WO1999010480A3 - Nouvelles calpaines specifiques au tissu, leur production et leur utilisation - Google Patents

Nouvelles calpaines specifiques au tissu, leur production et leur utilisation Download PDF

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Publication number
WO1999010480A3
WO1999010480A3 PCT/EP1998/005275 EP9805275W WO9910480A3 WO 1999010480 A3 WO1999010480 A3 WO 1999010480A3 EP 9805275 W EP9805275 W EP 9805275W WO 9910480 A3 WO9910480 A3 WO 9910480A3
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WO
WIPO (PCT)
Prior art keywords
calpaines
production
specific
new tissue
new
Prior art date
Application number
PCT/EP1998/005275
Other languages
German (de)
English (en)
Other versions
WO1999010480A2 (fr
Inventor
Thomas Boehm
Neil T Dear
Original Assignee
Basf Ag
Thomas Boehm
Neil T Dear
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Thomas Boehm, Neil T Dear filed Critical Basf Ag
Priority to AU92635/98A priority Critical patent/AU9263598A/en
Priority to CA002301815A priority patent/CA2301815A1/fr
Priority to EP98945265A priority patent/EP1009811A2/fr
Priority to IL13436198A priority patent/IL134361A0/xx
Priority to BR9811365-8A priority patent/BR9811365A/pt
Priority to JP2000507788A priority patent/JP2001513992A/ja
Priority to HU0004027A priority patent/HUP0004027A2/hu
Priority to KR1020007001916A priority patent/KR20010023282A/ko
Publication of WO1999010480A2 publication Critical patent/WO1999010480A2/fr
Publication of WO1999010480A3 publication Critical patent/WO1999010480A3/fr
Priority to NO20000961A priority patent/NO20000961L/no

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)

Abstract

L'invention concerne de nouvelles calpaines spécifiques au tissu, leur production et leur utilisation. L'invention concerne également un procédé de tri de nouveaux inhibiteurs de calpaines et leur utilisation.
PCT/EP1998/005275 1997-08-26 1998-08-19 Nouvelles calpaines specifiques au tissu, leur production et leur utilisation WO1999010480A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU92635/98A AU9263598A (en) 1997-08-26 1998-08-19 New tissue-specific calpaines, their production and their use
CA002301815A CA2301815A1 (fr) 1997-08-26 1998-08-19 Nouvelles calpaines specifiques au tissu, leur production et leur utilisation
EP98945265A EP1009811A2 (fr) 1997-08-26 1998-08-19 Nouvelles calpaines specifiques au tissu, leur production et leur utilisation
IL13436198A IL134361A0 (en) 1997-08-26 1998-08-19 New tissue-specific calpaines, their production and their use
BR9811365-8A BR9811365A (pt) 1997-08-26 1998-08-19 Gene de calpaìna capn6, construção de gene, sequência de aminoácidos, processos para identificar inibidores de calpaìna e para preparar a enzima capn6 e suas variantes ou análogos alélicos, e, usos de um inibidor de calpaìna, de uma sequência de aminoácidos e de genes, do mrna anti-sentido e de um gene de calpaìna e suas variantes ou análogos alélicos
JP2000507788A JP2001513992A (ja) 1997-08-26 1998-08-19 新規の組織特異的カルパイン、その製造およびその使用
HU0004027A HUP0004027A2 (en) 1997-08-26 1998-08-19 New tissue-specific calpaines, their production and their use
KR1020007001916A KR20010023282A (ko) 1997-08-26 1998-08-19 신규 조직 특이적 칼파인, 그의 제조 방법 및 용도
NO20000961A NO20000961L (no) 1997-08-26 2000-02-25 Nye vevs-spesifikke calpainer, samt fremgangsmåte for fremstilling og anvendelse derav

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19737105A DE19737105A1 (de) 1997-08-26 1997-08-26 Neue gewebsspezifische Calpaine, ihre Herstellung und Verwendung
DE19737105.1 1997-08-26

Publications (2)

Publication Number Publication Date
WO1999010480A2 WO1999010480A2 (fr) 1999-03-04
WO1999010480A3 true WO1999010480A3 (fr) 1999-05-27

Family

ID=7840195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005275 WO1999010480A2 (fr) 1997-08-26 1998-08-19 Nouvelles calpaines specifiques au tissu, leur production et leur utilisation

Country Status (13)

Country Link
EP (1) EP1009811A2 (fr)
JP (1) JP2001513992A (fr)
KR (1) KR20010023282A (fr)
CN (1) CN1277634A (fr)
AU (1) AU9263598A (fr)
BR (1) BR9811365A (fr)
CA (1) CA2301815A1 (fr)
DE (1) DE19737105A1 (fr)
HU (1) HUP0004027A2 (fr)
IL (1) IL134361A0 (fr)
NO (1) NO20000961L (fr)
WO (1) WO1999010480A2 (fr)
ZA (1) ZA987660B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19928021A1 (de) * 1999-06-18 2000-12-21 Basf Ag Neue Calpaine und deren Verwendung
AU7476900A (en) * 1999-09-09 2001-04-10 Millennium Pharmaceuticals, Inc. 26176, a novel calpain protease and uses thereof
AU4422401A (en) * 2000-03-28 2001-10-08 Bayer Aktiengesellschaft Regulation of human neutral protease-related enzyme
AUPQ656500A0 (en) * 2000-03-28 2000-04-20 Autogen Pty Ltd A method of treatment and agents for same
WO2002081684A2 (fr) * 2001-04-04 2002-10-17 Universite De Montreal Nucleotides de calpaine antisens et utilisations correspondantes
JP4593404B2 (ja) * 2005-08-29 2010-12-08 シスメックス株式会社 液体試料吸引監視方法及び装置、並びに液体試料分析装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002634A1 (fr) * 1994-07-15 1996-02-01 Cephalon, Inc. Calpaine active exprimee par un baculovirus
EP0799892A2 (fr) * 1996-04-05 1997-10-08 Takeda Chemical Industries, Ltd. Calpain, sa préparation et son utilisation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002634A1 (fr) * 1994-07-15 1996-02-01 Cephalon, Inc. Calpaine active exprimee par un baculovirus
EP0799892A2 (fr) * 1996-04-05 1997-10-08 Takeda Chemical Industries, Ltd. Calpain, sa préparation et son utilisation

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE TREMBL PROTEIN SEQUE 1 January 1900 (1900-01-01), XP002097046, Database accession no. O35646 *
EMBL Datenbank Emhum1, Eingang Af029232 Zugriffsnummer Af029232, 20.November 1997 Crotty P.L.: *
EMBL Datenbank Emhum1, Eingang Hscanpx Zugriffsnummer AJ000388, 22. Juli 1997 Belsito et al.: 'A novel X-linked calpain-like protease'; unpublished *
EMBL Datenbank Emrod, Eingang Af067793 Zugriffsnummer Af067793, 11. Juni 1998 Shimizu T.: 'Cellular genes modulated by transactivator Tax of HTLV1'; unpublished *
EMBL Datenbank Emrod, Eingang Mmcalpain Zugriffsnummer Y12582, 1. July 1997 Matena et al. "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily" *
MATENA ET AL.: "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily", GENOMICS, vol. 48, 1998, pages 117 - 120 *
MATENA ET AL.: "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily", GENOMICS, vol. 48, 1998, pages 117 - 120, XP002097044 *
SUZUKI K ET AL: "CALPAIN: NOVEL FAMILY MEMBERS, ACTIVATION, AND PHSIOLOGICAL FUNCTION", BIOLOGICAL CHEMISTRY HOPPE-SEYLER, vol. 376, September 1995 (1995-09-01), pages 523 - 529, XP002061847 *
WANG K K W ET AL: "CALPAIN INHIBITION: AN OVERVIEW OF ITS THERAPEUTIC POTENTIAL", TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 15, 1 November 1994 (1994-11-01), pages 412 - 417, XP000568894 *

Also Published As

Publication number Publication date
EP1009811A2 (fr) 2000-06-21
NO20000961D0 (no) 2000-02-25
IL134361A0 (en) 2001-04-30
ZA987660B (en) 2000-02-25
NO20000961L (no) 2000-04-14
CN1277634A (zh) 2000-12-20
WO1999010480A2 (fr) 1999-03-04
DE19737105A1 (de) 1999-03-04
KR20010023282A (ko) 2001-03-26
BR9811365A (pt) 2000-08-22
HUP0004027A2 (en) 2001-03-28
JP2001513992A (ja) 2001-09-11
CA2301815A1 (fr) 1999-03-04
AU9263598A (en) 1999-03-16

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