WO1999049015A3 - Cellules souches d'origine cardiaque - Google Patents

Cellules souches d'origine cardiaque Download PDF

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Publication number
WO1999049015A3
WO1999049015A3 PCT/US1999/006356 US9906356W WO9949015A3 WO 1999049015 A3 WO1999049015 A3 WO 1999049015A3 US 9906356 W US9906356 W US 9906356W WO 9949015 A3 WO9949015 A3 WO 9949015A3
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WO
WIPO (PCT)
Prior art keywords
stem cells
cells
cardiac
derived stem
cardiocytes
Prior art date
Application number
PCT/US1999/006356
Other languages
English (en)
Other versions
WO1999049015A2 (fr
Inventor
Theresa A Deisher
Birgit Hanson
Emma E Moore
Tamara L Robertson
Deborah L Thompson
Karen D Lum
Original Assignee
Zymogenetics Inc
Theresa A Deisher
Birgit Hanson
Emma E Moore
Tamara L Robertson
Deborah L Thompson
Karen D Lum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Theresa A Deisher, Birgit Hanson, Emma E Moore, Tamara L Robertson, Deborah L Thompson, Karen D Lum filed Critical Zymogenetics Inc
Priority to CA002324350A priority Critical patent/CA2324350A1/fr
Priority to AU31124/99A priority patent/AU3112499A/en
Priority to EP99912853A priority patent/EP1064356A2/fr
Priority to JP2000537976A priority patent/JP2002507407A/ja
Publication of WO1999049015A2 publication Critical patent/WO1999049015A2/fr
Publication of WO1999049015A3 publication Critical patent/WO1999049015A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des cellules souches hématopoïétiques d'origine cardiaque, qui une fois soumises à la prolifération et à la différentiation, peuvent produire divers types de cellules, notamment des cardiocytes, des fibroblastes, des cellules musculaires lisses, des cellules musculaires squelettiques, des kératinocytes, des ostéoblastes, et des chondrocytes. Les cellules de cette invention peuvent être utilisées dans différentes méthodes permettant de traiter des patients souffrant d'un tissu cardiaque nécrotique, ces cellules souches subissant la prolifération et la différentiation de manière à produire des cardiocytes destinés à remplacer ledit tissu nécrotique. Ces cellules peuvent également être utilisées pour détecter des composés qui présentent une activité favorisant la prolifération et/ou la différentiation de cellules souches d'origine cardiaque.
PCT/US1999/006356 1998-03-23 1999-03-23 Cellules souches d'origine cardiaque WO1999049015A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002324350A CA2324350A1 (fr) 1998-03-23 1999-03-23 Cellules souches d'origine cardiaque
AU31124/99A AU3112499A (en) 1998-03-23 1999-03-23 Cardiac-derived stem cells
EP99912853A EP1064356A2 (fr) 1998-03-23 1999-03-23 Cellules souches d'origine cardiaque
JP2000537976A JP2002507407A (ja) 1998-03-23 1999-03-23 心臓由来幹細胞

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7913298P 1998-03-23 1998-03-23
US60/079,132 1998-03-23

Publications (2)

Publication Number Publication Date
WO1999049015A2 WO1999049015A2 (fr) 1999-09-30
WO1999049015A3 true WO1999049015A3 (fr) 1999-12-16

Family

ID=22148638

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/006356 WO1999049015A2 (fr) 1998-03-23 1999-03-23 Cellules souches d'origine cardiaque

Country Status (5)

Country Link
EP (1) EP1064356A2 (fr)
JP (1) JP2002507407A (fr)
AU (1) AU3112499A (fr)
CA (1) CA2324350A1 (fr)
WO (1) WO1999049015A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846396B2 (en) 2003-07-31 2014-09-30 Universita Degli Studi Di Roma “La Sapienza” Methods for the isolation of cardiac stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells

Families Citing this family (50)

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US7514074B2 (en) 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
JP2002521493A (ja) * 1998-07-31 2002-07-16 ジェンザイム コーポレーション 間葉幹細胞移植による心機能の改善
EP1894997A1 (fr) * 1998-07-31 2008-03-05 Genzyme Corporation Amélioration de la fonction cardiaque par transplantation de cellules souches mésenchymateuses
FR2810045B1 (fr) * 2000-06-07 2004-09-03 Assist Publ Hopitaux De Paris Procede d'obtention de population cellulaires caracterisees d'origine musculaire et utilisations
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US20020061587A1 (en) 2000-07-31 2002-05-23 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
ES2549161T3 (es) * 2001-02-14 2015-10-23 Anthrogenesis Corporation Placenta post-parto de mamífero, su uso y células madre placentarias de la misma
DE60231035D1 (de) * 2001-04-24 2009-03-19 Ajinomoto Kk Stammzellen und verfahren zu deren trennung
WO2002086104A1 (fr) * 2001-04-24 2002-10-31 Dolores Baksh Populations de cellules souches, leur expansion, et production de tissus et d'especes de cellules non hematopoietiques a partir desdites cellules souches
JP2003018984A (ja) * 2001-07-06 2003-01-21 Mitsubishi Chemicals Corp 多分化能を有する細胞の製造法
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
EP1412479A4 (fr) 2001-07-12 2004-07-28 Geron Corp Cellules de la lignee des cardiomyocytes produites a partir de cellules souches humaines pluripotentielles
EP1435977A4 (fr) 2001-09-19 2005-06-08 Ford Henry Health System Transplantation cardiaque de cellules souches pour le traitement de l'insuffisance cardiaque
US20040247575A1 (en) * 2003-06-03 2004-12-09 Caplice Noel M. Smooth muscle progenitor cells
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
CN101437938B (zh) * 2004-11-08 2015-05-13 约翰霍普金斯大学 心脏干细胞
EP2236153A3 (fr) * 2005-01-25 2012-08-22 Five Prime Therapeutics, Inc. Composés et méthodes pour le traitement de maladies cardiaques
GB2441718B (en) 2005-06-22 2010-10-06 Geron Corp Differentiation of human embryonic stem cells to cardiomyocyte-lineage cells
EP1790350A1 (fr) * 2005-11-24 2007-05-30 Interstitial Therapeutics Utilisation d'une composition contenant de la kératinocyte pour le traitement de la restenose
WO2007093412A2 (fr) 2006-02-16 2007-08-23 Fondazione Centro San Raffaele Del Monte Tabor Periangioblastes du muscle squelettique et mesangioblastes du muscle cardiaque, procede d'isolation et leurs utilisations
JP5395672B2 (ja) * 2006-11-28 2014-01-22 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 心臓病理学を処置するための筋肉由来の細胞およびその作製法および使用法
WO2008081457A2 (fr) * 2007-01-04 2008-07-10 Ramot At Tel Aviv University Ltd. Méthodes d'isolation de cellules souches cardiaques, constitution de banques de cellules souches et utilisations de celles-ci
DE102007008650B4 (de) 2007-02-20 2012-06-06 Charité - Universitätsmedizin Berlin Zellen zur Therapie des Herzens
CA2743698A1 (fr) 2007-11-30 2009-06-11 New York Medical College Compositions comprenant des cellules progenitrices vasculaires et myocytaires et procedes permettant de les utiliser
CA2743682A1 (fr) 2007-11-30 2009-06-11 New York Medical College Procedes permettant de reduire le rejet de greffon et l'arteriosclerose acceleree du greffon cardiaque par implantation de cellules souches autologues
US8512696B2 (en) 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
CN105400735A (zh) 2008-01-30 2016-03-16 阿斯特利亚斯生物治疗股份公司 用于培养干细胞衍生的心肌细胞的合成表面
CN102712897B (zh) * 2009-07-09 2018-07-10 詹森生物科技公司 心脏组织来源细胞
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
WO2012094321A1 (fr) 2011-01-03 2012-07-12 Avm Biotechnology, Llc Production personnalisée d'agents biologiques et procédé de reprogrammation de cellules somatiques
EP2861238A4 (fr) 2012-06-05 2016-03-16 Capricor Inc Procédés optimisés pour générer des cellules souches cardiaques à partir de tissu cardiaque et leur utilisation dans une thérapie cardiaque
WO2014028493A2 (fr) 2012-08-13 2014-02-20 Cedars-Sinai Medical Center Exosomes et acides micro-ribonucléiques pour la régénération de tissus
US9617506B2 (en) 2013-11-16 2017-04-11 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3613841B1 (fr) 2014-03-25 2022-04-20 Terumo BCT, Inc. Remplacement passif de supports
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
CA2962444C (fr) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cellules derivees de la cardiosphere et exosomes secretes par ces cellules dans le traitement d'une dystrophie musculaire
WO2017004592A1 (fr) 2015-07-02 2017-01-05 Terumo Bct, Inc. Croissance cellulaire à l'aide de stimuli mécaniques
WO2017123662A1 (fr) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cellules dérivées de cardiosphères et exosomes sécrétés par ces cellules dans le traitement d'une insuffisance cardiaque à fraction d'éjection préservée
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
WO2018026766A1 (fr) 2016-08-01 2018-02-08 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions et procédés pour traiter une affection cardiaque
WO2018057542A1 (fr) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cellules dérivées de cardiosphères et leurs vésicules extracellulaires pour retarder ou inverser le vieillissement et des troubles liés à l'âge
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
AU2018255346B2 (en) 2017-04-19 2024-05-02 Capricor, Inc. Methods and compositions for treating skeletal muscular dystrophy
WO2019126068A1 (fr) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Vésicules extracellulaires modifiées pour une administration tissulaire améliorée

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846396B2 (en) 2003-07-31 2014-09-30 Universita Degli Studi Di Roma “La Sapienza” Methods for the isolation of cardiac stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells

Also Published As

Publication number Publication date
AU3112499A (en) 1999-10-18
EP1064356A2 (fr) 2001-01-03
JP2002507407A (ja) 2002-03-12
WO1999049015A2 (fr) 1999-09-30
CA2324350A1 (fr) 1999-09-30

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