WO1999006561A3 - Chemokine receptor ccr8 dna and uses thereof - Google Patents
Chemokine receptor ccr8 dna and uses thereof Download PDFInfo
- Publication number
- WO1999006561A3 WO1999006561A3 PCT/US1998/015730 US9815730W WO9906561A3 WO 1999006561 A3 WO1999006561 A3 WO 1999006561A3 US 9815730 W US9815730 W US 9815730W WO 9906561 A3 WO9906561 A3 WO 9906561A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ccr8
- hiv
- infection
- human
- chemokine receptor
- Prior art date
Links
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- 102100036305 C-C chemokine receptor type 8 Human genes 0.000 abstract 6
- 101000716063 Homo sapiens C-C chemokine receptor type 8 Proteins 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 5
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 4
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 230000034217 membrane fusion Effects 0.000 abstract 2
- 102000011005 CC chemokine receptor 8 Human genes 0.000 abstract 1
- 108010017148 CCR8 Receptors Proteins 0.000 abstract 1
- 108091006027 G proteins Proteins 0.000 abstract 1
- 102000030782 GTP binding Human genes 0.000 abstract 1
- 108091000058 GTP-Binding Proteins 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU86695/98A AU8669598A (en) | 1997-07-29 | 1998-07-29 | Chemokine receptor ccr8 dna and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5409497P | 1997-07-29 | 1997-07-29 | |
US60/054,094 | 1997-07-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999006561A2 WO1999006561A2 (en) | 1999-02-11 |
WO1999006561A3 true WO1999006561A3 (en) | 1999-04-22 |
Family
ID=21988764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/015730 WO1999006561A2 (en) | 1997-07-29 | 1998-07-29 | Chemokine receptor ccr8 dna and uses thereof |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU8669598A (en) |
WO (1) | WO1999006561A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
FR2771423A1 (en) * | 1997-11-21 | 1999-05-28 | Transgene Sa | Recombinant viral vector expressing polypeptide that inhibits viral binding |
WO2001058484A2 (en) * | 2000-02-10 | 2001-08-16 | Schering Corporation | Novel uses of mammalian ccr8 receptors and related reagents |
US6762341B2 (en) | 2000-02-10 | 2004-07-13 | Schering Corporation | Uses of mammalian CCR8 receptors and related reagents |
WO2002022651A2 (en) * | 2000-09-15 | 2002-03-21 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the ccr8 gene |
EP1432801A2 (en) * | 2001-02-06 | 2004-06-30 | Incyte Genomics, Inc. | Receptors and membrane-associated proteins |
AU2003229753A1 (en) * | 2002-05-13 | 2003-11-11 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with chemokine receptor 8 (ccr8) |
WO2007044756A2 (en) * | 2005-10-11 | 2007-04-19 | Icos Corporation | Monoclonal antibodies recognizing human ccr8 |
CA3023980A1 (en) * | 2016-05-16 | 2017-11-23 | Checkmab S.R.L. | Markers selectively deregulated in tumor-infiltrating regulatory t cells |
BR112021011431A2 (en) * | 2018-12-27 | 2021-11-23 | Univ Osaka | Monoclonal antibody or an antibody fragment thereof that binds to ccr8, its use, as well as pharmaceutical composition, polynucleotide, expression vector and kit |
EP3935151A1 (en) | 2019-03-08 | 2022-01-12 | Klinikum der Universität München | Ccr8 expressing lymphocytes for targeted tumor therapy |
JP2023546121A (en) * | 2020-10-16 | 2023-11-01 | ラノバ メディシンズ リミテッド | Anti-CCR8 monoclonal antibody and its use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996039434A1 (en) * | 1995-06-05 | 1996-12-12 | Human Genome Sciences, Inc. | Human g-protein receptor hgber32 |
-
1998
- 1998-07-29 WO PCT/US1998/015730 patent/WO1999006561A2/en active Application Filing
- 1998-07-29 AU AU86695/98A patent/AU8669598A/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996039434A1 (en) * | 1995-06-05 | 1996-12-12 | Human Genome Sciences, Inc. | Human g-protein receptor hgber32 |
Non-Patent Citations (8)
Title |
---|
BERNARDINI, G. ET AL.: "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, no. 2, February 1998 (1998-02-01), pages 582 - 588, XP002092743 * |
HORUK, R. ET AL.: "The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains", JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS), vol. 273, no. 1, 2 January 1998 (1998-01-02), MD US, pages 386 - 391, XP002092742 * |
ROOS, R. STUBER ET AL.: "Identification of CCR8, the receptor for the human CC Chemokine I-309", JOURNAL OF BIOLOGICAL CHEMISTRY (MICROFILMS), vol. 272, no. 28, 11 July 1997 (1997-07-11), MD US, pages 17251 - 17257, XP002092741 * |
RUCKER, J. ET AL.: "Utilization of chemokine receptors, orphan receptors, and Herpesvirus-encoded receptors by diverse Human and Simian Immunodeficiency Viruses", JOURNAL OF VIROLOGY., vol. 71, no. 12, December 1997 (1997-12-01), ICAN SOCIETY FOR MICROBIOLOGY US, pages 8999 - 9007, XP002092744 * |
SAMSON, M. ET AL.: "Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 26, 1996, pages 3021 - 3028, XP002092740 * |
TIFFANY, H. L. ET AL.: "A model system for inducible expression of the CC chemokine receptors CCR1, CCR3 and CCR8", JOURNAL OF LEUKOCYTE BIOLOGY, no. suppl, December 1997 (1997-12-01), pages 7, XP002092745 * |
TIFFANY, H. L. ET AL.: "Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 186, no. 1, 7 July 1997 (1997-07-07), pages 165 - 170, XP002092538 * |
ZABALLOS A ET AL: "MOLECULAR CLONING AND RNA EXPRESSION OF TWO NEW HUMAN CHEMOKINE RECEPTOR-LIKE GENES", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 227, no. 3, 23 October 1996 (1996-10-23), pages 846 - 853, XP002055490 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999006561A2 (en) | 1999-02-11 |
AU8669598A (en) | 1999-02-22 |
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