WO1999035497A2 - Dispositif pour tester des liquides - Google Patents

Dispositif pour tester des liquides Download PDF

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Publication number
WO1999035497A2
WO1999035497A2 PCT/GB1999/000052 GB9900052W WO9935497A2 WO 1999035497 A2 WO1999035497 A2 WO 1999035497A2 GB 9900052 W GB9900052 W GB 9900052W WO 9935497 A2 WO9935497 A2 WO 9935497A2
Authority
WO
WIPO (PCT)
Prior art keywords
location
base plate
capillary
cover plate
liquid
Prior art date
Application number
PCT/GB1999/000052
Other languages
English (en)
Other versions
WO1999035497A3 (fr
Inventor
Philip Rees Mico
David John Groves
Original Assignee
Bio-Diagnostics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio-Diagnostics Limited filed Critical Bio-Diagnostics Limited
Priority to AU19769/99A priority Critical patent/AU1976999A/en
Priority to BR9906844-3A priority patent/BR9906844A/pt
Priority to JP2000527828A priority patent/JP2002501173A/ja
Priority to EP99900552A priority patent/EP1046035A2/fr
Publication of WO1999035497A2 publication Critical patent/WO1999035497A2/fr
Publication of WO1999035497A3 publication Critical patent/WO1999035497A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/08—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/114—Single butt joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/302—Particular design of joint configurations the area to be joined comprising melt initiators
    • B29C66/3022—Particular design of joint configurations the area to be joined comprising melt initiators said melt initiators being integral with at least one of the parts to be joined
    • B29C66/30223—Particular design of joint configurations the area to be joined comprising melt initiators said melt initiators being integral with at least one of the parts to be joined said melt initiators being rib-like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/32—Measures for keeping the burr form under control; Avoiding burr formation; Shaping the burr
    • B29C66/322—Providing cavities in the joined article to collect the burr
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5346—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
    • B29C66/53461—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat joining substantially flat covers and/or substantially flat bottoms to open ends of container bodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/739—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/7392—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles

Definitions

  • the invention relates to a device for testing liquids and in particular to a testing
  • blood group can be determined by applying
  • Devices for this purpose generally comprise a
  • tested may be applied, an indicating location spaced from the receiving location, a
  • reagent and agglutination may or may not occur depending on
  • the presence of the substance being tested for can be determined by whether or not the fluid reaches the indicating location.
  • European Patent No. 0456699 discloses a device of this general type for the
  • a covered panel is formed with a hollow
  • the sample will not be able to flow along the whole length of the associated
  • the device contains reagents causing agglutination with the common blood groups, the device as a
  • whole may be arranged to indicate the blood group of a single sample placed in the
  • the present invention sets out to provide various improvements to testing
  • agglutination reliably prevents a blood sample flowing to the indicating location.
  • agglutination is not sufficient to prevent some of the
  • readings may be given by the device. According to one aspect of the invention,
  • the device for testing the presence of a substance in a liquid, the device including a sample
  • said pathway including a capillary passage in which there is at least
  • the localised region of reduced cross-section tends to inhibit the flow of liquid
  • the capillary passage may include a plurality of said localised regions of reduced
  • Each capillary passage may be substantially triangular in cross-
  • Said localised region of reduced cross-section may be provided by one or more
  • baffles extending partly across the capillary passage. Each baffle may extend across a
  • each d localised region of reduced cross section comprises
  • baffle which extends p.artly across its associated passage and has an upper surface
  • Said gap may increase in area in the direction of fluid
  • the cover plate may, for example, be secured in position by
  • the cross-sectional area of the capillary passages may need to be
  • welding or an adhesive may cause variation in the cross-sectional area of the capillary
  • the device including a sample receiving
  • the cover plate may be bonded to the upstanding ribs by thermal or ultrasonic welding or by an adhesive. Ultrasonic welding is preferred since the heat generated in
  • thermal welding may affect the reagents located in the device and, similarly, a chemical
  • adhesive may also have some adverse chemical effect on the reagents.
  • an overflow groove is formed in the base plate alongside each
  • overflow grooves Preferably overflow grooves
  • the capillary groove may be generally V-shaped in cross-section, .and each
  • overflow groove may also be generally V-shaped in cross-section.
  • each rib may be of inverted V-shape, opposites of each rib forming one side of each of the
  • a main undersurface of the cover plate is in abutting contact with
  • said location may be at least partly surrounded by an
  • groove is preferably formed in the base plate outside and adjacent said upstanding
  • peripheral rib
  • capillary passages lead from the indicating chambers to apertures in a side edge of the device which are open to the atmosphere.
  • the device including a sample receiving
  • a reservoir in the device By providing a reservoir in the device for
  • location preferably comprises a plurality of reservoirs with which the pathways
  • the device may comprise a base plate formed with recesses defining said locations and said pathway, and a cover plate which is secured in
  • each dumping reservoir may comprise a recess formed in the base plate and covered by
  • each said recess may be at least partly surrounded
  • groove is preferably formed in the base plate outside and adjacent said upstanding
  • peripheral rib
  • Said portion of the cover plate over the or each recess is preferably formed with
  • a removable cover such as a self-
  • adhesive label may be provided to close said aperture.
  • the cover plate may also include an aperture to provide access to the recess
  • a removable cover such as a self-adhesive label
  • the fluid being tested are located in chambers from which capillary passages lead to the
  • reagent in the chamber may be less than complete.
  • the device including a sample receiving
  • pathway a reagent which reacts to the presence of the aforesaid substance, said pathway
  • reagent is dispersed along
  • the internal surface of the capillary passage may be treated to enhance the
  • the treatment may be mechanical and/or
  • the surface of the passage may be roughened, or it may be
  • the pathways lead to different respective indicating
  • pathways are provided said pathways are preferably all of
  • Figure 1 is a plan view of the base plate of a testing device according to the
  • Figure 2 is a section through one of the capillary grooves of the base plate, prior
  • Figure 3 is a simil-ar view to Figure 2, but after fitting of the cover plate to the
  • Figure 4 is a section on the line 4-4 of Figure 1, after fitting of the cover plate,
  • Figure 5 is a section on the line 5-5 of Figure 1, after fitting of the cover plate,
  • Figure 6 is a section on the line 6-6 of Figure 1, after fitting of the cover plate
  • Figure 7 is a longitudinal section through a capillary groove, showing the baffle
  • Figure 8 is a similar view to Figure 6, showing -an alternative form of baffle, and
  • Figure 9 is a plan view of a portion of a capillary groove, showing one
  • the device comprises a rectangular base plate 10 which
  • a suitable plastics material for example it may be injection
  • part of the recess 21 is generally in the shape of a cross and part of the recess 21 is generally in the shape of a
  • a cover plate 24 (see Figure 3) is secured over the face of the base plate 10 so
  • the cover plate is formed with
  • apertures 26 are formed in the cover plate over each dumping recess 23 to serve as air
  • a self-adhesive label (indicated at 27) is adhered over the cover plate 24 and a
  • removable portion 27A of the label is positioned over the apertures 25 and 26 to prevent
  • portion 27A may be replaced after the device has been used, the device thereby being
  • the dumping recesses may contain neutralising agents to render harmless any
  • the capillary grooves 22 could lead to a single common dumping recess having
  • the cover plate 24 could be slightly smaller in size than the base plate 10 and
  • the device is designed for determining blood group.
  • capill-ary pas.sage 16 is uncoated.
  • passages may be pre-treated to allow the antibodies to bind to the surfaces of the
  • passages may be pre-coated with appropriate proteins,
  • passages may also be roughened.
  • the cover plate 24 is transparent and the label 27 applied to its outer surface has
  • recess 21 is shaped to reveal only the tick-shaped part of that recess). The portion of
  • transparent areas are white or some other non-red colour.
  • the label may also bear other
  • the label may
  • the panels 29, 30 and other information may be printed directly on the transparent cover plate 24 itself.
  • the label portion 27A is removed and a blood sample is introduced into
  • the agglutination causes the flow of blood in that passage
  • dumping recess 23 is of such a size that in normal use the recess will be big enough to
  • the capillaries 12, 13, 14 and 15 are coated with anti-A, anti-B, anti-AB and
  • the capillary passage 16 and tick-shaped indicating recess 21 act as a control.
  • portion of the recess should therefore turn red, indicating that the device is operating
  • agglutinated blood In the present case two such regions of reduced cross-section .are
  • each capillary passage as indicated, for example, at 31 and 32 in capillary
  • passage such as passage 12
  • baffle 33 which
  • FIG 8 shows an alternative arrangement where the baffle 37 extends only
  • baffles 37 spaced apart longitudinally of the capillary passage
  • baffle arrangements may be employed and different numbers and
  • baffles may be in the form of
  • passage 12 itself may be necked so as to reduce in cross-section at a specific location.
  • the effective cross-section may be locally reduced by the use of
  • each capillary which is coated with a chemical
  • capillaries should be of essentially the same length.
  • cover plate 24 may be secured to the base plate 10
  • each capillary groove such as groove 12, is generally V-
  • the melting material can flow outwardly into the overflow grooves as well
  • the depth of the gap is likely to vary, both between different
  • sectional area of the capillary passage also varies. This will affect the flow and may lead
  • capillary groove is substantially consistent and can therefore be allowed for when
  • each of the indicating recesses 17, 18, 19, 20 and 21 (as shown in
  • simile devices may be used for carrying out other diagnostic tests.
  • the reaction in the blood group test is an
  • the invention could, for example, be used in tests for the presence of infectious diseases
  • each reaction chamber containing one or more reagents
  • the ornamental design may be suitable to create agglutination, and hence the visualisation of a symbol.
  • reagents in such further reaction chambers may be instead of reagents located in the
  • capillary passages themselves, or in addition to such reagents. Additional enlarged
  • chambers may be provided for reaction transfer or reactions alone.
  • the lengths of the pathways may be required to vary if, for
  • the arrival of blood at an indicating recess may be employed. For example, the arrival of blood at an indicating recess
  • latex particles of different colours may be used, as well as
  • the indicating recesses may be treated with an appropriate chemical, either before or after use, to "fix" the image provided by the flow
  • cover plate 24 to be formed with grooves and/or recesses which cooperate with grooves
  • the device may be formed solely by grooves or recesses in the underside of the cover
  • the pathways may be in the

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  • Health & Medical Sciences (AREA)
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Abstract

L'invention concerne un dispositif permettant de détecter la présence d'une substance dans un liquide. Ce dispositif comprend un emplacement destiné à recevoir un échantillon et des passage capillaires par lesquels s'écoule le flux de liquide pour aller dudit emplacement destiné à recevoir l'échantillon vers une pluralité d'emplacements indicateurs différents, lesdits passages contenant des réactifs pouvant réagir avec la substance à détecter lorsqu'elle est présente. Le dispositif comprend une plaque de base dans laquelle sont formés des rainures et des évidements, ainsi qu'une plaque de couverture qui est soudée sur la plaque de base de façon à recouvrir les rainures et les évidements, formant ainsi les passages capillaires et d'autres emplacements. La plaque de base comporte des nervures verticales et des rainures à débordement qui s'étendent le long des côtés de chaque rainure capillaire et autour des autres évidements, de telle sorte que, lorsque la plaque de couverture est soudée à la plaque de base, la matière en fusion peut s'écouler dans les rainures à débordement, ce qui permet à la plaque de couverture de venir fermement en contact avec la plaque de base. Chaque passage capillaire comprend des chicanes qui servent à réduire le flux de liquide qui le traverse et ainsi à augmenter l'effet d'agglutination. Les passages conduisent, dans le dispositif, à des réservoirs individuels de déversement.
PCT/GB1999/000052 1998-01-08 1999-01-07 Dispositif pour tester des liquides WO1999035497A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU19769/99A AU1976999A (en) 1998-01-08 1999-01-07 A device for testing liquids
BR9906844-3A BR9906844A (pt) 1998-01-08 1999-01-07 Dispositivo para testar a presença de uma substância em um lìquido
JP2000527828A JP2002501173A (ja) 1998-01-08 1999-01-07 液体試験装置
EP99900552A EP1046035A2 (fr) 1998-01-08 1999-01-07 Dispositif pour tester des liquides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9800263.7 1998-01-08
GBGB9800263.7A GB9800263D0 (en) 1998-01-08 1998-01-08 A device for testing liquids

Publications (2)

Publication Number Publication Date
WO1999035497A2 true WO1999035497A2 (fr) 1999-07-15
WO1999035497A3 WO1999035497A3 (fr) 1999-10-28

Family

ID=10824926

Family Applications (1)

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PCT/GB1999/000052 WO1999035497A2 (fr) 1998-01-08 1999-01-07 Dispositif pour tester des liquides

Country Status (6)

Country Link
EP (1) EP1046035A2 (fr)
JP (1) JP2002501173A (fr)
AU (1) AU1976999A (fr)
BR (1) BR9906844A (fr)
GB (1) GB9800263D0 (fr)
WO (1) WO1999035497A2 (fr)

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KR100520896B1 (ko) * 2002-05-30 2005-10-12 주식회사 디지탈바이오테크놀러지 혈액형 검사방법 및 검사장치
WO2006046054A1 (fr) * 2004-10-28 2006-05-04 Platform Diagnostics Limited Systeme d'essai
WO2006047831A1 (fr) * 2004-11-03 2006-05-11 Agen Biomedical Limited Dispositif et procede de detection
EP2179794A1 (fr) * 2008-10-24 2010-04-28 Honeywell International Inc. Préparation de surface pour un canal microfluidique
US7850917B2 (en) 2008-03-11 2010-12-14 Ortho-Clinical Diagnostics, Inc. Particle agglutination in a tip
US8283182B2 (en) 2003-03-18 2012-10-09 Platform Diagnostics Limited Agglutination based sample testing device
EP2889121A1 (fr) * 2013-12-26 2015-07-01 Fujifilm Corporation Procédé de connexion et procédé de fabrication d'un dispositif à microcanaux
US9201065B2 (en) 2005-11-12 2015-12-01 Platform Diagnostics Limited Agglutination assay
EP1531003B1 (fr) * 2003-11-07 2016-08-17 Boehringer Ingelheim microParts GmbH Dispositif pour separer la phase liquides d'une suspension
WO2018095829A1 (fr) * 2016-11-23 2018-05-31 Koninklijke Philips N.V. Soudage par ultrasons d'un dispositif microfluidique
US10018640B2 (en) 2013-11-13 2018-07-10 Becton, Dickinson And Company Optical imaging system and methods for using the same
US10073093B2 (en) 2013-11-06 2018-09-11 Becton, Dickinson And Company Microfluidic devices, and methods of making and using the same

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CN101300470B (zh) * 2003-10-29 2011-01-26 Mec戴内米克公司 用于进行化验的微机械系统和方法
DE102004005193B4 (de) * 2004-02-02 2006-08-24 Medion Diagnostics Gmbh Vorrichtung zur Separation einzelner Partikel von Partikel-Agglutinationen
AU2006217719A1 (en) * 2005-02-25 2006-08-31 Alere Switzerland Gmbh Fluidic gating device
WO2014049704A1 (fr) * 2012-09-26 2014-04-03 テルモ株式会社 Embout de mesure
AU2014205215B2 (en) * 2013-01-11 2019-02-14 Becton, Dickinson And Company Low-cost point-of-care assay device

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WO1988001374A1 (fr) * 1986-08-19 1988-02-25 Angenics Inc. Procede et appareil de reaction d'agglutination
EP0306336A2 (fr) * 1987-09-04 1989-03-08 Syntex (U.S.A.) Inc. Dispositif d'essai à multiples orifices
EP0321736A2 (fr) * 1987-12-23 1989-06-28 Abbott Laboratories Dispositif pour réaction d'agglutination
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WO1992008974A1 (fr) * 1990-11-16 1992-05-29 Abbott Laboratories Dispositif de reaction d'agglutination ameliore utilisant une matiere poreuse selectivement impregnee
WO1992014132A1 (fr) * 1991-02-08 1992-08-20 Pharmacia Biosensor Ab Procede de production d'un moyen d'etancheite dans une structure microfluidique, et structure microfluidique le comportant
US5215713A (en) * 1990-07-17 1993-06-01 Boehringer Mannheim Gmbh Test kit for determining an analyte in a pasty sample
US5698406A (en) * 1993-02-18 1997-12-16 Biocircuits Corporation Disposable device in diagnostic assays

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EP0483117A2 (fr) * 1985-08-05 1992-04-29 Boehringer Mannheim Corporation Dispositif d'écoulement capillaire
EP0215419A2 (fr) * 1985-09-18 1987-03-25 Miles Inc. Appareil de dosage de volumes à vide capillaire pour l'application d'un échantillon liquide sur une surface réactive
WO1988001374A1 (fr) * 1986-08-19 1988-02-25 Angenics Inc. Procede et appareil de reaction d'agglutination
US5104811A (en) * 1986-12-19 1992-04-14 Boehringer Mannheim Gmbh Test carrier and method for the analytical determination of components of body fluids
EP0306336A2 (fr) * 1987-09-04 1989-03-08 Syntex (U.S.A.) Inc. Dispositif d'essai à multiples orifices
EP0321736A2 (fr) * 1987-12-23 1989-06-28 Abbott Laboratories Dispositif pour réaction d'agglutination
WO1990009596A1 (fr) * 1989-02-10 1990-08-23 David Roger Vale Controle de liquides
US5215713A (en) * 1990-07-17 1993-06-01 Boehringer Mannheim Gmbh Test kit for determining an analyte in a pasty sample
WO1992008974A1 (fr) * 1990-11-16 1992-05-29 Abbott Laboratories Dispositif de reaction d'agglutination ameliore utilisant une matiere poreuse selectivement impregnee
WO1992014132A1 (fr) * 1991-02-08 1992-08-20 Pharmacia Biosensor Ab Procede de production d'un moyen d'etancheite dans une structure microfluidique, et structure microfluidique le comportant
US5698406A (en) * 1993-02-18 1997-12-16 Biocircuits Corporation Disposable device in diagnostic assays

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100520896B1 (ko) * 2002-05-30 2005-10-12 주식회사 디지탈바이오테크놀러지 혈액형 검사방법 및 검사장치
US8691593B2 (en) 2003-03-18 2014-04-08 Platform Diagnositics Limited Agglutination based sample testing device
US8283182B2 (en) 2003-03-18 2012-10-09 Platform Diagnostics Limited Agglutination based sample testing device
EP2698632A1 (fr) 2003-03-18 2014-02-19 Platform Diagnostics Limited Dispositif d'analyse d'echantillon base sur l'agglutination
EP1531003B1 (fr) * 2003-11-07 2016-08-17 Boehringer Ingelheim microParts GmbH Dispositif pour separer la phase liquides d'une suspension
US8685715B2 (en) 2004-10-28 2014-04-01 Platform Diagnostics Limited Agglutination reaction system
WO2006046054A1 (fr) * 2004-10-28 2006-05-04 Platform Diagnostics Limited Systeme d'essai
WO2006047831A1 (fr) * 2004-11-03 2006-05-11 Agen Biomedical Limited Dispositif et procede de detection
US9201065B2 (en) 2005-11-12 2015-12-01 Platform Diagnostics Limited Agglutination assay
US8048376B2 (en) 2008-03-11 2011-11-01 Ortho-Clinical Diagnostics, Inc. Particle agglutination in a tip
US8273297B2 (en) 2008-03-11 2012-09-25 Ortho-Clinical Diagnostics, Inc. Particle agglutination in a tip
US7850917B2 (en) 2008-03-11 2010-12-14 Ortho-Clinical Diagnostics, Inc. Particle agglutination in a tip
US9034277B2 (en) 2008-10-24 2015-05-19 Honeywell International Inc. Surface preparation for a microfluidic channel
EP2179794A1 (fr) * 2008-10-24 2010-04-28 Honeywell International Inc. Préparation de surface pour un canal microfluidique
US10073093B2 (en) 2013-11-06 2018-09-11 Becton, Dickinson And Company Microfluidic devices, and methods of making and using the same
US10018640B2 (en) 2013-11-13 2018-07-10 Becton, Dickinson And Company Optical imaging system and methods for using the same
US10663476B2 (en) 2013-11-13 2020-05-26 Becton, Dickinson And Company Optical imaging system and methods for using the same
EP2889121A1 (fr) * 2013-12-26 2015-07-01 Fujifilm Corporation Procédé de connexion et procédé de fabrication d'un dispositif à microcanaux
WO2018095829A1 (fr) * 2016-11-23 2018-05-31 Koninklijke Philips N.V. Soudage par ultrasons d'un dispositif microfluidique
US10549480B2 (en) 2016-11-23 2020-02-04 Koninklijke Philips N.V. Ultrasonic welding of a microfluidic device

Also Published As

Publication number Publication date
GB9800263D0 (en) 1998-03-04
BR9906844A (pt) 2002-01-02
AU1976999A (en) 1999-07-26
WO1999035497A3 (fr) 1999-10-28
EP1046035A2 (fr) 2000-10-25
JP2002501173A (ja) 2002-01-15

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