgccga cctccagcag 60 cagtcggctt ctctacgcag aacccgggag taggagactc agaatcgaat ctcttctcccl20 tccccttctt gggcagcaag gcgaacccca tccctactca ctggagctca gctttgatttlδO ttaacctccc ttccccaccc ttccagaaca cacacattcc attccaaaac tgattttata240 aagacatttt aaacataatg atgcaacttg gtgtgcacta cagcaaatgt acaggtgttt300 tttttttaat tgtttccaaa accgggacct ggatttaaga tgtaattttt aaaatttcta360 tttctatttt ttcggcagca gttgggttag aggaggagga gccttttagc ctcccagaaa420 ctgacctctc tacttcctcg tgtattttta agattgattg atgatgtgga aagggctttg480 cttgtctgct actgaaaact ttatccttgc ggtttttgtg gaactgcgtt tggaaagaga540 aaagaaatga actttactga cttgacattt tgcacctccc ggttttcgaa tctgggcaat600 tttaattttg gttttacagt gagagttttt gatctcagca cagaagtaat ccaattttttββO ttagcatttt ccgact 676ggccattttg tgaagagacg aagactgagc ggttgtggcc gcgttgccga cctccagcag 60 cagtcggctt ctctacgcag aacccgggag taggagactc agaatcgaat ctcttctcccl20 tccccttctt gggcagcaag gcgaacccca tccctactca ctggagctca gctttgatttlδO ttaacctccc ttccccaccc ttccagaaca cacacattcc attccaaaac tgattttata240 aagacatttt aaacataatg atgcaacttg gtgtgcacta cagcaaatgt acaggtgttt300 tttttttaat tgtttccaaa accgggacct ggatttaaga tgtaattttt aaaatttcta360 tttctatttt ttcggcagca gttgggttag aggaggagga gccttttagc ctcccagaaa420 ctgacctctc tacttcctcg tgtattttta agattgattg atgatgtgga aagggctttg480 cttgtctgct actgaaaact ttatccttgc ggtttttgtg gaactgcgtt tggaaagaga540 aaagaaatga actttactga cttgacattt tgcacctccc ggttttcgaa tctgggcaat600 tttaattttg gttttacagt gagagttttt gatttatcccacagaga6
(2) INFORMATION ÜBER SEQ ID NO: 15:(2) INFORMATION ABOUT SEQ ID NO: 15:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1254 Basenpaare(A) LENGTH: 1254 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN (vi) HERKUNFT:(iii) ANTI-SENSE: NO (vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 15(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15
cggctcgagc agctcgagcg gctcaaacac ctcatttgac cttgccagct gaccttcaaa 60 ccctgcattt gaaccgacca acattaagtc cagagagtaa acttgaatgg aataacgaca 120 ttccagaagt taatcatttg aattctgaac actggagaaa aaccgaaaaa tggacggggc 180 atgaagagac taatcatctg gaaaccgatt tcagtggcga tggcatgaca gagctagagc 240 tcgggcccag ccccaggctg cagcccattc gcaggcaccc gaaagaactt ccccagtatg 300 gtggtcctgg aaaggacatt tttgaagatc aactatatct tcctgtgcat tccgatggaa 360 tttcagttca tcagatgttc accatggcca ccgcagaaca ccgaagtaat tccagcatag 420 cggggaagat gttgaccaag gtggagaaga atcacgaaaa ggagaagtca cagcacctag 480 aaggcagcgc ctcctcttca ctctcctctg attagatgaa actgttacct taccctaaac 540 acagtatttc tttttaactt ttttatttgt aaactaataa aggtaatcac agccaccaac 600 attccaagct accctgggta cctttgtgca gtagaagcta gtgagcatgt gagcaagcgg 660 tgtgcacacg gagactcatc gttataattt actatctgcc aagagtagaa agaaaggctg 720 gggatatttg ggttggcttg gttttgattt tttgcttgtt tgtttgtttt gtactaaaac 780 agtattatct tttgaatatc gtagggacat aagtatatac atgttatcca atcaagatgg 840 ctagaatggt gcctttctga gtgtctaaaa cttgacaccc ctggtaaatc tttcaacaca 900 cttccactgc ctgcgtaatg aagttttgat tcatttttaa ccactggaat ttttcaatgc 960 cgtcattttc agttagatga ttttgcactt tgagattaaa atgccatgtc tatttgattal020 gtcttatttt tttattttta caggcttatc agtctcactg ttggctgtca ttgtgacaaal080 gtcaaataaa cccccaagga cgacacacag tatggatcac atattgtttg acattaagctll40 tttgccagaa aatgttgcat gtgttttacc tcgacttgct aaaatcgatt agcagaaaggl200 catggctaat aatgttggtg gtgaaaataa ataaataagt aaacaaaaag aaaa 1254cggctcgagc agctcgagcg gctcaaacac ctcatttgac cttgccagct gaccttcaaa 60 ccctgcattt gaaccgacca acattaagtc cagagagtaa acttgaatgg aataacgaca 120 ttccagaagt taatcatttg aattctgaac actggagaaa aaccgaaaaa tggacggggc 180 atgaagagac taatcatctg gaaaccgatt tcagtggcga tggcatgaca gagctagagc 240 tcgggcccag ccccaggctg cagcccattc gcaggcaccc gaaagaactt ccccagtatg 300 gtggtcctgg aaaggacatt tttgaagatc aactatatct tcctgtgcat tccgatggaa 360 tttcagttca tcagatgttc accatggcca ccgcagaaca ccgaagtaat tccagcatag 420 cggggaagat gttgaccaag gtggagaaga atcacgaaaa ggagaagtca cagcacctag 480 aaggcagcgc ctcctcttca ctctcctctg attagatgaa actgttacct taccctaaac 540 acagtatttc tttttaactt ttttatttgt aaactaataa aggtaatcac agccaccaac 600 attccaagct accctgggta cctttgtgca gtagaagcta gtgagcatgt gagcaagcgg 660 tgtgcacacg gagactcatc gttataattt actatctgcc aagagtagaa agaaaggctg 720 gggatatttg ggttggcttg gttttgattt tttgcttgtt tgtttgtttt gtactaaaac 780 agtattatct tttgaatatc gtagggacat aagtatatac atgttatcca atcaagatgg 840 ctagaatggt gcctttctga gtgtctaaaa cttgacaccc ctggtaaatc tttcaacaca 900 cttccactgc ctgcgtaatg aagttttgat tcatttttaa ccactggaat ttttcaatgc 960 cgtcattttc agttagatga ttttgcactt tgagattaaa atgccatgtc tatttgattal020 gtcttatttt tttattttta caggcttatc agtctcactg ttggctgtca ttgtgacaaal080 gtcaaataaa cccccaagga cgacacacag tatggatcac atattgtttg acattaagctll40 tttgccagaa aatgttgcat gtgttttacc tcgacttgct aaaatcgatt agcagaaaggl200 catggctaat aatgttggtg gtgaaaataa ataaataagt aaacaaaaag aaaa 1254
(2) INFORMATION ÜBER SEQ ID NO: 16:(2) INFORMATION ABOUT SEQ ID NO: 16:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 537 Basenpaare(A) LENGTH: 537 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 16 ggcccgggcc cccaccctcg acatgcgctt ccggcgacgc cttagcgctg acccccacgc 60 aacccagcga aactccgcgg aggcgcgcgg cacgatggac ggtcgggtgc agctgatgaal20 ggccctcctg gccgggcccc tccggcccgc ggcgcgtcgc tggaggaacc cgattcccttlδO tcccgagacg tttgacggag ataccgaccg actcccggag ttcatcgtgc agacgtgctc240 ctacatgttc gtggacgaga acacgttctc caacgacgcc ctgaaggtga cgttcctcat300 cacccgcctc acggggccag ccctgcagtg ggtgatcccc tacatcagga aggagagccc360 cctgctcaat gattaccggg gctttctggc cgagatgaag cgagtctttg gatgggagga420 ggacgaggac ttctaggccg ggagaccctc gggcctgggg gcgggtgctc tgggaagagt460 tcgctgtgcc agtggccacc gctagggtct ccacaggcgc cctccccagg gaatgct 537(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16 ggcccgggcc cccaccctcg acatgcgctt ccggcgacgc cttagcgctg acccccacgc 60 aacccagcga aactccgcgg aggcgcgcgg cacgatggac ggtcgggtgc agctgatgaal20 ggccctcctg gccgggcccc tccggcccgc ggcgcgtcgc tggaggaacc cgattcccttlδO tcccgagacg tttgacggag ataccgaccg actcccggag ttcatcgtgc agacgtgctc240 ctacatgttc gtggacgaga acacgttctc caacgacgcc ctgaaggtga cgttcctcat300 cacccgcctc acggggccag ccctgcagtg ggtgatcccc tacatcagga aggagagccc360 cctgctcaat gattaccggg gctttctggc cgagatgaag cgagtctttg gatgggagga420 ggacgaggac ttctaggccg ggagaccctc gggcctgggg gcgggtgctc tgggaagagt460 tcgctgtgcc agtggccacc gctagggtct ccacaggcgc cctccccagg gaatgct 537
(2) INFORMATION ÜBER SEQ ID NO: 17:(2) INFORMATION ABOUT SEQ ID NO: 17:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 823 Basenpaare(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 823 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear (ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(C) STRAND: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN (iii) ANTI-SENSE: NEIN(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 17(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17
tagactgaac aggaggggga gtcctgggta gcgcgccggt ctaaatcgtt acttggcgga 60 aagttcccat gagtctttgc cagcgtcccc ctccttttgt gaggattggg atattccgacl20 tccttaaggg cctggcgcac ataaggtgtg accttttcat tcccgttgtt atggagggccl80 acatctgcca gagcctggag tctgcgaagg ccgggacccg gttccccggc ccacagtggg240 ggtgtgcaaa cccgagagaa ctgggttgca aattcgtgaa gaatcagcat catgtttggc300 agctgagtat tggagccagg agcctgccat gaggttttga gaacagagtg ctgttttaga360 gctggcagca gcatctcagc ccaagagaag gttatattcc cagaggatgt cagtcccaag420 gaccagtagc tgccatcagt ttggattctg aaaactaact ggcatcaaca ctgggtgtag480 aaacatgctt gccttatgta tcagaggaca tgctcagcag atccaagaga tatatttggc540 aactttttct agaaaaggca cattgggtat cattcattac attcttgagg tttttttgggβOO tttttttttt ttttttttga gacagtcttg ctgtattgcc caggctggga gtgtggtggc660 acaatcacag ctcattgcat cctcaatcac ccagggccta agcaatcctc ccaccttgta720 gctgggacta cagctcacag cacaccgggc taaaattttt ttttgttgag acggtttttc760 tatgttgccc gggtggtttt cagggtccgg ggttcagatg gtc 823tagactgaac aggaggggga gtcctgggta gcgcgccggt ctaaatcgtt acttggcgga 60 aagttcccat gagtctttgc cagcgtcccc ctccttttgt gaggattggg atattccgacl20 tccttaaggg cctggcgcac ataaggtgtg accttttcat tcccgttgtt atggagggccl80 acatctgcca gagcctggag tctgcgaagg ccgggacccg gttccccggc ccacagtggg240 ggtgtgcaaa cccgagagaa ctgggttgca aattcgtgaa gaatcagcat catgtttggc300 agctgagtat tggagccagg agcctgccat gaggttttga gaacagagtg ctgttttaga360 gctggcagca gcatctcagc ccaagagaag gttatattcc cagaggatgt cagtcccaag420 gaccagtagc tgccatcagt ttggattctg aaaactaact ggcatcaaca ctgggtgtag480 aaacatgctt gccttatgta tcagaggaca tgctcagcag atccaagaga tatatttggc540 aactttttct agaaaaggca cattgggtat cattcattac attcttgagg tttttttgggβOO tttttttttt ttttttttga gacagtcttg ctgtattgcc caggctggga gtgtggtggc660 acaatcacag ctcattgcat cctcaatcac ccagggccta agcaatcctc ccaccttgta720 gctgggacta cagctcacag cacaccgggc taaaattttt ttttgttgag acggtttttc760 tatgttgccc gggtggtttt cagggtccgg ggttcagatg gtc 823
(2) INFORMATION ÜBER SEQ ID NO: 18:(2) INFORMATION ABOUT SEQ ID NO: 18:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 1082 Basenpaare (B) TYP: Nukleinsäure (C) STRANG: einzel(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1082 base pairs (B) TYPE: nucleic acid (C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(C) ORGAN: (vii) SONSTIGE HERKUNFT:(C) ORGAN: (vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 18(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 18
gggcgcacat aaggtgtgac cttttcattc ccgttgttat ggagggccac atctgccaga 60 gcctggagtc tgcgaaggcc gggacccggt tccccggccc acagtggggg tgtgcaaacc 120 cgagagaact ggtcgctgaa acctctacaa cttagttgac cgtaactgcc agagccctgc 180 cctgaattcc tgtccttact ccctctttaa gattgcgtac ccactgcaga gtgctgaaga 240 cggggtagcc acgaggttgc aaattcgtga agaatcagca tcatgtttgg cagctgagta 300 ttggagccag gagcctgcca tgaggttttg agaacagagt gctgttttag agctggcagc 360 agcatctcag cccaagagaa ggttatattc ccagaggatg tcagtcccaa ggaccagtag 420 ctgccatcag tttggattct gaaaactaac tggcatcaac actgggtgta gaaacatgct 480 tgccttatgt atcagaggac atgctcagca gatccaagag atatatttgg caactttttc 540 tagaaaaggc acattgggta tcattcatta cattcttgag tttttttggg tttttttttt 600 ttttttttga gacagtcttg ctgtattgcc caggctggag tgtggtggca caatcacagc 660 tcattgcatc ctcaatcacc caggcctaag caatcctccc accttgtagc tgggactaca 720 gctcacagca cacctggcta aaattttttt tttgttgaga cggattctct atgttgccca 780 ggctggtctc aggctcctgg gctcagatgg tcctcctgcc tcagcttcca aaggcacagg 840 ccaagttgta gctttgtccc ttgccatcat gcccaacaag aggttctata ccttttaatg 900 aattgacttt cataaattgg ttatgttggt gggcaagttc tttaagctgg aaattgtaaa 960 ttcctcctga aatgtttttt catgcagtta ccatgaacta atactacaat aaaggatggtl020 cttgggtgtc aaaaaaaaaa aaaaaaaaaa aaaaagaaaa aaaaaaaaaa aaaaaaaaaalOδO aa 1082 (2) INFORMATION ÜBER SEQ ID NO: 19:gggcgcacat aaggtgtgac cttttcattc ccgttgttat ggagggccac atctgccaga 60 gcctggagtc tgcgaaggcc gggacccggt tccccggccc acagtggggg tgtgcaaacc 120 cgagagaact ggtcgctgaa acctctacaa cttagttgac cgtaactgcc agagccctgc 180 cctgaattcc tgtccttact ccctctttaa gattgcgtac ccactgcaga gtgctgaaga 240 cggggtagcc acgaggttgc aaattcgtga agaatcagca tcatgtttgg cagctgagta 300 ttggagccag gagcctgcca tgaggttttg agaacagagt gctgttttag agctggcagc 360 agcatctcag cccaagagaa ggttatattc ccagaggatg tcagtcccaa ggaccagtag 420 ctgccatcag tttggattct gaaaactaac tggcatcaac actgggtgta gaaacatgct 480 tgccttatgt atcagaggac atgctcagca gatccaagag atatatttgg caactttttc 540 tagaaaaggc acattgggta tcattcatta cattcttgag tttttttggg tttttttttt 600 ttttttttga gacagtcttg ctgtattgcc caggctggag tgtggtggca caatcacagc 660 tcattgcatc ctcaatcacc caggcctaag caatcctccc accttgtagc tgggactaca 720 gctcacagca cacctggcta aaattttttt tttgttgaga cggattctct atgttgccca 780 ggctggtctc aggctcctgg gctcagatgg tcctcctgcc tcagcttcca aaggcacagg 840 ccaagttgta gctttgtccc ttgccatcat gcccaacaag aggttctata ccttttaatg 900 aattgacttt cataaattgg ttatgttggt gggcaagttc tttaagctgg aaattgtaaa 960 ttcctcctga aatgtttttt catgcagtta ccatgaacta atactacaat aaaggatggtl020 cttgggtgtc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagaaaa aaaaaaaaaalOδO aa 1082 (2) INFORMATION ABOUT SEQ ID NO: 19:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1548 Basenpaare(A) LENGTH: 1548 base pairs
(B) TYP: Nukleinsäure (C) STRANG: einzel(B) TYPE: nucleic acid (C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN (iii) ANTI-SENSE: NEIN (vi) HERKUNFT:(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO (vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 19(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19
cccattccat agggaatgag ctgggctgtc ctttctcccc acgttcacct gcacttcgtt 60 agagagcagt gttcacatgc cacaccacaa gatccccaca atgacataac tccattcaga 120 gactggcgtg actgggctgg gtctccccac cccccccttc agctcttgta tcactcagaa 180 tctggcagcc agttccgtcc tgacagagtt cacagcatat attggtggat tcttgtccat 240 agtgcatctg ctttaagaat taacgaaagc agtgtcaaga cagtaaggat tcaaaccatt 300 tgccaaaaat gagtctaagt gcatttactc tcttcctggc attgattggt ggtaccagtg 360 gccagtacta tgattatgat tttcccctat caatttatgg gcaatcatca ccaaactgtg 420 caccagaatg taactgccct gaaagctacc caagtgccat gtactgtgat gagctgaaat 480 tgaaaagtgt accaatggtg cctcctggaa tcaagtatct ttaccttagg aataaccaga 540 ttgaccatat tgatgaaaag gcctttgaga atgtaactga tctgcagtgg ctcattctag 600 atcacaacct tctagaaaac tccaagataa aagggagagt tttctctaaa ttgaaacaac 660 tgaagaagct gcatataaac cacaacaacc tgacagagtc tgtgggccca cttcccaaat 720 ctctggagga tctgcagctt actcataaca agatcacaaa gctgggctct tttgaaggat 780 tggtaaacct gaccttcatc catctccagc acaatcggct gaaagaggat gctgtttcag 840 ctgcttttaa aggtcttaaa tcactcgaat accttgactt gagcttcaat cagatagcca 900 gactgccttc tggtctccct gtctctcttc taactctcta cttagacaac aataagatca 960 gcaacatccc tgatgagtat ttcaagcgtt ttaatgcatt gcagtatctg cgtttatctcl020 acaacgaact ggctgatagt ggaatacctg gaaattcttt caatgtgtca tccctggttglOδO agctggatct gtcctataac aagcttaaaa acataccaac tgtcaatgaa aaccttgaaall40 actattacct ggaggtcaat caacttgaga agtttgacat aaagagcttc tgcaagatccl200 tggggccatt atcctactcc aagatcaagc atttgcgttt ggatggcaat cgcatctcagl260 aaaccagtct tccaccggat atgtatgaat gtctacgtgt tgctaacgaa gtcactcttal320 attaatatct gtatcctgga acaatatttt atggttatgt ttttctgtgt gtcagttttcl360 atagtatcca tattttatta ctgtttatta cttccatgaa ttttaaaatc tgagggaaatl440 gttttgtaaa catttatttt tttttaaagg aaaaggatgg aaaggccagg gcctaatttcl500 catccaccaa ggaacacacc acattattcc acggaatagg ccatcggg 1548cccattccat agggaatgag ctgggctgtc ctttctcccc acgttcacct gcacttcgtt 60 agagagcagt gttcacatgc cacaccacaa gatccccaca atgacataac tccattcaga 120 gactggcgtg actgggctgg gtctccccac cccccccttc agctcttgta tcactcagaa 180 tctggcagcc agttccgtcc tgacagagtt cacagcatat attggtggat tcttgtccat 240 agtgcatctg ctttaagaat taacgaaagc agtgtcaaga cagtaaggat tcaaaccatt 300 tgccaaaaat gagtctaagt gcatttactc tcttcctggc attgattggt ggtaccagtg 360 gccagtacta tgattatgat tttcccctat caatttatgg gcaatcatca ccaaactgtg 420 caccagaatg taactgccct gaaagctacc caagtgccat gtactgtgat gagctgaaat 480 tgaaaagtgt accaatggtg cctcctggaa tcaagtatct ttaccttagg aataaccaga 540 ttgaccatat tgatgaaaag gcctttgaga atgtaactga tctgcagtgg ctcattctag 600 atcacaacct tctagaaaac tccaagataa aagggagagt tttctctaaa ttgaaacaac 660 tgaagaagct gcatataaac cacaacaacc tgacagagtc tgtgggccca cttcccaaat 720 ctctggagga tctgcagctt actcataaca agatcacaaa gctgggctct tttgaaggat 780 tggtaaacct gaccttcatc catctccagc acaatcggct gaaagaggat gctgtttcag 840 ctgcttttaa aggtcttaaa tcactcgaat accttgactt gagcttcaat cagatagcca 900 gactgccttc tggtctccct gtctctcttc taactctcta cttagacaac aataagatca 960 gcaacatccc tgatgagtat ttcaagcgtt ttaatgcatt gcagtatctg cgtttatctcl020 acaacgaact ggctgatagt ggaatacctg gaaattcttt caatgtgtca tccctggttglOδO agctggatct gtcctataac aagcttaaaa acataccaac tgtcaatgaa aaccttgaaall40 actattacct ggaggtcaat caacttgaga agtttgacat aaagagcttc tgcaagatccl200 tggggccatt atcctactcc aagatcaagc atttgcgttt ggatggcaat cgcatctcagl260 aaaccagtct tccaccggat atgtatgaat gtctacgtgt tgctaacgaa gtcactcttal320 attaatatct gtatcctgga acaatatttt atggttatgt ttttctgtgt gtcagttttcl360 atagtatcca tattttatta ctgtttatta cttccatgaa ttttaaaatc tgagggaaatl440 gttttgtaaa catttatttt tttttaaagg aaaaggatcattgaatt gattcccccggga gattaaccacccgclatt
(2) INFORMATION ÜBER SEQ ID NO: 20: (i) SEQUENZ CHARAKTERISTIK:(2) INFORMATION ABOUT SEQ ID NO: 20: (i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 844 Basenpaare(A) LENGTH: 844 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN: (vii) SONSTIGE HERKUNFT:(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 20(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 20
acctgcagag gggtccatac ggcgttgttc tggattcccg tcgtaactta aagggaaatt 60 ttcacaatgt ccggagccct tgatgtcctg caaatgaagg aggaggatgt ccttaagttcl20 cttgcagcag gaacccactt aggtggcacc aatcttgact tccagatgga acagtacatcl80 tataaaagga aaagtgatgg catctatatc ataaatctca agaggacctg ggagaagctt240 ctgctggcag ctcgtgcaat tgttgccatt gaaaaccctg ctgatgtcag tgttatatcc300 tccaggaata ctggccagag ggctgtgctg aagtttgctg ctgccactgg agccactcca360 attgctggcc gcttcactcc tggaaccttc actaaccaga tccaggcagc cttccgggag420 ccacggcttc ttgtggttac tgaccccagg gctgaccacc agcctctcac ggaggcatct480 tatgttaacc tacctaccat tgcgctgtgt aacacagatt ctcctctgcg ctatgtggac540 attgcaatcc catgcaacaa caaggtaatg attttaggat ctagagtttg tgaatgcgtg600 ctctagaaaa aacattcctg tgcacattgt tagagcttgg agttgaggct actgactggc660 cgatgaactc gcaagtgtag gtagtgtgct acatgagggg caagttttcg ctaacaccac720 aagggtctct ggcccaatga gtggagtttg atagtaattc ttgctacaag tataacatta780 ctgcatgaca gctttgtgga gaaatgaaaa catttggaaa atagtgtgtt ctctgccttg640 tcca 844acctgcagag gggtccatac ggcgttgttc tggattcccg tcgtaactta aagggaaatt 60 ttcacaatgt ccggagccct tgatgtcctg caaatgaagg aggaggatgt ccttaagttcl20 cttgcagcag gaacccactt aggtggcacc aatcttgact tccagatgga acagtacatcl80 tataaaagga aaagtgatgg catctatatc ataaatctca agaggacctg ggagaagctt240 ctgctggcag ctcgtgcaat tgttgccatt gaaaaccctg ctgatgtcag tgttatatcc300 tccaggaata ctggccagag ggctgtgctg aagtttgctg ctgccactgg agccactcca360 attgctggcc gcttcactcc tggaaccttc actaaccaga tccaggcagc cttccgggag420 ccacggcttc ttgtggttac tgaccccagg gctgaccacc agcctctcac ggaggcatct480 tatgttaacc tacctaccat tgcgctgtgt aacacagatt ctcctctgcg ctatgtggac540 attgcaatcc catgcaacaa caaggtaatg attttaggat ctagagtttg tgaatgcgtg600 ctctagaaaa aacattcctg tgcacattgt tagagcttgg agttgaggct actgactggc660 cgatgaactc gcaagtgtag gtagtgtgct acatgagggg caagttttcg ctaacaccac720 aagggtctct ggcccaatga gtggagtttg atagtaattc ttgctacaag tataacatta780 ctgcatgaca gctttgtgga gaaatgaaaa catttggaaa atagtgtgtt ctctgccttg640 TCCA 844
(2) INFORMATION ÜBER SEQ ID NO: 21 :(2) INFORMATION ABOUT SEQ ID NO: 21:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 862 Basenpaare(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 862 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear (ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN (iii) ANTI-SENSE: NEIN(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 21(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 21
gagcaagaga gaaggaggcc cagacagtga gggcaggagg gagagaagag acgcagaagg 60 agagcgagcg agagagaaag ggttctggat tgggggggag agcaagggag ggaggaaggcl20 ggtgagagag gcgggggcct cgggagggtg aaagggggga ggagaagggc ggggcacggal80 ggcccgagcg agggacaaga ctccgactcc agctctgact tttttcgcgg ctctcggctt240 ccactgcagc catgtcactc ctcttgctgg tggtctcagc ccttcacatc ctcattctta300 tactgctttt cgtggccact ttggacaagt cctggtggac tctccctggg aaagagtccc360 tgaatctctg gtacgactgc acgtggaaca acgacaccaa aacatgggcc tgcagtaatg420 tcagcgagaa tggctggctg aaggcggtgc aggtcctcat ggtgctctcc ctcattctct480 gctgtctctc cttcatcctg ttcatgttcc agctctacac catgcgacga ggaggtctct540 tctatgccac cggcctctgc cagctttgca ccagcgtggc ggtgtttact ggcgccttga600 tctatgccat tcacgccgag gagatcctgg agaagcaccc gcgagggggc agcttcggat660 actgcttcgc cctggcctgg gtggccttcc ccctcgccct ggtcagcggc atcatctaca720 tccacctacg gaagcgggag tgagcgcccc gcctcgctcg gctgcccccg ccccttcccg780 gcccccctcg ccgcgcgtcc tccaaaaaat aaaaccttaa ccgcggggaa aaaaaaaaaa840 aaaaaggaag gaaaaaaaaa aa 862gagcaagaga gaaggaggcc cagacagtga gggcaggagg gagagaagag acgcagaagg 60 agagcgagcg agagagaaag ggttctggat tgggggggag agcaagggag ggaggaaggcl20 ggtgagagag gcgggggcct cgggagggtg aaagggggga ggagaagggc ggggcacggal80 ggcccgagcg agggacaaga ctccgactcc agctctgact tttttcgcgg ctctcggctt240 ccactgcagc catgtcactc ctcttgctgg tggtctcagc ccttcacatc ctcattctta300 tactgctttt cgtggccact ttggacaagt cctggtggac tctccctggg aaagagtccc360 tgaatctctg gtacgactgc acgtggaaca acgacaccaa aacatgggcc tgcagtaatg420 tcagcgagaa tggctggctg aaggcggtgc aggtcctcat ggtgctctcc ctcattctct480 gctgtctctc cttcatcctg ttcatgttcc agctctacac catgcgacga ggaggtctct540 tctatgccac cggcctctgc cagctttgca ccagcgtggc ggtgtttact ggcgccttga600 tctatgccat tcacgccgag gagatcctgg agaagcaccc gcgagggggc agcttcggat660 actgcttcgc cctggcctgg gtggccttcc ccctcgccct ggtcagcggc atcatctaca720 tccacctacg gaagcgggag tgagcgcccc gcctcgctcg gctgcccccg ccccttcccg780 gcccccctcg ccgcgcgtcc tccaaaaaat aaaaccttaa ccgcggggaa aaaaaaaaaa840 aaaaaggaag gaaaaaaaaa aa 862
(2) INFORMATION ÜBER SEQ ID NO: 22:(2) INFORMATION ABOUT SEQ ID NO: 22:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 546 Basenpaare(A) LENGTH: 546 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library (xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO:22(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 22
cccagccaag ggtccttcag gtaggaggtc ctgggtgact ttggaagtcc gtagtgtctc 60 attgcagata atttttagct tagggcctgg tggctaggtc ggttctctcc tttccagtcgl20 gagacctctg ccgcaaacat gctccgccag atcatcggtc aggccaagaa gcatccgagcl80 ttgatccccc tctttgtatt tattggaact ggagctactg gagcaacact gtatctcttg240 cgtctggcat tgttcaatcc agatgtttgt tgggacagaa ataacccaga gccctggaac300 aaactgggtc ccaatgatca atacaagttc tactcagtga atgtggatta cagcaagctg360 aagaaggaac gtccagattt ctaaatgaaa tgtttcacta taacgctgct ttagaatgaa420 ggtcttccag aagccacatc cgcacaattt tccacttaac caggaaatat ttctcctctt460 aaatgaatga aatcaatggt ggggggcgct attggaagcc ctattggggt tcaagtgttg540 aataaa 546cccagccaag ggtccttcag gtaggaggtc ctgggtgact ttggaagtcc gtagtgtctc 60 attgcagata atttttagct tagggcctgg tggctaggtc ggttctctcc tttccagtcgl20 gagacctctg ccgcaaacat gctccgccag atcatcggtc aggccaagaa gcatccgagcl80 ttgatccccc tctttgtatt tattggaact ggagctactg gagcaacact gtatctcttg240 cgtctggcat tgttcaatcc agatgtttgt tgggacagaa ataacccaga gccctggaac300 aaactgggtc ccaatgatca atacaagttc tactcagtga atgtggatta cagcaagctg360 aagaaggaac gtccagattt ctaaatgaaa tgtttcacta taacgctgct ttagaatgaa420 ggtcttccag aagccacatc cgcacaattt tccacttaac caggaaatat ttctcctctt460 aaatgaatga aatcaatggt ggggggcgct attggaagcc ctattggggt tcaagtgttg540 aataaa 546
(2) INFORMATION ÜBER SEQ ID NO: 23:(2) INFORMATION ABOUT SEQ ID NO: 23:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1591 Basenpaare(A) LENGTH: 1591 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN (iii) ANTI-SENSE: NEIN (vi) HERKUNFT:(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing (iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO (vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT: (A) BIBLIOTHEK: cDNA library(vii) OTHER ORIGIN: (A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 23(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 23
gccgaggagc cgagcccgcc acccccccgc ccgcccgccg ccgccatggg ctgcctcggg 60 aacagtaaga ccgaggacca gcgcaacgag gagaaggcgc aggtgaggcc aacaaaaaga 120 tcgagaagca gctgcagaag gacaagcagg tctaccgggc cacgcaccgc ctgctgctgc 180 tgggtgctgg agaatctggt aaaagcacca ttgtgaagca gatgaggatc ctgcatgtta 240 atgggtttaa tggagacagt gagaaggcaa ccaaagtgca ggacatcaaa aacaacctga 300 aagaggcgat tgaaaccatt gtggccgcca tgagcaacct ggtgcccccc gtggagctgg 360 ccaaccccga gaaccagttc agagtggact acattctgag tgtgatgaac gtgcctgact 420 ttgacttccc tcccgaattc tatgagcatg ccaaggctct gtgggaggat gaaggagtgc 480 gtgcctgcta cgaacgctcc aacgagtacc agctgattga ctgtgcccag tacttcctgg 540 acaagatcga cgtgatcaag caggctgact atgtgccgag cgatcaggac ctgcttcgct 600 gccgtgtcct gacttctgga atctttgaga ccaagttcca ggtggacaaa gtcaacttcc 660 acatgtttga cgtgggtggc cagcgcgatg aacgccgcaa gtggatccag tgcttcaacg 720 atgtgactgc catcatcttc gtggtggcca gcagcagcta caacatggtc atccgggagg 780 acaaccagac caaccgcctg caggaggctc tgaacctctt caagagcatc tggaacaaca 840 gatggctgcg caccatctct gtgatcctgt tcctcaacaa gcaagatctg ctcgctgaga 900 aagtccttgc tgggaaatcg aagattgagg actactttcc agaatttgct cgctacacta 960 ctcctgagga tgctactccc gagcccggag aggacccacg cgtgacccgg gccaagtactl020 tcattcgaga tgagtttctg aggatcagca ctgccagtgg agatgggcgt cactactgctlOδO accctcattt cacctgcgct gtggacactg agaacatccg ccgtgtgttc aacgactgccll40 gtgacatcat tcagcgcatg caccttcgtc agtacgagct gctctaagaa gggaacccccl200 aaatttaatt aaagccttaa gcacaattaa ttaaaagtga aacgtaattg tacaagcagtl260 taatcaccca ccatagggca tgattaacaa agcaaccttt cccttccccc gagtgattttl320 gcgaaacccc cttttccctt cagcttgctt agatgttcca aatttagaaa gcttaaggcgl380 gcctacagaa aaaggaaaaa aggccacaaa agttccctct cactttcagt aaaaataaatl440 aaaacagcag cagcaaacaa ataaaatgaa ataaaagaaa caaatgaaat aaatattgtgl500 ttgtgcagca ttaaaaaaaa tcaaaataaa aattaaatgt gagcaaagga aaaaaaaaaal560 ggcaaaaggg gaaagaagaa aagggggggg g 1591gccgaggagc cgagcccgcc acccccccgc ccgcccgccg ccgccatggg ctgcctcggg 60 aacagtaaga ccgaggacca gcgcaacgag gagaaggcgc aggtgaggcc aacaaaaaga 120 tcgagaagca gctgcagaag gacaagcagg tctaccgggc cacgcaccgc ctgctgctgc 180 tgggtgctgg agaatctggt aaaagcacca ttgtgaagca gatgaggatc ctgcatgtta 240 atgggtttaa tggagacagt gagaaggcaa ccaaagtgca ggacatcaaa aacaacctga 300 aagaggcgat tgaaaccatt gtggccgcca tgagcaacct ggtgcccccc gtggagctgg 360 ccaaccccga gaaccagttc agagtggact acattctgag tgtgatgaac gtgcctgact 420 ttgacttccc tcccgaattc tatgagcatg ccaaggctct gtgggaggat gaaggagtgc 480 gtgcctgcta cgaacgctcc aacgagtacc agctgattga ctgtgcccag tacttcctgg 540 acaagatcga cgtgatcaag caggctgact atgtgccgag cgatcaggac ctgcttcgct 600 gccgtgtcct gacttctgga atctttgaga ccaagttcca ggtggacaaa gtcaacttcc 660 acatgtttga cgtgggtggc cagcgcgatg aacgccgcaa gtggatccag tgcttcaacg 720 atgtgactgc catcatcttc gtggtggcca gcagcagcta caacatggtc atccgggagg 780 acaaccagac caaccgcctg caggaggctc tgaacctctt caagagcatc tggaacaaca 840 gatggctgcg caccatctct gtgatcctgt tcctcaacaa gcaagatctg ctcgctgaga 900 aagtccttgc tgggaaatcg aagattgagg actactttcc agaatttgct cgctacacta 960 ctcctgagga tgctactccc gagcccggag aggacccacg cgtgacccgg gccaagtactl020 tcattcgaga tgagtttctg aggatcagca ctgccagtgg agatgggcgt cactactgctlOδO accctcattt cacctgcgct gtggacactg agaacatccg ccgtgtgttc aacgactgccll40 gtgacatcat tcagcgcatg caccttcgtc agtacgagct gctctaagaa gggaacccccl200 aaatttaatt aaagccttaa gcacaattaa ttaaaagtga aacgtaattg tacaagcagtl260 taatcaccca ccatagggca tgattaacaa agcaaccttt cccttccccc gagtgattttl320 gcgaaacccc cttttccctt cagcttgctt agatgttcca aatttagaaa gcttaaggcgl380 gcctacagaa aaaggaaaaa aggccacaaa agttccctct cactttcagt aaaaataaatl440 aaaacagcag cagcaaacaa ataaaatgaa ataaaagaaa caaatgaaat aaatattgtgl500 ttgtgcagca ttaaaaaaaa tcaaaataaa aattaaatgt gagcaaagga aaaaaaaaaal560 ggcaaaaggg gaaagaagaa aagggggggg 1591 g
(2) INFORMATION ÜBER SEQ ID NO: 24:(2) INFORMATION ABOUT SEQ ID NO: 24:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 441 Basenpaare(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 441 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN (vi) HERKUNFT:(iii) ANTI-SENSE: NO (vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN: (vii) SONSTIGE HERKUNFT:(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 24(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24
ggcaggcaga tacgttcgtc agcttgctcc tttctgcccg tggacgccgc cgaagaagca 60 tcgttaaagt ctctcttcac cctgccgtca tgtctaagtc agagtctcct aaagagcccgl20 aacagctgag gaagctcttc attggagggt tgagctttga aacaactgat gagagcctgal80 ggagccattt tgagcaatgg ggaacgctca cggactgtgt ggtaatgaga gatccaaaca240 ccaagcgctc caggggcttt gggtttgtca catatgccac tgtggaggag gtggatgcag300 ctatgaatgc aaggccacac aaggtggatg gaagagttgt ggaaccaaag agagctgttt360 cagagaagat ttgaaaagcc aggtgccact tacctgtgaa aaggtatttg ttggtggatt420 aaggagcact tgagacatca c 441ggcaggcaga tacgttcgtc agcttgctcc tttctgcccg tggacgccgc cgaagaagca 60 tcgttaaagt ctctcttcac cctgccgtca tgtctaagtc agagtctcct aaagagcccgl20 aacagctgag gaagctcttc attggagggt tgagctttga aacaactgat gagagcctgal80 ggagccattt tgagcaatgg ggaacgctca cggactgtgt ggtaatgaga gatccaaaca240 ccaagcgctc caggggcttt gggtttgtca catatgccac tgtggaggag gtggatgcag300 ctatgaatgc aaggccacac aaggtggatg gaagagttgt ggaaccaaag agagctgttt360 cagagaagat ttgaaaagcc aggtgccact tacctgtgaa aaggtatttg ttggtggatt420 aaggagcact tgagacatca c 441
(2) INFORMATION ÜBER SEQ ID NO: 25:(2) INFORMATION ABOUT SEQ ID NO: 25:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1131 Basenpaare(A) LENGTH: 1131 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(C) ORGAN:(C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 25(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 25
cgggaggtga aatccggttc taaccggtcc ggggctccca gcgctataaa aactttataa 60 accccccgga gcccgagcag tgtgaagaag aggcgagaac gacccccgga ccgaccaaag 120 cccgcgcgcc gctgcatccc gcgtccagca cctacgtccc gctgccgtcg ccgccgccac 180 catgcccaag agaaaggctg aaggggatgc taagggagat aaagcaaagg tgaaggacga 240 accacagaga agatccgcga ggttgtctgc taaacctgct cctccaaagc cagagcccaa 300 gcctaaaaag gcccctgcaa agaagggaga gaaggtaccc aaagggaaaa agggaaaagc 360 tgatgctggc aaggagggga ataaccctgc agaaaatgga gatgccaaaa cagaccaggc 420 acagaaagct gaaggtgctg gagatgccaa gtgaagtgtg tgcatttttg ataactgtgt 480 acttctggtg actgtacagt ttgaaatact attttttatc aagttttata aaaatgcaga 540 attttgtttt actttttttt tttttttaaa agctatgttg ttagcacaca gaacacttca 600 ttgttgtttt tgggggaagg ggcatatgtc actaatagaa tgtctccaaa gctggattga 660 tgtggagaaa acacctttcc cttctagttt tgagagactt cctcttggct cccaggagga 720 gggattccct gactttgaca cacatggcca ccttggcaca aaagccttgt ggtatagaaa 780 aacaaatttg tttttatgtc ctcttctccc tttccatctt tcagcataga cttaactccc 840 ttaagcccag acatctgttg agacctgacc cctagtcatt ggttaccagt gtgtcaggca 900 atctggactt tccagtgatg ccactgagat ggcacctgtc aaaagagcag tggttccatt 960 tctagattgt ggatcttcag ataaattctg ccattttcat ttcacttcct gaaagtcaggl020 gtcggcttgt gaaaagttgt taaacaacat gctaaatgtg aaatgtcaac cctcactctalOδO aaacttttcc crgggtcaga ggatccgatg gaggacttca attgggggtt t 1131cgggaggtga aatccggttc taaccggtcc ggggctccca gcgctataaa aactttataa 60 accccccgga gcccgagcag tgtgaagaag aggcgagaac gacccccgga ccgaccaaag 120 cccgcgcgcc gctgcatccc gcgtccagca cctacgtccc gctgccgtcg ccgccgccac 180 catgcccaag agaaaggctg aaggggatgc taagggagat aaagcaaagg tgaaggacga 240 accacagaga agatccgcga ggttgtctgc taaacctgct cctccaaagc cagagcccaa 300 gcctaaaaag gcccctgcaa agaagggaga gaaggtaccc aaagggaaaa agggaaaagc 360 tgatgctggc aaggagggga ataaccctgc agaaaatgga gatgccaaaa cagaccaggc 420 acagaaagct gaaggtgctg gagatgccaa gtgaagtgtg tgcatttttg ataactgtgt 480 acttctggtg actgtacagt ttgaaatact attttttatc aagttttata aaaatgcaga 540 attttgtttt actttttttt tttttttaaa agctatgttg ttagcacaca gaacacttca 600 ttgttgtttt tgggggaagg ggcatatgtc actaatagaa tgtctccaaa gctggattga 660 tgtggagaaa acacctttcc cttctagttt tgagagactt cctcttggct cccaggagga 720 gggattccct gactttgaca cacatggcca ccttggcaca aaagccttgt ggtatagaaa 780 aacaaatttg tttttatgtc ctcttctccc tttccatctt tcagcataga cttaactccc 840 ttaagcccag acatctgttg agacctgacc cctagtcatt ggttaccagt gtgtcaggca 900 atctggactt tccagtgatg ccactgagat ggcacctgtc aaaagagcag tggttccatt 960 tctagattgt ggatcttcag ataaattctg ccattttcat ttcacttcct gaaagtcaggl020 gtcggcttgt gaaaagttgt taaacaacat gctaaatgtg aaatgtcaac cctcactctalOδO aaacttttcc crgggtcaga ggatccgatg gaggacttca attgggggtt t 1131
(2) INFORMATION ÜBER SEQ ID NO: 26:(2) INFORMATION ABOUT SEQ ID NO: 26:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 1071 Basenpaare(A) LENGTH: 1071 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA (iii) HYPOTHETISCH: NEIN(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(C) ORGAN:(C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 26(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26
gtaccctcaa agacagagac accaagaaga atcggaacat acaggctttg atatcaaagg 60 tttataaagc caatatctgg gaaagagaaa accgtgagac ttccagatct tctctggtga 120 agtgttgttt cctgcaacga tcacgaacat gaacatcaaa ggatcgccat ggaaagggtc 180 cctcctgctg crgctggtgt caaacctgct cctgtgccag agcgtggccc ccttgcccat 240 ctgtcccggc ggggctgccc gatgccaggt gacccttcga gacctgtttg accgcgccgt 300 cgtcctgtcc cactacatcc ataacctctc ctcagaaatg ttcagcgaat tcgataaacg 360 gtatacccat ggccgggggt tcattaccaa ggccatcaac agctgccaca cttcttccct 420 tgccaccccc gaagacaagg agcaagccca acagatgaat caaaaagact ttctgagcct 480 gatagtcagc atattgcgat cctggaatga gcctctgtat catctggtca cggaagtacg 540 tggtatgcaa gaagccccgg aggctatcct atccaaagct gtagagattg aggagcaaac 600 caaacggctt cragagggca tggagctgat agtcagccag gttcatcctg aaaccaaaga 660 aaatgagatc taccctgtct ggtcgggact tccatccctg cagatggctg atgaagagtc 720 tcgcctttct gcttattata acctgctcca ctgcctacgc agggattcac ataaaatcga 780 caattatctc aagctcctga agtgccgaat catccacaac aacaactgct aagcccacat 840 ccatttcatc tatttctgag aaggtcctta atgatccgtt ccattgcaag cttcttttag 900 ttgtatctct tttgaatcca tgcttgggtg taacaggtct cctcttaaaa aataaaaact 960 gactccttag agacatcaaa atctaaaaaa acttaatggg ccgggcgcag tggctcatggl020 ctgtggtccc ggcactttgg gaggccgagg caggcggatc aggaggtcag g 1071gtaccctcaa agacagagac accaagaaga atcggaacat acaggctttg atatcaaagg 60 tttataaagc caatatctgg gaaagagaaa accgtgagac ttccagatct tctctggtga 120 agtgttgttt cctgcaacga tcacgaacat gaacatcaaa ggatcgccat ggaaagggtc 180 cctcctgctg crgctggtgt caaacctgct cctgtgccag agcgtggccc ccttgcccat 240 ctgtcccggc ggggctgccc gatgccaggt gacccttcga gacctgtttg accgcgccgt 300 cgtcctgtcc cactacatcc ataacctctc ctcagaaatg ttcagcgaat tcgataaacg 360 gtatacccat ggccgggggt tcattaccaa ggccatcaac agctgccaca cttcttccct 420 tgccaccccc gaagacaagg agcaagccca acagatgaat caaaaagact ttctgagcct 480 gatagtcagc atattgcgat cctggaatga gcctctgtat catctggtca cggaagtacg 540 tggtatgcaa gaagccccgg aggctatcct atccaaagct gtagagattg aggagcaaac 600 caaacggctt cragagggca tggagctgat agtcagccag gttcatcctg aaaccaaaga 660 aaatgagatc taccctgtct ggtcgggact tccatccctg cagatggctg atgaagagtc 720 tcgcctttct gcttattata acctgctcca ctgcctacgc agggattcac ataaaatcga 780 caattatctc aagctcctga agtgccgaat catccacaac aacaactgct aagcccacat 840 ccatttcatc tatttctgag aaggtcctta atgatccgtt ccattgcaag cttcttttag 900 ttgtatctct tttgaatcca tgcttgggtg taacaggtct cctcttaaaa aataaaaact 960 gactccttag agacatcaaa atctaaaaaaa acttaatggg ccggggggggg0c
(2) INFORMATION ÜBER SEQ ID NO: 27:(2) INFORMATION ABOUT SEQ ID NO: 27:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 896 Basenpaare (B) TYP: Nukleinsäure(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 896 base pairs (B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO:27(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 27
gtgaccggct cagaccggtt ctggagacaa aaggggccgc ggcggccgga gcgggacggg 60 cccggcgcgg gagggagcga agagcgcggg cagcgagcga gatgcagcac cgaggcttccl20 tcctcctcac cctcctcgcc ctgctggcgc tcacctccgc ggtcgccaaa aagaaagatalδO aggtgaagaa gggcggcccg gggagcgagt gcgctgagtg ggcctggggg ccctgcaccc240 ccagcagcaa ggattgcggc gtgggtttcc gcgagggcac ctgcggggcc cagacccagc300 gcatccggtg cagggtgccc tgcaactgga agaaggagtt tggagccgac tgcaagtaca360 agtttgagaa ctggggtgcg tgtgatgggg gcacaggcac caaagtccgc caaggcaccc420 tgaagaaggc gcgctacaat gctcagtgcc aggagaccat ccgcgtcacc aagccctgca480 cccccaagac caaagcaaag gccaaagcca agaaagggaa gggaaaggac tagacgccaa540 gcctggatgc caaggagccc ctggtgtcac atggggcctg gcccacgccc tccctctccc600 aggcccgaga tgtgacccac cagtgccttc tgtctgctcg ttagctttaa tcaatcatgc660 cctgccttgt ccctctcact ccccagcccc acccctaagt gcccaaagtg gggagggaca720 agggattctg ggaagcttga gcctccccca aagcaatgtg agtcccagag cccgcttttg780 ttcttcccca caattccatt actaagaaac acatcaaata aactgacttt ttccccccaa840 aaaaagctct tcttttttaa tataaaaaaa aaaaaaaaaa aaaaaaaaaa aagaaa 696gtgaccggct cagaccggtt ctggagacaa aaggggccgc ggcggccgga gcgggacggg 60 cccggcgcgg gagggagcga agagcgcggg cagcgagcga gatgcagcac cgaggcttccl20 tcctcctcac cctcctcgcc ctgctggcgc tcacctccgc ggtcgccaaa aagaaagatalδO aggtgaagaa gggcggcccg gggagcgagt gcgctgagtg ggcctggggg ccctgcaccc240 ccagcagcaa ggattgcggc gtgggtttcc gcgagggcac ctgcggggcc cagacccagc300 gcatccggtg cagggtgccc tgcaactgga agaaggagtt tggagccgac tgcaagtaca360 agtttgagaa ctggggtgcg tgtgatgggg gcacaggcac caaagtccgc caaggcaccc420 tgaagaaggc gcgctacaat gctcagtgcc aggagaccat ccgcgtcacc aagccctgca480 cccccaagac caaagcaaag gccaaagcca agaaagggaa gggaaaggac tagacgccaa540 gcctggatgc caaggagccc ctggtgtcac atggggcctg gcccacgccc tccctctccc600 aggcccgaga tgtgacccac cagtgccttc tgtctgctcg ttagctttaa tcaatcatgc660 cctgccttgt ccctctcact ccccagcccc acccctaagt gcccaaagtg gggagggaca720 agggattctg ggaagcttga gcctccccca aagcaatgtg agtcccagag cccgcttttg780 ttcttcccca caattccatt actaagaaac acatcaaata aactgacttt ttccccccaa840 aaaaagctct tcttttttaa tataaaaaaa aaaaaaaaaa aaaaaaaaaa aagaaa 696
(2) INFORMATION ÜBER SEQ ID NO: 28:(2) INFORMATION ABOUT SEQ ID NO: 28:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 1050 Basenpaare(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1050 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear (ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN: (vii) SONSTIGE HERKUNFT:(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 28(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 28
ttttcatttt tttttttttt tttttctcag ttcaagttta atacaaacta caaaagatta 60 atgggttgct ctactaatac atcatacaaa ccagtagcct gcccacaacg ccaactcagg 120 ccattcctac caaaggaaga aaggctggtc tctccacccc ctgtaggaaa ggcctgcctt 180 gtaagacacc acaattcggc tgaatctgaa gtcttgtgtt ttactaatgg aaaaaaaaaa 240 tacagaagag gttttgttct catggctgcc caccgcagcc tggcactaaa acagcccagc 300 gctcacttct gcttggagaa atattctttg ctcttttgga catcaggctt gatggtatca 360 ctgccaggtt tccagccagc tgggcacact tccccatgtt tgtcagtgaa ctggaaggcc 420 tgaactagtc tcaaagtctc atccacagag cggccaacag ggaggtcatt tacagtgatc 480 tgccgaagaa tacccttatc atcaatgata aaaaggcccc tgaacgagat gccttcatca 540 gcctttaaga ccccataatc ctgagcaatg gtgcgcttcg ggtctgatac caaaggaatg 600 ttcatgggtc ccagtcctcc ttgtttctta ggtgtattga cccatgctag atgacagaag 660 tgagaatcca cagaagcacc aatcacttgg cagttgagtt tcttaaattc ttctgcccta 720 tcactgaaag caatgatctc cgtggggcac acaaaggtga agtcaagagg gtaaaagaag 780 aacacaacat attttccttt gtagtcagac aggctgatat ctttaaactg accatctggc 840 ataacagctg tggctttgaa gttgggggca gggtgcccaa ttttagcatt tcctgaagac 900 atcttcctat cagcagtccc aacacaagtc gcagaaacta accaccgaca ccaggcaaga 960 acaagacgcg caagagctct ccggggcgct gcctttatag ccagtaggga tctcgccacal020 gtcggaacgg acgggggtgc cggagtagga 1050ttttcatttt tttttttttt tttttctcag ttcaagttta atacaaacta caaaagatta 60 atgggttgct ctactaatac atcatacaaa ccagtagcct gcccacaacg ccaactcagg 120 ccattcctac caaaggaaga aaggctggtc tctccacccc ctgtaggaaa ggcctgcctt 180 gtaagacacc acaattcggc tgaatctgaa gtcttgtgtt ttactaatgg aaaaaaaaaa 240 tacagaagag gttttgttct catggctgcc caccgcagcc tggcactaaa acagcccagc 300 gctcacttct gcttggagaa atattctttg ctcttttgga catcaggctt gatggtatca 360 ctgccaggtt tccagccagc tgggcacact tccccatgtt tgtcagtgaa ctggaaggcc 420 tgaactagtc tcaaagtctc atccacagag cggccaacag ggaggtcatt tacagtgatc 480 tgccgaagaa tacccttatc atcaatgata aaaaggcccc tgaacgagat gccttcatca 540 gcctttaaga ccccataatc ctgagcaatg gtgcgcttcg ggtctgatac caaaggaatg 600 ttcatgggtc ccagtcctcc ttgtttctta ggtgtattga cccatgctag atgacagaag 660 tgagaatcca cagaagcacc aatcacttgg cagttgagtt tcttaaattc ttctgcccta 720 tcactgaaag caatgatctc cgtggggcac acaaaggtga agtcaagagg gtaaaagaag 780 aacacaacat attttccttt gtagtcagac aggctgatat ctttaaactg accatctggc 840 ataacagctg tggctttgaa gttgggggca gggtgcccaa ttttagcatt tcctgaagac 900 atcttcctat cagcagtccc aacacaagtc gcagaaacta accaccgaca ccaggcaaga 960 acaagacgcg caagagctct ccggggcgct gcctttatag ccagtcgggggggcccccaggggggggcccccccgggggggcccccccgggggggcccccccgggggggcccccggggggggcccccccgggggggcccccgggggggccccccggggggc
(2) INFORMATION ÜBER SEQ ID NO: 29:(2) INFORMATION ABOUT SEQ ID NO: 29:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 581 Basenpaare (B) TYP: Nukleinsäure(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 581 base pairs (B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN: (vii) SONSTIGE HERKUNFT:(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 29(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 29
caggcttcct tctggcaaca ggcgtgggtc acgctctcgc tcggtctttc tgccgccatc 60 ttggttccgc gttccctgca caaaatgccc ggcgaacacc agaaaccgtc cctgctacagl20 agcaggagtt gccgcagccc caggctgaga cagggtctgg aacagaatct gacagtgatglδO aatcagtacc agagcttgaa gaacaggatt ccacccaggc aaccacacaa caagcccagc240 tggcggcagc agctgaaatc gatgaagaac cagtcagtaa agcaaaacag agtcggagtg300 aaaagaaggc acggaaggct atgtccaaac tgggtcttcg gcaggttaca ggagttacta360 gagtcactat ccggaaatct aagaatatcc tctttgtcat cacaaaacca gttgtctaca420 agagccctgc ttcagatacg tacatagttt ttggggaagc cagatcgaag attatcccag480 caagcacaac tagcagctgc tgagaagtca agttcaggtg aactgtctca acgttcagga540 aacccccggc ttccactgta gagggggagt aaggggaggg t 581caggcttcct tctggcaaca ggcgtgggtc acgctctcgc tcggtctttc tgccgccatc 60 ttggttccgc gttccctgca caaaatgccc ggcgaacacc agaaaccgtc cctgctacagl20 agcaggagtt gccgcagccc caggctgaga cagggtctgg aacagaatct gacagtgatglδO aatcagtacc agagcttgaa gaacaggatt ccacccaggc aaccacacaa caagcccagc240 tggcggcagc agctgaaatc gatgaagaac cagtcagtaa agcaaaacag agtcggagtg300 aaaagaaggc acggaaggct atgtccaaac tgggtcttcg gcaggttaca ggagttacta360 gagtcactat ccggaaatct aagaatatcc tctttgtcat cacaaaacca gttgtctaca420 agagccctgc ttcagatacg tacatagttt ttggggaagc cagatcgaag attatcccag480 caagcacaggggggtcggccggc40g
(2) INFORMATION ÜBER SEQ ID NO: 30:(2) INFORMATION ABOUT SEQ ID NO: 30:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 264 Basenpaare(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 264 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear (ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN (iii) ANTI-SENSE: NEIN(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 30(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30
gggactatgt tgtgagcctg cgaaagaagt ttgtgtgggg actgtgggca gtgaatgcgt 60 tgggaacaat atggaaaact gggagctgcc ctcagtttct ccccaagttg gactcactttl20 cggggtgtcc caaaagcctg attccagggc ctgctagccc gaccccggtg acgcctccaclδO ccgcgcctgg ccccagcctt cacccgcgat cgccgccctc cggggcacac cctccgccag240 aaaacagccg gcgggcggcg agac 264gggactatgt tgtgagcctg cgaaagaagt ttgtgtgggg actgtgggca gtgaatgcgt 60 tgggaacaat atggaaaact gggagctgcc ctcagtttct ccccaagttg gactcactttl20 cggggtgtcc caaaagcctg attccagggc ctgctagccc gaccccggtg acgcctccaclδO ccgcgcctgg ccccagcctt cacccgcgat cgccgccctc cggggcacac cctccgccag240 aaaacagccg gcgggcggcg agac 264
(2) INFORMATION ÜBER SEQ ID NO: 31 :(2) INFORMATION ABOUT SEQ ID NO: 31:
(i) SEQUENZ CHARAKTERISTIK: (A) LÄNGE: 111 Basenpaare(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 111 base pairs
(B) TYP: Nukleinsäure(B) TYPE: nucleic acid
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear (ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN (iii) ANTI-SENSE: NEIN(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH (C) ORGAN:(A) ORGANISM: HUMAN (C) ORGAN:
(vii) SONSTIGE HERKUNFT:(vii) OTHER ORIGIN:
(A) BIBLIOTHEK: cDNA library(A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 31(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31
cggcgaatca cttataaatg gcgccgaagc aggagcccga aggctaaatt gcaggagggg 60 tgagcgaatg ctgtgctttc atgggcctct tacgttgatg aggcaaagta t 111cggcgaatca cttataaatg gcgccgaagc aggagcccga aggctaaatt gcaggagggg 60 tgagcgaatg ctgtgctttc atgggcctct tacgttgatg aggcaaagta t 111
(2) INFORMATION ÜBER SEQ ID NO: 32:(2) INFORMATION ABOUT SEQ ID NO: 32:
(A) LÄNGE: 76 Aminosäuren (B) TYP: Protein(A) LENGTH: 76 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF(ii) MOLECULE TYPE: ORF
(iii) HYPOTHETISCH: ja(iii) HYPOTHETICAL: yes
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 32: PFCEETKTER LWPRCRPPAA VGFSTQNPGV GDSESNLFSL PFLGSKANPI PTHWSSALIF60 NLPSPPFQNT HIPFQN 76(xi) SEQUENCE DESCRIPTION: SEQ ID NO 32: PFCEETKTER LWPRCRPPAA VGFSTQNPGV GDSESNLFSL PFLGSKANPI PTHWSSALIF60 NLPSPPFQNT HIPFQN 76
(2) INFORMATION ÜBER SEQ ID NO: 33: (A) LÄNGE: 72 Aminosäuren(2) INFORMATION ABOUT SEQ ID NO: 33: (A) LENGTH: 72 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF(ii) MOLECULE TYPE: ORF
(iii) HYPOTHETISCH: ja(iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 33:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 33:
SSFLFSFQTQ FHKNRKDKVF SSRQAKPFPH HQSILKIHEE VERSVSGRLK GSSSSNPTAA60 EKIEIEILKI TS 72 (2) INFORMATION ÜBER SEQ ID NO: 34:SSFLFSFQTQ FHKNRKDKVF SSRQAKPFPH HQSILKIHEE VERSVSGRLK GSSSSNPTAA60 EKIEIEILKI TS 72 (2) INFORMATION ABOUT SEQ ID NO: 34:
(A) LÄNGE: 70 Aminosäuren(A) LENGTH: 70 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 34:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 34:
KKLDYFCAEI KNSHCKTKIK lAQIRKPGGA KCQVSKVHFF SLSKRSSTKT ARIKFSVADK60 QSPFHIINQS 70KKLDYFCAEI KNSHCKTKIK lAQIRKPGGA KCQVSKVHFF SLSKRSSTKT ARIKFSVADK60 QSPFHIINQS 70
(2) INFORMATION ÜBER SEQ ID NO: 35:(2) INFORMATION ABOUT SEQ ID NO: 35:
(A) LÄNGE: 60 Aminosäuren (B) TYP: Protein(A) LENGTH: 60 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF(ii) MOLECULE TYPE: ORF
(iii) HYPOTHETISCH: ja(iii) HYPOTHETICAL: yes
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 35: SSGPAPGCSP FAGTRKNFPS MVVLERTFLK INYIFLCIPM EFQFIRCSPW PPQNTEVIPA60(xi) SEQUENCE DESCRIPTION: SEQ ID NO 35: SSGPAPGCSP FAGTRKNFPS MVVLERTFLK INYIFLCIPM EFQFIRCSPW PPQNTEVIPA60
(2) INFORMATION ÜBER SEQ ID NO: 36:(2) INFORMATION ABOUT SEQ ID NO: 36:
(A) LÄNGE: 63 Aminosäuren (B) TYP: Protein(A) LENGTH: 63 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja (vi) HERKUNFT:(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes (vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 36:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 36:
ASGVHTETHR YNLLSAKSRK KGWGYLGWLG FDFLLVCLFC TKTVLS FEYR RDI S IYMLSN 60 QDG 63 (2) INFORMATION ÜBER SEQ ID NO: 37:ASGVHTETHR YNLLSAKSRK KGWGYLGWLG FDFLLVCLFC TKTVLS FEYR RDI S IYMLSN 60 QDG 63 (2) INFORMATION ABOUT SEQ ID NO: 37:
(A) LÄNGE: 170 Aminosäuren(A) LENGTH: 170 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 37:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 37:
ARAARAAQTP HLTLPADLQT LHLNRPTLSP ESKLEWNNDI PEVNHLNSEH WRKTEKWTGH 60ARAARAAQTP HLTLPADLQT LHLNRPTLSP ESKLEWNNDI PEVNHLNSEH WRKTEKWTGH 60
EETNHLETDF SGDGMTELEL GPSPRLQPIR RHPKELPQYG GPGKDIFEDQ LYLPVHSDGI120 SVHQMFTMAT AEHRSNSSIA GKMLTKVEKN HEKEKSQHLE GSASSSLSSD 170EETNHLETDF SGDGMTELEL GPSPRLQPIR RHPKELPQYG GPGKDIFEDQ LYLPVHSDGI120 SVHQMFTMAT AEHRSNSSIA GKMLTKVEKN HEKEKSQHLE GSASSSLSSD 170
(2) INFORMATION ÜBER SEQ ID NO: 38:(2) INFORMATION ABOUT SEQ ID NO: 38:
(A) LÄNGE: 144 Aminosäuren (B) TYP: Protein(A) LENGTH: 144 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF(ii) MOLECULE TYPE: ORF
(iii) HYPOTHETISCH: ja(iii) HYPOTHETICAL: yes
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 38: ARAPTLDMRF RRRLSADPHA TQRNSAEARG TMDGRVQLMK ALLAGPLRPA ARRWRNPIPF 60 PETFDGDTDR LPEFIVQTCS YMFVDENTFS NDALKVTFLI TRLTGPALQW VIPYIRKESP120 LLNDYRGFLA EMKRVFGWEE DEDF 144(xi) SEQUENCE DESCRIPTION: SEQ ID NO 38: ARAPTLDMRF RRRLSADPHA TQRNSAEARG TMDGRVQLMK ALLAGPLRPA ARRWRNPIPF 60 PETFDGDTDR LPEFIVQTCS YMFVDENTFS NDALKVTFLI TRLTGKESALVRGLWNKKALQRFGLWNKPALQRGLWNKKALQRFGLWNKKALQRFGLWNKKALQRFGLWNKKALQRFGLWNKKALQRFGLWGKKALQRFGLFGKDALQRFGLWGKKALQRFGLFGKDALQRFGWLLGKKALQRGFG
(2) INFORMATION ÜBER SEQ ID NO: 39: (A) LÄNGE: 178 Aminosäuren(2) INFORMATION ABOUT SEQ ID NO: 39: (A) LENGTH: 178 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 39:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 39:
HSLGRAPVET LAVATGTANS SQSTRPQARG SPGLEVLVLL PSKDSLHLGQ KAPVIIEQGA 60HSLGRAPVET LAVATGTANS SQSTRPQARG SPGLEVLVLL PSKDSLHLGQ KAPVIIEQGA 60
LLPDVGDHPL QGWPREAGDE ERHLQGVVGE RVLVHEHVGA RLHDELRESV GISVKRLGKG120 NRVPPATRRG PEGPGQEGLH QLHPTVHRAA RLRGVSLGCV GVSAKASPEA HVEGGGPG 178LLPDVGDHPL QGWPREAGDE ERHLQGVVGE RVLVHEHVGA RLHDELRESV GISVKRLGKG120 NRVPPATRRG PEGPGQEGLH QLHPTVHRAA RLRGVSLGCV GVSAKASPEA HVEGGGPG 178
(2) INFORMATION ÜBER SEQ ID NO: 40:(2) INFORMATION ABOUT SEQ ID NO: 40:
(A) LÄNGE: 89 Aminosäuren (B) TYP: Protein(A) LENGTH: 89 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 40: KLTGINTGCR NMLALCIRGH AQQIQEIYLA TFSRKGTLGI IHYILEVFLG FFFFFLRQSC60 CIAQAGSVVA QSQLIASSIT QGLSNPPTL 89(xi) SEQUENCE DESCRIPTION: SEQ ID NO 40: KLTGINTGCR NMLALCIRGH AQQIQEIYLA TFSRKGTLGI IHYILEVFLG FFFFFLRQSC60 CIAQAGSVVA QSQLIASSIT QGLSNPPTL 89
(2) INFORMATION ÜBER SEQ ID NO: 41 :(2) INFORMATION ABOUT SEQ ID NO: 41:
(A) LÄNGE: 95 Aminosäuren(A) LENGTH: 95 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF(ii) MOLECULE TYPE: ORF
(iii) HYPOTHETISCH: ja (vi) HERKUNFT:(iii) HYPOTHETICAL: yes (vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 41 :(xi) SEQUENCE DESCRIPTION: SEQ ID NO 41:
IVTWRKVPMS LCQRPPPFVR IGIFRLLKGL AHIRCDLFIP VVMEGHICQS LESAKAGTRF60 PGPQWGCANP RELGCKFVKN QHHVWQLSIG ARSLP 95IVTWRKVPMS LCQRPPPFVR IGIFRLLKGL AHIRCDLFIP VVMEGHICQS LESAKAGTRF60 PGPQWGCANP RELGCKFVKN QHHVWQLSIG ARSLP 95
(2) INFORMATION ÜBER SEQ ID NO: 42:(2) INFORMATION ABOUT SEQ ID NO: 42:
(A) LÄNGE: 154 Aminosäuren(A) LENGTH: 154 amino acids
(B) TYP: Protein (C) STRANG: einzel(B) TYPE: Protein (C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 42:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 42:
CQLVFRIQTD GSYWSLGLTS SGNITFSWAE MLLPALKQHS VLKTSWQAPG SNTQLPNMML 60 ILHEFATQFS RVCTPPLWAG EPGPGLRRLQ ALADVALHNN GNEKVTPYVR QALKESEYPN120CQLVFRIQTD GSYWSLGLTS SGNITFSWAE MLLPALKQHS VLKTSWQAPG SNTQLPNMML 60 ILHEFATQFS RVCTPPLWAG EPGPGLRRLQ ALADVALHNN GNEKVTPYVR QALKESEYPN120
PHKRRGTLAK THGNFPPSND LDRRATQDSP SCSV 154PHKRRGTLAK THGNFPPSND LDRRATQDSP SCSV 154
(2) INFORMATION ÜBER SEQ ID NO: 43: (A) LÄNGE: 79 Aminosäuren(2) INFORMATION ABOUT SEQ ID NO: 43: (A) LENGTH: 79 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear (ii) MOLEKÜLTYP: ORF(D) TOPOLOGY: linear (ii) MOLECULE TYPE: ORF
(iii) HYPOTHETISCH: ja(iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 43:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 43:
LASTLGVETC LPYVSEDMLS RSKRYIWQLF LEKAHWVSFI TFLSFFGFFF FFFETVLLYC60 PGWSVVAQSQ LIASSITQA 79LASTLGVETC LPYVSEDMLS RSKRYIWQLF LEKAHWVSFI TFLSFFGFFF FFFETVLLYC60 PGWSVVAQSQ LIASSITQA 79
(2) INFORMATION ÜBER SEQ ID NO: 44: (A) LÄNGE: 82 Aminosäuren(2) INFORMATION ABOUT SEQ ID NO: 44: (A) LENGTH: 82 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 44:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 44:
CQLVFRIQTD GSYWSLGLTS SGNITFSWAE MLLPALKQHS VLKTSWQAPG SNTQLPNMML60 ILHEFATSWL PRLQHSAVGT QS 62CQLVFRIQTD GSYWSLGLTS SGNITFSWAE MLLPALKQHS VLKTSWQAPG SNTQLPNMML60 ILHEFATSWL PRLQHSAVGT QS 62
(2) INFORMATION ÜBER SEQ ID NO: 45:(2) INFORMATION ABOUT SEQ ID NO: 45:
(A) LÄNGE: 68 Aminosäuren(A) LENGTH: 68 amino acids
(B) TYP: Protein (C) STRANG: einzel(B) TYPE: Protein (C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 45:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 45:
RGSKDRNSGQ GSGSYGQLSC RGFSDQFSRV CTPPLWAGEP GPGLRRLQAL ADVALHNNGN60 EKVTPYVR 68RGSKDRNSGQ GSGSYGQLSC RGFSDQFSRV CTPPLWAGEP GPGLRRLQAL ADVALHNNGN60 EKVTPYVR 68
(2) INFORMATION ÜBER SEQ ID NO: 46:(2) INFORMATION ABOUT SEQ ID NO: 46:
(A) LÄNGE: 87 Aminosäuren (B) TYP: Protein(A) LENGTH: 87 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja (vi) HERKUNFT:(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes (vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 46:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 46:
DYVVSLRKKF VWGLWAVNAL GTIWKTGSCP QFLPKLDSLS GCPKSLIPGP ASPTPVTPPP60 APGPSLHPRS PPSGAHPPPE NSRRAAR 87 (2) INFORMATION ÜBER SEQ ID NO: 47:DYVVSLRKKF VWGLWAVNAL GTIWKTGSCP QFLPKLDSLS GCPKSLIPGP ASPTPVTPPP60 APGPSLHPRS PPSGAHPPPE NSRRAAR 87 (2) INFORMATION ABOUT SEQ ID NO: 47:
(A) LÄNGE: 51 Aminosäuren(A) LENGTH: 51 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 47:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 47:
QALESGFWDT PKVSPTWGET EGSSQFSILF PTHSLPTVPT QTSFAGSQHS P 51 (2) INFORMATION ÜBER SEQ ID NO: 48:QALESGFWDT PKVSPTWGET EGSSQFSILF PTHSLPTVPT QTSFAGSQHS P 51 (2) INFORMATION ABOUT SEQ ID NO: 48:
(A) LÄNGE: 20 Aminosäuren(A) LENGTH: 20 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 48:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 48:
RRITYKWRRS RSPKAKLQEG 20 (2) INFORMATION ÜBER SEQ ID NO: 49:RRITYKWRRS RSPKAKLQEG 20 (2) INFORMATION ABOUT SEQ ID NO: 49:
(A) LÄNGE: 36 Aminosäuren(A) LENGTH: 36 amino acids
(B) TYP: Protein (C) STRANG: einzel(B) TYPE: protein (C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 49: GESLINGAEA GARRLNCRRG ERMLCFHGPL TLMRQS 36(xi) SEQUENCE DESCRIPTION: SEQ ID NO 49: GESLINGAEA GARRLNCRRG ERMLCFHGPL TLMRQS 36
(2) INFORMATION ÜBER SEQ ID NO: 50:(2) INFORMATION ABOUT SEQ ID NO: 50:
(A) LÄNGE: 26 Aminosäuren (B) TYP: Protein(A) LENGTH: 26 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 50: KHSIRSPLLQ FSLRAPASAP FISDSP 26(xi) SEQUENCE DESCRIPTION: SEQ ID NO 50: KHSIRSPLLQ FSLRAPASAP FISDSP 26
(2) INFORMATION ÜBER SEQ ID NO: 51 :(2) INFORMATION ABOUT SEQ ID NO: 51:
(A) LÄNGE: 25 Aminosäuren (B) TYP: Protein(A) LENGTH: 25 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF(ii) MOLECULE TYPE: ORF
(iii) HYPOTHETISCH: ja(iii) HYPOTHETICAL: yes
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH (xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 51 :(vi) ORIGIN: (A) ORGANISM: HUMAN (xi) SEQUENCE DESCRIPTION: SEQ ID NO 51:
EAHESTAFAH PSCNLAFGLL LRRHL 25 (2) INFORMATION ÜBER SEQ ID NO: 52:EAHESTAFAH PSCNLAFGLL LRRHL 25 (2) INFORMATION ABOUT SEQ ID NO: 52:
(i) SEQUENZ CHARAKTERISTIK:(i) SEQUENCE CHARACTERISTICS:
(A) LÄNGE: 3665 Basenpaare(A) LENGTH: 3665 base pairs
(B) TYP: Nukleinsäure (C) STRANG: einzel(B) TYPE: nucleic acid (C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: aus einzelnen ESTs durch Assemblierung und Editierung hergestellte partielle cDNA(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing
(iii) HYPOTHETISCH: NEIN(iii) HYPOTHETICAL: NO
(iii) ANTI-SENSE: NEIN(iii) ANTI-SENSE: NO
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(C) ORGAN:(C) ORGAN:
(vii) SONSTIGE HERKUNFT: (A) BIBLIOTHEK: cDNA library(vii) OTHER ORIGIN: (A) LIBRARY: cDNA library
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO: 52(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52
GGCCATTTTG TGAAGAGACG AAGACTGAGC GGTTGTGGCC GCGTTGCCGA CCTCCAGCAG 60 CAGTCGGCTT CTCTACGCAG AACCCGGGAG TAGGAGACTC AGAAATCGAA TCTCTTCTCC 120GGCCATTTTG TGAAGAGACG AAGACTGAGC GGTTGTGGCC GCGTTGCCGA CCTCCAGCAG 60 CAGTCGGCTT CTCTACGCAG AACCCGGGAG TAGGAGACTC AGAAATCGAA TCTCTTCTCC 120
CTCCCCTTCT TGGGCAGCAA GGCGAACCCC ATCCCTACTC ACTGGAGCTC AGCTTTGATT 160CTCCCCTTCT TGGGCAGCAA GGCGAACCCC ATCCCTACTC ACTGGAGCTC AGCTTTGATT 160
TTTAACCTCC CTTCCCCACC CTTCCAGAAC ACACACATTC CATTCCAAAA CTGATTTTAT 240TTTAACCTCC CTTCCCCACC CTTCCAGAAC ACACACATTC CATTCCAAAA CTGATTTTAT 240
AAAGACATTT TAAACATAAT GATGCAACTT GGTGTGCACT ACAGCAAATG TACAGGTGTT 300AAAGACATTT TAAACATAAT GATGCAACTT GGTGTGCACT ACAGCAAATG TACAGGTGTT 300
TTTTTTTTAA TTGTTTCCAA AACCGGGACC TGGATTTAAG ATGTAATTTT TAAAATTTCT 360 ATTTCTATTT TTTCTGCAGC AGTTGGGTTA GAGGAGGAGG AGCCTTTTAG CCTCTCATAA 420TTTTTTTTAA TTGTTTCCAA AACCGGGACC TGGATTTAAG ATGTAATTTT TAAAATTTCT 360 ATTTCTATTT TTTCTGCAGC AGTTGGGTTA GAGGAGGAGG AGCCTTTTAG CCTCTCATAA 420
ACTGACCTCT CTACTTCCTC GTGTATTTTT AAGATTGÄTT GATGATGTGG AAAGGGCTTT 480ACTGACCTCT CTACTTCCTC GTGTATTTTT AAGATTGÄTT GATGATGTGG AAAGGGCTTT 480
GCTTGTCTGC TACTGAAAAC TTTATCCTGC GGTTTTTGTG GAAACTGCTT TTGGAAAGAG 540GCTTGTCTGC TACTGAAAAC TTTATCCTGC GGTTTTTGTG GAAACTGCTT TTGGAAAGAG 540
AAAAGAAATG AACTTTACTG ACTTGACATT TTTGCACCTC CCGTTTTTCT AATCTGGGCT 600AAAAGAAATG AACTTTACTG ACTTGACATT TTTGCACCTC CCGTTTTTCT AATCTGGGCT 600
ATTTTTATTT TTGTTTTTTT ACAGTGAGAT TTTTTTGATC TTCAGCTTAC ATTTTCGGGC 660 TTTGTGAGGA AACCTTTACC CATCAAACAC GATGGCCAGC AACGTTACCA ACAAGACAGA 720ATTTTTATTT TTGTTTTTTT ACAGTGAGAT TTTTTTGATC TTCAGCTTAC ATTTTCGGGC 660 TTTGTGAGGA AACCTTTACC CATCAAACAC GATGGCCAGC AACGTTACCA ACAAGACAGA 720
TCCTCGCTCC ATGAACTCCC GTGTATTCAT TGGGAATCTC AACACTCTTG TGGTCAAGAA 780TCCTCGCTCC ATGAACTCCC GTGTATTCAT TGGGAATCTC AACACTCTTG TGGTCAAGAA 780
ATCTGATGTG GAGGCAATCT TTTCGAAGTA TGGCAAAATT GTGGGCTGCT CTGTTCATAA 840ATCTGATGTG GAGGCAATCT TTTCGAAGTA TGGCAAAATT GTGGGCTGCT CTGTTCATAA 840
GGGCTTTGCC TTCGTTCAGT ATGTTAATGA GAGAAATGCC CGGGCTGCTG TAGCAGGAGA 900GGGCTTTGCC TTCGTTCAGT ATGTTAATGA GAGAAATGCC CGGGCTGCTG TAGCAGGAGA 900
GGATGGCAGA ATGATTGCTG GCCAGGTTTT AGATATTAAC CTGGCTGCAG AGCCAAAAGT 960 GAACCGAGGA AAAGCAGGTG TGAAACGATC TGCAGCGGAG ATGTACGGCT CCTCTTTTGA1020GGATGGCAGA ATGATTGCTG GCCAGGTTTT AGATATTAAC CTGGCTGCAG AGCCAAAAGT 960 GAACCGAGGA AAAGCAGGTG TGAAACGATC TGCAGCGGAG ATGTACGGCT CCTCTTTTGA1020
CTTGGACTAT GACTTTCAAC GGGACTATTA TGATAGGATG TACAGTTACC CAGCACGTGT1080CTTGGACTAT GACTTTCAAC GGGACTATTA TGATAGGATG TACAGTTACC CAGCACGTGT1080
ACCTCCTCCT CCTCCTATTG CTCGGGCTGT AGTGCCCTCG AAACGTCAGC GTGTATCAGG1140ACCTCCTCCT CCTCCTATTG CTCGGGCTGT AGTGCCCTCG AAACGTCAGC GTGTATCAGG1140
AAACACTTCA CGAAGGGGCA AAAGTGGCTT CAATTCTAAG AGTGGACAGC GGGGATCTTC1200AAACACTTCA CGAAGGGGCA AAAGTGGCTT CAATTCTAAG AGTGGACAGC GGGGATCTTC1200
CAAGTCTGGA AAGTTGAAAG GAGATGACCT TCAGGCCATT AAGAAGGAGC TGACCCAGAT1260 AAAACAAAAA GTGGATTCTC TCCTGGAAAA CCTGGAAAAA ATTGAAAAGG AACAGAGCAA1320CAAGTCTGGA AAGTTGAAAG GAGATGACCT TCAGGCCATT AAGAAGGAGC TGACCCAGAT1260 AAAACAAAAA GTGGATTCTC TCCTGGAAAA CCTGGAAAAA ATTGAAAAGG AACAGAGCAA1320
ACAAGCAGTA GAGATGAAGA ATGATAAGTC AGAAGAGGAG CAGAGCAGCA GCTCCGTGAA1360ACAAGCAGTA GAGATGAAGA ATGATAAGTC AGAAGAGGAG CAGAGCAGCA GCTCCGTGAA1360
GAAAGATGAG ACTAATGTGA AGATGGAGTC TGAGGGGGGT GCAGATGACT CTGCTGAGGA1440GAAAGATGAG ACTAATGTGA AGATGGAGTC TGAGGGGGGT GCAGATGACT CTGCTGAGGA1440
GGGGGACCTA CTGGATGATG ATGATAATGA AGATCGGGGG GATGACCAGC TGGAGTTGAT1500GGGGGACCTA CTGGATGATG ATGATAATGA AGATCGGGGG GATGACCAGC TGGAGTTGAT1500
CAAGGATGAT GAAAAAGAGG CTGAGGAAGG AGAGGATGAC AGAGACAAGG CCAATGGCGA1560 GGATGACTCT TAAGCACATA GTGGGGTTTA GAAATCTTAT CCCATTATTT CTTTACCTAG1620CAAGGATGAT GAAAAAGAGG CTGAGGAAGG AGAGGATGAC AGAGACAAGG CCAATGGCGA1560 GGATGACTCT TAAGCACATA GTGGGGTTTA GAAATCTTAT CCCATTATTT CTTTACCTAG1620
GCGCTTGTCT AAGATCAAAT TTTTCACCAG ATCCTCTCCC CTAGTATCTT CAGCACATGC1660GCGCTTGTCT AAGATCAAAT TTTTCACCAG ATCCTCTCCC CTAGTATCTT CAGCACATGC1660
TCACTGTTCT CCCCATCCTT GTCCTTCCCA TGTTCATTAA TTCATATTGC CCCGCGCCTA1740 GTCCCATTTT CACTTCCTTT GACGCTCCTA GTAGTTTTGT TAAGTCTTAC CCTGTAATTT1800 TTGCTTTTAA TTTTGATACC TCTTTATGAC TTAACAATAA AAAGGATGTA TGGTTTTTAT1660 CAACTGTCTC CAAAATAATC TCTTGTTATG CAGGGAGTAC AGTTCTTTTC ATTCATACAT1920 AAGTTCAGTA GTTGCTTCCC TAACTGCAAA GGCAATCTCA TTTAGTTGÄG TAGCTCTTGA1980 AAGCAGCTTT GAGTTAGÄAG TATGTGTGTT ACACCCTCAC ATTAGTGTGC TGTGTGGGGC2040 AGTTCAACÄC AAATGTAACA ATGTATTTTT GTGAATGAGA GTTGGCATGT CAAATGCATC2100 CTCTAGAAAA ATAATTAGTG TTATAGTCTT AAGATTTGTT TTCTAAAGTT GATACTGTGG2160 GTTATTTTTG TGAACAGCCT GATGTTTGGG ACCTTTTTTC CTCAAAATAA ACAAGTCCTT2220 ATTAAACCAG GAATTTGGAG AAAAAAAAAA AAAAAAATTT TTTATTTTTG TATTTTATTA2280 TTGTTTACTT CAAACTTTGT TTTACAGCGT CCTCCACAAA ACCTCTAGAA TGCACTAGAT2340 ATATTTTTCT TGGAGTCATA ATCATGATGC ATACCAACAC AACACTACTC AAATTATATT2400 TCATTGAGAT GCATGTTGCA TTGAGGAGTC AACTTGACAT AGAGTGGAGA CTTTTTCAAA2460 ATGGCTTTTA CATCCTAATG AAAGTTTGGG AAGTATATCC TCTCTGCCTT TTCATCAGTG2520 CTTTGTGGTC CAGCTGGCAC CCTTTCTGAG GTTTGTGTTT TGTGCTAAAT GGTTTTGTCC2580 TTAAATAGGA GAGGCTCAAA AACATCAAGA TTTCAGGAAA ATGGCGACAC TGGCATAATG2640 GAACCCCCCT GCTTCTATTT TGTTCTTTTA ATTACTATTT ATAGCCCCAG TTACCTTCTG2700 AATTCTGAAG TGTATATACC TCCATGTTCC TGAAAACAAG AAAACTCTTA CTTCCTGATA2760 TTCCATAGAC TGCCTTCCCA GGTGATTGAG AACATAGAGA ATGTTACACA TTTATTTTAC2820 TCTAAATGAT CTTTTACCCC TGTTAGCTAA TCTTTGTGTT TTCCTCAACT TTATTAATTA2880 CAGTGATTGC ATTTTTAGCA TCCAGTTGTA AGATGAATAT ATTAAACAGC TACCAGTGTT2940 GGTGATACCT CATCCTTGAA AGGCTTAGTT CATTTGTGTT TTATACTTCA GTTTTTCCAG3000 CATAGCAGAA AATGCCGCTT ATAATTTTTG TGCACACAAA CCTTGGAATC CCCCTGTAAA3060 GTTGCTATGG TTTCATAGCA TGCGGCACTG GCCCCTTTTT CATCCCACTC ATTACAGGCA3120 AAACCCATGT CTTATTTATG AGGATTTTAT AGATCATTTT CTGTAACAGG TGACAAAAGC3180 AGAAAAGAAT GAAGAGGCTG AAGTATGAAC TACCCTTGGA GCCCATATAC ATGATATAGG3240 CAATTTCTTT TGTATGTTAA TTCAGTCAAA AATACTACCC ACTTGATGTT TTCTAATCTG3300 ATGTGAGCTC ATGTTACACA GACTTTTAGT AAGTAACCCG TGACTAGAAA ATAAACTGGA3360 TGCTTAGGAG AGAGTGTCAG ATGTATAAGA TGCTAATAAA ACCTGTTTAA TATTATTGTT3420 AGCTGTAAGT TTTTGGGAAA TACTGAACAA ATTAGTCCAC AATCAAGTGT CTACTTTTCC3480 CTTCACTGTA GGGCCTCTCC CTGCACAGAG CAGTCTGTTT AGCTGTGAAC ACCACAATCT3540 GCAGATGTTC AAGTCCCTTA CATAAAATGG CATAGTATTT ATATGTAACC TATGCATATT3600 CTCCTGTATA TTTTAAATCA TCTCTACATT AAAATACCTG ATAAAATCTA AATAAAAAAA3660 AAAAA 3665 (2) INFORMATION ÜBER SEQ ID NO: 53:TCACTGTTCT CCCCATCCTT GTCCTTCCCA TGTTCATTAA TTCATATTGC CCCGCGCCTA1740 GTCCCATTTT CACTTCCTTT GACGCTCCTA GTAGTTTTGT TAAGTCTTAC CCTGTAATTT1800 TTGCTTTTAA TTTTGATACC TCTTTATGAC TTAACAATAA AAAGGATGTA TGGTTTTTAT1660 CAACTGTCTC CAAAATAATC TCTTGTTATG CAGGGAGTAC AGTTCTTTTC ATTCATACAT1920 AAGTTCAGTA GTTGCTTCCC TAACTGCAAA GGCAATCTCA TTTAGTTGÄG TAGCTCTTGA1980 AAGCAGCTTT GAGTTAGÄAG TATGTGTGTT ACACCCTCAC ATTAGTGTGC TGTGTGGGGC2040 AGTTCAACÄC AAATGTAACA ATGTATTTTT GTGAATGAGA GTTGGCATGT CAAATGCATC2100 CTCTAGAAAA ATAATTAGTG TTATAGTCTT AAGATTTGTT TTCTAAAGTT GATACTGTGG2160 GTTATTTTTG TGAACAGCCT GATGTTTGGG ACCTTTTTTC CTCAAAATAA ACAAGTCCTT2220 ATTAAACCAG GAATTTGGAG AAAAAAAAAA AAAAAAATTT TTTATTTTTG TATTTTATTA2280 TTGTTTACTT CAAACTTTGT TTTACAGCGT CCTCCACAAA ACCTCTAGAA TGCACTAGAT2340 ATATTTTTCT TGGAGTCATA ATCATGATGC ATACCAACAC AACACTACTC AAATTATATT2400 TCATTGAGAT GCATGTTGCA TTGAGGAGTC AACTTGACAT AGAGTGGAGA CTTTTTCAAA2460 ATGGCTTTTA CATCCTAATG AAAGTTTGGG AAGTATATCC TCTCTGCCTT TTCATCAGTG2520 CTTTGTGGTC CAGCTGGCAC CCTTTCTGAG GTTTGTGTTT TGTGCTAAAT GGTTTTGTCC2580 TTAAATAGGA GAGGCT CAAA AACATCAAGA TTTCAGGAAA ATGGCGACAC TGGCATAATG2640 GAACCCCCCT GCTTCTATTT TGTTCTTTTA ATTACTATTT ATAGCCCCAG TTACCTTCTG2700 AATTCTGAAG TGTATATACC TCCATGTTCC TGAAAACAAG AAAACTCTTA CTTCCTGATA2760 TTCCATAGAC TGCCTTCCCA GGTGATTGAG AACATAGAGA ATGTTACACA TTTATTTTAC2820 TCTAAATGAT CTTTTACCCC TGTTAGCTAA TCTTTGTGTT TTCCTCAACT TTATTAATTA2880 CAGTGATTGC ATTTTTAGCA TCCAGTTGTA AGATGAATAT ATTAAACAGC TACCAGTGTT2940 GGTGATACCT CATCCTTGAA AGGCTTAGTT CATTTGTGTT TTATACTTCA GTTTTTCCAG3000 CATAGCAGAA AATGCCGCTT ATAATTTTTG TGCACACAAA CCTTGGAATC CCCCTGTAAA3060 GTTGCTATGG TTTCATAGCA TGCGGCACTG GCCCCTTTTT CATCCCACTC ATTACAGGCA3120 AAACCCATGT CTTATTTATG AGGATTTTAT AGATCATTTT CTGTAACAGG TGACAAAAGC3180 AGAAAAGAAT GAAGAGGCTG AAGTATGAAC TACCCTTGGA GCCCATATAC ATGATATAGG3240 CAATTTCTTT TGTATGTTAA TTCAGTCAAA AATACTACCC ACTTGATGTT TTCTAATCTG3300 ATGTGAGCTC ATGTTACACA GACTTTTAGT AAGTAACCCG TGACTAGAAA ATAAACTGGA3360 TGCTTAGGAG AGAGTGTCAG ATGTATAAGA TGCTAATAAA ACCTGTTTAA TATTATTGTT3420 AGCTGTAAGT TTTTGGGAAA TACTGAACAA ATTA GTCCAC AATCAAGTGT CTACTTTTCC3480 CTTCACTGTA GGGCCTCTCC CTGCACAGAG CAGTCTGTTT AGCTGTGAAC ACCACAATCT3540 GCAGATGTTC AAGTCCCTTA CATAAAATGG CATAGTATTAA ATATGTAACC TATGCATATATA3600 CTCCTAAAT3600
(A) LÄNGE: 301 Aminosäuren(A) LENGTH: 301 amino acids
(B) TYP: Protein(B) TYPE: protein
(C) STRANG: einzel (D) TOPOLOGIE: linear(C) STRAND: single (D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH(A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 53:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 53:
GNLYPSNTMA SNVTNKTDPR SMNSRVFIGN LNTLVVKKSD VEAIFSKYGK IVGCSVHKGF 60 AFVQYVNERN ARAAVAGEDG RMIAGQVLDI NLAAEPKVNR GKAGVKRSAA EMYGSSFDLD120 YDFQRDYYDR MYSYPARVPP PPPIARAVVP SKRQRVSGNT SRRGKSGFNS KSGQRGSSKS160 GKLKGDDLQÄ IKKELTQIKQ KVDSLLENLE KIEKEQSKQA VEMKNDKSEE EQSSSSVKKD240 ETNVKMESEG GADDSAEEGD LLDDDDNEDR GDDQLELIKD DEKEAEEGED DRDKANGEDD300 S 301 (2) INFORMATION ÜBER SEQ ID NO: 54:GNLYPSNTMA SNVTNKTDPR SMNSRVFIGN LNTLVVKKSD VEAIFSKYGK IVGCSVHKGF 60 AFVQYVNERN ARAAVAGEDG RMIAGQVLDI NLAAEPKVNR GKAGVKRSAA EMYGSSFDLD120 YDFQRDYYDR MYSYPARVPP PPPIARAVVP SKRQRVSGNT SRRGKSGFNS KSGQRGSSKS160 GKLKGDDLQÄ IKKELTQIKQ KVDSLLENLE KIEKEQSKQA VEMKNDKSEE EQSSSSVKKD240 ETNVKMESEG GADDSAEEGD LLDDDDNEDR GDDQLELIKD DEKEAEEGED DRDKANGEDD300 S 301 (2) INFORMATION ABOUT SEQ ID NO: 54:
(A) LÄNGE: 1 12 Aminosäuren(A) LENGTH: 1 12 amino acids
(B) TYP: Protein (C) STRANG: einzel(B) TYPE: Protein (C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF(ii) MOLECULE TYPE: ORF
(iii) HYPOTHETISCH: ja(iii) HYPOTHETICAL: yes
(vi) HERKUNFT:(vi) ORIGIN:
(A) ORGANISMUS: MENSCH :(A) ORGANISM: HUMAN:
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 54:(xi) SEQUENCE DESCRIPTION: SEQ ID NO 54:
ESSSPLALSL SSSPSSASFS SSLINSSWSS PRSSLSSSSS RSPSSAESSA PPSDSIFTLV 60 SSFFTELLLC SSSDLSFFIS TACLLCSFSI FSRFSRREST FCFIWVSSFL MA 112ESSSPLALSL SSSPSSASFS SSLINSSWSS PRSSLSSSSS RSPSSAESSA PPSDSIFTLV 60 SSFFTELLLC SSSDLSFFIS TACLLCSFSI FSRFSRREST FCFIWVSSFL MA 112
(2) INFORMATION ÜBER SEQ ID NO: 55:(2) INFORMATION ABOUT SEQ ID NO: 55:
(A) LÄNGE: 107 Aminosäuren (B) TYP: Protein(A) LENGTH: 107 amino acids (B) TYPE: protein
(C) STRANG: einzel(C) STRAND: single
(D) TOPOLOGIE: linear(D) TOPOLOGY: linear
(ii) MOLEKÜLTYP: ORF (iii) HYPOTHETISCH: ja(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes
(vi) HERKUNFT: (A) ORGANISMUS: MENSCH(vi) ORIGIN: (A) ORGANISM: HUMAN
(xi) SEQUENZ-BESCHREIBUNG: SEQ ID NO 55: TRNLEKKKKK NFLFLYFIIV YFKLCFTASS TKPLECTRYI FLGVIIMMHT NTTLLKLYFI 60 EMHVALRSQL DIEWRLFQNG FYILMKVWEV YPLCLFISAL WSSWHPF 107 (xi) SEQUENCE DESCRIPTION: SEQ ID NO 55: TRNLEKKKKK NFLFLYFIIV YFKLCFTASS TKPLECTRYI FLGVIIMMHT NTTLLKLYFI 60 EMHVALRSQL DIEWRLFQNG FYILMKVWEV YPLCLFISAL WSSWHPF 107

Claims

Patentansprüche claims
1. Eine Nukleinsäure-Sequenz, die ein Genprodukt oder ein Teil davon kodiert, umfassend a) eine Nukleinsäure-Sequenz, ausgewählt aus der Gruppe Seq ID No 14-18, 30, 31, 52.1. A nucleic acid sequence encoding a gene product or a part thereof, comprising a) a nucleic acid sequence selected from the group Seq ID No 14-18, 30, 31, 52.
b) eine allelische Variation der unter a) genannten Nukleinsäure-Sequenzen oder c) eine Nukleinsäure-Sequenz, die komplementär zu den unter a) oder b) genannten Nukleinsäure-Sequenzen ist.b) an allelic variation of the nucleic acid sequences mentioned under a) or c) a nucleic acid sequence which is complementary to the nucleic acid sequences mentioned under a) or b).
2. Eine Nukleinsäure-Sequenz gemäß einer der Sequenzen Seq ID Nos 14-18, 30, 31 ,52 oder eine komplementäre oder allelische Variante davon.2. A nucleic acid sequence according to one of the sequences Seq ID Nos 14-18, 30, 31, 52 or a complementary or allelic variant thereof.
3. Nukleinsäure-Sequenz Seq. ID No. 1 bis Seq. ID No. 31 und Seq.lD 52, dadurch gekennzeichnet, daß sie in Uterusmyomgewebe erhöht exprimiert sind.3. Nucleic acid sequence Seq. ID No. 1 to Seq. ID No. 31 and Seq.ID 52, characterized in that they are expressed in increased uterine fibroid tissue.
BAC, PAC und Cosmid-Klone, enthaltend funktionelle Gene und ihre chromosomale Lokalisation, entsprechend den Sequenzen Seq. ID. No. 1 bis Seq. ID No. 31 und Seq.lD 52, zur Verwendung als Vehikel zum Gentransfer.BAC, PAC and cosmid clones containing functional genes and their chromosomal localization, according to the sequences Seq. ID. No. 1 to Seq. ID No. 31 and Seq. ID 52, for use as a vehicle for gene transfer.
5. Eine Nukleinsäure-Sequenz gemäß den Ansprüchen 1 bis 4, dadurch gekennzeichnet, daß sie eine 90% ige Homologie zu einer humanen Nukleinsäure-Sequenz aufweist.5. A nucleic acid sequence according to claims 1 to 4, characterized in that it has a 90% homology to a human nucleic acid sequence.
6. Eine Nukleinsäure-Sequenz gemäß den Ansprüchen 1 bis 4, dadurch gekennzeichnet, daß sie eine 95% ige Homologie zu einer humanen Nukleinsäure-Sequenz aufweist.6. A nucleic acid sequence according to claims 1 to 4, characterized in that it has a 95% homology to a human nucleic acid sequence.
7. Eine Nukleinsäure-Sequenz, umfassend einen Teil der in den Ansprüchen 1 bis 6 genannten Nukleinsäure-Sequenzen, in solch einer ausreichenden Größe, daß sie mit den Sequenzen gemäß den Ansprüchen 1 bis 6 hybridisieren.7. A nucleic acid sequence comprising a part of the nucleic acid sequences mentioned in claims 1 to 6, in such a size that they hybridize with the sequences according to claims 1 to 6.
8. Ein Nukleinsäure-Sequenz gemäß den Ansprüchen 1 bis 7, dadurch gekennzeichnet, daß die Größe des Fragments eine Länge von mindestens 50 bis 4500 bp aufweist. 8. A nucleic acid sequence according to claims 1 to 7, characterized in that the size of the fragment has a length of at least 50 to 4500 bp.
9. Eine Nukleinsäure-Sequenz gemäß den Ansprüchen 1 bis 7, dadurch gekennzeichnet, daß die Größe des Fragments eine Länge von mindestens' 50 bis 4000 bp aufweist.9. A nucleic acid sequence according to claims 1 to 7, characterized in that the size of the fragment has a length of at least '50 to 4000 bp.
10. Eine Nukleinsäure-Sequenz gemäß einem der Ansprüche 1 bis 9, die mindestens eine Teilsequenz eines biologisch aktiven Polypeptids kodiert.10. A nucleic acid sequence according to any one of claims 1 to 9, which encodes at least a partial sequence of a biologically active polypeptide.
1 1 . Eine Expressionskassette, umfassend ein Nukleinsäure-Fragment oder eine Sequenz gemäß einem der Ansprüche 1 bis 9, zusammen mit mindestens einer Kontroil- oder regulatorischen Sequenz.1 1. An expression cassette comprising a nucleic acid fragment or a sequence according to any one of claims 1 to 9, together with at least one controil or regulatory sequence.
12. Eine Expressionskassette, umfassend ein Nukleinsäure-Fragment oder eine Sequenz gemäß Anspruch 1 1 , worin die Kontroll- oder regulatorische Sequenz ein geigneter Promotor ist.12. An expression cassette comprising a nucleic acid fragment or a sequence according to claim 1 1, wherein the control or regulatory sequence is a suitable promoter.
13. Eine Expressionskassette gemäß einem der Ansprüche 1 1 und 12, dadurch gekennzeichnet, daß die auf der Kassette befindlichen DNA-Sequenzen ein Fusionsprotein kodieren, das ein bekanntes Protein und ein biologisch aktives Polypeptid-Fragment umfaßt.13. An expression cassette according to one of claims 1 1 and 12, characterized in that the DNA sequences on the cassette encode a fusion protein which comprises a known protein and a biologically active polypeptide fragment.
14. Verwendung der Nukleinsäure-Sequenzen gemäß den Ansprüchen 1 bis 10 zur Herstellung von Vollängen-Genen.14. Use of the nucleic acid sequences according to claims 1 to 10 for the production of full-length genes.
15. Ein DNA-Fragment, umfassend ein Gen, das aus der Verwendung gemäß Anspruch 14 erhältlich ist.15. A DNA fragment comprising a gene obtainable from the use according to claim 14.
16. Wirtszelle, enthaltend als heterologen Teil ihrer exprimierbaren genetischen Information ein Nukleinsäure-Fragment gemäß einem der Ansprüche 1 bis 10.16. Host cell containing, as a heterologous part of its expressible genetic information, a nucleic acid fragment according to one of claims 1 to 10.
17. Wirtszelle gemäß Anspruch 16, dadurch gekennzeichnet, daß es ein prokaryontisches oder eukaryontische Zellsystem ist.17. Host cell according to claim 16, characterized in that it is a prokaryotic or eukaryotic cell system.
18. Wirtszelle gemäß einem der Ansprüche 16 oder 17, dadurch gekennzeichnet, daß das prokaryontische Zellsystem E. coli und das eukaryontische Zellsystem ein tierisches, humanes oder Hefe-Zellsystem ist.18. Host cell according to one of claims 16 or 17, characterized in that the prokaryotic cell system E. coli and the eukaryotic cell system is an animal, human or yeast cell system.
19. Ein Verfahren zur Herstellung eines Polypeptids oder eines Fragments, dadurch gekennzeichnet, daß die Wirtszellen gemäß den Ansprüchen 16 bis 18 kultiviert werden. 19. A method for producing a polypeptide or a fragment, characterized in that the host cells are cultivated according to claims 16 to 18.
20. Ein Antikörper, der gegen ein Polypeptid oder ein Fragment gerichtet ist, welches von den Nukleinsäuren der Sequenzen Seq. ID No. 1-31 und Seq.lD 52 kodiert' wird, das gemäß Anspruch 19 erhältlich ist.20. An antibody which is directed against a polypeptide or a fragment which is derived from the nucleic acids of the sequences Seq. ID No. 1-31 and Seq.ID 52 is encoded ' , which is obtainable according to claim 19.
21. Ein Antikörper gemäß Anspruch 20, dadurch gekennzeichnet, daß er monoklonal ist.21. An antibody according to claim 20, characterized in that it is monoclonal.
22. Ein Antikörper gemäß Anspruch 20 dadurch gekennzeichnet, daß er ein Phage- Display-Antikörper ist.22. An antibody according to claim 20, characterized in that it is a phage display antibody.
23. Polypeptid-Teilsequenzen, gemäß den Sequenzen Seq. ID Nos. Seq. 32-51 und Seq. ID Nos. 53-55.23. partial polypeptide sequences, according to the sequences Seq. ID Nos. Seq. 32-51 and Seq. ID Nos. 53-55.
24. Polypeptid-Teilsequenzen gemäß Anspruch 23, mit mindestens 80%iger Homologie zu diesen Sequenzen.24. polypeptide partial sequences according to claim 23, with at least 80% homology to these sequences.
25. Ein aus einem Phage-Display hervorgegangenen Polypeptid, welches an die Polypeptid-Teilsequenzen gemäß Anspruch 23 binden kann.25. A polypeptide resulting from a phage display, which can bind to the polypeptide partial sequences according to claim 23.
26. Polypeptid-Teilsequenzen gemäß Anspruch 23, mit mindestens 90%iger Homologie zu diesen Sequenzen.26. polypeptide partial sequences according to claim 23, with at least 90% homology to these sequences.
27. Verwendung der Polypeptid-Teilsequenzen gemäß den Sequenzen Seq. ID No. 32 bis 51 und Seq. ID Nos. 53-55, als Tools zum Auffinden von Wirkstoffen gegen das Uterusmyom.27. Use of the partial polypeptide sequences according to the sequences Seq. ID No. 32 to 51 and Seq. ID Nos. 53-55, as tools for finding drugs against the uterine fibroid.
28. Verwendung der Nukleinsäure-Sequenzen gemäß den Sequenzen Seq. ID No. 1- 31 und Seq ID No. 52 zur Expression von Polypeptiden, die als Tools zum Auffinden von Wirkstoffen gegen das Uterusmyom verwendet werden können.28. Use of the nucleic acid sequences according to the sequences Seq. ID No. 1- 31 and Seq ID No. 52 for the expression of polypeptides that can be used as tools for finding active substances against the uterine fibroid.
29. Verwendung der Nukleinsäure-Sequenzen Seq. ID No. 1-31 und und Seq ID No. 52 in sense oder antisense Form.29. Use of the nucleic acid sequences Seq. ID No. 1-31 and and Seq ID No. 52 in sense or antisense form.
30. Verwendung der Polypeptid-Teilsequenzen Seq. ID No. 32 bis Seq. ID No. 51 und Seq. ID Nos. 53-55 als Arzneimittel in der Gentherapie zur Behandlung des30. Use of the polypeptide partial sequences Seq. ID No. 32 to Seq. ID No. 51 and Seq. ID Nos. 53-55 as a drug in gene therapy for the treatment of
Uterusmyom.Uterine fibroid.
31. Verwendung der Polypeptid-Teilsequenzen Seq. ID No. 32 bis Seq. ID No. 51 und Seq. ID Nos. 53-55, zur Herstellung eines Arzneimittels zur Behandlung gegen das Uterusmyom. 31. Use of the polypeptide partial sequences Seq. ID No. 32 to Seq. ID No. 51 and Seq. ID Nos. 53-55, for the manufacture of a medicament for the treatment of uterine fibroids.
32. Arzneimittel, enthaltend mindestens eine Polypeptid-Teilsequenz Seq. ID No. 32 bis Seq. ID No. 51 und Seq. ID Nos. 53-55.32. Medicament containing at least one polypeptide partial sequence Seq. ID No. 32 to Seq. ID No. 51 and Seq. ID Nos. 53-55.
33. Eine Nukleinsäure-Sequenz gemäß den Ansprüchen 1 bis 10, dadurch gekennzeichnet, daß es eine genomische Sequenz ist.33. A nucleic acid sequence according to claims 1 to 10, characterized in that it is a genomic sequence.
34. Eine Nukleinsäure-Sequenz gemäß den Ansprüchen 1 bis 10, dadurch gekennzeichnet, daß es eine mRNA-Sequenz ist.34. A nucleic acid sequence according to claims 1 to 10, characterized in that it is an mRNA sequence.
35. Genomische Gene, ihre Promotoren, Enhancer, Silencer, Exonstruktur, Intronstruktur und deren Spleißvarianten, erhältlich aus den cDNAs der35. Genomic genes, their promoters, enhancers, silencers, exon structure, intron structure and their splice variants, obtainable from the cDNAs of the
Sequenzen Seq. ID No. 1 bis Seq. ID No. 31 und Seq. ID 52.Sequences Seq. ID No. 1 to Seq. ID No. 31 and Seq. ID 52.
36. Verwendung der genomischen Gene gemäß Anspruch 33, zusammen mit geeigneten regulativen Elementen.36. Use of the genomic genes according to claim 33, together with suitable regulatory elements.
37. Verwendung gemäß Anspruch 36, dadurch gekennzeichnet, daß das regulative Element ein geeigneter Promotor und/ oder Enhancer ist.37. Use according to claim 36, characterized in that the regulative element is a suitable promoter and / or enhancer.
38. Eine Nukleinsäure-Sequenz gemäß den Ansprüchen 1 bis 7, dadurch gekennzeichnet, daß die Größe des Fragments eine Länge von mindestens 300 bis 3500 bp aufweist. 38. A nucleic acid sequence according to claims 1 to 7, characterized in that the size of the fragment has a length of at least 300 to 3500 bp.
PCT/DE1999/001178 1998-04-17 1999-04-15 Human nucleic acid sequences, increased expression thereof in uterus myoma tissue WO1999054448A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2000544780A JP2002512024A (en) 1998-04-17 1999-04-15 Human nucleic acid sequences from fibroid tissue
EP99927686A EP1080188A2 (en) 1998-04-17 1999-04-15 Human nucleic acid sequences of uterus myoma tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19817947A DE19817947A1 (en) 1998-04-17 1998-04-17 New nucleic acid sequences expressed in uterine myoma, and derived polypeptides, for treatment of uterine carcinoma and identification of therapeutic agents
DE19817947.2 1998-04-17

Publications (2)

Publication Number Publication Date
WO1999054448A2 true WO1999054448A2 (en) 1999-10-28
WO1999054448A3 WO1999054448A3 (en) 2000-07-06

Family

ID=7865425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001178 WO1999054448A2 (en) 1998-04-17 1999-04-15 Human nucleic acid sequences, increased expression thereof in uterus myoma tissue

Country Status (4)

Country Link
EP (1) EP1080188A2 (en)
JP (1) JP2002512024A (en)
DE (1) DE19817947A1 (en)
WO (1) WO1999054448A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050594A2 (en) * 1999-02-26 2000-08-31 Zymogenetics, Inc. Mammalian alpha-helical protein, zsig83
WO2001036635A2 (en) * 1999-11-15 2001-05-25 Curagen Corporation Neurite outgrowth-promoting factor homologue and nucleic acids encoding same
WO2003027276A2 (en) * 2001-09-24 2003-04-03 University Of Aarhus Novel compositions and methods for diagnosis and treatment of lymphoma and leukemia
US8216580B2 (en) 2000-12-27 2012-07-10 The Regents Of The University Of California Sulfatases and methods of use thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002024867A2 (en) * 2000-09-22 2002-03-28 University Of Aarhus Novel compositions and methods for lymphoma and leukemia
WO2003006688A2 (en) * 2001-07-13 2003-01-23 University Of Aarhus Methods for diagnosis and treatment of diseases associated with altered expression of gnas

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Adams M.D. et al. EST43874, endometrial tumor Homo sapiens cDNA 5' end EMBL DATABASE ENTRY HSZZ43104; ACCESSION NUMBER AA338040; 18. April 1997 XP002128941 *
BONFIELD, J. ET AL.: "A new DNA sequence assembly program" NUCLEIC ACIDS RESEARCH, Bd. 23, 1995, Seiten 4992-4999, XP000872808 in der Anmeldung erw{hnt *
COLLINS, J.: "Phage display" ANNUAL REPORT IN COMBINATORIYL CHEMISTRY AND MOLECULAR DIVERSITY, Bd. 1, - 1997 Seiten 210-262, XP000770016 *
Hillier, L. et al.:"The WashU-Merck EST Project": ze64a03.r1 Soares retina N2b4HR homo sapiens cDNA clone 363724 5' EMBL DATABASE ENTRY HSAA20113; ACCESSION NUMBER AA20869, 27. November 1996 XP002128942 *
Hillier, L. et al.:"The WashU-Merck EST Project": zo28d01.r1 Stratagene colon; Homo sapiens cDNA clone 588193 5' EMBL DATABASE ENTRY HSAA35169; ACCESSION NUMBER AA135168, 10. Dezember 1996 XP002128940 *
LESSL, M. ET AL.: "Comparative messenger ribonucleic acid analysis of immediate early genes and sex steroid receptors in human leiomyoma and healthy myometrium" THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, Bd. 82, Nr. 8, 1997, Seiten 2596-2600, XP002128938 *
SCHMITT, A.O. ET AL.: "Exhaustive mining of EST libraries for genes differentially expressed in normal and tumor tissue" NUCLEIC ACIDS RESEARCH, Bd. 27, Nr. 21, 1. November 1999 (1999-11-01), Seiten 4251-4260, XP000872807 *
SCHULER, G.D.: "Sequence mapping by electronic PCR" GENOME RESEARCH, Bd. 7, - 1997 Seiten 541-550, XP002127628 in der Anmeldung erw{hnt *
SINGH, M. ET AL.: "Decreased expression of functional human chorionic gonadotropin/ luteinizing hormone receptor gene in human uterine leiomyomas" BIOLOGY OF REPRODUCTION, Bd. 53, 1995, Seiten 591-597, XP002128937 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050594A2 (en) * 1999-02-26 2000-08-31 Zymogenetics, Inc. Mammalian alpha-helical protein, zsig83
WO2000050594A3 (en) * 1999-02-26 2000-12-28 Zymogenetics Inc Mammalian alpha-helical protein, zsig83
WO2001036635A2 (en) * 1999-11-15 2001-05-25 Curagen Corporation Neurite outgrowth-promoting factor homologue and nucleic acids encoding same
WO2001036635A3 (en) * 1999-11-15 2002-03-21 Curagen Corp Neurite outgrowth-promoting factor homologue and nucleic acids encoding same
US8216580B2 (en) 2000-12-27 2012-07-10 The Regents Of The University Of California Sulfatases and methods of use thereof
WO2003027276A2 (en) * 2001-09-24 2003-04-03 University Of Aarhus Novel compositions and methods for diagnosis and treatment of lymphoma and leukemia
WO2003027276A3 (en) * 2001-09-24 2004-02-12 Univ Aarhus Novel compositions and methods for diagnosis and treatment of lymphoma and leukemia

Also Published As

Publication number Publication date
WO1999054448A3 (en) 2000-07-06
EP1080188A2 (en) 2001-03-07
DE19817947A1 (en) 1999-10-28
JP2002512024A (en) 2002-04-23

Similar Documents

Publication Publication Date Title
EP1291422A2 (en) Human nucleic acid from ovarian tumor tissue
DE19817948A1 (en) New nucleic acid sequences expressed in uterine cancer tissues, and derived polypeptides, for treatment of uterine and endometrial cancer and identification of therapeutic agents
EP1236799A2 (en) Human nucleic acid sequences derived from breast tumor tissue
DE19820190A1 (en) Human pancreatic tumor nucleic acid sequences
DE19816395A1 (en) Human nucleic acid sequences from ovarian normal tissue
EP1234879B1 (en) Human nucleic acid sequence from prostate tumour tissue
EP1071777A2 (en) Human nucleic acid sequences of normal uterus tissue
DE19818620A1 (en) New polypeptides and their nucleic acids, useful for treatment of bladder tumor and identification of therapeutic agents
WO1999054447A2 (en) Human nucleic acid sequences of bladder tumour tissue
WO1999054448A2 (en) Human nucleic acid sequences, increased expression thereof in uterus myoma tissue
DE19813835A1 (en) Human nucleic acid sequences and protein products from normal breast tissue, useful for breast cancer therapy
WO2001011040A1 (en) Tumor-associated antigen (r11)
DE19811194A1 (en) New nucleic acid expressed at high level in normal prostatic tissue and encoded polypeptides, used to treat cancer and screen for therapeutic agents
DE60117788T2 (en) HUMAN WINGLESS-SIMILAR GENES
WO1999054446A2 (en) Human nucleic acid sequences which are overexpressed in normal pancreas tissue
US20030105315A1 (en) Human nucleic acid sequences from ovarian tumor tissue
DE60122684T2 (en) AKUTER NEURONAL-INDUCED CALCIUM BINDING PROTEIN-1 LIGANDS
US20040002471A1 (en) Human nucleic acid sequences which are overexpressed in normal pancreas tissue
WO2001040461A2 (en) Cdna sequence of two interactors fancip4 and fancip5 of the fanconi anaemia proteins of the complementation groups a and c
WO2000046244A1 (en) cDNA SEQUENCE OF AN INTERACTOR FANCIP1 OF THE FANCONI ANAEMIA PROTEIN OF COMPLEMENTATION GROUP A

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

WWE Wipo information: entry into national phase

Ref document number: 1999927686

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 09673400

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999927686

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1999927686

Country of ref document: EP