WO1999042192A8 - Gepackte kapillaren, insbesondere für die enantiomerentrennung - Google Patents

Gepackte kapillaren, insbesondere für die enantiomerentrennung

Info

Publication number
WO1999042192A8
WO1999042192A8 PCT/EP1999/000844 EP9900844W WO9942192A8 WO 1999042192 A8 WO1999042192 A8 WO 1999042192A8 EP 9900844 W EP9900844 W EP 9900844W WO 9942192 A8 WO9942192 A8 WO 9942192A8
Authority
WO
WIPO (PCT)
Prior art keywords
capillaries
enantiomeric separation
packed
relates
sorbents
Prior art date
Application number
PCT/EP1999/000844
Other languages
English (en)
French (fr)
Other versions
WO1999042192A1 (de
Inventor
Gottfried Blaschke
Bezhan Chankvetadze
Michael Schulte
Marco Girod
Kerstin Krause
Original Assignee
Merck Patent Gmbh
Gottfried Blaschke
Bezhan Chankvetadze
Michael Schulte
Marco Girod
Kerstin Krause
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Gottfried Blaschke, Bezhan Chankvetadze, Michael Schulte, Marco Girod, Kerstin Krause filed Critical Merck Patent Gmbh
Priority to EP99914449A priority Critical patent/EP1054716A1/de
Priority to JP2000532197A priority patent/JP2002503823A/ja
Publication of WO1999042192A1 publication Critical patent/WO1999042192A1/de
Publication of WO1999042192A8 publication Critical patent/WO1999042192A8/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6073—Construction of the column body in open tubular form
    • G01N30/6078—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3833—Chiral chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3861—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36 using an external stimulus
    • B01D15/3885—Using electrical or magnetic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • G01N2030/562—Packing methods or coating methods packing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body

Abstract

Es werden mit partikulären Sorbentien gepackte Kapillaren offenbart, die über die gesamte Länge einen konstanten Innendurchmesser aufweisen, wobei das Sorbensbett durch verfestigte Bereiche begrenzt ist, die durch Hitzebehandlung erzeugt werden. Insbesondere werden Kapillaren offenbart, die mit einem chiralen Sorbens gefüllt sind. Weiterhin werden Verfahren zur Herstellung dieser Kapillaren, sowie die Verwendung dieser Kapillaren zur Stofftrennung offenbart.
PCT/EP1999/000844 1998-02-20 1999-02-09 Gepackte kapillaren, insbesondere für die enantiomerentrennung WO1999042192A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99914449A EP1054716A1 (de) 1998-02-20 1999-02-09 Gepackte kapillaren, insbesondere für die enantiomerentrennung
JP2000532197A JP2002503823A (ja) 1998-02-20 1999-02-09 特にエナンチオマー分離用の充填細管

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19807063A DE19807063A1 (de) 1998-02-20 1998-02-20 Gepackte Kapillaren, insbesondere für die Enantiomerentrennung
DE19807063.2 1998-02-20

Publications (2)

Publication Number Publication Date
WO1999042192A1 WO1999042192A1 (de) 1999-08-26
WO1999042192A8 true WO1999042192A8 (de) 1999-10-14

Family

ID=7858335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/000844 WO1999042192A1 (de) 1998-02-20 1999-02-09 Gepackte kapillaren, insbesondere für die enantiomerentrennung

Country Status (4)

Country Link
EP (1) EP1054716A1 (de)
JP (1) JP2002503823A (de)
DE (1) DE19807063A1 (de)
WO (1) WO1999042192A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10042451A1 (de) * 2000-08-29 2002-03-14 Studiengesellschaft Kohle Mbh High-Throughput Verfahren zur Bestimmung der Enantiomereneinheit von chiralen Verbindungen
JP2007268341A (ja) * 2006-03-30 2007-10-18 National Institute Of Advanced Industrial & Technology キャリア流体中から目的物質を吸着するための装置
KR101975686B1 (ko) 2014-10-27 2019-05-07 에프. 호프만-라 로슈 아게 2 차원 rplc-sfc 크로마토그래피를 위한 시스템들 및 방법들
CN115518415A (zh) * 2022-10-08 2022-12-27 沈阳化工大学 一种分离泮托拉唑消旋体的毛细管电色谱方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3706890A1 (de) * 1987-03-04 1988-09-15 Bayer Ag Optisch aktive (meth)acrylamide, verfahren zu ihrer herstellung und ihre verwendung zur racematspaltung
EP0459241B1 (de) * 1990-05-29 1994-10-26 Waters Investments Limited Verfahren und Vorrichtung zum Durchführen der Kapillarelektroforese
DE69630109T2 (de) * 1996-05-20 2004-04-08 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Kapillarsäule für chromatographische Trennungen und Verfahren zur Herstellung

Also Published As

Publication number Publication date
JP2002503823A (ja) 2002-02-05
WO1999042192A1 (de) 1999-08-26
EP1054716A1 (de) 2000-11-29
DE19807063A1 (de) 1999-08-26

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