WO1999025196A1 - Insectifuge contre insectes hematophages - Google Patents
Insectifuge contre insectes hematophages Download PDFInfo
- Publication number
- WO1999025196A1 WO1999025196A1 PCT/JP1998/005141 JP9805141W WO9925196A1 WO 1999025196 A1 WO1999025196 A1 WO 1999025196A1 JP 9805141 W JP9805141 W JP 9805141W WO 9925196 A1 WO9925196 A1 WO 9925196A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- repellent
- mixture
- blood
- indoor
- valencene
- Prior art date
Links
- 239000000077 insect repellent Substances 0.000 title abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 230000002940 repellent Effects 0.000 claims abstract description 12
- 239000005871 repellent Substances 0.000 claims abstract description 12
- WTOYNNBCKUYIKC-JMSVASOKSA-N (+)-nootkatone Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CC(=O)C=C21 WTOYNNBCKUYIKC-JMSVASOKSA-N 0.000 claims abstract description 11
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 claims abstract description 11
- WTOYNNBCKUYIKC-UHFFFAOYSA-N dl-nootkatone Natural products C1CC(C(C)=C)CC2(C)C(C)CC(=O)C=C21 WTOYNNBCKUYIKC-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 claims abstract description 10
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000443 aerosol Substances 0.000 claims abstract description 6
- 241000607479 Yersinia pestis Species 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000002386 air freshener Substances 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 238000002360 preparation method Methods 0.000 abstract description 5
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 241000255925 Diptera Species 0.000 description 13
- 239000003205 fragrance Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000010632 citronella oil Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 235000007586 terpenes Nutrition 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- -1 terpinene Chemical class 0.000 description 4
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229960001673 diethyltoluamide Drugs 0.000 description 3
- 239000010648 geranium oil Substances 0.000 description 3
- 235000019717 geranium oil Nutrition 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 150000003505 terpenes Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- MFKRHJVUCZRDTF-UHFFFAOYSA-N 3-methoxy-3-methylbutan-1-ol Chemical compound COC(C)(C)CCO MFKRHJVUCZRDTF-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000001846 repelling effect Effects 0.000 description 2
- 229930006978 terpinene Natural products 0.000 description 2
- 150000003507 terpinene derivatives Chemical class 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- XXUNIGZDNWWYED-UHFFFAOYSA-N 2-methylbenzamide Chemical compound CC1=CC=CC=C1C(N)=O XXUNIGZDNWWYED-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- TYRTXVSUGJUNBU-UHFFFAOYSA-N Valencen Natural products CC1CC=CC2CCC(CC12C)C(=C)C TYRTXVSUGJUNBU-UHFFFAOYSA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000010651 grapefruit oil Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 description 1
- 229960003988 indigo carmine Drugs 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000002667 nucleating agent Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- BXDAOUXDMHXPDI-UHFFFAOYSA-N trifluoperazine hydrochloride Chemical compound [H+].[H+].[Cl-].[Cl-].C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 BXDAOUXDMHXPDI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
- A01M3/00—Manual implements, other than sprayers or powder distributors, for catching or killing insects, e.g. butterfly nets
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
Definitions
- the present invention relates to a blood-sucking pest repellent for indoor space, which contains nutkaton, valencene or a mixture thereof.
- mosquito repellent As the typical blood-sucking pests that occur during the summer season, the mosquito repellent, the mosquito repellent, and the chikae mosquito are known.
- mosquito coils, matsut-type and liquid-type electric mosquito filters are used to escape from the blood-feeding damage of these pests. It is commonly used.
- These preparations exhibit the mosquito-repelling effect by burning or heating to volatilize the active ingredient into the air.However, such a method involves burning, heating or smoking even at bedtime, so heat is applied.
- the present inventors have conducted various studies on the repellent effect of volatile terpene-based substances on blood-sucking pests. The space was created, and it was found that it has a higher repellent effect than getyl toluamide (DEET), which is a typical repellent in recent years, and a fragrance composition having a mosquito repellent effect, and the present invention was completed based on these findings.
- DEET getyl toluamide
- the present invention provides a blood-sucking insect repellent for indoor space, which comprises nootkatone, valencene or a mixture thereof as an active ingredient.
- Noot power and valencene used in the present invention are compounds obtained according to a general separation and purification method of terpenes from natural products such as grapefruit oil, and compounds obtained by organic synthesis and the like can also be used.
- the blood-sucking pest repellent of the present invention creates a space for repelling pests such as mosquitoes, and is usually held in a liquid, solid, gel or gaseous carrier to provide indoor fragrances and aerosols. It is formulated into tablets, sheets, paints, etc. and applied.
- the amount of nootkatone, valencene or a mixture thereof in the blood-sucking insect repellent is determined as appropriate depending on the dosage form and application place, and is not particularly limited, but is based on nootkatone, valencen or a mixture thereof
- the repellent effect of mosquitoes depends on the air concentration, and the effect is exhibited at 0.4 g Z cm 3 , and the excellent effect is obtained at 0.4 g / cm 3 or more. It is desirable to prepare a preparation so that the weight of the preparation is 0.4 g / cm 3 or more.
- a nucleating agent, valencene or a mixture thereof of 5% by weight or more for an indoor fragrance and 0.1% by weight or more for an aerosol is used. It is preferable to mix them.
- the blood-sucking insect repellent of the present invention may contain a pyrethroid-based insecticide such as empentrin, a bactericide, a fungicide, an antioxidant, a coloring agent and various flavor components for flavoring. it can.
- FIG. 1 illustrates the method of Test Example 1.
- the blood-sucking insect repellent of the present invention can easily create a safe and safe space for repelling blood-sucking pests by having nootkatone, valencene or a mixture thereof at a certain concentration or higher.
- the present invention will be described specifically with reference to Examples and Test Examples, but the present invention is not limited to the following Examples.
- Nootkatone (1 g) and alcohol (25 g) were mixed, placed in a pressure vessel, and the propellant (275 g) was cooled or pressure-filled, and an injection port was attached to obtain an aerosol.
- This aerosol can be attached to an automatic sprayer with a timer and used as a regular sprayer.
- a liquid was obtained by mixing and stirring 10 g of noot force, 100 g of an 80% aqueous alcohol solution and 60 g of 3-methoxy-3-methyl-1-butanol.
- the liquid was filled in a closed container with a lid, and a rod-shaped liquid absorbing core was inserted into the lid to obtain a liquid indoor fragrance.
- a 10% solution of nutkatone, valencene, and a control sample dissolved in alcohol and add 0.1 ml of the solution to a filter paper with a diameter of 11 cm (Toyo Roshi Kaisha, Ltd.).
- a filter paper with a diameter of 11 cm (Toyo Roshi Kaisha, Ltd.).
- the wall of 20 female adult females of Aegypti is attached to the top of a flexible plastic net cage (30 cm square).
- the cage is placed in a plastic bag with an inner volume of 4500 cm 3 , a mouse fixed with a wire mesh is placed under the cage, and the mouth of the plastic bag is closed. After that, observe the number of mosquitoes that fly and the behavior.
- Example 2 The room air freshener of Example 2 is placed in a test box on the right side of three connected 0.5 m3 test boxes. Put the mouse fixed with wire mesh and the cup filled with water in the left and right test boxes, and release 50 cacaecames into the center test box. Then observe the number of mosquitoes in each box and their behavior.
- control samples terpene aldehydes citronella oil and geranidium oil, which are known to have a mosquito repellent effect, and DEET, a typical repellent, were prepared using indoor fragrances prepared in the same manner as in Example 2. Tested. As a blank, an indoor fragrance prepared only with alcohol was used. Table 2 shows the number of mosquitoes in each test box 1 hour and 4 hours later, and Table 3 shows the total number of mosquitoes that flew to each test box 1 hour after the start of the test. Table 2. Number of mosquitoes in each test box
- a blood-sucking pest repellent for indoor space which is excellent in safety and effect.
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Insects & Arthropods (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
Description
明細書 吸血害虫忌避剤 技術分野
本発明はヌ一トカ トン、 バレンセンまたはこれらの混合物を配合した 屋内空間用吸血害虫忌避剤に関するものである。 背景技術
夏期に発生する代表的な吸血害虫としてはァカイエ力、 ヒ トスジシマ 力、 チカイエ力等が知られており、 一般家庭ではこれら害虫の吸血被害 から逃れるために蚊取り線香、 マツ ト式および液体式電気蚊取りが汎用 されている。 これらの製剤は、 燃焼あるいは加熱により有効成分を空中 に揮散させて、 蚊取り効果を発揮するものであるが、 このような方法で は就寝中も燃焼、 加熱あるいは発煙をともなうことから、 熱を加えない で容易に揮散する、 シトラ一ル、 シトロネラールを含むテルペン系アル デヒ ド、 リモネン、 テルピネンを含むテルペン系炭化水素等の蚊取り効 果のある香料組成物を利用する方法が提案されている （特開平 3— 2 8 5 9 9 3号公報） 。
しかしながら、 蚊取り効果のある上記香料組成物を用いた製剤では、 蚊取り効果および忌避効果は満足できるものではなかった。 発明の開示
本発明者らは、 揮発性テルペン系物質の吸血害虫に対する忌避効果を 種々検討した結果、 柑橘類精油中より見いだされ、 飲料などのフレーバ 一に用いられるバレンセンおよびヌート力 トンが、 吸血害虫の忌避する
空間を作り出し、 近年の代表的な忌避剤であるジェチルトルアミ ド （D E E T ) および蚊取り効果のある香料組成物より高い忌避効果を有する ことを見いだし、 これらの知見を基に本発明を完成した。
すなわち本発明は、 ヌートカ トン、 バレンセンまたはこれらの混合物 を有効成分として含有することを特徴とする屋内空間用吸血害虫忌避剤 を提供するものである。
本発明に用いるヌート力 トンおよびバレンセンは、 グレープフルーツ 油等の天然物より一般のテルペン類の分離 · 精製法に準じて得られる化 合物であり、 有機合成などにより得られる化合物も用いることができる。 本発明の吸血害虫忌避剤は、 蚊等の吸血害虫に対する忌避空間を作り 出すものであり、 通常は液状、 固体状、 ゲル状またはガス状の担体に保 持させて、 室内芳香剤、 エアゾール剤、 シート、 塗料等に製剤化されて 施用される。 吸血害虫忌避剤中のヌートカ トン、 バレンセンまたはこれ らの混合物の配合量は、 剤型および適用場所に応じて適宜決定し、 特に 制限されるわけではないが、 ヌートカ トン、 バレンセンまたはこれらの 混合物による蚊の忌避効果は気中濃度に依存し、 0 . 4 g Z c m 3で効 果を発現して 0 . マ 11 g / c m 3以上で優れた効果が得られることから、 これらを気中濃度で 0 . 4 g / c m 3以上となるように製剤を調製する ことが望ましい。 このような気中濃度を得るためには、 例えば室内芳香 剤の場合には 5重量％以上、 エアゾール剤の場合には 0 . 1重量％以上 のヌ一卜力 トン、 バレンセンまたはこれらの混合物を配合することが好 ましい。
また、 本発明の吸血害虫忌避剤には、 ェンペントリ ン等のピレスロイ ド系殺虫剤、 殺菌剤、 防かび剤、 酸化防止剤、 着色料および調香のため の各種香料成分等を配合することができる。
図面の簡単な説明
第 1図は試験例 1の方法を図示したものである。 発明を実施するための最良の形態
本発明にかかる吸血害虫忌避剤は、 ヌートカ トン、 バレンセンまたは これらの混合物を一定濃度以上で存在させることにより、 容易に安全性 に優れた吸血害虫が忌避する空間を作ることができる。 以下に実施例お よび試験例を示し、 本発明を具体的に説明するが、 本発明は下記の実施 例に制限されるものではない。 実施例 1
ヌートカ トン l g、 アルコール 2 5 gを混合して耐圧容器にとり、 噴 射剤 2 7 5 gを冷却または圧力充填し、 噴射口を取り付けてエアゾール 剤を得た。 本エアゾールはタイマー付き自動噴霧装置に装着し、 定時噴 霧装置として用いることもできる。 実施例 2
ヌート力 トン 1 0 g、 アルコール 8 0 %水溶液 6 0 gおよび 3—メ ト キシ— 3—メチル— 1 —ブ夕ノール 4 0 gを混合攪拌して液剤を得た。 液剤を蓋付き密閉容器に充填し、 棒状の吸液芯を蓋に差し込み液体の室 内芳香剤を得た。 実施例 3
カラギーナン 2 g、 口一カス 卜ビーンガム 0 . 5 g、 プロピレンダリ コール 5 gに精製水 8 0 gを混合加熱して融解したものに、 塩化ベンザ ルコニゥム 0 . l g、 インジゴカルミン 0 . 0 5 gおよびヌートカ トン
5 gを加え、 容器に移して冷却成型し固形の室内芳香剤を得た。 実施例 4
カラギーナン 1. 5 g、 塩化カリウム 0. 2 5 g、 3—メ トキシー 3 —メチル— 1—ブ夕ノール 1 5 g、 塩化べンゼトニゥム 0. l g、 夕一 トラジン 0. 0 1 gに精製水 6 7. 1 4 gを混合加熱して融解したもの に、 硬化ヒマシ油 6 g、 ヌートカ トン 1 0 gを添加混合した後、 容器に 移して冷却成型し固形の室内芳香剤を得た。 試験例 1
ヌ一トカ トン、 バレンセンおよび対照試料をアルコールに溶解した 1 0 %溶液を調製し、 直径 1 1 c mのろ紙 （東洋濾紙株式会社） に 0. 1 m l滴下する。 次に図 1に示すように、 ヒ トスジシマ力メス成虫が 2 0 頭入った壁面が柔軟なプラスチック網製のケージ （ 3 0 c m四方） 上部 に貼付する。 該ケージを内容積 4 5 0 0 0 c m3のビニール袋に入れ、 ケ ージの下に金網で固定したマウスを設置して、 ビニール袋の口を閉じる。 その後、 吸血に飛来する蚊の数およびその行動を観察する。 また、 対照 試料として蚊取り効果が知られているテルペン系アルデヒ ドのシトロネ ラオイルおよびゼラニゥムオイル、 代表的な忌避剤である D E E Tを各 々上記と同様に 0. 1 m 1滴下したろ紙を用いて試験した。 ブランクと しては、 アルコールのみを滴下したろ紙を用いた。 表 1に一定時間経過 後に飛来した蚊の頭数を示す。
表 1 . 吸血に飛来する蚊の頭数 試料 5分後 1 0分後 ヌートカ トン 0 0 バレンセン 0 1 シトロネラオイル 1 0 8 ゼラニゥムオイル 4 2
D E E T 3 5 ブランク 1 0 7
試験例 2
実施例 2の室内芳香剤を連結された 3個の容積 0 . 5 m 3試験箱の右側 試験箱に設置する。 左右の試験箱に金網で固定したマウスおよび水の入 つたカツプを入れて、 中央の試験箱に 5 0頭のァカイエカメスを放す。 その後、 各箱の蚊の頭数およびその行動を観察する。 また、 対照試料と して蚊取り効果が知られているテルペン系アルデヒ ドのシトロネラオイ ルおよびゼラニゥムオイル、 代表的な忌避剤である D E E Tを各々実施 例 2 と同様にして調製した室内芳香剤を用いて試験した。 ブランクとし ては、 アルコールのみで調製した室内芳香剤を用いた。 表 2には 1時間 後および 4時間後の各試験箱中の蚊の頭数、 表 3には各試験箱に試験開 始から 1時間迄に飛来した蚊ののべ頭数を示す。
表 2 . 各試験箱中の蚊の頭数
1時間後 4時間後 試料
左 中 右 左 中 右 ヌ一卜カ トン 3 0 2 0 0 3 8 1 2 0 シトロネラオイル 2 3 1 8 9 2 0 1 6 1 4 ゼラニゥムオイル 2 2 2 0 8 2 6 1 3 1 1
D E E T 2 5 1 5 1 0 2 5 8 1 7 ブランク 2 0 8 2 2 2 5 2 2 3
表 3 . 各試験箱への蚊ののべ飛来数
試料 左 中 右 ヌ一卜カ トン 9 5 5 6 2 シトロネラオイル 7 8 5 9 2 8 ゼラニゥムオイル 8 5 6 2 2 1
D E E T 6 9 7 1 3 8 ブランク 8 2 7 1 7 9
産業上の利用可能性
安全性および効果に優れた屋内空間用吸血害虫忌避剤を提供する。
Claims
1 . ヌートカ トン、 バレンセンまたはこれらの混合物を有効成分として 含有することを特徴とする屋内空間用吸血害虫忌避剤。
2 . ヌ一トガトン、 バレンセンまたはこれらの混合物を 5重量％以上配 合したことを特徴とする室内芳香剤。
3 . ヌートカ トン、 ノ レンセンまたはこれらの混合物を 0 . 1重量％以 上配合したことを特徴とするエアゾール剤。
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020007005306A KR20010032119A (ko) | 1997-11-17 | 1998-11-16 | 흡혈해충기피제 |
| EP98953056A EP1033076A4 (en) | 1997-11-17 | 1998-11-16 | MEANS TO DISPOSE BLOOD-SUCTION INSECTS |
| AU10536/99A AU1053699A (en) | 1997-11-17 | 1998-11-16 | Hematophagous insect repellent |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31498897 | 1997-11-17 | ||
| JP9/314988 | 1997-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1999025196A1 true WO1999025196A1 (fr) | 1999-05-27 |
Family
ID=18060067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1998/005141 WO1999025196A1 (fr) | 1997-11-17 | 1998-11-16 | Insectifuge contre insectes hematophages |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1033076A4 (ja) |
| KR (1) | KR20010032119A (ja) |
| CN (1) | CN1282219A (ja) |
| AU (1) | AU1053699A (ja) |
| WO (1) | WO1999025196A1 (ja) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001028343A1 (en) * | 1999-10-19 | 2001-04-26 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Vetiver oil extracts as termite repellent and toxicant |
| US6890960B1 (en) | 1999-10-19 | 2005-05-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Vetiver oil extracts as termite repellent and toxicant |
| US7629387B2 (en) * | 2000-12-08 | 2009-12-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compounds for pest control and methods for their use |
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| US7230033B2 (en) | 2000-12-08 | 2007-06-12 | United States of America as represented by the Secretary of the Department of Health and Human Services, Center for Disease Control and Prevention | Pest control compositions and methods for their use |
| US6906108B2 (en) | 2001-08-17 | 2005-06-14 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Extracts of vetiver oil as repellent and toxicant to ants, ticks, and cockroaches |
| US6897244B2 (en) | 2002-07-03 | 2005-05-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Dihydronootkatone and tetrahydronootkatone as repellents to arthropods |
| US7442785B2 (en) | 2003-07-24 | 2008-10-28 | The University Of Kentucky Research Foundation | Sesquiterpene synthase gene and protein |
| US20150250166A1 (en) * | 2012-08-23 | 2015-09-10 | Allylix, Inc. | Nootkatone as an insecticide and insect repellent |
| SG11201701278RA (en) | 2014-08-21 | 2017-03-30 | Manus Biosynthesis Inc | Methods for production of oxygenated terpenes |
| EP3432711A1 (en) | 2016-03-24 | 2019-01-30 | Evolva SA | Methods and compositions for the prevention of infections and arthropod infestation |
| EP3432710A1 (en) | 2016-03-24 | 2019-01-30 | Evolva SA | Compositions and methods for treating and preventing dust mite infestation |
| WO2017162887A1 (en) | 2016-03-24 | 2017-09-28 | Evolva Sa | Use of nootkatone to kill sap-sucking insects |
| BR112019004120A2 (pt) * | 2016-09-02 | 2019-05-28 | Evolva Sa | uso de nootkatone para tratar e impedir infestações de mosquito |
| WO2018042023A1 (en) * | 2016-09-02 | 2018-03-08 | Evolva Sa | Use of nootkatone as a larvicide |
| WO2018051344A1 (en) * | 2016-09-14 | 2018-03-22 | Grace Breeding Ltd. | Compositions comprising a non-pathogenic bacteria and methods for protecting plant and animal hosts from fungal, bacterial and viral diseases |
| WO2018140732A1 (en) | 2017-01-27 | 2018-08-02 | Bedoukian Research, Inc. | Formulations for control and repellency of biting arthropods |
| WO2018178322A1 (en) * | 2017-03-31 | 2018-10-04 | Evolva Sa | Use of nootkatone to treat infections caused by nematodes, trematodes, cestodes, or endoparasitic helminths |
| WO2022147076A1 (en) * | 2020-12-29 | 2022-07-07 | Manus Bio Inc. | Insect repellent compositions |
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- 1998-11-16 KR KR1020007005306A patent/KR20010032119A/ko not_active Application Discontinuation
- 1998-11-16 WO PCT/JP1998/005141 patent/WO1999025196A1/ja not_active Application Discontinuation
- 1998-11-16 AU AU10536/99A patent/AU1053699A/en not_active Abandoned
- 1998-11-16 CN CN98812443A patent/CN1282219A/zh active Pending
- 1998-11-16 EP EP98953056A patent/EP1033076A4/en not_active Withdrawn
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001028343A1 (en) * | 1999-10-19 | 2001-04-26 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Vetiver oil extracts as termite repellent and toxicant |
| AU771326B2 (en) * | 1999-10-19 | 2004-03-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The | Vetiver oil extracts as termite repellent and toxicant |
| US6890960B1 (en) | 1999-10-19 | 2005-05-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Vetiver oil extracts as termite repellent and toxicant |
| US7629387B2 (en) * | 2000-12-08 | 2009-12-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compounds for pest control and methods for their use |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010032119A (ko) | 2001-04-16 |
| EP1033076A1 (en) | 2000-09-06 |
| AU1053699A (en) | 1999-06-07 |
| CN1282219A (zh) | 2001-01-31 |
| EP1033076A4 (en) | 2001-04-11 |
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