WO1999027930A1 - Thrombin inhibitors - Google Patents

Thrombin inhibitors Download PDF

Info

Publication number
WO1999027930A1
WO1999027930A1 PCT/US1998/025362 US9825362W WO9927930A1 WO 1999027930 A1 WO1999027930 A1 WO 1999027930A1 US 9825362 W US9825362 W US 9825362W WO 9927930 A1 WO9927930 A1 WO 9927930A1
Authority
WO
WIPO (PCT)
Prior art keywords
mammal
blood
pharmaceutically acceptable
compound
6alkyl
Prior art date
Application number
PCT/US1998/025362
Other languages
English (en)
French (fr)
Inventor
Craig Coburn
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809784.3A external-priority patent/GB9809784D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Priority to EP98959636A priority Critical patent/EP1039907A4/en
Priority to CA002309347A priority patent/CA2309347A1/en
Priority to JP2000522916A priority patent/JP2001524522A/ja
Priority to AU15395/99A priority patent/AU741766B2/en
Publication of WO1999027930A1 publication Critical patent/WO1999027930A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PCT/US1998/025362 1997-12-01 1998-11-25 Thrombin inhibitors WO1999027930A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98959636A EP1039907A4 (en) 1997-12-01 1998-11-25 THROMBIN INHIBITORS
CA002309347A CA2309347A1 (en) 1997-12-01 1998-11-25 Thrombin inhibitors
JP2000522916A JP2001524522A (ja) 1997-12-01 1998-11-25 トロンビン阻害剤
AU15395/99A AU741766B2 (en) 1997-12-01 1998-11-25 Thrombin inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6709697P 1997-12-01 1997-12-01
US60/067,096 1997-12-01
GB9809784.3 1998-05-07
GBGB9809784.3A GB9809784D0 (en) 1998-05-07 1998-05-07 Thrombin Inhibitors

Publications (1)

Publication Number Publication Date
WO1999027930A1 true WO1999027930A1 (en) 1999-06-10

Family

ID=26313616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/025362 WO1999027930A1 (en) 1997-12-01 1998-11-25 Thrombin inhibitors

Country Status (5)

Country Link
EP (1) EP1039907A4 (ja)
JP (1) JP2001524522A (ja)
AU (1) AU741766B2 (ja)
CA (1) CA2309347A1 (ja)
WO (1) WO1999027930A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040583A2 (de) * 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5-c]-pyridin-4-on-derivate
EP1124822A1 (en) * 1998-10-30 2001-08-22 Merck & Co., Inc. Thrombin inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
US11926616B2 (en) 2018-03-08 2024-03-12 Incyte Corporation Aminopyrazine diol compounds as PI3K-γ inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001338A1 (en) * 1995-06-27 1997-01-16 Merck & Co., Inc. Pyridinone-thrombin inhibitors
CA2245811A1 (en) * 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BANTICK J R, ET AL.: "NEW NON-PEPTIDE ANGIOTENSIN II RECEPTOR ANTAGONISTS 2: STRUCTURE - ACTIVITY RELATIONSHIPS OF A SERIES OF ANNELATED 2(1H)-PYRIDINONES", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 04, no. 01, 1 January 1994 (1994-01-01), AMSTERDAM, NL, pages 127 - 132, XP002916792, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(01)81134-3 *
BROWN F J, ET AL.: "DESIGN OF ORALLY ACTIVE, NON-PEPTIDE INHIBITORS OF HUMAN LEUKOCYTE ELASTASE", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 37, 1 January 1994 (1994-01-01), US, pages 1259 - 1261, XP002916793, ISSN: 0022-2623, DOI: 10.1021/jm00035a004 *
See also references of EP1039907A4 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1124822A1 (en) * 1998-10-30 2001-08-22 Merck & Co., Inc. Thrombin inhibitors
EP1124822A4 (en) * 1998-10-30 2002-04-03 Merck & Co Inc THROMBIN INHIBITORS
WO2000040583A2 (de) * 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5-c]-pyridin-4-on-derivate
WO2000040583A3 (de) * 1999-01-08 2000-09-21 Merck Patent Gmbh Imidazo[4,5-c]-pyridin-4-on-derivate
US11926616B2 (en) 2018-03-08 2024-03-12 Incyte Corporation Aminopyrazine diol compounds as PI3K-γ inhibitors
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Also Published As

Publication number Publication date
AU1539599A (en) 1999-06-16
EP1039907A1 (en) 2000-10-04
AU741766B2 (en) 2001-12-06
CA2309347A1 (en) 1999-06-10
JP2001524522A (ja) 2001-12-04
EP1039907A4 (en) 2001-09-19

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