WO1999051213A3 - Utilisation de polyamines dans le traitement de symptomes dermatologiques - Google Patents

Utilisation de polyamines dans le traitement de symptomes dermatologiques Download PDF

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Publication number
WO1999051213A3
WO1999051213A3 PCT/CA1999/000285 CA9900285W WO9951213A3 WO 1999051213 A3 WO1999051213 A3 WO 1999051213A3 CA 9900285 W CA9900285 W CA 9900285W WO 9951213 A3 WO9951213 A3 WO 9951213A3
Authority
WO
WIPO (PCT)
Prior art keywords
epithelial tissue
disorders
polyamines
treatment
skin
Prior art date
Application number
PCT/CA1999/000285
Other languages
English (en)
Other versions
WO1999051213A2 (fr
Inventor
Theodore Toney Ilenchuk
William Stuart Maddin
Original Assignee
Theodore Toney Ilenchuk
William Stuart Maddin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theodore Toney Ilenchuk, William Stuart Maddin filed Critical Theodore Toney Ilenchuk
Priority to JP2000541984A priority Critical patent/JP2002510618A/ja
Priority to CA002326614A priority patent/CA2326614A1/fr
Priority to EP99913032A priority patent/EP1075254A2/fr
Priority to AU31333/99A priority patent/AU3133399A/en
Priority to MXPA00009705A priority patent/MXPA00009705A/es
Priority to IL13873299A priority patent/IL138732A0/xx
Publication of WO1999051213A2 publication Critical patent/WO1999051213A2/fr
Publication of WO1999051213A3 publication Critical patent/WO1999051213A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne l'utilisation de polyamines non toxiques dans le traitement palliatif de maladies et troubles chroniques du tissu épithélial. L'efficacité du traitement est mise en évidence par l'allégement des symptômes et troubles qui se manifestent au niveau d'un tissu épithélial tel que la peau, notamment le prurit, l'érythème, la douleur, la paresthésie et l'inconfort général, et sont consécutifs à l'administration topique de certaines polyamines. De tels symptômes se produisent à partir de conditions chroniques et/ou sont associés à ces conditions chroniques, telles que: (i) maladies cutanées du type dermatoses inflammatoires comprenant l'eczéma constitutionnel et de contact, notamment le xérosis comme la peau sèche et le prurit hivernal; (ii) les infections du tissu épithélial (par exemple le passage nasal, vulvaire ou anal) par des trichomonas ou champignons, les fissures anales, l'écoulement fistulaire, le suintement de plaies, ou le drainage de plaies chirurgicales; (iii) des maladies secondaires dans lesquelles le tissu épithélial présente des manifestations de l'atteinte initiale comme le SIDA, la varicelle et les troubles du métabolisme (par exemple le diabète, les anomalies fonctionnelles hépatiques et rénales et l'hématopoïèse); et (iv) des troubles provenant d'agressions directes du tissu épithélial, soit naturelles (tumeurs locales, hémorroïdes), soit consécutives à une intervention chirurgicale et accompagnant la formation de cicatrices ou la radiothérapie.
PCT/CA1999/000285 1998-04-03 1999-04-06 Utilisation de polyamines dans le traitement de symptomes dermatologiques WO1999051213A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2000541984A JP2002510618A (ja) 1998-04-03 1999-04-06 皮膚科症状の治療へのポリアミンの使用
CA002326614A CA2326614A1 (fr) 1998-04-03 1999-04-06 Utilisation de polyamines dans le traitement de symptomes dermatologiques
EP99913032A EP1075254A2 (fr) 1998-04-03 1999-04-06 Utilisation de polyamines dans le traitement de symptomes dermatologiques
AU31333/99A AU3133399A (en) 1998-04-03 1999-04-06 The use of polyamines in the treatment of dermatological symptoms
MXPA00009705A MXPA00009705A (es) 1998-04-03 1999-04-06 Uso de poliaminas en el tratamiento de sintomas dermatologicos.
IL13873299A IL138732A0 (en) 1998-04-03 1999-04-06 The use of polyamines in the treatment of dermatological symptoms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,234,196 1998-04-03
CA2234196 1998-04-03

Publications (2)

Publication Number Publication Date
WO1999051213A2 WO1999051213A2 (fr) 1999-10-14
WO1999051213A3 true WO1999051213A3 (fr) 1999-12-23

Family

ID=4162303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000285 WO1999051213A2 (fr) 1998-04-03 1999-04-06 Utilisation de polyamines dans le traitement de symptomes dermatologiques

Country Status (6)

Country Link
EP (1) EP1075254A2 (fr)
JP (1) JP2002510618A (fr)
AU (1) AU3133399A (fr)
IL (1) IL138732A0 (fr)
MX (1) MXPA00009705A (fr)
WO (1) WO1999051213A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003013245A1 (fr) 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines et analogues assurant une protection des cellules a l'occasion des chimiotherapies et radiotherapies anticancereuses
DE10219644A1 (de) * 2002-05-02 2003-11-20 Johannes Wohlrab Verwendung vom Agmatin zur topischen Applikation
US7652039B2 (en) 2002-05-17 2010-01-26 Sequella, Inc. Methods of use and compositions for the diagnosis and treatment of infectious disease
US7456222B2 (en) 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
US20040033986A1 (en) 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
WO2004073701A1 (fr) * 2003-02-19 2004-09-02 Kuniyasu Soda Inhibiteurs de lfa-1 et leur utilisation
ITMI20031570A1 (it) * 2003-07-31 2005-02-01 Giuliani Spa Composizione per uso dietetico, farmaceutico o cosmetico
WO2005034857A2 (fr) 2003-09-05 2005-04-21 Sequella, Inc. Procedes et compositions renfermant des diamines comme nouveaux produits therapeutiques antituberculeux
EP1765272B1 (fr) * 2004-06-14 2009-12-16 Unilever PLC Procede de diminution de la fabrication de sebum et du diametre des pores
US20060193814A1 (en) 2005-02-25 2006-08-31 Eduardo Ruvolo Compositions for the treatment of signs of aging
US8221046B2 (en) 2005-02-25 2012-07-17 Johnson & Johnson Consumer Companies, Inc. Compositions containing amines and use thereof
US8278359B2 (en) * 2005-02-25 2012-10-02 Johnson & Johnson Consumer Companies, Inc. Compositions containing amines and use thereof to treat acne or reduce the appearance of oil or pores on the skin
JP2008156330A (ja) * 2006-04-26 2008-07-10 Toyobo Co Ltd 賦活化剤及び抗老化剤
WO2008051080A1 (fr) * 2006-10-25 2008-05-02 Fridtjof Bjerke Crème pour l'épiderme comprenant une combinaison d'aloès officinal et de spermine
WO2008113364A2 (fr) * 2007-03-20 2008-09-25 Recepticon Aps Prévention de la néphrotoxicité iii
WO2009067799A1 (fr) * 2007-11-27 2009-06-04 The University Of Manitoba Utilisation d'un inhibiteur de transglutaminase pour le traitement de la peau
RS58287B1 (sr) * 2010-08-04 2019-03-29 Pierrel Pharma S R L Preparati koji sadrže supramolekulske komplekse polianjonskih polimera i spermidina za upotrebu u lečenju periodontuma i oštećenih oralnih tkiva
PL2898881T3 (pl) * 2010-08-04 2019-04-30 Pierrel Pharma S R L Kompozycja obejmująca kompleksy nadcząsteczkowe polimerów polianionowych i spermidyny do zastosowania w leczeniu przyzębia i tkanek jamy ustnej
KR101420267B1 (ko) 2011-10-10 2014-07-17 대구대학교 산학협력단 폴리아민을 유효성분으로 함유하는 염증의 예방 및 치료용 약학 조성물
ITMI20120363A1 (it) * 2012-03-08 2013-09-09 Carlo Angelo Ghisalberti Composizioni per il trattamento della vulvodinia
WO2018059214A1 (fr) 2016-09-29 2018-04-05 广州君赫生物科技有限公司 Composés affectant la synthèse de saicar, et applications
US20190298688A1 (en) * 2016-11-21 2019-10-03 Vivier Canada Inc. Putrescine slow-release topical formulations
WO2018126321A1 (fr) * 2017-01-06 2018-07-12 Vivier Canada Inc. Formulation de barrière topique à base de putrescine
AU2018253671B2 (en) 2017-04-20 2020-08-20 Geneheal Biotechnology Co., Ltd. Applications of spermine and its derivative in preparation of antitumor drug
EP3613731A4 (fr) * 2017-04-20 2021-01-13 Geneheal Biotechnology Co., Ltd. Applications de la spermidine et de son dérivé
AU2019263969B2 (en) 2018-05-04 2024-08-01 Orphalan Crystalline form of triethylenetetramine tetrahydrochloride and its pharmaceutical use
WO2019232644A1 (fr) * 2018-06-08 2019-12-12 Vivier Canada Inc. Formulation de putrescine saline topique stérile et ses utilisations
JP7411983B2 (ja) * 2019-08-27 2024-01-12 国立研究開発法人物質・材料研究機構 抗炎症剤、プレフィルドシリンジ、及び、キット
JP2021075495A (ja) * 2019-11-12 2021-05-20 東洋紡株式会社 抗炎症剤
WO2023182342A1 (fr) * 2022-03-22 2023-09-28 佐藤製薬株式会社 Agent de renforcement du muscle squelettique

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061775A (en) * 1975-09-02 1977-12-06 Merck & Co., Inc. Polyamine compounds as antibacterial agents
US4112067A (en) * 1977-02-17 1978-09-05 The Dow Chemical Company Method for treating poison ivy dermatitis using certain polyamines and polytertiaryamides
US4507321A (en) * 1982-02-17 1985-03-26 The Research Foundation Of State University Of New York Epithelial cell growth regulating composition containing polyamines and a method of using same
EP0378146A2 (fr) * 1989-01-10 1990-07-18 Merrell Pharmaceuticals Inc. Dérivés de polyamine comme agents antinéoplastiques
WO1993018760A1 (fr) * 1992-03-23 1993-09-30 University Of Manitoba Utilisation d'un inhibiteur de transglutaminase pour le traitement de tissus cicatriciels
WO1996023490A1 (fr) * 1995-02-03 1996-08-08 Cosmederm Technologies Formulations et procedes permettant de reduire l'irritation cutanee
EP0884046A1 (fr) * 1997-05-30 1998-12-16 Sara Lee/DE N.V. Composition cosmétique à propriétés photoprotectrices

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061775A (en) * 1975-09-02 1977-12-06 Merck & Co., Inc. Polyamine compounds as antibacterial agents
US4112067A (en) * 1977-02-17 1978-09-05 The Dow Chemical Company Method for treating poison ivy dermatitis using certain polyamines and polytertiaryamides
US4507321A (en) * 1982-02-17 1985-03-26 The Research Foundation Of State University Of New York Epithelial cell growth regulating composition containing polyamines and a method of using same
EP0378146A2 (fr) * 1989-01-10 1990-07-18 Merrell Pharmaceuticals Inc. Dérivés de polyamine comme agents antinéoplastiques
WO1993018760A1 (fr) * 1992-03-23 1993-09-30 University Of Manitoba Utilisation d'un inhibiteur de transglutaminase pour le traitement de tissus cicatriciels
WO1996023490A1 (fr) * 1995-02-03 1996-08-08 Cosmederm Technologies Formulations et procedes permettant de reduire l'irritation cutanee
EP0884046A1 (fr) * 1997-05-30 1998-12-16 Sara Lee/DE N.V. Composition cosmétique à propriétés photoprotectrices

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DOLYNCHUK K N ET AL: "TOPICAL PUTRESCINE (FIBROSTAT) IN TREATMENT OF HYPERTROPHIC SCARS: PHASE II STUDY", PLASTIC AND RECONSTRUCTIVE SURGERY, vol. 97, no. 1, 1 January 1996 (1996-01-01), pages 117 - 123, XP000609865, ISSN: 0032-1052 *

Also Published As

Publication number Publication date
EP1075254A2 (fr) 2001-02-14
AU3133399A (en) 1999-10-25
MXPA00009705A (es) 2003-07-14
WO1999051213A2 (fr) 1999-10-14
IL138732A0 (en) 2001-10-31
JP2002510618A (ja) 2002-04-09

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